Fibrous wound dressings encapsulating essential oils as natural antimicrobial agents

2015 ◽  
Vol 3 (8) ◽  
pp. 1583-1589 ◽  
Author(s):  
I. Liakos ◽  
L. Rizzello ◽  
H. Hajiali ◽  
V. Brunetti ◽  
R. Carzino ◽  
...  
Keyword(s):  
Essential Oils ◽  
Cellulose Acetate ◽  
Antimicrobial Agents ◽  
Antibiotic Activity ◽  
Wound Dressings ◽  
Natural Polymer ◽  
Natural Antimicrobial ◽  
Electrospinning Technique

Essential oils with high antibiotic activity were incorporated into cellulose acetate natural polymer. By using the electrospinning technique, nanofibrous matrices were prepared to be used as effective antimicrobial wound dressings.

scholarly journals Application of essential oils and polyphenols as natural antimicrobial agents in postharvest treatments: Advances and challenges

2020 ◽  
Vol 8 (6) ◽  
pp. 2555-2568 ◽  
Author(s):  
Laura Maryoris Aguilar‐Veloz ◽  
Montserrat Calderón‐Santoyo ◽  
Yuliana Vázquez González ◽  
Juan Arturo Ragazzo‐Sánchez
Keyword(s):  
Essential Oils ◽  
Antimicrobial Agents ◽  
Natural Antimicrobial ◽  
Postharvest Treatments

scholarly journals Poly(butylene succinate) fibrous dressings containing natural antimicrobial agents

2021 ◽  
pp. 152808372098720
Author(s):  
Kinana Aliko ◽  
Mohamad Basel Aldakhlalla ◽  
Laura J Leslie ◽  
Tony Worthington ◽  
Paul D Topham ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Linoleic Acid ◽  
Essential Oils ◽  
Antimicrobial Agents ◽  
High Surface ◽  
Wound Dressings ◽  
Skin Substitute ◽  
Great Promise ◽  
Natural Food ◽  
Butylene Succinate

Poly(butylene succinate) (PBSU) is a biodegradable and biocompatible synthetic aliphatic polyester, which has been used extensively in packaging, catering and agriculture, and more recently in drug delivery and bone and cartilage repair. PBSU-based mats created by electrospinning show promise as wound dressing materials because of their good mechanical properties, high surface area-to-volume ratio and increased levels of porosity. In this work, we present the creation of antimicrobial PBSU fibrous mats through the incorporation of natural food grade agents via blend electrospinning. Three types of edible gums (namely arabic, karaya and tragacanth), two essential oils (coriander and lavender), and one free fatty acid (linoleic acid) were added to PBSU containing a chain extender and their effect on six clinically relevant pathogens was evaluated. Mats containing essential oils at the highest concentration studied (7% w/v) showed some antimicrobial behaviour against S. aureus, E. hirae and P. aeruginosa, whereas the incorporation of linoleic acid at both concentrations tested (3% and 5% w/v) gave a strong reaction against S. pyogenes. Gum arabic was the only gum that had a considerable impact on S. aureus. Furthermore, the three gums enhanced the mechanical properties of the polymer mats and brought them closer to those of the human skin, whilst all agents maintained the high biocompatibility of the PBSU mats when contacted with mouse fibroblasts. This work, for the first time, shows the great promise of PBSU blended fibres as a skin substitute and paves the way towards bioactive and cost effective wound dressings from renewable materials.

scholarly journals Electrospun Asymmetric Membranes as Promising Wound Dressings: A Review

Pharmaceutics ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 183
Author(s):  
Mariana F. P. Graça ◽  
Duarte de Melo-Diogo ◽  
Ilídio J. Correia ◽  
André F. Moreira
Keyword(s):  
Wound Healing ◽  
Phase Inversion ◽  
Antimicrobial Agents ◽  
Skin Layer ◽  
Wound Dressings ◽  
Electrospinning Technique ◽  
Asymmetric Membranes ◽  
Structural And Functional Properties ◽  
Wet Phase Inversion ◽  
Native Skin

Despite all the efforts that have been done up to now, the currently available wound dressings are still unable to fully re-establish all the structural and functional properties of the native skin. To overcome this situation, researchers from the tissue engineering area have been developing new wound dressings (hydrogels, films, sponges, membranes) aiming to mimic all the features of native skin. Among them, asymmetric membranes emerged as a promising solution since they reproduce both epidermal and dermal skin layers. Wet or dry/wet phase inversion, scCO2-assisted phase inversion, and electrospinning have been the most used techniques to produce such a type of membranes. Among them, the electrospinning technique, due to its versatility, allows the development of multifunctional dressings, using natural and/or synthetic polymers, which resemble the extracellular matrix of native skin as well as address the specific requirements of each skin layer. Moreover, various therapeutic or antimicrobial agents have been loaded within nanofibers to further improve the wound healing performance of these membranes. This review article provides an overview of the application of asymmetric electrospun membranes as wound dressings displaying antibacterial activity and as delivery systems of biomolecules that act as wound healing enhancers.

scholarly journals Chemical Composition of Apiaceae Family Essential Oils from Different Plants and in-vitro Antimicrobial Activities on Probiotic Microorganisms

2021 ◽  
pp. 1-4
Author(s):  
Alper Çimik ◽  
Keyword(s):  
Chemical Composition ◽  
Antifungal Activity ◽  
Essential Oils ◽  
Human Body ◽  
Antimicrobial Agents ◽  
Antimicrobial Activities ◽  
Natural Antimicrobial ◽  
Ms Analysis ◽  
Antimicrobial And Antifungal Activity

Coriander, fennel, caraway and anise species which have major characteristic specialities of Apiaceae family, have antimicrobial activities on pathogene microorganisms. Probiotic microorganisms have fundamental effects on human body and extermination of probiotics causes many diseases. In this study, it was aimed to determine investigate probiotic resistance against natural antimicrobial agents (as essential oils) compare to pathogenes in previous studies. Analysis of essential oils (Eos) from were analyzed by GC-FID and GC/MS, analysis of Eos antimicrobial and antifungal activity from were analyzed by Microdilution test (as described in CLSI). Linalool (%74.927), (E)-anethole (%68.239), carvone (%61.087) and (E)-anethole (%95.577) were found as major compounds of EOs respectively. All essential oils have antimicrobial activities on probiotic microorganisms.

scholarly journals (187) The Use of Essential Oils as Natural Preservatives for Berry Fruits

HortScience ◽  
2006 ◽  
Vol 41 (4) ◽  
pp. 1042E-1043 ◽  
Author(s):  
Chien Wang
Keyword(s):  
Essential Oils ◽  
Shelf Life ◽  
Antimicrobial Agents ◽  
Fungal Growth ◽  
Vaccinium Corymbosum ◽  
Antimicrobial Compounds ◽  
Natural Antimicrobial ◽  
Microbial Invasion ◽  
Berry Fruits ◽  
Natural Preservatives

Berry fruits such as blackberries (Rubus sp.) and blueberries (Vaccinium corymbosum L.) are highly perishable after harvest. In addition to rapid deterioration in quality, they are also very susceptible to microbial invasion. The shelf life of these berries is usually terminated by decay. Several natural antimicrobial compounds derived from essential oils of plants were studied for their efficacies in inhibiting decay and extending shelf life of berry fruits. The severity of decay in blackberries and blueberries stored at 10 °C was significantly reduced by treatment with thymol. Treatments with menthol or eugenol also suppressed the fungal growth, but to a lesser extent. All of these three natural antimicrobial compounds extended shelf life of blackberries and blueberries as compared to the control. Berries treated with thymol, menthol, or eugenol also maintained better fruit quality with higher levels of sugars, organic acids, and oxygen radical absorbance capacity than the untreated fruits. The effects of these natural antimicrobial agents on the quality and shelf life of other fruits will be investigated.

scholarly journals Treatment Strategies for Infected Wounds

Molecules ◽  
2018 ◽  
Vol 23 (9) ◽  
pp. 2392 ◽  
Author(s):  
Irina Negut ◽  
Valentina Grumezescu ◽  
Alexandru Grumezescu
Keyword(s):  
Essential Oils ◽  
Antimicrobial Agents ◽  
Bacterial Colonization ◽  
Healing Process ◽  
Treatment Strategies ◽  
Pharmaceutical Formulations ◽  
Multidrug Resistant ◽  
Wound Dressings ◽  
Therapeutic Effects ◽  
Tea Tree

The treatment of skin wounds is a key research domain owing to the important functional and aesthetic role of this tissue. When the skin is impaired, bacteria can soon infiltrate into underlying tissues which can lead to life-threatening infections. Consequently, effective treatments are necessary to deal with such pathological conditions. Recently, wound dressings loaded with antimicrobial agents have emerged as viable options to reduce wound bacterial colonization and infection, in order to improve the healing process. In this paper, we present an overview of the most prominent antibiotic-embedded wound dressings, as well as the limitations of their use. A promising, but still an underrated group of potential antibacterial agents that can be integrated into wound dressings are natural products, especially essential oils. Some of the most commonly used essential oils against multidrug-resistant microorganisms, such as tea tree, St. John’s Wort, lavender and oregano, together with their incorporation into wound dressings are presented. In addition, another natural product that exhibits encouraging antibacterial activity is honey. We highlight recent results of several studies carried out by researchers from different regions of the world on wound dressings impregnated with honey, with a special emphasis on Manuka honey. Finally, we highlight recent advances in using nanoparticles as platforms to increase the effect of pharmaceutical formulations aimed at wound healing. Silver, gold, and zinc nanoparticles alone or functionalized with diverse antimicrobial compounds have been integrated into wound dressings and demonstrated therapeutic effects on wounds.

Antimicrobial Protein Produced by Lactobacillus plantarum ATCC8014 in the Presence of Cymbopogon Sp. Essential Oils

2015 ◽  
Vol 754-755 ◽  
pp. 1045-1053
Author(s):  
Hanina Mohd Noor ◽  
Hairul Shahril Muhamad ◽  
Ismatul Nurul Asyikin Ismail ◽  
A’firah Mohd Sakri Shukri ◽  
Salina Mat Radzi ◽  
...  
Keyword(s):  
Essential Oils ◽  
Antimicrobial Agents ◽  
Antimicrobial Protein ◽  
Gram Negative Bacteria ◽  
Natural Antimicrobial ◽  
Specific Chemical ◽  
Low Concentration ◽  
Transcription Process ◽  
Sds Page ◽  
Intracellular Proteins

Protein production by bacteria might be increased in stressful conditions such as in the presence of antimicrobial agents. Many studies proved that antibiotics or antimicrobial agents at low concentration are able to activate or repress gene transcription process in bacteria. However, there are still few studies on potential of natural antimicrobial compounds such asCymbopogonessential oils acting as specific chemical signal that can trigger biological functions of bacteria. Therefore, this study aims to explore the potential of natural antimicrobial compound (Cymbopogon flexuosusandCymbopogon nardus) at low concentration in regulating proteins production byLactobacillus plantarumATCC8014. The bacteria cells ofL. plantarumATCC8014 are exposed toCymbopogonessential oils at low concentration in fermentation process for 48 hours at 37°C. SDS-PAGE analysis showed that a new intracellular protein with approximate size of 40 kDa was produced byL. plantarumATCC8014 after being enhanced withC. nardusessential oil. Besides, the intracellular proteins, each with approximate size of 85 kDa, 45 kDa and 28 kDa synthesized byL. plantarumATCC8014 prior to inducing withC. nardusorC. flexuosuswere expressed differently. Some of the intracellular proteins were highly expressed and some of the proteins were repressed based on the intensity of protein bands appeared. Hence,L. plantarumATCC8014 in the presence ofCymbopogonessential oils at low concentration could regulate the intracellular proteins production. The isolated protein also showed antimicrobial activity against selected Gram-positive and Gram-negative bacteria.

scholarly journals Evaluation of selected parameters of edam type cheese packed under foil with natural antimicrobial agents

10.5219/1110 ◽  
2019 ◽  
Vol 13 (1) ◽  
pp. 598-603
Author(s):  
Alena Saláková ◽  
Libor Kalhotka ◽  
Miroslav Jůzl ◽  
Eva Burdová ◽  
Gabriela Růžičková ◽  
...  
Keyword(s):  
Essential Oils ◽  
Antimicrobial Agents ◽  
Viable Count ◽  
Coliform Bacteria ◽  
Natural Antimicrobial ◽  
Dry Coating ◽  
Antibacterial And Antifungal Activities ◽  
Sensory Parameters ◽  
Antibacterial And Antifungal ◽  
Plant Sources

The aim of this study was to evaluate the properties of essential oils packed in foils derived from different plant sources used in Edam type cheese on selected parameters (total viable count of microorganism, coliform bacteria, micromycetes, sensory parameters and instrumental colour). Essential oils have antibacterial and antifungal activities against microorganisms. However, the concentration of these substances applied in cheeses should be considered carefully because of their possible negative influences on sensory parameters. Mixture of the essential oils (clove/cinnamon/thymol in a 1:2:1 ratio), three concentrations (3.9 %, 6.6 %, 9.0 %), respectively mixture of the essential oils (eugenol/thymol/cinnamon in a 1:1:1 ratio), three concentrations (0.10 %, 0.19 %, 0.24 % as a 5% solution in limonene in a dry coating) were used. Samples wrapped in polystyrene dishes were stored in the refrigerator at 3 – 6 °C. Analyses were made after 48 h, 168 h (144 h), 216 h (240 h) respectively. Taste is the most affected by presence of essential oils. The effectiveness of the film with the mixture A seems to be more effective in eliminating microorganisms. Negative sensory changes were observed at higher concentration. Based on the results, the tested foils seem to be promising materials suitable for packaging of cheese.

scholarly journals Electrospun Polyvinylpyrrolidone-Gelatin and Cellulose Acetate Bi-Layer Scaffold Loaded with Gentamicin as Possible Wound Dressing

Polymers ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 2311 ◽  
Author(s):  
Héctor D. López-Calderón ◽  
Hamlet Avilés-Arnaut ◽  
Luis J. Galán-Wong ◽  
Verónica Almaguer-Cantú ◽  
J. R. Laguna-Camacho ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Cellulose Acetate ◽  
Wound Dressing ◽  
Contact Angle Measurement ◽  
Angle Measurement ◽  
Electrospinning Process ◽  
Wound Dressings ◽  
Electrospinning Technique ◽  
Polymeric Scaffold ◽  
And Staphylococcus Aureus

Acceleration of wound healing can be achieved with the use of wound dressings. Through the electrospinning technique, a polymeric scaffold composed of two layers was processed: a gelatin and polyvinylpyrrolidone layer with gentamicin, and a second layer of cellulose acetate. The conditions for the electrospinning process were standardized for voltage parameters, feed flow and the distance from the injector to the collector. Once the values of the main variables for the electrospinning were optimized, a three-hour processing time was established to allow the separation of the material from the collector. The obtained material was characterized by observations on scanning electron microscopy, Fourier transform infrared spectroscopy and thermal analysis; contact angle measurement was performed to evaluate wettability properties, and antibacterial activity against Pseudomonas aeruginosa and Staphylococcus aureus were evaluated using the Kirby–Bauer test. The obtained fibers that form the bi-layer scaffold present diameters from 100 to 300 nm. The scaffold presents chemical composition, thermal stability, wettability characteristics and antibacterial activity that fulfill the proposal from this study, based on obtaining a scaffold that could be used as a drug delivery vehicle and a wound dressing material.

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