scholarly journals Exposure to food additive mixtures in 106,000 French adults from the NutriNet-Santé cohort

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Eloi Chazelas ◽  
Nathalie Druesne-Pecollo ◽  
Younes Esseddik ◽  
Fabien Szabo de Edelenyi ◽  
Cédric Agaesse ◽  
...  
Keyword(s):  
Large Scale ◽  
Monosodium Glutamate ◽  
Food Additives ◽  
Experimental Studies ◽  
Health Impact ◽  
Potassium Nitrate ◽  
Population Based ◽  
Food Additive ◽  
Potassium Sorbate ◽  
Chi Square

AbstractFood additives (e.g. artificial sweeteners, emulsifiers, dyes, etc.) are ingested by billions of individuals daily. Some concerning results, mainly derived from animal and/or cell-based experimental studies, have recently emerged suggesting potential detrimental effects of several widely consumed additives. Profiles of additive exposure as well as the potential long-term impact of multiple exposure on human health are poorly documented. This work aimed to estimate the usual intake of food additives among participants of the French NutriNet-Santé cohort and to identify and describe profiles of exposure (single substances and mixtures). Overall, 106,489 adults from the French NutriNet-Santé cohort study (2009-ongoing) were included. Consumption of 90 main food additives was evaluated using repeated 24 h dietary records including information on brands of commercial products. Qualitative information (as presence/absence) of each additive in food products was determined using 3 large-scale composition databases (OQALI, Open Food Facts, GNPD), accounting for the date of consumption of the product. Quantitative ingested doses were estimated using a combination of laboratory assays on food matrixes (n = 2677) and data from EFSA and JECFA. Exposure was estimated in mg per kg of body weight per day. Profiles of exposure to food additive mixtures were extracted using Non-negative Matrix Factorization (NMF) followed by k-means clustering as well as Graphical Lasso. Sociodemographic and dietary comparison of clusters of participants was performed by Chi-square tests or linear regressions. Data were weighted according to the national census. Forty-eight additives were consumed by more than 10% of the participants, with modified starches and citric acid consumed by more than 90%. The top 50 also included several food additives for which potential adverse health effects have been suggested by recent experimental studies: lecithins (86.6% consumers), mono- and diglycerides of fatty acids (78.1%), carrageenan (77.5%), sodium nitrite (73.9%), di-, tri- and polyphosphates (70.1%), potassium sorbate (65.8%), potassium metabisulphite (44.8%), acesulfame K (34.0%), cochineal (33.9%), potassium nitrate (31.6%), sulfite ammonia caramel (28.8%), bixin (19.5%), monosodium glutamate (15.1%) and sucralose (13.5%). We identified and described five clusters of participants more specifically exposed to five distinct additive mixtures and one additional cluster gathering participants with overall low additive exposure. Food additives, including several for which health concerns are currently debated, were widely consumed in this population-based study. Furthermore, main mixtures of additives were identified. Their health impact and potential cocktail effects should be explored in future epidemiological and experimental studies.

scholarly journals Food additives: distribution and co-occurrence in 126 000 food products of the French market

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
E Chazelas ◽  
M Deschasaux ◽  
B Srour ◽  
N Druesne-Pecollo ◽  
S Hercberg ◽  
...  
Keyword(s):  
Chronic Disease ◽  
Large Scale ◽  
Disease Risk ◽  
Monosodium Glutamate ◽  
Food Additives ◽  
Food Products ◽  
Food Additive ◽  
Potassium Sorbate ◽  
Chronic Disease Risk ◽  
The Way

Abstract Background More than 330 food additives (e.g. artificial sweeteners, emulsifiers, dyes) are authorized in Europe, with a great variability of use across food products. The objective of this study was to investigate the distribution and co-occurrence of food additives in a large-scale database of foods and beverages available on the French market. Methods The open access Open Food Facts database was used to retrieve the composition of food and beverage products commonly marketed on the French market (n = 126 556), based on the ingredients list. Clustering of food additive variables was used in order to determine groups of additives frequently co-occurring in food products. The clusters were confirmed by network analysis, using the eLasso method. Results 53.8% of food products contained at least 1 food additive and 11.3% at least 5. Food categories most likely to contain food additives (in more than 85% of food items) were artificially sweetened beverages, ice creams, industrial sandwiches, biscuits and cakes. The most frequently used food additives were citric acid, lecithins and modified starches (>10,000 products each). Some food additives with suspected health effects also pertained to the top 50: sodium nitrite, potassium nitrate, carrageenan, monosodium glutamate, sulfite ammonia caramel, acesulfame K, sucralose, (di/tri/poly) phosphates, mono- and diglycerides of fatty acids, potassium sorbate, cochineal, potassium metabisulphite, sodium alginate, and bixin (>800 food products each). We identified 6 clusters of food additives frequently co-occurring in food products. Conclusions Food additives are widespread in industrial French products and some clusters of additives frequently co-occurring in food products were identified. These results pave the way to future etiological studies merging composition data to food consumption data to investigate their association with chronic disease risk, in particular potential 'cocktail effects'. Key messages Food additives are widespread in industrial French products and some clusters of additives frequently co-occurring in food products were identified. These results pave the way to future etiological studies to investigate their association with chronic disease risk, in particular potential ‘cocktail effects’.

Health Impacts of Large-Scale Floods: Governmental Decision-Making and Resilience of the Citizens

2008 ◽  
Vol 23 (S2) ◽  
pp. s70-s73 ◽  
Author(s):  
Dick Q.P. Fundter ◽  
Bas Jonkman ◽  
Steve Beerman ◽  
Corsmas L.P.M. Goemans ◽  
Rosanna Briggs ◽  
...  
Keyword(s):  
Decision Making ◽  
Large Scale ◽  
Health Impact ◽  
Population Based ◽  
Chronic Illnesses ◽  
Decision Makers ◽  
Natural Resistance ◽  
First Year ◽  
The Public ◽  
Life Saving

AbstractDuring the 15th World Congress on Disaster and Emergency Medicine in Amsterdam, May 2007 (15WCDEM), a targeted agenda program (TAP) about the public health aspects of large-scale floods was organized. The main goal of the TAP was the establishment of an overview of issues that would help governmental decision-makers to develop policies to increase the resilience of the citizens during floods. During the meetings, it became clear that citizens have a natural resistance to evacuations. This results in death due to drowning and injuries. Recently, communication and education programs have been developed that may increase awareness that timely evacuation is important and can be life-saving. After a flood, health problems persist over prolonged periods, including increased death rates during the first year after a flood and a higher incidence of chronic illnesses that last for decades after the flood recedes. Population-based resilience (bottom-up) and governmental responsibility (top-down) must be combined to prepare regions for the health impact of evacuations and floods. More research data are needed to become better informed about the health impact and consequences of translocation of health infrastructures after evacuations. A better understanding of the consequences of floods will support governmental decision-making to mitigate the health impact. A top-10 priority action list was formulated.

Attitudes to the return of incidental and targeted genomic findings obtained in a high-risk pediatric cancer versus an inherited genetic condition research setting.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. 10066-10066
Author(s):  
Conrad Vincent Fernandez ◽  
Nada Jabado ◽  
Kym Boycott ◽  
David Malkin ◽  
Eric Bouffet ◽  
...  
Keyword(s):  
Pediatric Cancer ◽  
Large Scale ◽  
Health Impact ◽  
Genomic Research ◽  
Childhood Onset ◽  
Genetic Condition ◽  
Chi Square ◽  
Research Results ◽  
Pediatric Cancer Patients ◽  
Almost All

10066 Background: The disclosure of clinically significant, validated incidental and target findings to participants in genomic research is often recommended. There have been no reports on whether attitudes of parents differ if these findings emerge from an acquired pediatric cancer versus an inherited genetic condition setting. Methods: Parents in 3 large-scale projects [Canadian Pediatric Cancer Genome Consortium (CPCGC), the Finding of Rare Genes Canada Consortium (FORGE) and the Orphan Diseases: identifying Genes and Novel Therapeutics to Enhance Treatment Project (IGNITE)] were surveyed using a mailed, validated 29-item questionnaire. Two reminders were sent. Analysis was by descriptive and Chi-square statistics. Results: Response rate: 64% (n=307/480). 40% were > 50 yrs age; more than half had a grade 12 education. 86 were parents of poor risk pediatric cancer patients and 221 were parents or individuals with rare inherited conditions. Most stated a very strong or strong right to genomic research results, irrespective if from the target condition (97%) or incidental (86%). 70% wish genetic counselling pre- and post-research testing; an additional 20% were uncertain what this entails. Almost all indicated that genomic research for childhood onset conditions should occur, regardless of whether therapy existed (99%) or not (91%). A few indicated that they would not want incidental results showing an untreatable fatal condition (17%). Most want results, even if these suggest susceptibility to multiple conditions (87%) or are of uncertain health impact (84%). Most felt a right to genomic research that showed a serious condition in siblings, whether treatable (94%) or not (89%). 74% strongly support that results discovered after death of the proband be shared with family. Conclusions: Parents of children in both cancer and inherited rare conditions genomic research do not differ in indicating a strong right and desire to receive research results, even if they are of uncertain impact, of childhood onset, or after death of the proband. Clear delineation of what will or will not be offered from genomic research should be established at the time of consent.

scholarly journals Gender-Specific Differences of Oxidative Processes in the Population of Circulating Neutrophils of Rats in a Setting of Prolonged Administration of Monosodium Glutamate

2019 ◽  
Vol 26 (2) ◽  
pp. 119-127
Author(s):  
Inna Krynytska ◽  
Mariya Marushchak ◽  
Anastasiia Rutska
Keyword(s):  
Monosodium Glutamate ◽  
Food Additives ◽  
Experimental Studies ◽  
Reactive Oxygen ◽  
Male Rats ◽  
Prolonged Administration ◽  
White Rats ◽  
Species Formation ◽  
Oxide Synthase ◽  
Gender Specific

Abstract Background and aims: Monosodium salt of glutamic acid (MSG) is one of the most common food additives. The aim of study was to assess, in gender-specific terms, how prolonged administration of MSG effects on reactive oxygen and nitrogen species formation and the apoptotic/necrotic processes in the population of rats circulating neutrophils. Material and methods: Experimental studies were conducted on 32 mature white rats. MSG was administered intragastrical at a dose of 30 mg/kg body weight for 30 days. The analysis of cell samples to determine neutrophils with overproduction of reactive oxygen species (ROS) and signs of apoptosis\necrosis was evaluated with flow laser cytometry method. The total nitric oxide synthase (NOS) activity was determined by monitoring the rate of conversion of L-arginine into citrulline. The total quantity of NO metabolites was assessed by evaluating of nitrite and nitrate ions. Results: We found a significant increase in generation of ROS, intensification of nitroxydergic processes, an increase in the percentage of apoptotic neutrophils and no changes in the percentage of necrotic neutrophils. Conclusions: We observed activation of oxidative and nitroxydergic processes in rats with prolonged administration of MSG, which initiate apoptosis. In gender-specific terms, a more pronounced changes were seen in male rats.

scholarly journals MODERN CONCEPTS ABOUT IMPACT OF DIFFERENT FOOD ADDITIVES ON THE HUMAN BODY

2021 ◽  
Vol 21 (1) ◽  
pp. 194-198
Author(s):  
Н. M. Mustafina ◽  
I. I. Starchenko ◽  
V. М. Koka ◽  
Ye. I. Lukachina ◽  
V. V. Chernyak
Keyword(s):  
Human Body ◽  
Negative Impact ◽  
Monosodium Glutamate ◽  
Food Additives ◽  
Experimental Studies ◽  
The Elderly ◽  
Malignant Tumours ◽  
Internal Organs ◽  
Negative Effect ◽  
The Impact

This article highlights the analysis of available data about the impact of food additives on a human body. We specified the meaning of the term "food additives", paid attention to the history of discovering and applying food additives, described the differences between natural and synthetic food additives. According to the literature, most food additives used in modern food industry can be considered quite safe. The safety of food additives is determined on the basis of extensive comparative studies, and the use of food additives is prohibited unless they have been tested and approved by the relevant authorities. But, with the development of analytical methods, the emergence of new experimental data, the question of the possible negative impacts of one or another additive on individual organs and systems of the human body can be reconsidered. In particular, certain food additives that were previously considered harmless, for example E 240, E 121, are now recognized as very dangerous and prohibited for use. It has been proven that food supplements that are harmless to one person can have a negative effect on another. Therefore, it is recommended to limit the use of food additives for children, the elderly and people prone to allergic reactions. The article describes in detail the results of experimental studies about the negative impact of specific additives, in particular ponceau 4R, sodium nitrite and monosodium glutamate on individual internal organs. Attention is focused on the group of food additives such as nitrogen compounds, which due to the biotransformation can result in the nitrite formation. An excess of the latter, in turn, according to some researchers, can provoke the development of malignant tumours in various organs, primarily in the terminal parts of the colon. Thus, the impact of various combinations of food additives on the morpho-functional state of the internal organs requires further detailed research.

Histomorphometric study on effects of monosodium glutamate in liver tissue of Wistar rats

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Anil Kumar Reddy ◽  
Joy A. K. Ghoshal ◽  
Sankaran PK ◽  
Ganesh N. Trivedi ◽  
Kondam Ambareesha
Keyword(s):  
Wistar Rats ◽  
Monosodium Glutamate ◽  
Food Additives ◽  
Experimental Studies ◽  
Control Groups ◽  
Food Industries ◽  
Histomorphometric Study ◽  
Histochemical Observation ◽  
Dose Dependent ◽  
Different Doses

Abstract Objectives Thousands of food additives are being used by the food industries in ready to eat packed food. These food additives act as either preservatives or enhancers of palatability. Monosodium glutamate (MSG), a sodium salt of glutamic acid is a widely used food additive for enhancing taste. It gives the unique taste to the food called “Umami” or “Savory taste”, which is different from four primary tastes namely, sweet, sour, salty, and bitter. The current experimental study was investigated by dose-related effects of MSG on adult Wistar rats using histological and histomorphometric techniques. Methods Twenty-eight adult Wistar rats were divided into four groups i.e.; one control and three experimental groups. Rats were administered orally with different doses of MSG to the experimental groups and distilled water to the control groups consecutively for 45 days. At the end of the study, rats were sacrificed and tissues were collected for the examination. Results Histomorphometric data of the nuclei diameter of hepatocytes showed significant variation between control and experimental groups. Less PAS-positive material found in a higher dose of MSG-induced rats in histochemical observation. Conclusions One of the challenges of the problem of animal experimental studies is the application of results to human dietary intake of MSG. Based on the dose-dependent findings of the current study; it is evident that the administration of MSG is hepatotoxic in adult Wistar rats.

PENGETAHUAN PENGGUNAAN MONOSODIUM GLUTAMATE (MSG) IBU RUMAH TANGGA

2018 ◽  
Vol 12 (1) ◽  
pp. 1
Author(s):  
Siti Nur Rochimiwati ◽  
Sukmawati Sukmawati ◽  
Budiman Budiman
Keyword(s):  
Health Hazard ◽  
Monosodium Glutamate ◽  
Food Additives ◽  
Descriptive Study ◽  
Interview Method ◽  
Level Of Knowledge ◽  
Lower Intelligence ◽  
Use Of Knowledge ◽  
Health Objective ◽  
Flavor Enhancer

Background : flavor enhancing food additives are often added as a flavor enhancer known as MSG that exceed the dose . if the addition of the additive is often done to cause dependence , so it will pose a health hazard to the consumer , such as stomach disorders, allergies , hypertension , asthma , cancer , diabetes , and lower intelligence. Most housewives do not know the information would adversely affect health. Objective : This study aims to describe the level of knowledge of the use of monosodium glutamate ( MSG ) housewife in backwoods village sauleya timbuseng Polongbangkeng northern districts Kab.Takalar. Methods : This is a descriptive study. samples are all housewives in the hamlet village sauleya timbuseng Polongbangkeng northern districts Kab. Takalar , who meet the criteria as much as 49 people . Data on the use MSG knowledge samples obtained by the interview method which uses a questionnaire instrument.the data presented in the from of frequency distribution graphic and narrative. Result : Results of research on the use of knowledge MSG housewives generally less category as many as 25 ( 51.0 % ) , use of MSG housewives generally can not be tolerated as many as 36 ( 73.5 % ). Conclusion : Knowledge of the use of MSG housewife classified as less and use MSG can not be tolerated.

Reaction-based Enumeration, Active Learning, and Free Energy Calculations to Rapidly Explore Synthetically Tractable Chemical Space and Optimize Potency of Cyclin Dependent Kinase 2 Inhibitors

2019 ◽  
Author(s):  
Kyle Konze ◽  
Pieter Bos ◽  
Markus Dahlgren ◽  
Karl Leswing ◽  
Ivan Tubert-Brohman ◽  
...  
Keyword(s):  
Free Energy ◽  
Drug Discovery ◽  
Active Learning ◽  
Large Scale ◽  
Chemical Space ◽  
Population Based ◽  
Free Energy Calculations ◽  
Computational Technique ◽  
Cyclin Dependent Kinase ◽  
Energy Calculations

We report a new computational technique, PathFinder, that uses retrosynthetic analysis followed by combinatorial synthesis to generate novel compounds in synthetically accessible chemical space. Coupling PathFinder with active learning and cloud-based free energy calculations allows for large-scale potency predictions of compounds on a timescale that impacts drug discovery. The process is further accelerated by using a combination of population-based statistics and active learning techniques. Using this approach, we rapidly optimized R-groups and core hops for inhibitors of cyclin-dependent kinase 2. We explored greater than 300 thousand ideas and identified 35 ligands with diverse commercially available R-groups and a predicted IC<sub>50</sub> < 100 nM, and four unique cores with a predicted IC<sub>50</sub> < 100 nM. The rapid turnaround time, and scale of chemical exploration, suggests that this is a useful approach to accelerate the discovery of novel chemical matter in drug discovery campaigns.

Reaction-based Enumeration, Active Learning, and Free Energy Calculations to Rapidly Explore Synthetically Tractable Chemical Space and Optimize Potency of Cyclin Dependent Kinase 2 Inhibitors

2019 ◽  
Author(s):  
Kyle Konze ◽  
Pieter Bos ◽  
Markus Dahlgren ◽  
Karl Leswing ◽  
Ivan Tubert-Brohman ◽  
...  
Keyword(s):  
Free Energy ◽  
Drug Discovery ◽  
Active Learning ◽  
Large Scale ◽  
Chemical Space ◽  
Population Based ◽  
Free Energy Calculations ◽  
Computational Technique ◽  
Cyclin Dependent Kinase ◽  
Energy Calculations

We report a new computational technique, PathFinder, that uses retrosynthetic analysis followed by combinatorial synthesis to generate novel compounds in synthetically accessible chemical space. Coupling PathFinder with active learning and cloud-based free energy calculations allows for large-scale potency predictions of compounds on a timescale that impacts drug discovery. The process is further accelerated by using a combination of population-based statistics and active learning techniques. Using this approach, we rapidly optimized R-groups and core hops for inhibitors of cyclin-dependent kinase 2. We explored greater than 300 thousand ideas and identified 35 ligands with diverse commercially available R-groups and a predicted IC<sub>50</sub> < 100 nM, and four unique cores with a predicted IC<sub>50</sub> < 100 nM. The rapid turnaround time, and scale of chemical exploration, suggests that this is a useful approach to accelerate the discovery of novel chemical matter in drug discovery campaigns.

Micellization Behaviour of Cationic Surfactants in the Presence of Food Additives: Conductance and Spectroscopic Investigations

2020 ◽  
Vol 10 ◽  
Author(s):  
Sonika Arti ◽  
Neha Aggarwal
Keyword(s):  
Glutamic Acid ◽  
Cationic Surfactants ◽  
Hydrophobic Interactions ◽  
Food Additives ◽  
Specific Conductance ◽  
Food Additive ◽  
Nmr Studies ◽  
Degree Of Ionization ◽  
Increase With Increase ◽  
Micellization Process

Aim: The micellization behavior of cationic surfactants have been studied in the presence of food additives. Objectives: Micellization behaviour of cationic surfactants, cetyltrimethylammonium bromide (CTAB) and tetradecyltrimethylammonium bromide (TTAB) has been studied in water and in various concentrations of salts (food additives) L-glutamic acid, sodium propionate, sodium citrate tribasic dihydrate and disodium tartrate dihydrate at (298.15, 308.15 and 318.15) K. Methods: Two methods used in the present study are specific conductance measurements and spectroscopy (NMR) studies. Results: From the specific conductance(κ), various parameters such as critical micelle concentration (CMC), degree of ionization of micelle (α), standard Gibbs free energy (ΔGom), enthalpy (ΔHom), and entropy (ΔSom) of micellization have also been calculated. Thermodynamic parameters related to the micellization process were also analyzed through NMR studies. Conclusion: The CMC values are influenced by the presence of food additive. The magnitude of CMC values increase with increase in concentration of food additive. In all the cases, enthalpy of micellization, ∆Hom values are found to be negative whereas entropy of micellization, ∆S om values are positive which indicate that hydrophobic interactions play a major role in the micellization process. Also, NMR studies reveal that tartrate and citrate are more hydrated than glutamic acid and propionate, resulting in more downfield shift.

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