Five-year follow-up of waist circumference, insulin and ALT levels in familial combined hyperlipidaemia

FCHL (familial combined hyperlipidaemia), an entity with many features of the metabolic syndrome, is characterized by changes in cholesterol and triacylglycerol (triglyceride) phenotype over time. The present study was conducted to investigate the relationship of ALT (alanine aminotransferase) levels, used as a surrogate marker for the amount of hepatic fat, with the switch in triacylglycerol phenotype and the increased susceptibility to develop hypertriglyceridaemia in FCHL. BMI (body mass index), waist circumference and plasma triacylglycerols, insulin and ALT levels were measured in 145 FCHL family members and 54 spouses at baseline and after a 5-year follow-up. A switch from normotriglyceridaemia to hypertriglyceridaemia or vice versa, as observed in 22 of 145 FCHL family members, was associated with changes in plasma ALT levels (P=0.001), but not with insulin levels or waist circumference. At 5 years of follow-up, an intra-individual relationship was observed between waist circumference and plasma triacylglycerols, insulin and ALT levels. For each waist circumference, FCHL patients, but not their NL (normolipidaemic) relatives, exhibited higher triacylglycerol and insulin levels than spouses (P<0.001). Remarkably, both FCHL patients and the NL relatives had higher ALT levels for each waist circumference compared with spouses (P<0.001 for FCHL patients, and P=0.035 for NL relatives). In conclusion, the present study shows that the longitudinal relationship of abdominal obesity–ALT is more specific for all FCHL family members, i.e. patients and their NL relatives, than the relationship of abdominal obesity–triacylglycerols. Additionally, the association of ALT with the switch in triacylglycerol phenotype suggests a central role of the liver in the pathogenesis of FCHL.

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Influence of uric acid on the correlation between waist circumference and triglyceride glucose index: an analysis from CHARLS

Lipids in Health and Disease ◽

10.1186/s12944-021-01474-0 ◽

2021 ◽

Vol 20 (1) ◽

Author(s):

Jia Zheng ◽

Min Jiang ◽

Yanxia Xie

Keyword(s):

Uric Acid ◽

Waist Circumference ◽

Mediation Effects ◽

Panel Model ◽

Triglyceride Glucose Index ◽

Study Population ◽

Relationship Of ◽

The Relationship ◽

Longitudinal Relationships

Abstract Background Waist circumference (WC) and uric acid (UA) are significantly related. Still, their temporal sequence and how the sequence works on future risk of triglyceride glucose (TyG) are unknown, especially in the Chinese population. Methods Cross-lagged panel model was used to analyze the reciprocal, longitudinal relationships among a set of interrelated variables. The mediation model was constructed to test the effect of the relationship between WC and UA on TyG. Results A total of 5727 subjects were enrolled in our study population, of which 53.5% were women, and the mean age was 59.0 (standard deviation, 8.62) years. After adjusting for traditional confounding factors, the results showed that a higher level of baseline WC was significantly associated with a higher level of follow-up UA (β = 0.003, P = 0.031) and follow-up TyG (β = 0.003, P < 0.001);. Simultaneously, there was no statistical association between the level of baseline UA and the level of follow-up WC (β = − 0.009, P = 0.951). The mediation effects of UA on WC-TyG were estimated to be 18.1% in adults, and 36.2% in women. Conclusions The current study demonstrated that higher baseline level of WC probably preceded UA’ level in general population. In addition, UA mediated the relationship of WC to TyG, especially in females. And the possible mechanism would require further clarification.

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Impact of Uric Acid on the Relationship between Waist Circumference and Insulin Resistance: Results from CHARLS

10.21203/rs.3.rs-141137/v1 ◽

2021 ◽

Author(s):

Jia Zheng ◽

Min Jiang ◽

Yanxia Xie

Keyword(s):

Insulin Resistance ◽

Uric Acid ◽

Waist Circumference ◽

Mediation Effect ◽

Mediation Effects ◽

Panel Model ◽

Relationship Of ◽

The Impact ◽

The Relationship

Abstract BackgroundWaist circumference (WC) and uric acid (UA) are significantly related. Still, their temporal sequence and how the sequence works on future risk of insulin resistance (IR) are unknown, especially in the Chinese population. MethodsCross-lagged panel model was used to analyze the reciprocal, longitudinal relationships between a set of inter-related variables. The mediation model was constructed to test the impact of the relationship between WC and UA on IR.ResultsA total of 5,727 subjects in our study population were enrolled, of which 53.5% were women, and the mean age was 59.0 (SD, 8.62) years. After adjusting for traditional confounding factors, we found that a higher level of baseline WC was significantly associated with a higher level of follow-up UA (β = 0.003, P = 0.031) and follow-up triglycerides glucose index (TyG) (β = 0.003, P < 0.001);. Simultaneously, there was no statistical association between the level of baseline UA and the level of follow-up WC (β = -0.009, P = 0.951). Besides, the cross-lagged panel model showed that the baseline WC had influenced the level of follow-up UA. The mediation effects of UA on WC-IR were estimated to be 18.1% in general adults, and 36.2% in women.ConclusionsThe current study demonstrated that the higher WC levels probably preceded UA in general population, and UA mediated the relationship of WC to TyG, especially among females. However, the mediation effect was different between men and women, and the possible mechanism would require further clarification.

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A Decade of Disparities in Diabetes Technology Use and HbA1c in Pediatric Type 1 Diabetes: A Trans-Atlantic Comparison

10.2337/figshare.12808301 ◽

2020 ◽

Author(s):

Ananta Addala ◽

Marie Auzanneau ◽

Kellee Miller ◽

Werner Maier ◽

Nicole Foster ◽

...

Keyword(s):

Type 1 Diabetes ◽

Technology Use ◽

Hemoglobin A1c ◽

Diabetes Technology ◽

Design And Methods ◽

Relationship Of ◽

The Relationship ◽

Pediatric Type 1 Diabetes

Objective: As diabetes technology use in youth increases worldwide, inequalities in access may exacerbate disparities in hemoglobin A1c (HbA1c). We hypothesized an increasing gap in diabetes technology use by socioeconomic status (SES) would be associated with increased HbA1c disparities. Research Design and Methods: Participants aged <18 years with diabetes duration ≥1 year in the Type 1 Diabetes Exchange (T1DX, US, n=16,457) and Diabetes Prospective Follow-up (DPV, Germany, n=39,836) registries were categorized into lowest (Q1) to highest (Q5) SES quintiles. Multiple regression analyses compared the relationship of SES quintiles with diabetes technology use and HbA1c from 2010-2012 and 2016-2018. Results: HbA1c was higher in participants with lower SES (in 2010-2012 & 2016-2018, respectively: 8.0% & 7.8% in Q1 and 7.6% & 7.5% in Q5 for DPV; and 9.0% & 9.3% in Q1 and 7.8% & 8.0% in Q5 for T1DX). For DPV, the association between SES and HbA1c did not change between the two time periods, whereas for T1DX, disparities in HbA1c by SES increased significantly (p<0.001). After adjusting for technology use, results for DPV did not change whereas the increase in T1DX was no longer significant. Conclusions: Although causal conclusions cannot be drawn, diabetes technology use is lowest and HbA1c is highest in those of the lowest SES quintile in the T1DX and this difference for HbA1c broadened in the last decade. Associations of SES with technology use and HbA1c were weaker in the DPV registry.

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EVALUATION OF THE RELATIONSHIP OF LEVELS OF C-REACTIVE PROTEIN AND HOMOCYSTEIN IN PATIENTS WITH ABDOMINAL OBESITY AND PATHOLOGICAL CHANGES IN THE LIVER DEFINED BY BIOPROGNOSTIC TEST STEATOSCREEN.

10.26226/morressier.59a6b341d462b80290b53e58 ◽

2017 ◽

Author(s):

Ekaterina Chernetcova

Keyword(s):

Abdominal Obesity ◽

Pathological Changes ◽

C Reactive Protein ◽

Reactive Protein ◽

Relationship Of ◽

The Relationship

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Relationship of Sodium Intake with Overweight/Obesity among Chinese Children and Adolescents: Data from the CNNHS 2010–2012

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18094551 ◽

2021 ◽

Vol 18 (9) ◽

pp. 4551

Author(s):

Kehong Fang ◽

Yuna He ◽

Yuehui Fang ◽

Yiyao Lian

Keyword(s):

Children And Adolescents ◽

Abdominal Obesity ◽

Sodium Intake ◽

Saturated Fatty Acids ◽

Positive Association ◽

Chinese Children ◽

Weighing Method ◽

Relationship Of ◽

The Relationship ◽

Chinese Children And Adolescents

This study aims to examine association between sodium intake and overweight/obesity among Chinese children and adolescents. Data were obtained from China National Nutrition and Health Surveillance (CNNHS), 2010–2012. All participants recruited in this study aged 7–18 years old and provided complete dietary data on three-day consecutive 24 h dietary recalls combining with the household weighing method. Body Mass Index (BMI) was used to define overweight/obesity, and waist-to-height ratio (WHtR) was used to define abdominal obesity. Sodium intake showed association with risk of overweight/obesity assessed by BMI in the highest tertile group with OR of 1.48 (95%CI 1.13–1.94) and 1.89 (95%CI 1.33–2.67) for WHtR. After adjusted for gender, age, household income, area, energy, carbohydrates, protein, fat, saturated fatty acids, and fiber intake, the relationship between sodium intake and overweight/obesity and abdominal obesity are not changed. The same results were founded in subjects aged 10–18 years old. Our results reveal a positive association between sodium intake and overweight/obesity in Chinese children and adolescents, independent of energy consumption.

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Assessment of the relationship of serum liver enzymes activity with general and abdominal obesity in an urban Bangladeshi population

Scientific Reports ◽

10.1038/s41598-021-86216-z ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Nurshad Ali ◽

Abu Hasan Sumon ◽

Khandaker Atkia Fariha ◽

Md Asaduzzaman ◽

Rahanuma Raihanu Kathak ◽

...

Keyword(s):

General Population ◽

Abdominal Obesity ◽

Liver Enzymes ◽

Serum Levels ◽

General Obesity ◽

Enzymes Activity ◽

Elevated Liver Enzymes ◽

Bangladeshi Population ◽

Relationship Of ◽

The Relationship

AbstractObesity is a global health concern because of its increasing trend both in developed and developing countries. A limited number of studies have evaluated the association of liver enzymes with both general and abdominal obesity in the general population; data for the Bangladeshi population are not available yet. This study aimed to assess the relationship of serum liver enzymes activity with both general and abdominal obesity in Bangladeshi adults. In total, 540 blood samples were obtained from the participants (388 males and 152 females) and analyzed for serum levels of ALT, AST, GGT, and ALP using standard methods. General obesity was defined as body mass index (BMI) ≥ 27.5 kg/m2 and abdominal obesity was defined as waist circumference (WC) ≥ 90 cm in males and ≥ 80 cm in females. The relationship between liver enzymes and obesity was evaluated by multivariate logistic regression models. Overall, 58% of participants in the general obesity group and 55% of the participants in the abdominal obesity group had at least one or more elevated levels of liver enzymes. The prevalence of elevated liver enzymes was significantly higher in the obesity group compared to the normal BMI and WC groups (p < 0.05 for all cases). The mean level of serum ALT, AST and GGT were significantly higher in the obesity group than the normal BMI group (p < 0.05). In the WC groups, mean AST and GGT were significantly higher in the obesity group compared to the normal group (p < 0.05). In regression analysis, serum levels of ALT showed an independent and significant association with general obesity, whereas, serum GGT showed a significant association with both general and abdominal obesity. In conclusion, a high prevalence of elevated liver enzymes was observed among participants included in the present study. Of the four enzymes, serum GGT was independently associated with both general and abdominal obesity. Further studies are required to understand the complex relationship between liver enzymes and obesity in the general population.

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Investigation of the Correlation between Postherpetic Itch and Neuropathic Pain over Time

Pain Research and Management ◽

10.1155/2018/9305126 ◽

2018 ◽

Vol 2018 ◽

pp. 1-6 ◽

Cited By ~ 4

Author(s):

Rie Ishikawa ◽

Masako Iseki ◽

Rie Koga ◽

Eiichi Inada

Keyword(s):

Neuropathic Pain ◽

Herpes Zoster ◽

Pain Intensity ◽

Visual Analog Scale ◽

Analog Scale ◽

Paindetect Questionnaire ◽

Relationship Of ◽

The Relationship ◽

Over Time

Postherpetic itch (PHI), or herpes zoster itch, is an intractable and poorly understood disease. We targeted 94 herpes zoster patients to investigate their pain and itch intensities at three separate stages of the condition (acute, subacute, and chronic). We used painDETECT questionnaire (PDQ) scores to investigate the correlation between PHI and neuropathic pain. Seventy-six patients were able to complete follow-up surveys. The prevalence of PHI was 47/76 (62%), 28/76 (37%), and 34/76 (45%) at the acute, subacute, and chronic stages, respectively. PHI manifestation times and patterns varied. We investigated the relationship of PHI with neuropathic pain using the visual analog scale (VAS), which is a measure of pain intensity, and the PDQ, which is a questionnaire used to evaluate the elements of neuropathic pain. The VAS and PDQ scores did not differ significantly between PHI-positive and PHI-negative patients. A large neuropathic component was not found for herpes zoster itch, suggesting that neuropathic pain treatments may not able to adequately control the itch. Accordingly, we suggest that a more PHI-focused therapy is required to address this condition.

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The Relationship of Left Ventricular Trabeculation to Ventricular Function and Structure Over a 9.5-Year Follow-Up

Journal of the American College of Cardiology ◽

10.1016/j.jacc.2014.08.035 ◽

2014 ◽

Vol 64 (19) ◽

pp. 1971-1980 ◽

Cited By ~ 105

Author(s):

Filip Zemrak ◽

Mark A. Ahlman ◽

Gabriella Captur ◽

Saidi A. Mohiddin ◽

Nadine Kawel-Boehm ◽

...

Keyword(s):

Ventricular Function ◽

Left Ventricular ◽

Relationship Of ◽

The Relationship

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Serum IGF1, metabolic syndrome, and incident cardiovascular disease in older people: a population-based study

Acta Endocrinologica ◽

10.1530/eje-12-0784 ◽

2013 ◽

Vol 168 (3) ◽

pp. 393-401 ◽

Cited By ~ 28

Author(s):

Christa C van Bunderen ◽

Mirjam M Oosterwerff ◽

Natasja M van Schoor ◽

Dorly J H Deeg ◽

Paul Lips ◽

...

Keyword(s):

Metabolic Syndrome ◽

Older People ◽

Population Based ◽

Mortality Data ◽

The Metabolic Syndrome ◽

Longitudinal Aging Study Amsterdam ◽

Aging Study ◽

Definition Of ◽

Relationship Of ◽

The Relationship

ObjectiveHigh as well as low levels of IGF1 have been associated with cardiovascular diseases (CVD). The relationship of IGF1 with (components of) the metabolic syndrome could help to clarify this controversy. The aims of this study were: i) to investigate the association of IGF1 concentration with prevalent (components of) the metabolic syndrome; and ii) to examine the role of (components of) the metabolic syndrome in the relationship between IGF1 and incident CVD during 11 years of follow-up.MethodsData were used from the Longitudinal Aging Study Amsterdam, a cohort study in a representative sample of the Dutch older population (≥65 years). Data were available in 1258 subjects. Metabolic syndrome was determined using the definition of the US National Cholesterol Education Program Adult Treatment Panel III. CVD were ascertained by self-reports and mortality data.ResultsLevels of IGF1 in the fourth quintile were associated with prevalent metabolic syndrome compared with the lowest quintile (odds ratio: 1.59, 95% confidence interval (CI) 1.09–2.33). The middle up to the highest quintile of IGF1 was positively associated with high triglycerides in women. Metabolic syndrome was not a mediator in the U-shaped relationship of IGF1 with CVD. Both subjects without the metabolic syndrome and low IGF1 levels (hazard ratio (HR) 1.75, 95% CI 1.12–2.71) and subjects with the metabolic syndrome and high IGF1 levels (HR 2.28, 95% CI 1.21–4.28) demonstrated increased risks of CVD.ConclusionsIn older people, high-normal IGF1 levels are associated with prevalent metabolic syndrome and high triglycerides. Furthermore, this study suggests the presence of different pathomechanisms for both low and high IGF1 levels and incident CVD.

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