scholarly journals Using of immunomodulating substances in optimizing cucumber nutrition in protected soil conditions

2021 ◽  
Vol 34 ◽  
pp. 05005
Author(s):  
Maria Selivanova ◽  
Timur Aysanov ◽  
Elena Romanenko ◽  
Elena Mironova ◽  
Natalia Esaulko
Keyword(s):  
Arachidonic Acid ◽  
Salicylic Acid ◽  
Scientific Research ◽  
Biologically Active ◽  
Soil Conditions ◽  
Protective Properties ◽  
Triterpenic Acids ◽  
Greenhouse Cucumber ◽  
Immunomodulatory Properties ◽  
Active Substances

Studies on the influence of biologically active substances with immunomodulatory properties on the productivity of greenhouse cucumber were conducted in the winter-spring turnover of the sixth light zone in 2019-2020. The paper analyzes data on the prevalence of major diseases in cucumber plantings, the intensity of respiration and photosynthesis in plants, the level of yield and yielding of standard crop products, depending on the use of immunomodulating substances against the background of the main nutrition scheme. As a result of scientific research, it was found that the use of immunomodulators (arachidonic acid, hydroxycinnamic acids, triterpenic acids, salicylic acid) in the technology of cucumber cultivation activated the protective properties of plants against pathogens, contributed to the activation of the intensity of respiration, photosynthesis, obtaining an increased yields and the output of standard products.

scholarly journals Evaluation of in vitro immunomodulatory properties of biologically active substances and drugs

2019 ◽  
Vol 16 (2) ◽  
pp. 234-243
Author(s):  
A. V. Duzh ◽  
A. Y. Hancharou
Keyword(s):  
Biologically Active ◽  
Interleukin 12 ◽  
Oxygen Species ◽  
Combined Method ◽  
Hla Dr ◽  
Immunomodulatory Properties ◽  
Factor Α ◽  
Active Substances ◽  
Necrosis Factor

A new combined method for screening of immunomodulatory properties of drugs was developed, including: expression of CD80, HLA-DR, CD32, CD205 and CD197, interleukin-12 production and apoptosis by DCs; production of reactive oxygen species and evaluation of phagocytosis by neutrophils; expression of CD69 and production of tumor necrosis factor-α by Jurkat-tat cells; and CD80 and HLA-DR expression, viability and apoptosis using the Daudi cell line.

scholarly journals Quantitative and qualitative profile of biologically active substances extracted from purple echinacea (EChinacea Purpurea L.) growing in the Kemerovo region: functional foods application

2019 ◽  
pp. 84-92 ◽  
Author(s):  
Alexandra Zaushintsena ◽  
Irina Milentyeva ◽  
Olga Babich ◽  
Svetlana Noskova ◽  
Tatyana Kiseleva ◽  
...  
Keyword(s):  
Dietary Supplements ◽  
Hormonal Regulation ◽  
Functional Foods ◽  
Echinacea Purpurea ◽  
Ethanol Solution ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Soil Conditions ◽  
Anti Inflammatory ◽  
Active Substances

Immunodeficiency causes a lot of modern diseases. Immunodeficiency, in its turn, is caused by such fac- tors as polluted environment, chronic stress, sedentary lifestyle, unbalanced diet, etc. All these factors weaken respi- ratory organs and gastrointestinal tract, disturb hormonal regulation, and destabilize immune defence. Food industry responds to these challenges by developing functional foods and dietary supplements from medicinal plants. Dietary supplements made from natural plant extracts have more advantages than their numerous synthetic analogues. They produce a mild therapeutic effect and no pronounced side effects. Purple Echinacea (Echinacea purpurea L.) posses- ses immunomodulatory, anti-inflammatory, antiviral, and tonic properties. However, climatic and soil conditions are known to affect the qualitative and quantitative profile of biologically active substances. The present paper describes the micronutrient profile of various parts of Echinacea purpurea grown in the Kemerovo region. The study employed a complex of physical and chemical methods. The research featured leaves, roots, and flowers, as well as components extracted from the plant with the help of a 70% ethanol solution. The latter was chosen for its universal properties in micronutrient extraction. The methods included high performance liquid chromatography (HPLC), thin layer chro- matography (TLC), and IR spectroscopy. A set of triple experiments showed that the extracts contained substances with anti-inflammatory, antioxidant, and immunomodulating properties. Thus, Echinacea extract can be recommen- ded for functional foods and dietary supplements.

Conference "Pharmacology and toxicology of organophosphorus compounds and other biologically active substances" dedicated to the 75th anniversary of Prof. I.V. Zaikonnikova

1997 ◽  
Vol 78 (3) ◽  
pp. 236-236
Author(s):  
I. A. Studentsova
Keyword(s):  
Organophosphorus Compounds ◽  
Scientific Research ◽  
Main Direction ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
75Th Anniversary ◽  
The Past ◽  
Pharmacology And Toxicology ◽  
Active Substances

The conference was opened by Prof. R.S. Garaev, Head of the Department of Pharmacology. In the report "The main directions of scientific research of the Department of Pharmacology" he gave an overview of the works carried out over the past 5 years. The main direction is still the study of new organophosphorus compounds synthesized in Kazan.

Biochemistry of the lipoxygenase pathways in neutrophils

1989 ◽  
Vol 67 (8) ◽  
pp. 936-942 ◽  
Author(s):  
Pierre Borgeat
Keyword(s):  
Arachidonic Acid ◽  
Ring Opening ◽  
Arachidonic Acid Metabolism ◽  
Biologically Active ◽  
Eicosatetraenoic Acid ◽  
Major Pathway ◽  
Inflammatory Reactions ◽  
Conjugated Triene ◽  
Hydroxyeicosatetraenoic Acids ◽  
Active Substances

Three mammalian lipoxygenases have been reported to date. They catalyze the insertion of oxygen at positions 5, 12, and 15 of various 20-carbon polyunsaturated fatty acids. In the case of arachidonic acid, the immediate products are hydroperoxyeicosatetraenoic acids (HPETEs). HPETEs can undergo different transformations. One reaction is a reduction of the hydroperoxy group yielding the corresponding hydroxyeicosatetraenoic acids (HETEs). In the neutrophils, the major pathway of arachidonic acid metabolism is the 5-lipoxygenase. In these cells the 5-HPETE undergoes a cyclization reaction leading to a 5(6)-epoxy(oxido)eicosatetraenoic acid or leukotriene A4. The 5(6)-epoxy fatty acid can undergo three additional transformations: (a) a nonenzymatic hydrolysis to epimeric dihydroxyeicosatetraenoic acids (diHETEs); (b) stereospecific enzymatic hydrolysis to a specific diHETE, leukotriene B4; or (c) ring opening by reduced glutathione (GSH) to yield a peptidolipid, named leukotriene C4, in which GSH is attached via a sulfoether linkage. The leukotrienes constitute a group of biologically active substances probably involved in allergic and inflammatory reactions. The 5(6)-epoxy-eicosatetraenoic acid and the products derived from it contain a conjugated triene unit; the term leukotriene also denotes the cells (leukocytes) recognized to form these products, mainly the neutrophils, eosinophils, basophils, monocytes, mast cells, and macrophages. In the present article various aspects of the biochemistry of the lipoxygenase pathways of neutrophils are reviewed.Key words: arachidonic acid, leukotrienes, leukocytes, lipoxygenase, inflammation.

scholarly journals Phytochemical Analysis of Phillyrea latifolia L., a New Source of Oleuropeoside

2001 ◽  
Vol 56 (5-6) ◽  
pp. 353-356 ◽  
Author(s):  
Cristina Recuero Carretero ◽  
Ana M. Díaz Lanza ◽  
Lidia Fernández Matellano ◽  
Angel Rumbero Sánchezb ◽  
Lucinda Villaescusa Castillo
Keyword(s):  
Chemical Constituents ◽  
Biologically Active ◽  
Phytochemical Analysis ◽  
Mediterranean Species ◽  
Aerial Parts ◽  
Phillyrea Latifolia ◽  
Triterpenic Acids ◽  
Phenylpropanoid Glycosides ◽  
Secoiridoid Glycosides ◽  
Active Substances

As a part of our studies on the biologically active substances from Spanish plants, we have undertaken an investigation of the chemical constituents of a typical mediterranean species, Phillyrea latifolia L. (Oleaceae). Two secoiridoid glycosides, three phenylpropanoid glycosides, one lignane and two triterpenic acids were isolated from the leaves of this species and identified. The phytochemical analysis of the aerial parts of P. latifolia revealed that it is a rich source of oleuropeoside.

scholarly journals Development of technology for a fermented drink with cancer protective properties

2020 ◽  
Vol 175 ◽  
pp. 08012
Author(s):  
Tatyana Belyakova ◽  
Lyudmila Zabodalova ◽  
Ekaterina Antonceva
Keyword(s):  
Dairy Products ◽  
Quality Parameters ◽  
Biologically Active ◽  
Food Sources ◽  
Native Form ◽  
Protective Properties ◽  
Milk Fermentation ◽  
Golden Ball ◽  
Plant Sources ◽  
Active Substances

Some plant sources of biologically active substances particularly cruciferous vegetables, both in native form and as extracts, display effects towards carcinogenesis that make these food sources cancer protective and recurrence preventive agents. In the currently developing tendency towards functional foodstuffs like dairy products targeted at nutritional-dependent diseases, development of a dairy beverage containing sulforaphane deserves attention. Creating a recipe for such a product includes: selecting a plant sulforaphane source, testing its compatibility with the milk base, choosing the addition dosage and methods and experimental beverage preparation. In pursuit of these goals in the study, firstly, turnip (Brassica rapa l.) root, an affordable sulforaphane provider, was chosen. Glucoraphanin content in various turnip varieties was determined and the Golden Ball variety selected. Sulforaphane was introduced to milk in turnip purée and aqueous extract forms. The effect of purée/extract dosage on milk fermentation process and the final producťs quality parameters was investigated. Both purée and extract containing products had a pleasant taste with a vegetable note and uniform consistency. Sulforaphane content in 200 g beverage servings was (23.5 ± 2.1) mg and (29.5 ± 0.5) mg (extract), both values approximately one tenth of therapeutic dose estimates, which is enough for cancer preventive purposes.

scholarly journals RESEARCH OF THE PROPERTIES OF GRAPE PROCESSING PRODUCTS IN RELATION TO ITS APPLICATION IN SPA AND WELLNESS INDUSTRIES

2019 ◽  
Vol 13 (1) ◽  
Author(s):  
G. Sarkisian
Keyword(s):  
Psychological Health ◽  
Endocrine System ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Specific Power ◽  
Extraction Temperature ◽  
Protective Properties ◽  
Grape Marc ◽  
Antioxidant Protection System ◽  
Active Substances

The work analyzes the global experience of using wines and grape-processing products to support a person’sphysical, mental, and psychological health, to slow down aging, to prevent and treat many diseases, in particular cardiovascular andoncological ones, endocrine system disorders, etc. It has been shown that a great deal of waste, including marc, is obtained whileprocessing grapes and producing wine. The fact has been pointed out that in Ukraine, the technologies of using wine-making waste infood and cosmetic industries and in medicine are being developed and introduced but slowly, though the level of viticulture is high.The importance and prospects of finding ways to process grape marc have been proved, as its valuable chemical composition allowsobtaining dietary supplements and oenotherapeutic products for spa and wellness industry. The following rational parameters havebeen suggested to extract the most valuable biologically active substances (polyphenols) from grape marc: microwave extraction;specific power of the microwave installation 1.6–1.7 kW/kg; 40% ethyl alcohol as the extractant; proportion of water(hydromodulus) 1:5; extraction temperature 60–65°C; 4 heating stages; stage interval 1.5–2 minutes; total extraction time 12–14minutes. The physico-chemical parameters of the marc extracts obtained from the grapes harvested in 2016 and 2017 have beendetermined. It has been established that, besides polyphenols, a whole complex of biologically active substances is extracted. It hasbeen shown that grape marc can be used to produce dietary fibre, pectins, and other valuable substances. The medical and biologicalproperties of the polyphenolic complex obtained from marc (the Odesky Chorny variety of grapes) have been studied on laboratoryrats to determine its antioxidant activity and the prospects of its use in treating type 2 diabetes. The protective properties of theobtained product have been proved. Such processes have been established to take place as the mobilization of the antioxidant systemof cells, the normalization of the enzyme activity of the antioxidant protection system, and a decrease in the level of markers ofoxidative modification of proteins and lipids (that are higher than normal with diabetes mellitus). It has been suggested to usepolyphenolic complex extracts in oenotherapy as a skin and face care product with protective properties.

scholarly journals Analysis of innovative technologies of hydrogels from uronate polysaccharides and biodegradable films on their basis

2019 ◽  
Vol 21 (91) ◽  
pp. 100-103
Author(s):  
N. V. Kondratiuk ◽  
T. M. Stepanova ◽  
O. O. Chernushenko
Keyword(s):  
Scientific Research ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Innovative Technologies ◽  
Food Engineering ◽  
Hydrogel Matrix ◽  
The Matrix ◽  
The Creation ◽  
Search For Information ◽  
Active Substances

The article is devoted to the analysis of the state and dynamics of scientific developments in the field of creating products for life and health, based on hydrogels from uronate polysaccharides (HUP). The article is reflected the results of the global scientific research monitoring and their changes in the field of technologies for the creation and use of HUP. The results of a retrospective analysis of existing technologies based on poorly studied in the field of food technologies uronic acids, as glucuronic, idouronic, hyaluronic were presented. The study showed, that nowadays the industry of products with their content is acquiring market traits, although it has insufficient scientific substantiation. Development segments with widely used uronate polysaccharides – pectins and alginates – according to the types of hydrogels (swollen hydrogel, cross-linked hydrogel, xerogel) were developed. The article presents examples and identified the required properties of substances intended for immobilization or encapsulation in the hydrogel matrix of uronate polysaccharides. The basic principles of uronate polysaccharides crosslinking chains in the hydrogel phase are determined. Possible methods of biologically active substances (BAS) retention in the matrix of uronate polysaccharides to reduce the risk of premature oxidation, destruction, decomposition, decomposition, evaporation were described. The search for information allowed us to identify key technological areas for the development of scientific research on the creation and use of HUP to improve people's lives and health. The archives of the world's leading publications in the field of food chemistry, biotechnology, food engineering, chemistry of new materials, food polymers and hydrocolloids were analyzed. The authors used in their work the resources of the Science Direct search system, which made it possible to determine the most promising and modern lines of development of HUP technologies and products based on them. The analysis of technologies has shown that existing innovative technologies are formed on “basic” technologies for producing solutions of high-molecular compounds under various conditions. Active modernization is carried out in the direction of creating products with immobilized biologically active substances, as well as in attempts to compose a composition with other polysaccharides and/or peptide components. The article notes that existing technologies allow developing other technologies with the help of which it is possible to expand the field of HUP application.

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