Effect of light on physicochemical and biological properties of nanocrystalline silver dressings

RSC Advances ◽  
2015 ◽  
Vol 5 (19) ◽  
pp. 14294-14304 ◽  
Author(s):  
Loredana S. Dorobantu ◽  
Greg G. Goss ◽  
Robert E. Burrell
Keyword(s):  
Antimicrobial Activity ◽  
Physicochemical Properties ◽  
Biological Properties ◽  
Wound Dressings ◽  
Interactive Effects ◽  
Physicochemical And Biological Properties ◽  
Effect Of Light

The purpose of this study was to characterize the interactive effects of light and aging on physicochemical properties and antimicrobial activity of nanocrystalline silver wound dressings Acticoat that might find their way into the environment.

scholarly journals Biocompatible and biodegradable wound dressings on the basis of seaweed polysaccharides (review of literature)

2020 ◽  
Vol 179 (4) ◽  
pp. 109-115
Author(s):  
T. A. Kuznetsova ◽  
N. N. Besednova ◽  
V. V. Usov ◽  
B. G. Andryukov
Keyword(s):  
Green Algae ◽  
Red Algae ◽  
Brown Algae ◽  
Wound Dressing ◽  
Biological Properties ◽  
Wound Dressings ◽  
Review Of Literature ◽  
Clinical Tests ◽  
Physicochemical And Biological Properties ◽  
Treatment Of Wounds

The review presents the characteristics of modern biocompatible and biodegradable wound dressings on the basis of seaweed polysaccharides (carrageenans of red algae, fucoidans and alginates of brown algae, ulvans of green algae) and notes the key physicochemical and biological properties that are important for constructing wounds dressings. There are information on various types of wound dressings and results of experimental and clinical tests of dressings in the treatment of wounds of various origins. Particular attention is paid to hydrogel dressings, since hydrogels meet the basic requirements for an ideal wound dressing, and many marine polysaccharides are able to form hydrogels.

scholarly journals Electrospun Fibers and Sorbents as a Possible Basis for Effective Composite Wound Dressings

Micromachines ◽  
2020 ◽  
Vol 11 (4) ◽  
pp. 441 ◽  
Author(s):  
Alan Saúl Álvarez-Suárez ◽  
Syed G. Dastager ◽  
Nina Bogdanchikova ◽  
Daniel Grande ◽  
Alexey Pestryakov ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Physicochemical Properties ◽  
Water Uptake ◽  
Inductively Coupled Plasma ◽  
Optical Emission ◽  
Physiological Solution ◽  
Wound Dressings ◽  
Vinyl Pyrrolidone ◽  
Scanning Calorimetry ◽  
Polymeric Scaffold

Skin burns and ulcers are considered hard-to-heal wounds due to their high infection risk. For this reason, designing new options for wound dressings is a growing need. The objective of this work is to investigate the properties of poly (ε-caprolactone)/poly (vinyl-pyrrolidone) (PCL/PVP) microfibers produced via electrospinning along with sorbents loaded with Argovit™ silver nanoparticles (Ag-Si/Al2O3) as constituent components for composite wound dressings. The physicochemical properties of the fibers and sorbents were characterized using scanning electron microscopy (SEM), differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR) and inductively coupled plasma optical emission spectroscopy (ICP-OES). The mechanical properties of the fibers were also evaluated. The results of this work showed that the tested fibrous scaffolds have melting temperatures suitable for wound dressings design (58–60 °C). In addition, they demonstrated to be stable even after seven days in physiological solution, showing no macroscopic damage due to PVP release at the microscopic scale. Pelletized sorbents with the higher particle size demonstrated to have the best water uptake capabilities. Both, fibers and sorbents showed antimicrobial activity against Gram-negative bacteria Pseudomona aeruginosa and Escherichia coli, Gram-positive Staphylococcus aureus and the fungus Candida albicans. The best physicochemical properties were obtained with a scaffold produced with a PCL/PVP ratio of 85:15, this polymeric scaffold demonstrated the most antimicrobial activity without affecting the cell viability of human fibroblast. Pelletized Ag/Si-Al2O3-3 sorbent possessed the best water uptake capability and the higher antimicrobial activity, over time between all the sorbents tested. The combination of PCL/PVP 85:15 microfibers with the chosen Ag/Si-Al2O3-3 sorbent will be used in the following work for creation of wound dressings possessing exudate retention, biocompatibility and antimicrobial activity.

Effect of Nonylphenol Ethoxylation on the Biological Activity of Three Herbicides with Different Water Solubilities

1999 ◽  
Vol 13 (4) ◽  
pp. 840-842 ◽  
Author(s):  
Jerry M. Green
Keyword(s):  
Biological Activity ◽  
Ethylene Oxide ◽  
Physicochemical Properties ◽  
Water Solubility ◽  
Biological Properties ◽  
Intermediate Water ◽  
Giant Foxtail ◽  
Hydrophilic Lipophilic Balance ◽  
Physicochemical And Biological Properties ◽  
Herbicide Glyphosate

Changing the number of ethylene oxide (EO) units on a nonylphenol surfactant changes its physicochemical and biological properties. Increasing the number of EO units makes the surfactant more hydrophilic and increases its hydrophilic-lipophilic balance (HLB). Surfactants with high HLB values, more than 16, were the most active with the hydrophilic herbicide glyphosate. More lipophilic surfactants with HLB values from 11 to 13 were more active with the lipophilic herbicide, the ethyl ester of quizalofop-P. Surfactants with intermediate HLB values were the most active with the herbicide that had intermediate water solubility, nicosulfuron. Matching the physicochemical properties of the herbicide and surfactant improved biological efficacy on giant foxtail.

scholarly journals Comparative evaluation of the physicochemical properties of nano-hydroxyapatite/collagen and natural bone ceramic/collagen scaffolds and their osteogenesis-promoting effect on MC3T3-E1 cells

2019 ◽  
Vol 6 (6) ◽  
pp. 361-371 ◽  
Author(s):  
Xiongxin Lei ◽  
Jianping Gao ◽  
Fangyu Xing ◽  
Yang Zhang ◽  
Ye Ma ◽  
...  
Keyword(s):  
Physicochemical Properties ◽  
Photoelectron Spectroscopy ◽  
Type I Collagen ◽  
Composite Scaffold ◽  
Calcium Phosphates ◽  
Biological Properties ◽  
Type I ◽  
X Ray ◽  
Natural Bone ◽  
Physicochemical And Biological Properties

Abstract The use of various types of calcium phosphate has been reported in the preparation of repairing materials for bone defects. However, the physicochemical and biological properties among them might be vastly different. In this study, we prepared two types of calcium phosphates, nano-hydroxyapatite (nHA) and natural bone ceramic (NBC), into 3D scaffolds by mixing with type I collagen (CoL), resulting in the nHA/CoL and NBC/CoL scaffolds. We then evaluated and compared the physicochemical and biological properties of these two calcium phosphates and their composite scaffold with CoL. Scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction spectroscopy (XRD) and compressive tests were used to, respectively, characterize the morphology, composition, distribution and the effect of nHA and NBC to collagen. Next, we examined the biological properties of the scaffolds using cytotoxicity testing, flow cytometry, immunofluorescence staining, biocompatibility testing, CCK-8 assays and RT-PCR. The results reflected that the Ca2+ released from nHA and NBC could bind chemically with collagen and affect its physicochemical properties, including the infrared absorption spectrum and compression modulus, among others. Furthermore, the two kinds of scaffolds could promote the expression of osteo-relative genes, but showed different gene induction properties. In short, NBC/CoL could promote the expression of early osteogenic genes, while nHA/CoL could upregulate late osteogenic genes. Conclusively, these two composite scaffolds could provide MC3T3-E1 cells with a biomimetic surface for adhesion, proliferation and the formation of mineralized extracellular matrices. Moreover, nHA/CoL and NBC/CoL had different effects on the period and extent of MC3T3-E1 cell mineralization.

scholarly journals The Influence of Bloom Index, Endotoxin Levels and Polyethylene Glycol Succinimidyl Glutarate Crosslinking on the Physicochemical and Biological Properties of Gelatin Biomaterials

Biomolecules ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 1003
Author(s):  
Zhuning Wu ◽  
Stefanie H. Korntner ◽  
Jos Olijve ◽  
Anne Maria Mullen ◽  
Dimitios I. Zeugolis
Keyword(s):  
Elastic Modulus ◽  
Polyethylene Glycol ◽  
Enzymatic Degradation ◽  
Structural Integrity ◽  
Biological Response ◽  
Biological Properties ◽  
Compression Stress ◽  
Free Amine ◽  
Amine Content ◽  
Physicochemical And Biological Properties

In the medical device sector, bloom index and residual endotoxins should be controlled, as they are crucial regulators of the device’s physicochemical and biological properties. It is also imperative to identify a suitable crosslinking method to increase mechanical integrity, without jeopardising cellular functions of gelatin-based devices. Herein, gelatin preparations with variable bloom index and endotoxin levels were used to fabricate non-crosslinked and polyethylene glycol succinimidyl glutarate crosslinked gelatin scaffolds, the physicochemical and biological properties of which were subsequently assessed. Gelatin preparations with low bloom index resulted in hydrogels with significantly (p < 0.05) lower compression stress, elastic modulus and resistance to enzymatic degradation, and significantly higher (p < 0.05) free amine content than gelatin preparations with high bloom index. Gelatin preparations with high endotoxin levels resulted in films that induced significantly (p < 0.05) higher macrophage clusters than gelatin preparations with low endotoxin level. Our data suggest that the bloom index modulates the physicochemical properties, and the endotoxin content regulates the biological response of gelatin biomaterials. Although polyethylene glycol succinimidyl glutarate crosslinking significantly (p < 0.05) increased compression stress, elastic modulus and resistance to enzymatic degradation, and significantly (p < 0.05) decreased free amine content, at the concentration used, it did not provide sufficient structural integrity to support cell culture. Therefore, the quest for the optimal gelatin crosslinker continues.

scholarly journals Protein-Engineered Polymers Functionalized with Antimicrobial Peptides for the Development of Active Surfaces

2021 ◽  
Vol 11 (12) ◽  
pp. 5352
Author(s):  
Ana Margarida Pereira ◽  
Diana Gomes ◽  
André da Costa ◽  
Simoni Campos Dias ◽  
Margarida Casal ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Antimicrobial Peptides ◽  
Recombinant Dna ◽  
Biological Properties ◽  
Resistant Bacteria ◽  
Recombinant Dna Technology ◽  
Free Standing ◽  
Microbial Cell Factories ◽  
Cell Factories ◽  
Antimicrobial Materials

Antibacterial resistance is a major worldwide threat due to the increasing number of infections caused by antibiotic-resistant bacteria with medical devices being a major source of these infections. This suggests the need for new antimicrobial biomaterial designs able to withstand the increasing pressure of antimicrobial resistance. Recombinant protein polymers (rPPs) are an emerging class of nature-inspired biopolymers with unique chemical, physical and biological properties. These polymers can be functionalized with antimicrobial molecules utilizing recombinant DNA technology and then produced in microbial cell factories. In this work, we report the functionalization of rPBPs based on elastin and silk-elastin with different antimicrobial peptides (AMPs). These polymers were produced in Escherichia coli, successfully purified by employing non-chromatographic processes, and used for the production of free-standing films. The antimicrobial activity of the materials was evaluated against Gram-positive and Gram-negative bacteria, and results showed that the polymers demonstrated antimicrobial activity, pointing out the potential of these biopolymers for the development of new advanced antimicrobial materials.

scholarly journals Development of Spanish Broom and Flax Dressings with Glycyrrhetinic Acid-Loaded Films for Wound Healing: Characterization and Evaluation of Biological Properties

Pharmaceutics ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1192
Author(s):  
Angela Abruzzo ◽  
Concettina Cappadone ◽  
Valentina Sallustio ◽  
Giovanna Picone ◽  
Martina Rossi ◽  
...  
Keyword(s):  
Wound Healing ◽  
Drug Loading ◽  
Healing Process ◽  
In Vitro Release ◽  
Sodium Hyaluronate ◽  
Biological Properties ◽  
Glycyrrhetinic Acid ◽  
Wound Dressings ◽  
Biological Studies

The selection of an appropriate dressing for each type of wound is a very important procedure for a faster and more accurate healing process. So, the aim of this study was to develop innovative Spanish Broom and flax wound dressings, as alternatives to cotton used as control, with polymeric films containing glycyrrhetinic acid (GA) to promote wound-exudate absorption and the healing process. The different wound dressings were prepared by a solvent casting method, and characterized in terms of drug loading, water uptake, and in vitro release. Moreover, biological studies were performed to evaluate their biocompatibility and wound-healing efficacy. Comparing the developed wound dressings, Spanish Broom dressings with GA-loaded sodium hyaluronate film had the best functional properties, in terms of hydration ability and GA release. Moreover, they showed a good biocompatibility, determining a moderate induction of cell proliferation and no cytotoxicity. In addition, the wound-healing test revealed that the Spanish Broom dressings promoted cell migration, further facilitating the closure of the wound.

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