NocU is a Cytochrome P450 Oxygenase Catalyzing N-Hydroxylation of the Indolic Moiety during the Maturation of the Thiopeptide Antibiotics Nocathiacins

2021 ◽  
Author(s):  
Heng Guo ◽  
Xuebing Bai ◽  
Qian Yang ◽  
Yufeng Xue ◽  
Dandan Chen ◽  
...  
Keyword(s):  
Natural Products ◽  
Cytochrome P450 ◽  
The Family ◽  
Thiopeptide Antibiotics

The ribosomally synthesized and post-translationally modified peptide (RiPP) natural products include the family of thiopeptide antibiotics, where nocathiacins (NOCs) and nosiheptide (NOS) are structurally related bicyclic members featuring an indolic...

scholarly journals Correction: NocU is a cytochrome P450 oxygenase catalyzing N-hydroxylation of the indolic moiety during the maturation of the thiopeptide antibiotics nocathiacins

2021 ◽  
Author(s):  
Heng Guo ◽  
Xuebing Bai ◽  
Qian Yang ◽  
Yufeng Xue ◽  
Dandan Chen ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Thiopeptide Antibiotics

Correction for ‘NocU is a cytochrome P450 oxygenase catalyzing N-hydroxylation of the indolic moiety during the maturation of the thiopeptide antibiotics nocathiacins’ by Heng Guo et al., Org. Biomol. Chem., 2021, DOI: 10.1039/d1ob01284c.

Mechanism-based inactivation of cytochrome P450 enzymes by natural products based on metabolic activation

2020 ◽  
Vol 52 (4) ◽  
pp. 501-530
Author(s):  
Tingting Zhang ◽  
Jinqiu Rao ◽  
Wei Li ◽  
Kai Wang ◽  
Feng Qiu
Keyword(s):  
Natural Products ◽  
Cytochrome P450 ◽  
Metabolic Activation ◽  
Cytochrome P450 Enzymes

scholarly journals Chemical and Biological Explorations of the Family of CC-1065 and the Duocarmycin Natural Products

2009 ◽  
Vol 9 (16) ◽  
pp. 1494-1524 ◽  
Author(s):  
Nandita Ghosh ◽  
Helen Sheldrake ◽  
Mark Searcey ◽  
Klaus Pors
Keyword(s):  
Natural Products ◽  
The Family

Research progress on secondary metabolites from the ascidians of Aplidium genus

2020 ◽  
Vol 17 ◽  
Author(s):  
Qing-Hua Han ◽  
Xiao-Qing Tian ◽  
Shu-Ming Zhao ◽  
Ya-Nan Lu ◽  
Cheng-Qi Fan
Keyword(s):  
Natural Products ◽  
Secondary Metabolites ◽  
Marine Environment ◽  
Chemical Diversity ◽  
Research Progress ◽  
China Seas ◽  
Bioactive Natural Products ◽  
The Family ◽  
Further Development

Abstract: Ascidians (tunicates) are widely recognized as one of the most prolific producers of bioactive natural products in the marine environment. This present study reviewed the chemical diversity of marine ascidians from the Aplidium genus and their pharmacological applications since Jan 2005. The resources of this genus from China Seas, including the changes of their names in the family Polydinidae were also summarized in this paper. In addition, a concise outlook on their chemi-cal and pharmaceutical investigation is made to support further development

Naringenin Scaffold As A Template For Drug Designing

2019 ◽  
Vol 05 ◽  
Author(s):  
Yogesh Murti ◽  
Bhupesh Chander Semwal ◽  
Ahsas Goyal ◽  
Pradeep Mishra
Keyword(s):  
Health Care ◽  
Natural Products ◽  
Molecular Mechanisms ◽  
Therapeutic Agents ◽  
Lead Compound ◽  
Enhancer Activity ◽  
New Era ◽  
The Family ◽  
Drug Designing ◽  
Memory Enhancer

: Natural products provides cornucopia of heterocyclic systems. 2-Phenyl chromane nucleus is one of the important and well known heterocycles present in natural products. Naringenin, a plant-derived flavanone (2-phenyl chroman-4-one) belongs to the family of flavanoids. It possesses diverse biologic activities such as antidiabetic, antiatherogenic, antidepressant, antiandrogenic, antiestrogenic, immunomodulatory, antitumor, antimicrobial, anti-inflammatory, antiviral, hypolipidemic, antihypertensive, antioxidant, neuroprotective, anti-obesity, anti-Alzheimer, and memory enhancer activity. It has potential to be used as an active pharmacophore. A number of molecular mechanisms underlying its beneficial activities have been reported. With emerging interest in the traditional medicine and exploit their potentials based on different health care system, it was thought to explore literature on naringenin. Further, this review aims to provide newer insights of naringenin and its derivatives as lead compound in drug design to a new era of flavonoid based therapeutic agents.

Synthetic studies on heterocyclic natural products

2014 ◽  
Vol 92 (3) ◽  
pp. 186-193 ◽  
Author(s):  
Marco A. Ciufolini
Keyword(s):  
Organic Chemistry ◽  
Natural Products ◽  
Synthetic Organic Chemistry ◽  
Thiopeptide Antibiotics ◽  
Erythrina Alkaloids ◽  
Synthetic Studies

This paper highlights ongoing efforts toward Erythrina alkaloids, himandrine, tetrodotoxin, and thiopeptide antibiotics such as nosiheptide and describes representative spinoffs in biomedicine that emanated from the author’s research in synthetic organic chemistry.

In vitro inhibition of human cytochrome P450-mediated metabolism of marker substrates by natural products

Phytomedicine ◽  
2003 ◽  
Vol 10 (4) ◽  
pp. 334-342 ◽  
Author(s):  
B.C. Foster ◽  
S. Vandenhoek ◽  
J. Hana ◽  
A. Krantis ◽  
M.H. Akhtar ◽  
...  
Keyword(s):  
Natural Products ◽  
Cytochrome P450 ◽  
Human Cytochrome ◽  
In Vitro Inhibition

Evolution of insect P450

2006 ◽  
Vol 34 (6) ◽  
pp. 1252-1255 ◽  
Author(s):  
R. Feyereisen
Keyword(s):  
Natural Products ◽  
Cytochrome P450 ◽  
Insecticide Resistance ◽  
Insect Genome ◽  
Physiological Functions ◽  
Environmental Challenges

The first fully sequenced insect genomes were those of the fruitfly and the mosquito, both from the order Diptera. Now, with an increasing number and diversity of insect genomes becoming available, the diversity of insect P450 genes can be better appreciated and tentative ideas about the evolution of the CYP (cytochrome P450) superfamily in insects can be proposed. There are four large clades of insect P450 genes that existed before the divergence of the class Insecta and that are also represented by CYP families in vertebrates: the CYP2 clade, the CYP3 clade, the CYP4 clade and the mitochondrial P450 clade. P450s with known or suspected physiological functions are present in each of these clades and only a dozen genes appear to have orthologues or very close paralogues in each insect genome. P450 enzymes from each of these clades have been linked to insecticide resistance or to the metabolism of natural products and xenobiotics. In particular, insects appear to maintain a repertoire of mitochondrial P450 paralogues devoted to the response to environmental challenges.

scholarly journals Evaluation of Physico-chemical And chromatographic profile of Kababchini Fruit(Pipercubeba)

2018 ◽  
Vol 6 (01) ◽  
Author(s):  
Dipshikha Sitaram Rakhunde ◽  
Deepak Sharma ◽  
Surekha Landge
Keyword(s):  
Natural Products ◽  
Asian Countries ◽  
Physico Chemical ◽  
The Family ◽  
Future Drug ◽  
Chromatographic Profile ◽  
Dried Fruit ◽  
Medicinal Properties ◽  
Therapeutic Properties ◽  
Standard Profile

ABSTRACT:- Indian spices that provide flavor, to food also possess many therapeutic properties. Ancient Indian texts of Ayurveda, an Indian system of medicine, detailed the medicinal properties of these plants and their therapeutic usage. Natural products have traditionally provided many of the drugs in use . Kababchini is a spice commonly used in Asian countries for cooking purposes. It is the dried fruit of an evergreen small tree. Pimentadioica which belongs to the family of creepers. The pimenta is a parasitic plant and grows on other full-grown trees. The kababchini’s plant is about nine meters in height and its leaves are egg-shaped and 10–12 cm in length. Its fruit is tiny and green in color. It keeps the digestive tract normal and is very effective in case of piles. It strengthens heart. It helps in treating cough and asthmatic conditions. It regularizes the menstrual cycle. It is very effective in erectile dysfunction. It is very effective in toning up of the urinary tract.With the increasing interests in the reservoir of untested natural products, many future drug developments will be based on natural products. The standard profile of kababchini is not given in API, so that’s why the present article reviews the Ayurvedic aspects of Kababchini  well supported by the available literature and its  physico-chemical  and Chromatographic profile. Key words:- Physico-chemicals, Chromatographic profile,  Kababchini   

scholarly journals RESOLUSI KEMISKINAN RUMAH TANGGA NELAYAN DI NEGERI SEILALE

KRITIS ◽  
2020 ◽  
Vol 29 (1) ◽  
pp. 78-86
Author(s):  
Susi Maria Mariwy ◽  
Wilson M.A. Therik
Keyword(s):  
Natural Products ◽  
Data Collection ◽  
Research Data ◽  
Community Life ◽  
Daily Consumption ◽  
Modern Equipment ◽  
Exploratory Approach ◽  
The Family ◽  
Low Education ◽  
Cycle Of Poverty

Fishermen's household poverty is something that should not be underestimated because of its abundant natural products, but they are still under the cycle of poverty. A household is said to be poor if it is not able to meet the needs of their lives. Household economic characteristics are an important part of family or community life in general. Economic characteristics arise because of the desire to act in a situation that is possible with the aim of obtaining benefits for the family. Which aims to understand the household life of fishermen in the State of Seilale. In this research, data collection was done by interview, observation and documentation study using an exploratory approach. The poverty problem that occurs in Seilale fishing households is inseparable from various causes of poverty. The factors that cause poverty in the form of changes in catching season, this factor has caused uncertainty of the catches of the fishermen, so that when the season is not catching fish the fishermen find it very difficult to meet their daily consumption needs. Low education, low expertise makes fishermen stay afloat to become a traditional fisherman. Fishing equipment that is still simple and inadequate makes them also have to compete with fishermen who have modern equipment.

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