Recent Advances in Tinnitus

1992 ◽  
Vol 1 (4) ◽  
pp. 36-44 ◽  
Author(s):  
Richard S. Tyler ◽  
Jean-Marie Aran ◽  
René Dauman
Keyword(s):  
Electrical Stimulation ◽  
Animal Models ◽  
Future Research ◽  
Clinical Protocols ◽  
Hearing Impairments ◽  
Preliminary Results ◽  
Psychological Techniques ◽  
The Past ◽  
Recent Advances

Tinnitus can be the most debilitating symptom faced by people with hearing impairments. In the past 10 years, there has been a large increase in tinnitus research and in the development of clinical protocols. New animal models and physiological procedures provide an important contribution to the understanding and measurement of tinnitus. The annoyance of tinnitus likely depends on its loudness and the psychological makeup of the patient. The loudness of a person's tinnitus can be compared with the equivalent loudness of a 1000 Hz tone in a normal ear. Several questionnaires have recently been introduced to quantify the handicap caused by tinnitus. Tinnitus maskers are apparently ineffective for most patients but they can be helpful in a few patients. Medications are largely ineffective in reducing tinnitus in most people. However, several psychological techniques for reducing the stress associated with tinnitus are currently under investigation, and preliminary results show some promise. Tinnitus can be reduced by electrical stimulation in a few patients, and this is also an important area for future research.

scholarly journals Recent advances in biochar application for water and wastewater treatment: a review

PeerJ ◽  
2020 ◽  
Vol 8 ◽  
pp. e9164
Author(s):  
Xiaoqing Wang ◽  
Zizhang Guo ◽  
Zhen Hu ◽  
Jian Zhang
Keyword(s):  
Wastewater Treatment ◽  
Future Research ◽  
Water And Wastewater Treatment ◽  
Research Directions ◽  
The Past ◽  
Recent Advances ◽  
Future Research Directions ◽  
Water And Wastewater ◽  
Contaminants Removal ◽  
Sorption Mechanisms

In the past decade, researchers have carried out a massive amount of research on the application of biochar for contaminants removal from aqueous solutions. As an emerging sorbent with great potential, biochar has shown significant advantages such as the broad sources of feedstocks, easy preparation process, and favorable surface and structural properties. This review provides an overview of recent advances in biochar application in water and wastewater treatment, including a brief discussion of the involved sorption mechanisms of contaminants removal, as well as the biochar modification methods. Furthermore, environmental concerns of biochar that need to be paid attention to and future research directions are put forward to promote the further application of biochar in practical water and wastewater treatment.

Oxford Textbook of Rheumatoid Arthritis

2020 ◽  
Keyword(s):  
Rheumatoid Arthritis ◽  
Clinical Presentation ◽  
Disease Assessment ◽  
Future Research ◽  
Clinical Aspects ◽  
Comprehensive Overview ◽  
Future Directions ◽  
The Past ◽  
Recent Advances ◽  
Drug Treatments

This new textbook provides a comprehensive overview of the scientific and clinical aspects of rheumatoid arthritis (RA). Split into eight sections—history, diagnosis, and epidemiology; pathogenesis; clinical presentation; disease assessment; impact on life; non-drug treatments; drug treatments; and management and outcomes—it collects the contemporary ideas about RA and explains the revolutionary changes that have taken place over the past two decades, and indicates areas of future research. Witten by leading clinicians and scientists in the field, each chapter gives a detailed background, key recent advances, areas of doubt, and future directions of research.

scholarly journals Recent Advances in Smellscape Research for the Built Environment

2021 ◽  
Vol 12 ◽  
Author(s):  
Jieling Xiao ◽  
Francesco Aletta ◽  
Antonella Radicchi ◽  
Kate McLean ◽  
Larry E. Shiner ◽  
...  
Keyword(s):  
Social Justice ◽  
Built Environment ◽  
Policy Making ◽  
Building Materials ◽  
Future Research ◽  
The Past ◽  
Recent Advances ◽  
Odour Control ◽  
Methodological Approaches ◽  
Control And Management

The interrelationships between humans, smells and the built environment have been the focus of increasing numbers of research studies in the past ten years. This paper reviews these trends and identifies the challenges in smellscape research from three aspects: methodological approaches, artistic design interventions and museum practices, and odour policy making. In response to the gaps and challenges identified, three areas of future research have also been identified for this field: smell archives and databases, social justice within odour control and management, and research into advanced building materials.

scholarly journals Recent advances in the chemistry of bicyclo- and 1-azabicyclo[1.1.0]butanes

2020 ◽  
Vol 92 (5) ◽  
pp. 751-765 ◽  
Author(s):  
Alexander Fawcett
Keyword(s):  
Nitrogen Atom ◽  
Short Review ◽  
Future Research ◽  
The Past ◽  
New Methods ◽  
Recent Advances ◽  
Recent Developments ◽  
The 1950S ◽  
Highly Strained

AbstractBicyclo[1.1.0]- and 1-azabicyclo[1.1.0]butanes are structurally unique compounds that exhibit diverse chemistry. Bicyclo[1.1.0]butane is a four-membered carbocycle with a bridging C(1)-C(3) bond and 1-azabicyclo[1.1.0]butane is an analog of bicyclo[1.1.0]butane featuring a nitrogen atom at one bridgehead. These structures are highly strained, allowing them to participate in a range of strain-releasing reactions which typically cleave the central, strained bond to deliver cyclobutanes or azetidines. However, despite these molecules being discovered in the 1950s and 1960s, and possessing a myriad of alluring chemical features, the chemistry and applications of bicyclo[1.1.0]- and 1-azabicyclo[1.1.0]butanes remain underexplored. In the past 5 years, there has been a resurgent interest in their chemistry driven by the pharmaceutical industry’s increasing desire for new methods to access cyclobutanes and azetidines. This short review intends to provide a timely summary of the most recent developments in the chemistry of bicyclo[1.1.0]- and 1-azabicyclo[1.1.0]butane to highlight the diverse chemistry they can access, their value as synthetic precursors to cyclobutanes and azetidines, and to identify areas for future research.

Granular bainite or granular ferrite? A preliminary TEM investigation of an HSLA-100 steel

1991 ◽  
Vol 49 ◽  
pp. 584-585
Author(s):  
R. Varughese ◽  
S. W. Thompson ◽  
P. R. Howell
Keyword(s):  
Room Temperature ◽  
Transformation Products ◽  
Accurate Description ◽  
Granular Bainite ◽  
Preliminary Results ◽  
The Past ◽  
Light Micrograph ◽  
Multiphase Reaction ◽  
Detailed Nature

Ever since Habraken and Economopoulos first employed the term granular bainite to classify certain unconventional transformation products in continuously cooled steels, the term has been widely accepted and used, despite the lack of a clear consensus as to the detailed nature of the transformation products which constitute granular bainite. This paper presents the preliminary results of a TEM investigation of an 0.04 wt% C, copper-containing steel (designated HSLA-100). It is suggested that the term granular ferrite rather than granular bainite is a more accurate description of this multiphase reaction product.Figure 1 is a light micrograph of a sample which had been air-cooled from 900°C to room temperature. The microstructure is typical of that which has been termed granular bainite in the past and appears to consist of equiaxed ferritic grains together with other minor transformation products. In order to examine these structures in more detail, both continuously cooled and isothermally transformed and quenched materials have been examined with TEM. Granular bainite has been found in virtually all samples.

Old-growth forest reserves in Slovenia: the past, present, and future

2012 ◽  
Vol 163 (6) ◽  
pp. 240-246 ◽  
Author(s):  
Thomas A. Nagel ◽  
Jurij Diaci ◽  
Dusan Rozenbergar ◽  
Tihomir Rugani ◽  
Dejan Firm
Keyword(s):  
Stand Structure ◽  
Growth Conditions ◽  
Ecosystem Functions ◽  
Future Research ◽  
Old Growth ◽  
Forest Reserves ◽  
The Past ◽  
Old Growth Forest ◽  
Forest Remnants ◽  
Basic Characteristics

Old-growth forest reserves in Slovenia: the past, present, and future Slovenia has a small number of old-growth forest remnants, as well as many forest reserves approaching old-growth conditions. In this paper, we describe some of the basic characteristics of these old-growth remnants and the history of their protection in Slovenia. We then trace the long-term development of research in these old-growth remnants, with a focus on methodological changes. We also review some of the recent findings from old-growth research in Slovenia and discuss future research needs. The conceptual understanding of how these forests work has slowly evolved, from thinking of them in terms of stable systems to more dynamic and unpredictable ones due to the influence of natural disturbances and indirect human influences. In accordance with this thinking, the methods used to study old-growth forests have changed from descriptions of stand structure to studies that address natural processes and ecosystem functions.

Bioengineered in vitro Vascular Models for Applications in Interventional Radiology

2019 ◽  
Vol 24 (45) ◽  
pp. 5367-5374 ◽  
Author(s):  
Xiaoyun Li ◽  
Seyed M. Moosavi-Basri ◽  
Rahul Sheth ◽  
Xiaoying Wang ◽  
Yu S. Zhang
Keyword(s):  
Interventional Radiology ◽  
Animal Models ◽  
Blood Vessels ◽  
In Vitro Models ◽  
The Past ◽  
Endovascular Interventions ◽  
Conventional Animal ◽  
Vascular Structures

The role of endovascular interventions has progressed rapidly over the past several decades. While animal models have long-served as the mainstay for the advancement of this field, the use of in vitro models has become increasingly widely adopted with recent advances in engineering technologies. Here, we review the strategies, mainly including bioprinting and microfabrication, which allow for fabrication of biomimetic vascular models that will potentially serve to supplement the conventional animal models for convenient investigations of endovascular interventions. Besides normal blood vessels, those in diseased states, such as thrombosis, may also be modeled by integrating cues that simulate the microenvironment of vascular disorders. These novel engineering strategies for the development of biomimetic in vitro vascular structures will possibly enable unconventional means of studying complex endovascular intervention problems that are otherwise hard to address using existing models.

Chinese Medicine Protein and Peptide in Gene and Cell Therapy

2019 ◽  
Vol 20 (3) ◽  
pp. 251-264 ◽  
Author(s):  
Yinlu Feng ◽  
Zifei Yin ◽  
Daniel Zhang ◽  
Arun Srivastava ◽  
Chen Ling
Keyword(s):  
Chinese Medicine ◽  
Cell Therapy ◽  
Future Research ◽  
The Past ◽  
Promising Strategy ◽  
Wide Range ◽  
New Directions ◽  
Gene And Cell Therapy ◽  
Proteins And Peptides

The success of gene and cell therapy in clinic during the past two decades as well as our expanding ability to manipulate these biomaterials are leading to new therapeutic options for a wide range of inherited and acquired diseases. Combining conventional therapies with this emerging field is a promising strategy to treat those previously-thought untreatable diseases. Traditional Chinese medicine (TCM) has evolved for thousands of years in China and still plays an important role in human health. As part of the active ingredients of TCM, proteins and peptides have attracted long-term enthusiasm of researchers. More recently, they have been utilized in gene and cell therapy, resulting in promising novel strategies to treat both cancer and non-cancer diseases. This manuscript presents a critical review on this field, accompanied with perspectives on the challenges and new directions for future research in this emerging frontier.

Recent Advances in Therapeutic Applications of Bisbenzimidazoles

2020 ◽  
Vol 16 (4) ◽  
pp. 454-486 ◽  
Author(s):  
Smita Verma ◽  
Vishnuvardh Ravichandiran ◽  
Nihar Ranjan ◽  
Swaran J.S. Flora
Keyword(s):  
Heterocyclic Compounds ◽  
Wide Spectrum ◽  
Dna Recognition ◽  
Present Review ◽  
Pharmacological Activities ◽  
Structural Motifs ◽  
Therapeutic Applications ◽  
The Past ◽  
Recent Advances

Nitrogen-containing heterocycles are one of the most common structural motifs in approximately 80% of the marketed drugs. Of these, benzimidazoles analogues are known to elicit a wide spectrum of pharmaceutical activities such as anticancer, antibacterial, antiparasitic, antiviral, antifungal as well as chemosensor effect. Based on the benzimidazole core fused heterocyclic compounds, crescent-shaped bisbenzimidazoles were developed which provided an early breakthrough in the sequence-specific DNA recognition. Over the years, a number of functional variations in the bisbenzimidazole core have led to the emergence of their unique properties and established them as versatile ligands against several classes of pathogens. The present review provides an overview of diverse pharmacological activities of the bisbenzimidazole analogues in the past decade with a brief account of its development through the years.

Attraction of prey

2018 ◽  
Author(s):  
John D. Horner ◽  
Bartosz J. Płachno ◽  
Ulrike Bauer ◽  
Bruno Di Giusto
Keyword(s):  
Visual Cues ◽  
Synergistic Action ◽  
Carnivorous Plants ◽  
Future Research ◽  
Acoustic Cues ◽  
Qualitative And Quantitative Analysis ◽  
Qualitative And Quantitative ◽  
The Past ◽  
The Cost ◽  
Prey Attraction

The ability to attract prey has long been considered a universal trait of carnivorous plants. We review studies from the past 25 years that have investigated the mechanisms by which carnivorous plants attract prey to their traps. Potential attractants include nectar, visual, olfactory, and acoustic cues. Each of these has been well documented to be effective in various species, but prey attraction is not ubiquitous among carnivorous plants. Directions for future research, especially in native habitats in the field, include: the qualitative and quantitative analysis of visual cues, volatiles, and nectar; temporal changes in attractants; synergistic action of combinations of attractants; the cost of attractants; and responses to putative attractants in electroantennograms and insect behavioral tests.

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