Association between the ABCA1 (R219K) polymorphism and lipid profiles: a meta-analysis

AbstractConflicting evidence was found about the relationship between lipid profiles and R219K polymorphism in adenosine triphosphate-binding cassette exporter A1 (ABCA1) gene. In this study, four meta-analyses were conducted to assess the effect of R219K on lipid levels, including high-density lipoprotein cholesterol (HDLC), low-density lipoprotein cholesterol, total cholesterol, and triglycerides (TG). A total of 125 samples of 87 studies (about 60,262 subjects) were included. The effect of each study was expressed using the standard mean difference (SMD) and 95% confidence interval (95% CI) and pooled by meta-analysis in the random-effects model. Subgroup and meta-regression analyses were conducted to explore potential heterogeneity sources. The overall pooled effect showed the following results. (1) The R219K was significantly associated with HDLC level (SMD = − 0.25 mmol/L, 95%CI − 0.32 to − 0.18, z = − 6.96, P < 0.01, recessive genetic model). People with different genotypes had significantly different HDLC levels under the recessive, codominant and dominant genetic models (all Ps < 0.01). (2) A weak and indeterminate relationship between R219K and TG level was observed (SMD = 0.18 mmol/L, 95%CI 0.06–0.30, z = 3.01, P < 0.01, recessive genetic model). These findings suggested that R219K was associated with HDLC and TG levels, which might implicate a promising clinical application for lipid-related disorders, though the influences of race, health status, BMI, and other heterogeneity sources should be considered when interpreting current findings. The protocol was registered at PROSPERO (registration number: CRD42021231178).

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The Effect of Helicobacter pylori Eradication on Lipid Levels: A Meta-Analysis

Journal of Clinical Medicine ◽

10.3390/jcm10050904 ◽

2021 ◽

Vol 10 (5) ◽

pp. 904

Author(s):

Jun Watanabe ◽

Masato Hamasaki ◽

Kazuhiko Kotani

Keyword(s):

Helicobacter Pylori ◽

Cardiovascular Diseases ◽

Meta Analysis ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Lipoprotein Cholesterol ◽

Lipid Levels ◽

Pubmed Database ◽

H Pylori ◽

Meta Analyses

Introduction: Helicobacter pylori (H. pylori) infection is positively associated with cardiovascular diseases, but the involvement of lipids in this association remains unclear. The present study reviewed the changes in circulating lipid levels following H. pylori eradication. Methods: A PubMed database was searched until December 2020 to identify randomized control trials (RCTs) and non-RCTs investigating the effect of H. pylori eradication on the lipid levels in inverse variance-weighted, random-effects meta-analyses. Results: A total of 24 studies (four RCTs and 20 non-RCTs) with 5270 participants were identified. The post-eradication levels were increased for high-density lipoprotein cholesterol (HDL-C; mean difference (MD) 2.28 mg/dL, 95% confidence interval (CI) 1.90 to 2.66) and triglyceride (TG; MD 3.22 mg/dL, 95% CI 1.13 to 5.31) compared with the pre-eradication levels. H. pylori eradication resulted in little to no difference in the low-density lipoprotein-cholesterol levels (MD −2.33 mg/dL, 95% CI −4.92 to 0.26). In the analyses of RCTs only, the findings for elevated HDL-C levels, but not TG, were robust. Conclusions: H. pylori eradication increases the HDL-C levels. Further studies are needed to elucidate the effects of lipid changes following H. pylori eradication on cardiovascular diseases.

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Maternal lipid profile and risk of pre-eclampsia in African pregnant women: A systematic review and meta-analysis

PLoS ONE ◽

10.1371/journal.pone.0243538 ◽

2020 ◽

Vol 15 (12) ◽

pp. e0243538

Author(s):

Endalamaw Tesfa ◽

Endalkachew Nibret ◽

Abaineh Munshea

Keyword(s):

Pregnant Women ◽

Meta Analysis ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Hdl Cholesterol ◽

Lipid Profiles ◽

Maternal Serum ◽

Lipoprotein Cholesterol ◽

Low Density Lipoprotein Cholesterol ◽

Standardized Mean Difference

Introduction Some studies have reported the association between maternal serum lipid profile abnormalities and pre-eclampsia. However, many studies have reported controversial results. Hence, this systematic review and meta-analysis was planned to generate summarized evidence on the association between maternal serum lipid profiles and pre-eclampsia in African women. Methods Four electronic databases such as; PubMed, Hinari, Google Scholar, and African Journals Online were searched for studies published in English. Joanna Briggs Institute Meta-Analysis of Statistics Assessment and Review Instrument and Newcastle-Ottawa Scale were used for data extraction and quality assessment of the included studies. The meta- regression analysis was performed by Stata 14 software. The standardized mean difference (SMD) values of lipid profiles were computed to assess their association with pre-eclampsia at 95% CI. Results In this review a total of 15 observational studies were included. The mean values of triglyceride (TG), total cholesterol (TC), low density lipoprotein- cholesterol (LDL-c) and very low density lipoprotein- cholesterol (VLDL-c) were significantly higher in pre-eclamptic women as compared with normotensive pregnant women (TG = 229.61±88.27 and 147.00 ± 40.47, TC = 221.46 ± 45.90 and 189.67 ± 39.18, LDL = 133.92 ± 38.77 and 112.41 ± 36.08, VLDL = 41.44 ± 19.68 and 26.64 ± 7.87), respectively. The serum high density lipoprotein cholesterol (HDL-c) level was lower, but it is not statistically significant (HDL-c = 51.02 ± 16.01 and 61.80 ± 25.63) in pre-eclamptic women as compared with controls. The pooled standardized mean difference (SMD) of TG, TC, LDL-C and VLDL-C were significantly increased in pre-eclamptic women as compared with normotensive pregnant women with the SMD of (TG = 1.65 (1.10, 2.21), TC = 0.84 (0.40, 1.29), LDL-C = 0.95 (0.46, 1.45) and VLDL-C = 1.27 (0.72, 1.81)) at 95% CI, respectively, but the pooled SMD of HDL-cholesterol was decreased in pre-eclamptic women as compared with normotensive pregnant women (SMD = -0.91 (95% CI: -1.43, -0.39). Conclusions In this review, the maternal serum levels of TG, TC, LDL-c and VLDL-c were significantly associated with the risk of preeclampsia. However, HDL- cholesterol was not significantly associated but it was lower in pre-eclamptic women. Further, large scale prospective studies should verify these outcomes and it is recommended that lipid profiles should be included as a routine diagnostic test for pre-eclamptic women.

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Associations of m.5178C>A variant with serum lipids levels: A systematic review and meta-analysis

Bioscience Reports ◽

10.1042/bsr20212246 ◽

2021 ◽

Author(s):

Fuqiang Liu ◽

Jiyun He ◽

Shengping Wang ◽

Feng Yu ◽

Zhi Luo

Keyword(s):

Meta Analysis ◽

Low Density Lipoprotein ◽

Population Attributable Risk ◽

Density Lipoprotein ◽

Lipoprotein Cholesterol ◽

Chinese Populations ◽

Asian Populations ◽

Standard Mean Difference ◽

Artery Disease ◽

Cad Risk

Background: Emerging evidence shows that m.5178C>A variant is associated with a lower risk of coronary artery disease (CAD). However, the specific mechanisms remain elusive. Since dyslipidemia is one of the most critical risk factors for CAD and accounts for at least 50% of the population-attributable risk, it is tempting to speculate that the reduced CAD risk caused by the m.5178C>A variant may stem from an improved lipid profile. In order to verify this hypothesis, we conducted this study to clarify the associations of m.5178C>A variant with lipid levels.  Methods: By searching ten databases for studies published before June 30, 2021. Thirteen East Asian populations (7,587 individuals) were included for the analysis.</p>  Results: The present study showed that m.5178C>A variant was associated with higher high-density lipoprotein cholesterol (HDL-C) [standard mean difference (SMD) = 0.12, 95% CI = 0.06—0.17, P< 0.001] and total cholesterol (TC) (SMD = 0.08, 95% CI = 0.02—0.14, P= 0.01) levels. In subgroup analysis, the association of m.5178C>A variant with higher HDL-C levels were observed in Japanese (SMD = 0.09, 95% CI = 0.01—0.17, P= 0.03) and Chinese populations (SMD = 0.13, 95% CI = 0.07—0.20, P< 0.001). However, the association of m.5178C>A variant with lower low-density lipoprotein cholesterol (LDL-C) levels were only observed in Japanese populations (SMD = -0.11, 95% CI = -0.22—-0.00, P= 0.04).</p>  Conclusions: The m.5178C>A variant was associated with higher HDL-C and lower LDL-C levels in Japanese populations, which may contribute to decreased CAD risk and longevity of Japanese.

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Cumulative burden of lipid profiles predict future incidence of ischaemic stroke and residual risk

Stroke and Vascular Neurology ◽

10.1136/svn-2020-000726 ◽

2021 ◽

pp. svn-2020-000726

Author(s):

Liye Dai ◽

Jie Xu ◽

Yijun Zhang ◽

Anxin Wang ◽

Zimo Chen ◽

...

Keyword(s):

Ischaemic Stroke ◽

Primary Outcome ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Lipid Profiles ◽

Lipoprotein Cholesterol ◽

Confounding Variables ◽

Registration Number ◽

The Impact

ObjectivesIncident ischaemic stroke (IS) risk may increase not only with lipids concentration but also with longer duration of exposure. This study aimed to investigate the impact of cumulative burden of lipid profiles on risk of incident IS.MethodsA total of 43 836 participants were enrolled who participated in four surveys during 2006–2013. Individual cumulative lipid burden was calculated as number of years (2006–2013) multiplied by the levels of low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), non-HDL-C and triglyceride (TG), respectively. The primary outcome was defined as the incident IS during 2012–2017.ResultsDuring 4.67 years (±0.70 years) follow-up on average, we identified 1023 (2.33%) incident IS. Compared with respective reference groups, the HRs (95% CIs) of the upper tertile in cumulative TG burden, cumulative LDL-C burden, cumulative TC burden and cumulative non-HDL-C burden were 1.26 mmol/L (1.02–1.55 mmol/L), 1.47 mmol/L (1.25–1.73 mmol/L), 1.33 mmol/L (1.12–1.57 mmol/L) and 1.51 mmol/L (1.28–1.80 mmol/L) for incidence of IS, respectively. However, this association was not significant in cumulative HDL-C burden and IS (HR: 1.09; 95% CI: 0.79 to 1.52), after adjustment for confounding variables. Among 16 600 participants with low cumulative LDL-C burden, HRs (95% CI) for TC, TG, non-HDL-C and HDL-C with IS were 1.63 mmol/L (1.03–2.57 mmol/L), 1.65 mmol/L (1.19–2.31 mmol/L), 1.57 mmol/L (1.06–2.32 mmol/L) and 0.98 mmol/L (0.56–1.72 mmol/L), respectively.ConclusionsWe observed the correlation between cumulative burden of lipid profiles, except for cumulative burden of HDL-C, with the risk of incident IS. Cumulative burden of TC, TG and non-HDL-C may still predict IS in patients with low cumulative LDL-C burden.Trial registration numberChiCTR-TNRC-11001489.

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Effect of exercise training on lipid profiles in the elderly: A systematic review and meta-analysis of randomized controlled trials

Journal of Shahrekord University of Medical Sciences ◽

10.34172/jsums.2020.32 ◽

2020 ◽

Vol 22 (4) ◽

pp. 200-207

Author(s):

Mahdi Ghafari ◽

Mohammad Faramarzi ◽

Timoty Baghurst

Keyword(s):

Sensitivity Analysis ◽

Lipid Profile ◽

Meta Analysis ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

The Elderly ◽

Lipid Profiles ◽

Lipoprotein Cholesterol ◽

Training Methods ◽

Study Heterogeneity

Background and aims: There are many articles about the effects of different training methods on lipid profiles in the elderly. The objective of the present study was to investigate the influence of training on the lipid profile in the elderly. Methods: In this study, databases of PubMed, Embase, Scopus, ScienceDirect, Web of Science, SID, Magiran, and Google Scholar were searched. Intervention effects were presented as mean difference (MD) with a random-effects model. Subgroup analysis and sensitivity analysis were performed to study heterogeneity, following the primary screening of the full text of the articles. Results: A total of 23 trials with 1654 individuals were included in the meta-analysis. Levels of high-density lipoprotein cholesterol (HDL-C) (MD = 0.47 mg/dL; P<0.001, SE = 0.08, V = 0.01, 95% CI = 0.31 0.63, Z = 5.73, 19 trials), low-density lipoprotein cholesterol (LDL-C) (MD = -0.46; P<0.001, SE = 0.11, V = 0.01, 95% CI = -0.68 -0.25, Z = -4.24), triglyceride (MD = -0.62; P=0.001, SE = 0.12, V = 0.01, 95% CI = -0.86 -0.38, Z = -5.03, 20 trials), and total cholesterol (TC) (MD = -0.33; P<0.001, SE = 0.09, V = 0.01, 95% CI = -0.52 -0.15, Z = -3.57, 16 trials) were investigated. Following sensitivity analysis and heterogeneity testing, the results were still strong and impressive. Conclusion: Lipid profiles improved in training groups, indicating higher levels of HDL-C and lower levels of LDL-C, TC, and triglyceride. Overall, training leads to a better lipid profile. However, closer scrutiny seems necessary.

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Effects of olanzapine treatment on lipid profiles in patients with schizophrenia: a systematic review and meta-analysis

Scientific Reports ◽

10.1038/s41598-020-73983-4 ◽

2020 ◽

Vol 10 (1) ◽

Author(s):

Rong Li ◽

Yiqi Zhang ◽

Wenqiang Zhu ◽

Chen Ding ◽

Wenjie Dai ◽

...

Keyword(s):

Meta Analysis ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Lipid Profiles ◽

Lipoprotein Cholesterol ◽

Cochrane Library ◽

Low Density Lipoprotein Cholesterol ◽

Olanzapine Treatment ◽

Olanzapine Therapy ◽

The Cochrane Library

Abstract Olanzapine-induced dyslipidemia significantly increases the risk of cardiovascular disease in patients with schizophrenia. However, the clinical features of olanzapine-induced dyslipidemia remain hitherto unclear because of inconsistencies in the literature. This meta-analysis thus investigated the effects of olanzapine treatment on lipid profiles among patients with schizophrenia. Studies of the effects of olanzapine on lipids were obtained through the PubMed, Web of science, The Cochrane Library and Embase databases (up to January 1, 2020). Twenty-one studies and 1790 schizophrenia patients who received olanzapine therapy were included in our analysis. An olanzapine-induced increase was observed in plasma triglyceride (TG), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C) levels in patients with schizophrenia (all P < 0.05). Moreover, the time points analyzed included the following: baseline, 4 weeks, 6 weeks, 8 weeks, 12 weeks, and ≥ 24 weeks (data of ≥ 24 weeks were integrated). The significant elevation of TG, TC, and LDL-C was observed in patients with schizophrenia already by 4 weeks of olanzapine therapy (all P < 0.05), with no obvious changes observed in high-density lipoprotein cholesterol (HDL-C) (P > 0.05). In conclusion, olanzapine-induced dyslipidemia, characterized by increased TG, TC, and LDL-C levels, was observed in patients with schizophrenia already by 4 weeks of olanzapine treatment.

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Cholesterol and Alzheimer’s Disease Risk: A Meta-Meta-Analysis

Brain Sciences ◽

10.3390/brainsci10060386 ◽

2020 ◽

Vol 10 (6) ◽

pp. 386 ◽

Cited By ~ 3

Author(s):

Olalla Sáiz-Vazquez ◽

Alicia Puente-Martínez ◽

Silvia Ubillos-Landa ◽

Joaquín Pacheco-Bonrostro ◽

Javier Santabárbara

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Disease Risk ◽

Meta Analysis ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Serum Levels ◽

Lipoprotein Cholesterol ◽

Meta Analyses ◽

The Relationship

Background: Alzheimer’s disease (AD) is the most common subtype of dementia. In the last ten years, the relationship between cholesterol and AD has been investigated. Evidence suggests that cholesterol is associated with AD and represents promising targets for intervention. However, the causality of these associations is unclear. Therefore, we sought to conduct a meta-meta-analysis to determine the effect of cholesterol on the development AD. Then, we assessed the effect of serum levels of low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC) and triglycerides (TG), on AD risk. Methods: A systematic search of meta-analyses was conducted. Scopus, Web of Science, Science direct, PubMed and Google academic system databases were reviewed. Results: We found 100 primary studies and five meta-analyses to analyze the relationships between cholesterol and AD. The total effect of cholesterol on risk of AD was significant and heterogeneous. Subgroup analysis shows that LDL-C levels influence the development of AD. However, non-significant effects of HDL-C, TC and TG levels on AD were found. Conclusions: These results strengthen the evidence that LDL-C cholesterol levels increase risk for AD. More initiatives to investigate the relationship between cholesterol and AD are needed.

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Differences in the Effects of Anthocyanin Supplementation on Glucose and Lipid Metabolism According to the Structure of the Main Anthocyanin: A Meta-Analysis of Randomized Controlled Trials

Nutrients ◽

10.3390/nu13062003 ◽

2021 ◽

Vol 13 (6) ◽

pp. 2003

Author(s):

Risa Araki ◽

Akira Yada ◽

Hirotsugu Ueda ◽

Kenichi Tominaga ◽

Hiroko Isoda

Keyword(s):

Lipid Metabolism ◽

Meta Analysis ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Resistance Index ◽

Lipoprotein Cholesterol ◽

Controlled Trials ◽

Oh Groups ◽

Chemical Structures ◽

Glucose And Lipid Metabolism

The effectiveness of anthocyanins may differ according to their chemical structures; however, randomized clinical controlled trials (RCTs) or meta-analyses that examine the consequences of these structural differences have not been reported yet. In this meta-analysis, anthocyanins in test foods of 18 selected RCTs were categorized into three types: cyanidin-, delphinidin-, and malvidin-based. Delphinidin-based anthocyanins demonstrated significant effects on triglycerides (mean difference (MD): −0.24, p < 0.01), low-density lipoprotein cholesterol (LDL-C) (MD: −0.28, p < 0.001), and high-density lipoprotein cholesterol (HDL-C) (MD: 0.11, p < 0.01), whereas no significant effects were observed for cyanidin- and malvidin-based anthocyanins. Although non-significant, favorable effects on total cholesterol (TC) and HDL-C were observed for cyanidin- and malvidin-based anthocyanins, respectively (both p < 0.1). The ascending order of effectiveness on TC and LDL-C was delphinidin-, cyanidin-, and malvidin-based anthocyanins, and the differences among the three groups were significant (both p < 0.05). We could not confirm the significant effects of each main anthocyanin on glucose metabolism; however, insulin resistance index changed positively and negatively with cyanidin- and delphinidin-based anthocyanins, respectively. Therefore, foods containing mainly unmethylated anthocyanins, especially with large numbers of OH groups, may improve glucose and lipid metabolism more effectively than those containing methylated anthocyanins.

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Sulforaphane ameliorates lipid profile in rodents: an updated systematic review and meta-analysis

Scientific Reports ◽

10.1038/s41598-021-87367-9 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Kaili Du ◽

Yuxin Fan ◽

Dan Li

Keyword(s):

Systematic Review ◽

Weight Control ◽

Weighted Mean Difference ◽

Meta Analysis ◽

Low Density Lipoprotein ◽

Disease Model ◽

Density Lipoprotein ◽

Liver Weight ◽

Lipoprotein Cholesterol ◽

Alcoholic Fatty Liver

AbstractSulforaphane (SFN), a naturally-occurring isothiocyanate enriched in cabbage and broccoli, has been provided as food supplements to improve weight management and reduce lipid levels. However, its effects on serum lipid profiles are contradictory. In this review, a meta-analysis and systematic review of SFN on lipid reduction and weight control is assessed with mice and rats fed on high-fat diet. The effects of SFN supplementation were evaluated by weighted mean difference (WMD) in body weight (BW), liver weight (LW) and also by its effect on serum lipids. A random-effects model was applied to estimate the overall summary effect. SFN reduced BW (WMD: − 2.76 g, 95% CI: − 4.19, − 1.34) and LW (WMD: − 0.93 g, 95% CI: − 1.63, − 0.23) significantly in our ten trials. Its effects on serum total cholesterol (TC) (WMD: − 15.62 mg/dL, 95% CI: − 24.07, − 7.18), low-density lipoprotein cholesterol (LDL-C) (WMD: − 8.35 mg/dL, 95% CI: − 15.47, − 1.24) and triglyceride (TG) (WMD: − 40.85 mg/dL, 95% CI: − 67.46, − 14.24) were significant except for high-density lipoprotein cholesterol (HDL-C) component (WMD: 1.05 mg/dL, 95% CI: − 3.44, 5.54). However, species, disease model, duration, SFN dosage as well as route of administration did not explain the heterogeneity among studies. In summary, these findings provide new insights concerning preclinical strategies for treating diseases including obesity, diabetes, hypertension, non-alcoholic fatty liver disease as well as cardiovascular disease with SFN supplements.

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Potential Biomarkers for Post-Stroke Cognitive Impairment: A Systematic Review and Meta-Analysis

International Journal of Molecular Sciences ◽

10.3390/ijms23020602 ◽

2022 ◽

Vol 23 (2) ◽

pp. 602

Author(s):

Ka Young Kim ◽

Ki Young Shin ◽

Keun-A Chang

Keyword(s):

Systematic Review ◽

Uric Acid ◽

Cognitive Impairment ◽

Meta Analysis ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Lipoprotein Cholesterol ◽

Cochrane Library ◽

Blood Proteins ◽

Post Stroke

Stroke is a primary debilitating disease in adults, occurring in 15 million individuals each year and causing high mortality and disability rates. The latest estimate revealed that stroke is currently the second leading cause of death worldwide. Post-stroke cognitive impairment (PSCI), one of the major complications after stroke, is frequently underdiagnosed. However, stroke has been reported to increase the risk of cognitive impairment by at least five to eight times. In recent decades, peripheral blood molecular biomarkers for stroke have emerged as diagnostic, prognostic, and therapeutic targets. In this study, we aimed to evaluate some blood-derived proteins for stroke, especially related to brain damage and cognitive impairments, by conducting a systematic review and meta-analysis and discussing the possibility of these proteins as biomarkers for PSCI. Articles published before 26 July 2021 were searched in PubMed, Embase, the Web of Science, and the Cochrane Library to identify all relevant studies reporting blood biomarkers in patients with stroke. Among 1820 articles, 40 were finally identified for this study. We meta-analyzed eight peripheral biomarker candidates: homocysteine (Hcy), high-density lipoprotein cholesterol (HDL-C), C-reactive protein (CRP), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), triglyceride (TG), uric acid, and glycated hemoglobin (HbA1c). The Hcy, CRP, TC, and LDL-C levels were significantly higher in patients with PSCI than in the non-PSCI group; however, the HDL-C, TG, uric acid, and HbA1c levels were not different between the two groups. Based on our findings, we suggest the Hcy, CRP, TC, and LDL-C as possible biomarkers in patients with post-stroke cognitive impairment. Thus, certain blood proteins could be suggested as effective biomarkers for PSCI.

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