Enhancing the effects of transcranial magnetic stimulation with intravenously injected magnetic nanoparticles

2019 ◽  
Vol 7 (6) ◽  
pp. 2297-2307 ◽  
Author(s):  
Rongrong Li ◽  
Jun Wang ◽  
Xiaoya Yu ◽  
Pengfei Xu ◽  
Shuai Zhang ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Transcranial Magnetic Stimulation ◽  
Brain Stimulation ◽  
Neurological Disorders ◽  
Magnetic Stimulation ◽  
Non Invasive ◽  
Stimulation Method ◽  
The Brain

Magnetic nanoparticles SPIONs are non-invasively introduced into the brain to enhance the effects of a non-invasive clinical brain stimulation method for treating neurological disorders.

SAFETY AND TOLERABILITY OF DIFFERENT PROTOCOLS OF HIGH-FREQUENCY RHYTHMIC TRANSCRANIAL MAGNETIC STIMULATION

2019 ◽  
pp. 26-37
Author(s):  
I.S. Bakulin ◽  
A.G. Poydasheva ◽  
D.Yu. Lagoda ◽  
K.M. Evdokimov ◽  
A.Kh. Zabirova ◽  
...  
Keyword(s):  
Transcranial Magnetic Stimulation ◽  
Side Effects ◽  
Healthy Volunteers ◽  
Brain Stimulation ◽  
High Frequency ◽  
Magnetic Stimulation ◽  
Facial Muscle ◽  
Non Invasive ◽  
Mood Changes ◽  
Invasive Method

Rhythmic transcranial magnetic stimulation (rTMS) is a non-invasive method for brain stimulation, widely used in the treatment of various diseases and in research. In this regard, the problems of rTMS safety and tolerability are becoming especially relevant. Most studies describe only serious side effects of rTMS, which, in fact, are extremely rare. Other side effects which affect rTMS tolerability have been studied to a much lesser extent. The objective of the study is to examine all side effects which occur during and after rTMS sessions through prospective open observation of patients and healthy volunteers. Materials and Methods. Using standardized questionnaires, the authors analyzed the incidence of side effects during high-frequency rTMS and within 24 hours after the procedure in 51 patients with various diseases of the nervous system and in 11 healthy volunteers. Results. The overall frequency of side effects was 59.5 % during stimulation and 50.2 % within 24 hours after the procedure. Serious side effects, which led to cessation of stimulation were recorded in 5 % of cases (n=3). They were associated with the syncope development (n=1) and severe headache (n=2). During rTMS, the most frequent manifestations of side effects were drowsiness (30.4 %), headache (25.8 %) and facial muscle contraction (14.7 %). Twenty-four hours after rTMS the most common manifestations were headache (15.7 %), mood changes (10.2 %) and mental alertness problems (9.4 %). It was found out, that headache was statistically more frequent at the beginning of the rTMS course. During rTMS, headache is often not so heavy and it is usually throbbing. However, within 24 hours after stimulation headache is usually moderate, pressing or dull. Conclusion. The obtained data confirm the importance of using standardized questionnaires for studying side effects and developing methods for their prevention and relief. Keywords: transcranial magnetic stimulation, non-invasive brain stimulation, safety, tolerance, side effects, headache, syncope.

scholarly journals Transcranial magnetic stimulation: studying the brain--behaviour relationship by induction of ‘virtual lesions’

1999 ◽  
Vol 354 (1387) ◽  
pp. 1229-1238 ◽  
Author(s):  
Alvaro Pascual-Leone
Keyword(s):  
Transcranial Magnetic Stimulation ◽  
Magnetic Stimulation ◽  
Brain Connectivity ◽  
Brain Activity ◽  
Causal Link ◽  
Non Invasive ◽  
Invasive Method ◽  
Normal Humans ◽  
The Brain ◽  
Neuroimaging Techniques

Transcranial magnetic stimulation (TMS) provides a non-invasive method of induction of a focal current in the brain and transient modulation of the function of the targeted cortex. Despite limited understanding about focality and mechanisms of action, TMS provides a unique opportunity of studying brain-behaviour relations in normal humans. TMS can enhance the results of other neuroimaging techniques by establishing the causal link between brain activity and task performance, and by exploring functional brain connectivity.

scholarly journals Transcranial magnetic stimulation reveals diminished homoeostatic metaplasticity in cognitively impaired adults

2020 ◽  
Vol 2 (2) ◽  
Author(s):  
Mark H Sundman ◽  
Koeun Lim ◽  
Viet Ton That ◽  
Jack-Morgan Mizell ◽  
Chidi Ugonna ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Impairment ◽  
Transcranial Magnetic Stimulation ◽  
Brain Stimulation ◽  
Magnetic Stimulation ◽  
Cognitive Status ◽  
Synaptic Activity ◽  
Cognitively Impaired ◽  
Non Invasive ◽  
Potential Value

Abstract Homoeostatic metaplasticity is a neuroprotective physiological feature that counterbalances Hebbian forms of plasticity to prevent network destabilization and hyperexcitability. Recent animal models highlight dysfunctional homoeostatic metaplasticity in the pathogenesis of Alzheimer’s disease. However, the association between homoeostatic metaplasticity and cognitive status has not been systematically characterized in either demented or non-demented human populations, and the potential value of homoeostatic metaplasticity as an early biomarker of cognitive impairment has not been explored in humans. Here, we report that, through pre-conditioning the synaptic activity prior to non-invasive brain stimulation, the association between homoeostatic metaplasticity and cognitive status could be established in a population of non-demented human subjects (older adults across cognitive spectrums; all within the non-demented range). All participants (n = 40; age range, 65–74, 47.5% female) underwent a standardized neuropsychological battery, magnetic resonance imaging and a transcranial magnetic stimulation protocol. Specifically, we sampled motor-evoked potentials with an input/output curve immediately before and after repetitive transcranial magnetic stimulation to assess neural plasticity with two experimental paradigms: one with voluntary muscle contraction (i.e. modulated synaptic activity history) to deliberately introduce homoeostatic interference, and one without to serve as a control condition. From comparing neuroplastic responses across these experimental paradigms and across cohorts grouped by cognitive status, we found that (i) homoeostatic metaplasticity is diminished in our cohort of cognitively impaired older adults and (ii) this neuroprotective feature remains intact in cognitively normal participants. This novel finding suggests that (i) future studies should expand their scope beyond just Hebbian forms of plasticity that are traditionally assessed when using non-invasive brain stimulation to investigate cognitive ageing and (ii) the potential value of homoeostatic metaplasticity in serving as a biomarker for cognitive impairment should be further explored.

Mechanisms and the Current State of Transcranial Magnetic Stimulation

CNS Spectrums ◽  
2003 ◽  
Vol 8 (7) ◽  
pp. 496-514 ◽  
Author(s):  
Mark S. George ◽  
Ziad Nahas ◽  
F. Andrew Kozel ◽  
Xingbao Li ◽  
Kaori Yamanaka ◽  
...  
Keyword(s):  
Transcranial Magnetic Stimulation ◽  
Brain Stimulation ◽  
Magnetic Stimulation ◽  
Functional Brain Imaging ◽  
New Developments ◽  
Magnetic Seizure Therapy ◽  
Non Invasive ◽  
Current State ◽  
Core Technology ◽  
Neuroscience Research

ABSTRACTTranscranial magnetic stimulation (TMS) is unique among the current brain stimulation techniques because it is relatively non-invasive. TMS markedly differs from vagus nerve stimulation, deep brain stimulation and magnetic seizure therapy, all of which require either an implanted prosthesis or general anesthesia, or both. Since its rebirth in its modern form in 1985, TMS has already shown potential usefulness in at least three important domains—as a basic neuroscience research instrument, as a potential clinical diagnostic tool, and as a therapy for several different neuropsychiatric conditions. The TMS scientific literature has now expanded beyond what a single summary article can adequately cover. This review highlights several new developments in combining TMS with functional brain imaging, using TMS as a psychiatric therapy, potentially using TMS to enhance performance, and finally recent advances in the core technology of TMS. TMS' ability to non-invasively and focally stimulate the brain of an awake human is proving to be a most important development for neuroscience in general, and neuropsychiatry in particular.

scholarly journals Modern concepts of the pathogenesis of obesity and new approaches to its correction

2018 ◽  
Vol 15 (2) ◽  
pp. 11-16
Author(s):  
Oksana V. Logvinova ◽  
Alexandra G. Poydasheva ◽  
Ilya S. Bakulin ◽  
Olga V. Lagoda ◽  
Elena I. Kremneva ◽  
...  
Keyword(s):  
Eating Disorders ◽  
Electrical Stimulation ◽  
Transcranial Magnetic Stimulation ◽  
Brain Stimulation ◽  
Magnetic Stimulation ◽  
Cellular Level ◽  
Transcranial Electrical Stimulation ◽  
Food Behavior ◽  
Physiological Mechanisms ◽  
Non Invasive

The present review considers modern concepts of the physiological mechanisms of the formation of food behavior in a norm at several levels, beginning with the cellular level and ending with the level of functional systems. Neuroimaging methods used for both the study of the pathophysiological foundations of eating disorders and for determining the target for neurostimulation techniques are described. Methods of non-invasive brain stimulation such as transcranial magnetic stimulation and transcranial electrical stimulation, the mechanisms of their influence and aspects of safety of application are reviewed, the latest data on the results of studies on the use of the above methods in the therapy of obesity are summarized.

scholarly journals Transcranial magnetic stimulation in exploring neurophysiology of cortical circuits and potential clinical implications

2021 ◽  
Vol 64 ◽  
pp. 244-257
Author(s):  
Kaviraja Udupa
Keyword(s):  
Transcranial Magnetic Stimulation ◽  
Psychiatric Disorders ◽  
Brain Stimulation ◽  
Magnetic Stimulation ◽  
Academic Research ◽  
Therapeutic Interventions ◽  
Cortical Circuits ◽  
Non Invasive ◽  
Technical Details ◽  
Exciting Area

Transcranial magnetic stimulation (TMS) is a non-invasive, painless technique to stimulate the human brain. Although it has been used in clinical research both as an investigative tool and treatment modality for the past three decades, its use has been restricted to tertiary health centres or higher-end academic research institutions. The aim of this review is to popularise the concepts of this effective non-invasive brain stimulation technique, further facilitating its use both in research and clinical practice among clinical physiologists. In the first part of this article, a brief physiologic overview of TMS will be provided with basic as well as the basic technical details. This is followed by a discussion of TMS parameters that can be studied using single and paired pulses of TMS which could be used to investigate the altered excitability of cortical circuits. Finally, how rTMS and patterned TMS could be used to induce plasticity which, in turn, could be potentially used as therapeutic interventions in various neurological and psychiatric disorders will be illustrated. In each section of this article, diagnostic as well as therapeutic utilities of TMS in Neurology and Psychiatric disorders will be discussed. These discussions could not only facilitate the understanding of pathophysiology of mood and movement disorders but also to manage various neurological and psychiatric disorders with novel therapeutic options. In the end, few future directions, limitations of this technique and comparison with other techniques will be provided. I hopefully, this review would elicit some interest in physiologists to take up this exciting area of brain stimulation as a research subject and work further on understanding the functions of brain and use it effectively in the management of various brain-related disorders.

scholarly journals Magnetically Induced Temporal Interference for Focal and Deep-Brain Stimulation

2021 ◽  
Vol 15 ◽  
Author(s):  
Zonghao Xin ◽  
Akihiro Kuwahata ◽  
Shuang Liu ◽  
Masaki Sekino
Keyword(s):  
Deep Brain Stimulation ◽  
Electric Field ◽  
Brain Stimulation ◽  
Magnetic Stimulation ◽  
Brain Regions ◽  
Potential Candidate ◽  
Non Invasive ◽  
Neural Modulation ◽  
Stimulation Method ◽  
Deep Brain

Transcranial magnetic stimulation (TMS) is a non-invasive brain stimulation technique that has been clinically applied for neural modulation. Conventional TMS systems are restricted by the trade-off between depth penetration and the focality of the induced electric field. In this study, we integrated the concept of temporal interference (TI) stimulation, which has been demonstrated as a non-invasive deep-brain stimulation method, with magnetic stimulation in a four-coil configuration. The attenuation depth and spread of the electric field were obtained by performing numerical simulation. Consequently, the proposed temporally interfered magnetic stimulation scheme was demonstrated to be capable of stimulating deeper regions of the brain model while maintaining a relatively narrow spread of the electric field, in comparison to conventional TMS systems. These results demonstrate that TI magnetic stimulation could be a potential candidate to recruit brain regions underneath the cortex. Additionally, by controlling the geometry of the coil array, an analogous relationship between the field depth and focality was observed, in the case of the newly proposed method. The major limitations of the methods, however, would be the considerable intensity and frequency of the input current, followed by the frustration in the thermal management of the hardware.

scholarly journals Aberrant neuroplasticity in autism spectrum disorder

2021 ◽  
Vol 6 (8) ◽  
Keyword(s):  
Autism Spectrum Disorder ◽  
Transcranial Magnetic Stimulation ◽  
Magnetic Stimulation ◽  
Therapeutic Potential ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Future Directions ◽  
Non Invasive ◽  
Repetitive Tms ◽  
The Brain

Developments have taken place within the neurobiology research in Autism spectrum disorder (ASD), and results from these studies indicate that the brain in ASD is related to aberrant neuroplasticity. Transcranial magnetic stimulation (TMS) has quickly evolved to become a widely used, safe, and non-invasive neuroscientific tool to analyze a spread of neuroscience processes, as neuroplasticity. The diagnostic and therapeutic potential of TMS in ASD is setting out to be realized. during this article, we concisely reviewed the proof of aberrant neuroplasticity in ASD, steered future directions in assessing neuroplasticity exploitation repetitive TMS (rTMS), and mentioned the potential of rTMS in rectifying aberrant neuroplasticity in ASD.

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