scholarly journals Alchemilla vulgaris agg. (Lady's mantle) from central Balkan: antioxidant, anticancer and enzyme inhibition properties

RSC Advances ◽  
2019 ◽  
Vol 9 (64) ◽  
pp. 37474-37483 ◽  
Author(s):  
Sanja Vlaisavljević ◽  
Sanja Jelača ◽  
Gökhan Zengin ◽  
Neda Mimica-Dukić ◽  
Sanja Berežni ◽  
...  
Keyword(s):  
Enzyme Inhibition ◽  
Biological Properties ◽  
Phytochemical Profile

The current study was designed to evaluate the phytochemical profile and biological properties of extracts of Alchemilla vulgaris from Southeast Serbia which was traditionally used to alleviate and treat many diseases.

scholarly journals Phytochemical profile, enzyme inhibition activity and molecular docking analysis of Feijoa sellowiana O. Berg

2021 ◽  
Vol 36 (1) ◽  
pp. 618-626 ◽  
Author(s):  
Fatema R. Saber ◽  
Rehab M. Ashour ◽  
Ali M. El-Halawany ◽  
Mohamad Fawzi Mahomoodally ◽  
Gunes Ak ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Enzyme Inhibition ◽  
Inhibition Activity ◽  
Docking Analysis ◽  
Phytochemical Profile ◽  
Molecular Docking Analysis

scholarly journals Rose Flowers—A Delicate Perfume or a Natural Healer?

Biomolecules ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 127
Author(s):  
Milka Mileva ◽  
Yana Ilieva ◽  
Gabriele Jovtchev ◽  
Svetla Gateva ◽  
Maya Margaritova Zaharieva ◽  
...  
Keyword(s):  
Essential Oils ◽  
Food Industry ◽  
Raw Materials ◽  
Biological Activities ◽  
Biological Properties ◽  
Rosa Damascena ◽  
Oil Sand ◽  
Rosa Gallica ◽  
Therapeutic Properties ◽  
Phytochemical Profile

Plants from the Rosacea family are rich in natural molecules with beneficial biological properties, and they are widely appreciated and used in the food industry, perfumery, and cosmetics. In this review, we are considering Rosa damascena Mill., Rosa alba L., Rosa centifolia L., and Rosa gallica L. as raw materials important for producing commercial products, analyzing and comparing the main biological activities of their essential oils, hydrolates, and extracts. A literature search was performed to find materials describing (i) botanical characteristics; (ii) the phytochemical profile; and (iii) biological properties of the essential oil sand extracts of these so called “old roses” that are cultivated in Bulgaria, Turkey, India, and the Middle East. The information used is from databases PubMed, Science Direct, and Google Scholar. Roses have beneficial healing properties due to their richness of beneficial components, the secondary metabolites as flavonoids (e.g., flavones, flavonols, anthocyanins), fragrant components (essential oils, e.g., monoterpenes, sesquiterpenes), and hydrolysable and condensed tannins. Rose essential oils and extracts with their therapeutic properties—as respiratory antiseptics, anti-inflammatories, mucolytics, expectorants, decongestants, and antioxidants—are able to act as symptomatic prophylactics and drugs, and in this way alleviate dramatic sufferings during severe diseases.

Phytochemical profile, antioxidant, antiproliferative, and enzyme inhibition-docking analyses of Salvia ekimiana Celep & Doğan

2022 ◽  
Vol 146 ◽  
pp. 36-47
Author(s):  
Gökçe Şeker Karatoprak ◽  
Fatih Göger ◽  
İsmail Çelik ◽  
Ümit Budak ◽  
Esra Küpeli Akkol ◽  
...  
Keyword(s):  
Enzyme Inhibition ◽  
Phytochemical Profile

scholarly journals Phytochemical Profile and Biological Properties of Colchicum triphyllum (Meadow Saffron)

Foods ◽  
2020 ◽  
Vol 9 (4) ◽  
pp. 457 ◽  
Author(s):  
Biancamaria Senizza ◽  
Gabriele Rocchetti ◽  
Murat Ali Okur ◽  
Gokhan Zengin ◽  
Evren Yıldıztugay ◽  
...  
Keyword(s):  
High Performance ◽  
Biological Activities ◽  
Reducing Power ◽  
Extraction Methods ◽  
Biological Properties ◽  
Leaf Extracts ◽  
Antioxidant Power ◽  
Phytochemical Profile ◽  
First Time

In this work, the phytochemical profile and the biological properties of Colchicum triphyllum (an unexplored Turkish cultivar belonging to Colchicaceae) have been comprehensively investigated for the first time. Herein, we focused on the evaluation of the in vitro antioxidant and enzyme inhibitory effects of flower, tuber, and leaf extracts, obtained using different extraction methods, namely maceration (both aqueous and methanolic), infusion, and Soxhlet. Besides, the complete phenolic and alkaloid untargeted metabolomic profiling of the different extracts was investigated. In this regard, ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-QTOF-MS) allowed us to putatively annotate 285 compounds when considering the different matrix extracts, including mainly alkaloids, flavonoids, lignans, phenolic acids, and tyrosol equivalents. The most abundant polyphenols were flavonoids (119 compounds), while colchicine, demecolcine, and lumicolchicine isomers were some of the most widespread alkaloids in each extract analyzed. In addition, our findings showed that C. triphyllum tuber extracts were a superior source of both total alkaloids and total polyphenols, being on average 2.89 and 10.41 mg/g, respectively. Multivariate statistics following metabolomics allowed for the detection of those compounds most affected by the different extraction methods. Overall, C. triphyllum leaf extracts showed a strong in vitro antioxidant capacity, in terms of cupric reducing antioxidant power (CUPRAC; on average 96.45 mg Trolox Equivalents (TE)/g) and ferric reducing antioxidant power (FRAP) reducing power (on average 66.86 mg TE/g). Interestingly, each C. triphyllum methanolic extract analyzed (i.e., from tuber, leaf, and flower) was active against the tyrosinase in terms of inhibition, recording the higher values for methanolic macerated leaves (i.e., 125.78 mg kojic acid equivalent (KAE)/g). On the other hand, moderate inhibitory activities were observed against AChE and α-amylase. Strong correlations (p < 0.01) were also observed between the phytochemical profiles and the biological activities determined. Therefore, our findings highlighted, for the first time, the potential of C. triphhyllum extracts in food and pharmaceutical applications.

scholarly journals Feijoa Fruit Peel: Micro-morphological Features, Evaluation of Phytochemical Profile, and Biological Properties of Its Essential Oil

Antioxidants ◽  
2019 ◽  
Vol 8 (8) ◽  
pp. 320 ◽  
Author(s):  
Antonella Smeriglio ◽  
Marcella Denaro ◽  
Clara De Francesco ◽  
Laura Cornara ◽  
Davide Barreca ◽  
...  
Keyword(s):  
Essential Oil ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Antimicrobial Properties ◽  
Biological Properties ◽  
Fruit Peel ◽  
Cytoprotective Activity ◽  
Phytochemical Profile ◽  
Acca Sellowiana

Acca sellowiana (O. Berg) Burret (Feijoa) is an evergreen shrub, belonging to the Mirtaceae family. The aim of this study was to investigate the micromorphological features of the feijoa fruit peel and to evaluate the phytochemical profile, as well as the antioxidant, cytoprotective, and antimicrobial properties of its essential oil (EO), by several in vitro cell-free and cell-based assays. The micromorphological analysis showed several schizogenic secretory cavities, immediately below the epidermal layer. Forty compounds were identified and quantified by GC-FID and GC-MS analyses. Sesquiterpenes were the most abundant ones (76.89%), followed by monoterpene hydrocarbons (3.26%), and oxygenated monoterpenes (0.34%). The main compounds were γ-Selinene (17.39%), α-Cariophyllene (16.74%), β-Cariophyllene (10.37%), and Germacene D (5.32%). The EO showed a strong and dose-dependent antioxidant, and free-radical scavenging activity. Furthermore, it showed cytoprotective activity on the lymphocytes, that have been pre-treated with 100 μM tert-butyl-hydroperoxide (t-BOOH), as well as a decrease in intracellular reactive oxygen species (ROS), induced by t-BOOH on erythrocytes. A preliminary antimicrobial screening against GRAM+ and GRAM− bacteria, as well as on fungi highlighted that EO showed the best activity against S. aureus and C. albicans (MIC 2.7 mg/mL). In light of these results, feijoa fruit EO could find various applications, especially in the food, nutraceutical, and pharmaceutical fields.

scholarly journals Anti-Inflammatory and Cytotoxic Potential of New Phenanthrenoids from Luzula sylvatica

Molecules ◽  
2020 ◽  
Vol 25 (10) ◽  
pp. 2372
Author(s):  
Maël Gainche ◽  
Isabelle Ripoche ◽  
François Senejoux ◽  
Juliette Cholet ◽  
Clémence Ogeron ◽  
...  
Keyword(s):  
Antioxidant Activities ◽  
Leukemia Cell ◽  
2D Nmr ◽  
Biological Properties ◽  
Leukemia Cell Line ◽  
Monocytic Leukemia ◽  
Bioassay Guided Fractionation ◽  
Phytochemical Profile ◽  
Anti Inflammatory ◽  
Coumarin 1

Phenanthrenoids have been widely described, in the Juncaceae family, for their biological properties such as antitumor, anxiolytic, anti-microbial, spasmolytic, and anti-inflammatory activities. The Juncaceae family is known to contain a large variety of phenanthrenoids possessing especially anti-inflammatory and cytotoxic properties. Luzula sylvatica, a Juncaceae species, is widely present in the Auvergne region of France, but has never been studied neither for its phytochemical profile nor for its biological properties. We investigated the phytochemical profile and evaluated the potential anti-inflammatory activities of L. sylvatica aerial parts extracts. A bioassay-guided fractionation was carried out to identify the most active fractions. Nine compounds were isolated, one coumarin 1 and eight phenanthrene derivatives (2–9), including four new compounds (4, 5, 8 and 9), from n-hexane and CH2Cl2, fractions. Their structures were established by HRESIMS, 1D and 2D NMR experiments. The biological properties, especially the anti-inflammatory/antioxidant activities (ROS production) and antiproliferative activity on THP-1, a monocytic leukemia cell line, of each compound, were evaluated. Three phenanthrene derivatives 4, 6, and 7 showed very promising antiproliferative activities.

scholarly journals Phytochemical profile and pharmacological properties of Trifolium repens

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Sultan Ahmad ◽  
Alam Zeb
Keyword(s):  
Trifolium Repens ◽  
Biological Properties ◽  
Leafy Vegetables ◽  
Pharmacological Properties ◽  
Bioactive Components ◽  
Cyanogenic Glucosides ◽  
Comprehensive Overview ◽  
Potential Source ◽  
The Family ◽  
Phytochemical Profile

AbstractTrifolium repens belongs to the family Leguminosae and has been used for therapeutic purposes as traditional medicine. The plant is widely used as fodder and leafy vegetables for human uses. However, there is a lack of a detailed review of its phytochemical profile and pharmacological properties. This review presents a comprehensive overview of the phytochemical profile and biological properties of T. repens. The plant is used as antioxidants and cholinesterase inhibitors and for anti-inflammatory, antiseptic, analgesic, antirheumatic ache, and antimicrobial purposes. This review has summarized the available updated useful information about the different bioactive compounds such as simple phenols, phenolic acids, flavones, flavonols, isoflavones, pterocarpans, cyanogenic glucosides, saponins, and condensed tannins present in T. repens. The pharmacological roles of these secondary metabolites present in T. repens have been presented. It has been revealed that T. repens contain important phytochemicals, which is the potential source of health-beneficial bioactive components for food and nutraceuticals industries.

scholarly journals Phytochemical profile, acute dermal toxicity and wound healing activity of Guettarda calyptrata A. Rich

2021 ◽  
Vol 10 (2) ◽  
pp. 249-256
Author(s):  
Yamilet Irene Gutiérrez Gaitén ◽  
Jennifer Melissa Norden ◽  
Ramón Scull Lizama ◽  
Alejandro Felipe González ◽  
Loida Oruña Sánchez ◽  
...  
Keyword(s):  
Wound Healing ◽  
Chemical Composition ◽  
High Performance ◽  
Statistical Significance ◽  
Scientific Information ◽  
Biological Properties ◽  
Positive Control ◽  
Dermal Toxicity ◽  
Hydroalcoholic Extract ◽  
Phytochemical Profile

Introduction: The leaves and barks of Guettarda calyptrata have been attributed to the property of healing wounds on the skin and mucous membranes. However, the scientific information about the phytochemical composition and biological properties is scarce. This research evaluates the chemical composition, dermal safety, and wound healing properties of a hydroalcoholic extract of G. calyptrata. Methods: Hydroalcoholic extract of G. calyptrata was obtained from leaves. The phytochemical profile was analyzed by phytochemical screening, thin layer chromatography, high performance liquid chromatography (HPLC), and quantification of phenols and flavonoids by Folin-Ciocalteu and aluminum chloride methods, respectively. An acute dermal toxicity test was performed in rats, and the healing activity was evaluated using the excision wound model at 100 mg/kg of the extracts. Statistical significance (P < 0.05) was determined by an analysis of variance followed by the Student-Newman-Keuls test. Results: The presence of alkaloids, saponins, terpenoids, phenolic compounds, rutin, and quercetin flavonoids, among others, was suggested. The extract did not cause toxicity at the dose of 2000 mg/kg and was able to reduce the size of the wounds during the seven days of the test, with a healing effect comparable to the silver sulfadiazine cream used as a positive control, favoring collagen deposition and re-epithelialization. Conclusion: This work makes an important contribution to the chemical composition and provides the first findings on the efficacy in the healing of topical wounds, which justify the use of G. calyptrata in traditional Cuban medicine.

scholarly journals Microalgae as a Potential Functional Ingredient: Evaluation of the Phytochemical Profile, Antioxidant Activity and In-Vitro Enzymatic Inhibitory Effect of Different Species

Molecules ◽  
2021 ◽  
Vol 26 (24) ◽  
pp. 7593
Author(s):  
Marta Vinha Vieira ◽  
Igor Piotr Turkiewicz ◽  
Karolina Tkacz ◽  
Claudio Fuentes-Grünewald ◽  
Lorenzo M. Pastrana ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Biological Effects ◽  
Inhibitory Effect ◽  
Biological Properties ◽  
Porphyridium Purpureum ◽  
Promising Alternative ◽  
Functional Ingredient ◽  
Phytochemical Profile ◽  
The Impact

The functional food market has been in a state of constant expansion due to the increasing awareness of the impact of the diet on human health. In the search for new natural resources that could act as a functional ingredient for the food industry, microalgae represent a promising alternative, considering their high nutritional value and biosynthesis of numerous bioactive compounds with reported biological properties. In the present work, the phytochemical profile, antioxidant activity, and enzymatic inhibitory effect aiming at different metabolic disorders (Alzheimer’s disease, Type 2 diabetes, and obesity) were evaluated for the species Porphyridium purpureum, Chlorella vulgaris, Arthorspira platensis, and Nannochloropsis oculata. All the species presented bioactive diversity and important antioxidant activity, demonstrating the potential to be used as functional ingredients. Particularly, P. purpureum and N. oculata exhibited higher carotenoid and polyphenol content, which was reflected in their superior biological effects. Moreover, the species P. purpureum exhibited remarkable enzymatic inhibition for all the analyses.

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