scholarly journals Chemical and Biological Explorations of the Family of CC-1065 and the Duocarmycin Natural Products

2009 ◽  
Vol 9 (16) ◽  
pp. 1494-1524 ◽  
Author(s):  
Nandita Ghosh ◽  
Helen Sheldrake ◽  
Mark Searcey ◽  
Klaus Pors
Keyword(s):  
Natural Products ◽  
The Family

NocU is a Cytochrome P450 Oxygenase Catalyzing N-Hydroxylation of the Indolic Moiety during the Maturation of the Thiopeptide Antibiotics Nocathiacins

2021 ◽  
Author(s):  
Heng Guo ◽  
Xuebing Bai ◽  
Qian Yang ◽  
Yufeng Xue ◽  
Dandan Chen ◽  
...  
Keyword(s):  
Natural Products ◽  
Cytochrome P450 ◽  
The Family ◽  
Thiopeptide Antibiotics

The ribosomally synthesized and post-translationally modified peptide (RiPP) natural products include the family of thiopeptide antibiotics, where nocathiacins (NOCs) and nosiheptide (NOS) are structurally related bicyclic members featuring an indolic...

Research progress on secondary metabolites from the ascidians of Aplidium genus

2020 ◽  
Vol 17 ◽  
Author(s):  
Qing-Hua Han ◽  
Xiao-Qing Tian ◽  
Shu-Ming Zhao ◽  
Ya-Nan Lu ◽  
Cheng-Qi Fan
Keyword(s):  
Natural Products ◽  
Secondary Metabolites ◽  
Marine Environment ◽  
Chemical Diversity ◽  
Research Progress ◽  
China Seas ◽  
Bioactive Natural Products ◽  
The Family ◽  
Further Development

Abstract: Ascidians (tunicates) are widely recognized as one of the most prolific producers of bioactive natural products in the marine environment. This present study reviewed the chemical diversity of marine ascidians from the Aplidium genus and their pharmacological applications since Jan 2005. The resources of this genus from China Seas, including the changes of their names in the family Polydinidae were also summarized in this paper. In addition, a concise outlook on their chemi-cal and pharmaceutical investigation is made to support further development

Naringenin Scaffold As A Template For Drug Designing

2019 ◽  
Vol 05 ◽  
Author(s):  
Yogesh Murti ◽  
Bhupesh Chander Semwal ◽  
Ahsas Goyal ◽  
Pradeep Mishra
Keyword(s):  
Health Care ◽  
Natural Products ◽  
Molecular Mechanisms ◽  
Therapeutic Agents ◽  
Lead Compound ◽  
Enhancer Activity ◽  
New Era ◽  
The Family ◽  
Drug Designing ◽  
Memory Enhancer

: Natural products provides cornucopia of heterocyclic systems. 2-Phenyl chromane nucleus is one of the important and well known heterocycles present in natural products. Naringenin, a plant-derived flavanone (2-phenyl chroman-4-one) belongs to the family of flavanoids. It possesses diverse biologic activities such as antidiabetic, antiatherogenic, antidepressant, antiandrogenic, antiestrogenic, immunomodulatory, antitumor, antimicrobial, anti-inflammatory, antiviral, hypolipidemic, antihypertensive, antioxidant, neuroprotective, anti-obesity, anti-Alzheimer, and memory enhancer activity. It has potential to be used as an active pharmacophore. A number of molecular mechanisms underlying its beneficial activities have been reported. With emerging interest in the traditional medicine and exploit their potentials based on different health care system, it was thought to explore literature on naringenin. Further, this review aims to provide newer insights of naringenin and its derivatives as lead compound in drug design to a new era of flavonoid based therapeutic agents.

scholarly journals Evaluation of Physico-chemical And chromatographic profile of Kababchini Fruit(Pipercubeba)

2018 ◽  
Vol 6 (01) ◽  
Author(s):  
Dipshikha Sitaram Rakhunde ◽  
Deepak Sharma ◽  
Surekha Landge
Keyword(s):  
Natural Products ◽  
Asian Countries ◽  
Physico Chemical ◽  
The Family ◽  
Future Drug ◽  
Chromatographic Profile ◽  
Dried Fruit ◽  
Medicinal Properties ◽  
Therapeutic Properties ◽  
Standard Profile

ABSTRACT:- Indian spices that provide flavor, to food also possess many therapeutic properties. Ancient Indian texts of Ayurveda, an Indian system of medicine, detailed the medicinal properties of these plants and their therapeutic usage. Natural products have traditionally provided many of the drugs in use . Kababchini is a spice commonly used in Asian countries for cooking purposes. It is the dried fruit of an evergreen small tree. Pimentadioica which belongs to the family of creepers. The pimenta is a parasitic plant and grows on other full-grown trees. The kababchini’s plant is about nine meters in height and its leaves are egg-shaped and 10–12 cm in length. Its fruit is tiny and green in color. It keeps the digestive tract normal and is very effective in case of piles. It strengthens heart. It helps in treating cough and asthmatic conditions. It regularizes the menstrual cycle. It is very effective in erectile dysfunction. It is very effective in toning up of the urinary tract.With the increasing interests in the reservoir of untested natural products, many future drug developments will be based on natural products. The standard profile of kababchini is not given in API, so that’s why the present article reviews the Ayurvedic aspects of Kababchini  well supported by the available literature and its  physico-chemical  and Chromatographic profile. Key words:- Physico-chemicals, Chromatographic profile,  Kababchini   

scholarly journals RESOLUSI KEMISKINAN RUMAH TANGGA NELAYAN DI NEGERI SEILALE

KRITIS ◽  
2020 ◽  
Vol 29 (1) ◽  
pp. 78-86
Author(s):  
Susi Maria Mariwy ◽  
Wilson M.A. Therik
Keyword(s):  
Natural Products ◽  
Data Collection ◽  
Research Data ◽  
Community Life ◽  
Daily Consumption ◽  
Modern Equipment ◽  
Exploratory Approach ◽  
The Family ◽  
Low Education ◽  
Cycle Of Poverty

Fishermen's household poverty is something that should not be underestimated because of its abundant natural products, but they are still under the cycle of poverty. A household is said to be poor if it is not able to meet the needs of their lives. Household economic characteristics are an important part of family or community life in general. Economic characteristics arise because of the desire to act in a situation that is possible with the aim of obtaining benefits for the family. Which aims to understand the household life of fishermen in the State of Seilale. In this research, data collection was done by interview, observation and documentation study using an exploratory approach. The poverty problem that occurs in Seilale fishing households is inseparable from various causes of poverty. The factors that cause poverty in the form of changes in catching season, this factor has caused uncertainty of the catches of the fishermen, so that when the season is not catching fish the fishermen find it very difficult to meet their daily consumption needs. Low education, low expertise makes fishermen stay afloat to become a traditional fisherman. Fishing equipment that is still simple and inadequate makes them also have to compete with fishermen who have modern equipment.

scholarly journals Identification of Broad-Spectrum MMP Inhibitors by Virtual Screening

Molecules ◽  
2021 ◽  
Vol 26 (15) ◽  
pp. 4553
Author(s):  
Aleix Gimeno ◽  
Doretta Cuffaro ◽  
Elisa Nuti ◽  
María José Ojeda-Montes ◽  
Raúl Beltrán-Debón ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Natural Products ◽  
Virtual Screening ◽  
Broad Spectrum ◽  
In Silico ◽  
Mmp Inhibitors ◽  
Bioactivity Assay ◽  
The Family ◽  
Skin Wrinkling

Matrix metalloproteinases (MMPs) are the family of proteases that are mainly responsible for degrading extracellular matrix (ECM) components. In the skin, the overexpression of MMPs as a result of ultraviolet radiation triggers an imbalance in the ECM turnover in a process called photoaging, which ultimately results in skin wrinkling and premature skin ageing. Therefore, the inhibition of different enzymes of the MMP family at a topical level could have positive implications for photoaging. Considering that the MMP catalytic region is mostly conserved across different enzymes of the MMP family, in this study we aimed to design a virtual screening (VS) workflow to identify broad-spectrum MMP inhibitors that can be used to delay the development of photoaging. Our in silico approach was validated in vitro with 20 VS hits from the Specs library that were not only structurally different from one another but also from known MMP inhibitors. In this bioactivity assay, 18 of the 20 compounds inhibit at least one of the assayed MMPs at 100 μM (with 5 of them showing around 50% inhibition in all the tested MMPs at this concentration). Finally, this VS was used to identify natural products that have the potential to act as broad-spectrum MMP inhibitors and be used as a treatment for photoaging.

scholarly journals In-vitro Antiviral Activity of Natural Products against Coronavirus Strains: A Systemic Review

2020 ◽  
Author(s):  
Sindhu KC ◽  
Manoj Pandit ◽  
Amit Kumar Shrivastava
Keyword(s):  
Natural Products ◽  
Antiviral Activity ◽  
Viral Infections ◽  
Chemical Compounds ◽  
Systemic Review ◽  
Human Beings ◽  
Inclusion Criteria ◽  
The Family ◽  
Antiviral Activities

Abstract Coronavirus is a non-segmented, positive-sense RNA genome belonging to the family coronaviridae in the order Nidovirales Corona viral infections have created serious threats in the last couple of decades and recently claiming the death of thousands of human beings. Natural products provide a valuable and powerful resource of chemical compounds alkaloids, tannins, caffeine, biopterin, actinophnine, etc. displaying antiviral properties. The data was reviewed from various databases or search engines: PubMed, Science Direct, MedLine, Google Scholar, and Biomed central for published articles. The data inclusion criteria was natural products and their isolated and different synthetic compounds. Data duplication and titles or contents that do not meet the inclusion criteria and Reports on antiviral activities of natural products or their derivatives against other than CoV strains were excluded. We encountered 49 plants and 19 compound chemically defined natural molecules reported in the literature, which have evaluated for potent antiviral activity against different coronavirus strains. The listed plants and their compounds in this review are highly potent with promising results against coronavirus. These can be further screened for invasive tests and used for making different formulations or may be polyherbal formulations considering its safety profile and toxicity.

scholarly journals Neuroprotective Potential of Limonene and Limonene Containing Natural Products

Molecules ◽  
2021 ◽  
Vol 26 (15) ◽  
pp. 4535
Author(s):  
Lujain Eddin ◽  
Niraj Jha ◽  
M. F. Nagoor Meeran ◽  
Kavindra Kumar Kesari ◽  
Rami Beiram ◽  
...  
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
Neurodegenerative Diseases ◽  
Apoptotic Cell ◽  
Biological Properties ◽  
Therapeutic Drugs ◽  
The Family ◽  
Alternative Agent ◽  
Preclinical And Clinical Studies

Limonene is a monoterpene confined to the family of Rutaceae, showing several biological properties such as antioxidant, anti-inflammatory, anticancer, antinociceptive and gastroprotective characteristics. Recently, there is notable interest in investigating the pharmacological effects of limonene in various chronic diseases due to its mitigating effect on oxidative stress and inflammation and regulating apoptotic cell death. There are several available studies demonstrating the neuroprotective role of limonene in neurodegenerative diseases, including Alzheimer’s disease, multiple sclerosis, epilepsy, anxiety, and stroke. The high abundance of limonene in nature, its safety profile, and various mechanisms of action make this monoterpene a favorable molecule to be developed as a nutraceutical for preventive purposes and as an alternative agent or adjuvant to modern therapeutic drugs in curbing the onset and progression of neurodegenerative diseases. This manuscript presents a comprehensive review of the available scientific literature discussing the pharmacological activities of limonene or plant products containing limonene which attribute to the protective and therapeutic ability in neurodegenerative disorders. This review has been compiled based on the existing published articles confined to limonene or limonene-containing natural products investigated for their neurotherapeutic or neuroprotective potential. All the articles available in English or the abstract in English were extracted from different databases that offer an access to diverse journals. These databases are PubMed, Scopus, Google Scholar, and Science Direct. Collectively, this review emphasizes the neuroprotective potential of limonene against neurodegenerative and other neuroinflammatory diseases. The available data are indicative of the nutritional use of products containing limonene and the pharmacological actions and mechanisms of limonene and may direct future preclinical and clinical studies for the development of limonene as an alternative or complementary phytomedicine. The pharmacophore can also provide a blueprint for further drug discovery using numerous drug discovery tools.

scholarly journals REVIEW OF IPOMOEA PES-TIGRIDIS L.: ETHNO BOTANICAL CHARACTERISTICS, PHARMACOLOGICAL ACTIVITIES

2018 ◽  
Vol 10 (6) ◽  
pp. 1
Author(s):  
N. Venkateshan ◽  
M. Subramaniyam ◽  
M. Santhanakumar
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Medical Information ◽  
Pharmacological Activities ◽  
Primary Metabolites ◽  
Novel Drugs ◽  
The Family ◽  
Scientific Justification ◽  
Botanical Characteristics ◽  
Phytochemical Studies

Nowadays there is a need for scientific justification of plants that have been used in traditional medicine because of loss of information, improvement of therapy and deforestation that is taking place. The majority of the natural products are compounds biosynthetically derived from primary metabolites and are generally categorized as secondary metabolites. These are the major sources of the pharmaceutical industry to discover novel drugs. The basis for interest in natural product chemistry serves as a lead compound for newer drugs, give as much information on possible mechanism and thus on the molecular origin and basis of diseases. Natural products are permanent challenges with respect to total synthesis and stimulate the development of new reagents and reactions. The present study has been taken up to review one of the ethno medicinal significant of Ipomoea pes-tigridis L plant belonging to the family convolvulaceae. The ethno medical information of the plant reveals that the herb Ipomoea pes-tigridis Linn was used as an antidote to dogbite, boils and carbuncles, the leaves were applied as a poultice for boils, carbuncles and sores. The root of this plant was found to possess purgative action. The phytochemical studies on the leaves have been reported for the presence of carbohydrates, proteins and resins.

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