scholarly journals Modern concepts of the fibrinolytic system

2020 ◽  
Vol 215 ◽  
pp. 05002
Author(s):  
Sergei Sorokin ◽  
Mark Shamtsyan ◽  
Nicolai Petrishchev

Among all medical pathologies, cardiovascular diseases are the most dangerous and deadly. On the one hand, thrombosis is a natural reaction of a person to damage to blood vessels, on the other hand, thrombosis is often the cause of death in the event of cardiovascular disease. There is a natural process called fibrinolysis to dissolve a blood clot after the bleeding has stopped and preventing vascular occlusion. This article examines current understanding of the human fibrinolytic system, main elements of fibrinolytic system and also addresses the topic of thrombolytic therapy.

2011 ◽  
pp. 5-12
Author(s):  
Anh Tien Hoang ◽  
Van Minh Huynh ◽  
Khanh Hoang ◽  
Huu Dang Tran ◽  
Viet An Tran

NT-ProBNP is a high value cardiac biomarker and widely applies in many cardiovascular diseases. The evaluation of concentration of NT-ProBNP needs the concern about age, gender, obesity and especially we need each cut-off point for each cause of cardiovascular disease in evaluation and clinical application. Because NT-ProBNP is a new cardiac marker and has been researched in 5 recent years, the cut-off of NT-ProBNP is still being studied for the clinical application in cardiovascular diseases. Only the cut-off of NT-ProBNP in diagnosis heart failure was guided by European Society of Cardiology. The meaning of introduce cut-off value of value plays an role as pilot study for the other relate study and brings the NT-ProBNP closely approach to clinical application.


2021 ◽  
Vol 15 (9) ◽  
pp. 2748-2752
Author(s):  
Roman Evgenyevich Tokmachev ◽  
Andrey Valerievich Budnevsky ◽  
Andrey Yakovlevich Kravchenko ◽  
Tatiana Alexandrovna Chernik ◽  
Sudakov Oleg Valerievich ◽  
...  

Nowadays, more than 485 million people in the world suffer from cardiovascular diseases (CVD). According to large epidemiological studies, the group of CVD is the leading cause of death in the world. One of the neurohumoral mechanisms that appears to be a risk factor for CVD is thyroid dysfunction. In this regard, in recent years, more and more attention is paid to the study the influence of subclinical hypothyroidism on the occurrence and development of cardiovascular disorders. MeSH words: cardiovascular diseases, subclinical hypothyroidism


1982 ◽  
Vol 16 (4) ◽  
pp. 265-278
Author(s):  
Bruce Boman

In a recent article appearing in this journal, a decision of the Administrative Appeals Tribunal granting a war pension for ischaemic heart disease arising out of the stresses of military service in World War II was severely criticised. The following is a literature review supporting the Tribunal's judgement by providing evidence for an association between both neurotic illness and stresses of varying severity on the one hand and cardiovascular disease on the other.


2013 ◽  
Vol 4 (4) ◽  
pp. 25-32
Author(s):  
V. S Zadionchenko ◽  
G. G Shehyan ◽  
A. A Yalymov

Despite the facts, revealing the mechanisms of pathogenesis and enhancing the effectiveness of the treatment of cardiovascular disease (CVD), the latter continues to be the leading cause of death and disability in the population. In this regard, the search for new treatments for CVD remains the most relevant in modern cardiology. In the treatment of CVD many classes of drugs are used, among which are calcium antagonists (AA). This class of drugs has been successfully used in the treatment of patients with arterial hypertension (AH) and coronary heart disease [1-3, 5].CA are a heterogeneous group of drugs that have the similar actionmechanism, but differ in a number of properties, including pharmacokinetics, tissue selectivity, effect on heart rate, etc. The main feature of all is the ability of CA to reversibly inhibit calcium current through the slow calcium channels. These funds are used in cardiology from the end of the 1960s and have since become so widely popular that in most developed countries they hold one of the first places on the prescription rate of drugs used for the treatment of cardiovascular disease. This is due, on the one hand, to the CA high clinical efficacy, and on the other to a relatively small number of contraindications to their purpose and the comparatively small number of side effects. [1, 2, 4, 5].


Author(s):  
Yuldashev Soatboy Jiyanboyevich ◽  
◽  
Dr. Imran Aslam ◽  
Arslonova Rayxon Rajabboevna ◽  
◽  
...  

This study is based on the comparison between management versus PCI in patients with CAD. The prevalence of the major forms of cardiovascular disease (CVDs), mostly coronary artery disease (CAD), has changed dramatically in recent years. Cardiovascular disorders are now the one of the major cause of death and disability in the world.1 In 2015, 17.7 million individuals died from cardiovascular disease (CVD), which is around 31% of all deaths worldwide; 7.4 million pass away from coronary artery disease (CAD), and 6.7 million expired from stroke. 2 CAD is also the major cause of death, count for 13.2% of all deaths globally.3 It is responsible for one-quarter of all deaths in the United States of America (USA). About 75 percent of people with CAD in European countries are between the ages of 27 and 34.4 CAD was accountable for 16% of all man deaths and 10% of all female deaths in the England.5 Sudden death and CAD have a close connection. According to post-mortem reports and death certificates, 62-85 percent of patients who expired outside of the clinic have a past of CAD.6 As per informations from the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2014, myocardial infraction affects 3.0% of the mature people in the USA (3.3 percent of males and 2.3 percent of females). An MI occurs every 40 seconds or so in the USA. In the USA, the mean age at 1st MI is 65.6 years for guys and 72.0 years for ladies.7 In this study the management and PCI are compared in patients with CVD.


2018 ◽  
Vol 2018 ◽  
pp. 1-21 ◽  
Author(s):  
Ya-Dan Wen ◽  
Hong Wang ◽  
Yi-Zhun Zhu

The recognition of hydrogen sulfide (H2S) has been evolved from a toxic gas to a physiological mediator, exhibiting properties similar to NO and CO. On the one hand, H2S is produced from L-cysteine by enzymes of cystathionineγ-lyase (CSE) and cystathionineβ-synthase (CBS), 3-mercaptopyruvate sulfurtransferase (3MST) in combination with aspartate aminotransferase (AAT) (also called as cysteine aminotransferase, CAT); on the other hand, H2S is produced from D-cysteine by enzymes of D-amino acid oxidase (DAO). Besides sulfide salt, several sulfide-releasing compounds have been synthesized, including organosulfur compounds, Lawesson’s reagent and analogs, and plant-derived natural products. Based on garlic extractions, we synthesized S-propargyl-L-cysteine (SPRC) and its analogs to contribute our endeavors on drug development of sulfide-containing compounds. A multitude of evidences has presented H2S is widely involved in the roles of physiological and pathological process, including hypertension, atherosclerosis, angiogenesis, and myocardial infarcts. This review summarizes current sulfide compounds, available H2S measurements, and potential molecular mechanisms involved in cardioprotections to help researchers develop further applications and therapeutically drugs.


2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Stella Bernardi ◽  
Fleur Bossi ◽  
Barbara Toffoli ◽  
Bruno Fabris

Cardiovascular diseases (CVD) remain the major cause of death and premature disability in Western societies. Assessing the risk of CVD is an important aspect in clinical decision-making. Among the growing number of molecules that are studied for their potential utility as CVD biomarkers, a lot of attention has been focused on osteoprotegerin (OPG) and its ligands, which are receptor activator of nuclear factorκB ligand (RANKL) and TNF-related apoptosis-inducing ligand. Based on the existing literature and on our experience in this field, here we review what the possible roles of OPG and TRAIL in CVD are and their potential utility as CVD biomarkers.


2004 ◽  
Vol 3 (3) ◽  
pp. 59
Author(s):  
SK Sharma ◽  
P Karki ◽  
N Shrestha ◽  
S Dhakal ◽  
PR Gupta ◽  
...  

Cardiovascular diseases are the major cause of death In diabetes patients. Many factors including hypertension contribute to the high prevalence of cardiovascular disease in diabetes.


2020 ◽  
Vol 18 (6) ◽  
pp. 643-647
Author(s):  
V. S. Holyshko ◽  
◽  
V. A. Snezhitskiy ◽  
N. V. Matsiyeuskaya ◽  
◽  
...  

The COVID-19 pandemic caused by SARS-CoV-2 is the greatest medical problem of our time. The presence of concomitant cardiovascular pathology in a patient predisposes to a severe course and the formation of adverse outcomes of COVID-19. It is currently known that SARS-CoV-2 infection leads, on the one hand, to exacerbation and decompensation of the patient's cardiovascular disease, on the other hand, it is the origin of acute cardiovascular pathology. Understanding the impact of COVID-19 on the cardiovascular system is essential for providing comprehensive care to critically ill patients. In this review, we summarize the rapidly changing data on cardiovascular damage associated with COVID-19.


2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
A Polimeni ◽  
S Sorrentino ◽  
P Crea ◽  
C Spaccarotella ◽  
A Mongiardo ◽  
...  

Abstract Background Recent reports evidenced gender differences in the knowledge, perception and awareness of cardiovascular risk factors and cardiovascular diseases. Purposes To evaluate trends in awareness of cardiovascular risk, as well as knowledge of symptoms and preventive behaviors related to cardiovascular disease (CVD). Methods As part of Vivi con il Cuore (campaign with the goal of raising awareness about women's heart disease) a nationwide survey was conducted. Standardized questions on awareness of CVD risk, as well as prevention behaviors and barriers, were provided through a computer-assisted web interviewing platform to a large sample of Italians citizens ranging from 40 to 70 years old. The sample was representative of the population by age, sex, and area of geographical residence. Results A total of 1,000 subjects were included in this survey, of which 511 (51%) female. About 60% of women indicated cancer as the leading cause of death among female sex, while only 22% indicated cardiovascular disease. Similarly, when the same question was asked to men, 44% indicated cancer and 21% cardiovascular disease, observations that were consistent across age categories. Although a well sizable part of the population (90% of the interviewees) have consulted the general practitioner in the last year, only 45% of women and 56% of men declared to receive information about CVD risk. Almost 84% among men and women, recognized the importance of knowing how to understand the symptoms of a heart attack due to the possibility of survival. An additional survey was conducted among young cardiologists under 40 years old, including a total of 200 young cardiologists, similarly distributed among men and women (47% and 53% respectively). About 24% of young cardiologists indicated breast cancer as the leading cause of death in women, while only 70% reported cardiovascular diseases. Furthermore, 35% of participants reported that they did not have adequate training on the risks of heart disease in women. Conclusions In this survey, only 22% of women were aware that cardiovascular disease is the number one killer of women. Likewise, a well sizable part of young cardiologists (30%) does not recognize cardiovascular disease as the leading cause of death in women. These data should inform public health campaigns to focus on evidence-based strategies to prevent CVD and to help target messages that resonate and motivate women to take action. Funding Acknowledgement Type of funding source: Private company. Main funding source(s): Abbott


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