scholarly journals Halomonas as a chassis

2021 ◽  
Author(s):  
Jian-Wen Ye ◽  
Guo-Qiang Chen
Keyword(s):  
Synthetic Biology ◽  
Rapid Development ◽  
High Energy ◽  
Strain Engineering ◽  
Current Status ◽  
Industrial Biotechnology ◽  
Cell Factories ◽  
Energy Consuming ◽  
Significant Cost Reduction ◽  
Process Complexity

Abstract With the rapid development of systems and synthetic biology, the non-model bacteria, Halomonas spp., have been developed recently to become a cost-competitive platform for producing a variety of products including polyesters, chemicals and proteins owing to their contamination resistance and ability of high cell density growth at alkaline pH and high salt concentration. These salt-loving microbes can partially solve the challenges of current industrial biotechnology (CIB) which requires high energy-consuming sterilization to prevent contamination as CIB is based on traditional chassis, typically, Escherichia coli, Bacillus subtilis, Pseudomonas putida and Corynebacterium glutamicum. The advantages and current status of Halomonas spp. including their molecular biology and metabolic engineering approaches as well as their applications are reviewed here. Moreover, a systematic strain engineering streamline, including product-based host development, genetic parts mining, static and dynamic optimization of modularized pathways and bioprocess-inspired cell engineering are summarized. All of these developments result in the term called next-generation industrial biotechnology (NGIB). Increasing efforts are made to develop their versatile cell factories powered by synthetic biology to demonstrate a new biomanufacturing strategy under open and continuous processes with significant cost-reduction on process complexity, energy, substrates and fresh water consumption.

Antagonizing leptin: current status and future directions

2014 ◽  
Vol 395 (5) ◽  
pp. 499-514 ◽  
Author(s):  
Lennart Zabeau ◽  
Frank Peelman ◽  
Jan Tavernier
Keyword(s):  
Nutritional Status ◽  
Immune Responses ◽  
Autoimmune Diseases ◽  
High Energy ◽  
Current Status ◽  
Metabolic Switch ◽  
Future Directions ◽  
Leptin Signaling ◽  
Energy Consuming

Abstract The adipocyte-derived hormone/cytokine leptin acts as a metabolic switch, connecting the body’s nutritional status to high energy consuming processes such as reproduction and immune responses. Inappropriate leptin responses can promote autoimmune diseases and tumorigenesis. In this review we discuss the current strategies to modulate leptin signaling and the possibilities for their use in research and therapy.

scholarly journals Research on the development of green buildings under the high-speed development mode

2021 ◽  
Vol 272 ◽  
pp. 01021
Author(s):  
Shihan Zhu ◽  
Jingjing Liu ◽  
Chenjie Wu
Keyword(s):  
Construction Industry ◽  
High Speed ◽  
Rapid Development ◽  
Green Buildings ◽  
High Energy ◽  
Social Investigation ◽  
Development Mode ◽  
Real Estate Enterprises ◽  
The Social ◽  
Energy Consuming

In the rapid development of science and technology today, environmental problems are becoming more and more serious; the construction industry as the first high energy-consuming field with human production and life, the promotion of green buildings is of great significance. Under the high-speed development mode, how to make green buildings develop steadily has become a problem to be solved by various industries in China. Through the literature research method and the social investigation method, this paper analyses the development constraints of green buildings from the perspective of the four participants of market economy: government, real estate enterprises, consumers and practitioners. Respectively put forward some suggestions such as policy regulation, enterprise norms, green talents cultivation and collect feedback.

scholarly journals Bacillus subtilis Chassis in Biomanufacturing 4.0

2021 ◽  
Author(s):  
Wenbo Zhang ◽  
Xinshu Zhu ◽  
Yan Wang ◽  
Tao Li
Keyword(s):  
Bacillus Subtilis ◽  
Synthetic Biology ◽  
Driving Force ◽  
Disruptive Innovation ◽  
Research Field ◽  
Review Article ◽  
Microbial Consortia ◽  
Industrial Biotechnology ◽  
Cell Factories ◽  
Synthetic Microbial Consortia

Synthetic biology, an emerging research field, can promote biomanufacturing by offering various efficient chassis. Engineering Bacillus subtilis, an important workhorse in industrial biotechnology, through synthetic biology approaches may be a disruptive innovation. Advancements in chassis engineering, a synthetic biology strategy for genome-reduced cell factories, cell-free systems, and synthetic microbial consortia would be a driving force facilitating microbial production. We discussed chassis engineering categories and applications for B. subtilis. Prospects and challenges for chassis engineering in B. subtilis were also analyzed in this review article.

scholarly journals X-change symposium: status and future of modern radiation oncology—from technology to biology

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Stefanie Corradini ◽  
Maximilian Niyazi ◽  
Dirk Verellen ◽  
Vincenzo Valentini ◽  
Seán Walsh ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Radiation Oncology ◽  
Trial Design ◽  
Rapid Development ◽  
Clinical Trial Design ◽  
Current Status ◽  
Treatment Modalities ◽  
Special Treatment ◽  
Image Guided Radiotherapy

AbstractFuture radiation oncology encompasses a broad spectrum of topics ranging from modern clinical trial design to treatment and imaging technology and biology. In more detail, the application of hybrid MRI devices in modern image-guided radiotherapy; the emerging field of radiomics; the role of molecular imaging using positron emission tomography and its integration into clinical routine; radiation biology with its future perspectives, the role of molecular signatures in prognostic modelling; as well as special treatment modalities such as brachytherapy or proton beam therapy are areas of rapid development. More clinically, radiation oncology will certainly find an important role in the management of oligometastasis. The treatment spectrum will also be widened by the rational integration of modern systemic targeted or immune therapies into multimodal treatment strategies. All these developments will require a concise rethinking of clinical trial design. This article reviews the current status and the potential developments in the field of radiation oncology as discussed by a panel of European and international experts sharing their vision during the “X-Change” symposium, held in July 2019 in Munich (Germany).

scholarly journals A Compact Review of Laser Welding Technologies for Amorphous Alloys

Metals ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 1690
Author(s):  
Jian Qiao ◽  
Peng Yu ◽  
Yanxiong Wu ◽  
Taixi Chen ◽  
Yixin Du ◽  
...  
Keyword(s):  
Amorphous Alloy ◽  
Laser Welding ◽  
Amorphous Alloys ◽  
High Energy ◽  
Industrial Applications ◽  
High Energy Density ◽  
Current Status ◽  
Future Research ◽  
Technological Parameters ◽  
Fast Heating

Amorphous alloys have emerged as important materials for precision machinery, energy conversion, information processing, and aerospace components. This is due to their unique structure and excellent properties, including superior strength, high elasticity, and excellent corrosion resistance, which have attracted the attention of many researchers. However, the size of the amorphous alloy components remains limited, which affects industrial applications. Significant developments in connection with this technology are urgently needed. Laser welding represents an efficient welding method that uses a laser beam with high energy-density for heating. Laser welding has gradually become a research hotspot as a joining method for amorphous alloys due to its fast heating and cooling rates. In this compact review, the current status of research into amorphous-alloy laser welding technology is discussed, the influence of technological parameters and other welding conditions on welding quality is analyzed, and an outlook on future research and development is provided. This paper can serve as a useful reference for both fundamental research and engineering applications in this field.

Professional Psychology in Portugal

1997 ◽  
Vol 81 (3_suppl) ◽  
pp. 1211-1222 ◽  
Author(s):  
Teresa Fagulha ◽  
Richard H. Dana
Keyword(s):  
Rapid Development ◽  
Well Being ◽  
Professional Psychology ◽  
Current Status ◽  
Environmental Concerns ◽  
Advanced Degrees ◽  
Professional Degree ◽  
History Of ◽  
Training Research

This paper describes the history and current status of professional psychology in Portugal where a unique perspective combines training, research, and practical contributions from Europe and the Americas with their own history of psychological tradition and expertise. Training in professional psychology includes Social Psychology and Educational and Vocational Guidance specializations in addition to Clinical Psychology and Psychotherapy and Counseling for the professional degree, Licenciatura. Advanced degrees are offered in Environmental Psychology, Career Development, Social Cognition, and other areas, primarily for academic positions. Research in all of these areas is expected to have applied outcomes that contribute to individual well being and an improved quality of life for the entire population. The result has been a rapid development of an indigenous professional psychology to address mental health, social, and environmental concerns that compel psychological attention and resources worldwide as well as those problems of local and national origins.

scholarly journals Non-invasive imaging of the coronary arteries

2018 ◽  
Vol 40 (29) ◽  
pp. 2444-2454 ◽  
Author(s):  
Philip D Adamson ◽  
David E Newby
Keyword(s):  
Coronary Arteries ◽  
Randomized Clinical Trials ◽  
Rapid Development ◽  
Current Status ◽  
Future Research ◽  
Research Perspective ◽  
Non Invasive ◽  
Positron Emission ◽  
Prognostic Stratification

Abstract Non-invasive imaging of the coronary arteries is an enterprise in rapid development. From the research perspective, there is great demand for in vivo techniques that can reliably identify features of high-risk plaque that may offer insight into pathophysiological processes and act as surrogate indicators of response to therapeutic intervention. Meanwhile, there is clear clinical need for greater accuracy in diagnosis and prognostic stratification. Fortunately, ongoing technological improvements and emerging data from randomized clinical trials are helping make these elusive goals a reality. This review provides an update on the current status of non-invasive coronary imaging with computed tomography, magnetic resonance, and positron emission tomography with a focus on current clinical applications and future research directions.

scholarly journals Privacy-Preserving Efficient Data Retrieval in IoMT Based on Low-Cost Fog Computing

Complexity ◽  
2021 ◽  
Vol 2021 ◽  
pp. 1-13
Author(s):  
Na Wang ◽  
Yuanyuan Cai ◽  
Junsong Fu ◽  
Jie Xu
Keyword(s):  
Energy Cost ◽  
Data Privacy ◽  
Low Cost ◽  
Rapid Development ◽  
Fog Computing ◽  
Bat Algorithm ◽  
Data Retrieval ◽  
High Energy ◽  
Physiological Data ◽  
Range Tree

The rapid development of Internet of Medical Things (IoMT) is remarkable. However, IoMT faces many problems including privacy disclosure, long delay of service orders, low retrieval efficiency of medical data, and high energy cost of fog computing. For these, this paper proposes a data privacy protection and efficient retrieval scheme for IoMT based on low-cost fog computing. First, a fog computing system is located between a cloud server and medical workers, for processing data retrieval requests of medical workers and orders for controlling medical devices. Simultaneously, it preprocesses physiological data of patients uploaded by IoMT, collates them into various data sets, and transmits them to medical institutions in this way. It makes the entire execution process of low latency and efficient. Second, multidimensional physiological data are of great value, and we use ciphertext retrieval to protect privacy of patient data in this paper. In addition, this paper uses range tree to build an index for storing physiological data vectors, and meanwhile a range retrieval method is also proposed to improve data search efficiency. Finally, bat algorithm (BA) is designed to allocate cost on a fog server group for significant energy cost reduction. Extensive experiments are conducted to demonstrate the efficiency of the proposed scheme.

scholarly journals Epidemic Preparedness—Leishmania tarentolae as an Easy-to-Handle Tool to Produce Antigens for Viral Diagnosis: Application to COVID-19

2021 ◽  
Vol 12 ◽  
Author(s):  
Ilaria Varotto-Boccazzi ◽  
Alessandro Manenti ◽  
Francesca Dapporto ◽  
Louise J. Gourlay ◽  
Beatrice Bisaglia ◽  
...  
Keyword(s):  
Rapid Development ◽  
Antibody Detection ◽  
Molecular Diagnostic ◽  
Serological Tests ◽  
Leishmania Tarentolae ◽  
Cell Factories ◽  
Effective System ◽  
Human Sera ◽  
Antiviral Antibody ◽  
Viral Diagnosis

To detect and prevent emerging epidemics, discovery platforms are urgently needed, for the rapid development of diagnostic assays. Molecular diagnostic tests for COVID-19 were developed shortly after the isolation of SARS-CoV-2. However, serological tests based on antiviral antibody detection, revealing previous exposure to the virus, required longer testing phases, due to the need to obtain correctly folded and glycosylated antigens. The delay between the identification of a new virus and the development of reliable serodiagnostic tools limits our readiness to tackle future epidemics. We suggest that the protozoan Leishmania tarentolae can be used as an easy-to-handle microfactory for the rapid production of viral antigens to face emerging epidemics. We engineered L. tarentolae to express the SARS-CoV-2 receptor-binding domain (RBD) and we recorded the ability of the purified RBD antigen to detect SARS-CoV-2 infection in human sera, with a sensitivity and reproducibility comparable to that of a reference antigen produced in human cells. This is the first application of an antigen produced in L. tarentolae for the serodiagnosis of a Coronaviridae infection. On the basis of our results, we propose L. tarentolae as an effective system for viral antigen production, even in countries that lack high-technology cell factories.

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