Markers of Metabolic Syndrome in Patients with Pituitary Adenoma: A Case Series of 303 Patients

AbstractTo assess the demographic characteristics and hormonal status of patients who presented to our clinic with pituitary adenoma and to demonstrate the presence, prevalence, and relationship of metabolic syndrome parameters in these patients. The study included 303 patients with known or newly diagnosed pituitary adenoma and 52 age- and sex-matched healthy controls. The patients were classified into 3 groups; acromegaly (ACRO) (n=54),prolactinoma (PRLoma) (n=163), and non-functional adenoma (NFA) (n=86). in 55.6% (n=172) and 52% (n=163) of the patients, respectively. The waist circumference of all patients (p<0.001) and body mass index (BMI) of patients with PRLoma (p=0.03) and ACRO (p<0.001) were found to be significantly higher than in the controls. The HbA1c, insulin and HOMA-IR values were significantly higher in the ACRO and PRLoma groups, whereas the insulin and HOMA-IR values were significantly higher in the NFA group compared with the control group (p<0.001 and p<0.001, respectively). When the 3 patient groups were compared, waist circumference and BMI were significantly higher in the ACRO group than in the PRLoma group (p=0.04 and p=0.03, respectively). In patients developing pituitary failure after treatment, age, waist circumference, plasma glucose, low-density lipoproteins and triglyceride values were significantly increased when compared with those without pituitary failure after treatment (p<0.001). In our study, it was found that there was increased metabolic and cardiovascular risk in functional pituitary adenoma and NFA.

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Changes in metabolic syndrome and risk of psoriasis: a nationwide population-based study

Scientific Reports ◽

10.1038/s41598-021-03174-2 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Hyun Ji Lee ◽

Kyung Do Han ◽

Hae Eun Park ◽

Ju Hee Han ◽

Chul Hwan Bang ◽

...

Keyword(s):

Metabolic Syndrome ◽

Health Insurance ◽

Waist Circumference ◽

Confidence Interval ◽

Density Lipoprotein ◽

Population Based ◽

Control Group ◽

Newly Diagnosed ◽

Population Based Study ◽

The Relationship

AbstractMetabolic syndrome (MetS) is associated with psoriasis, but it remains unclear whether risk of psoriasis remains in patients whose MetS diagnosis changes. To assess the relationship between risk of psoriasis and changes in MetS components. We obtained data from the National Health Insurance Service of Korea and divided the participants into four groups: individuals without MetS (control); individuals with MetS in 2009, but without MetS in 2012 (pre-MetS); individuals without MetS in 2009, but with newly diagnosed MetS in 2012 (post-MetS); and individuals with MetS during the 2009–2012, period (continuous-MetS). We calculated the risk of psoriasis for each group. Risk of psoriasis was similar in the control and pre-MetS groups but was significantly higher in the post-MetS group (hazard ratio [HR], 1.08; 95% confidence interval [CI], 1.04–1.12) and in the continuous-MetS group (HR, 1.11; 95% CI, 1.07–1.15) than in the control group. Among MetS components, waist circumference showed the strongest association with psoriasis, followed by high-density lipoprotein and triglyceride levels. Risk of psoriasis was higher in patients with continuous- or post-MetS than in those with pre-MetS (regardless of prior MetS status).

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Individual Diet Modification Reduces the Metabolic Syndrome in Patients Before Pharmacological Treatment

Nutrients ◽

10.3390/nu13062102 ◽

2021 ◽

Vol 13 (6) ◽

pp. 2102

Author(s):

Małgorzata Elżbieta Zujko ◽

Marta Rożniata ◽

Kinga Zujko

Keyword(s):

Physical Activity ◽

Metabolic Syndrome ◽

Fatty Acids ◽

Waist Circumference ◽

Nutrition Education ◽

Dietary Habits ◽

Fasting Glucose ◽

Intervention Group ◽

Control Group ◽

The Metabolic Syndrome

Modification of lifestyle, including healthy nutrition, is the primary approach for metabolic syndrome (MetS) therapy. The aim of this study was to estimate how individual nutrition intervention affects the reduction of MetS components. Subjects diagnosed with MetS were recruited in the Lomza Medical Centre. The study group consisted of 90 participants and was divided into one intervention group (individual nutrition education group (INEG)) and one control group (CG). The research was conducted over 3 months. The following measurements were obtained during the first visit and after completion of the 3 months intervention: body mass, waist circumference, body composition, blood pressure, fasting glucose, and blood lipids. Dietary assessments were performed before and post-intervention using 3-day 24-h dietary recalls. Dietary knowledge was evaluated with the KomPAN questionnaire. The total polyphenol content of the diet was calculated. Sociodemographic and lifestyle characteristics were collected from a self-reported questionnaire. The physical activity was assessed by the short version of the International Physical Activity Questionnaire (IPAQ). It was found that the individual nutrition education was an effective method to improve the knowledge, dietary habits, and physical activity of the study participants. The modification of the diet in terms of higher intake of polyphenols (flavonoids and anthocyanins), fiber, polyunsaturated fatty acids (PUFA), PUFA n-3, and lower intake of saturated fatty acids (SFA) had a significant impact on the improvement of some MetS risk factors (waist circumference, fasting glucose, and HDL-cholesterol).

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Long-Term Lifestyle Intervention in Elderly With Metabolic Syndrome

Clinical Nursing Research ◽

10.1177/1054773817749923 ◽

2017 ◽

Vol 28 (6) ◽

pp. 658-675 ◽

Cited By ~ 1

Author(s):

Shu-Hung Chang ◽

Nai-Hui Chien ◽

Ching-Yi Yu

Keyword(s):

Metabolic Syndrome ◽

Waist Circumference ◽

Lifestyle Intervention ◽

Exercise Intervention ◽

Controlled Trial ◽

Density Lipoprotein ◽

Control Group ◽

Elderly Adults ◽

Community Based

The purpose of this study was to examine the effects of a long-term community-based lifestyle intervention on the biochemical indicators and prevalence of metabolic syndrome among elderly adults. This was a randomized controlled trial in northern Taiwan from August 2013 to February 2015. Sixty-nine elderly adults participated in this study. There were three measurements. The experimental group participated in exercise and diet interventions. The control group participated in the exercise intervention. Repeated measurement and ANCOVA were performed to evaluate the effectiveness. After 18 months, body weight (1.06 kg), body mass index (1.21 kg/m2), waist circumference (3.32 cm), blood pressure, and prevalence (30.4%) of metabolic syndrome were significantly reduced in all subjects. There were significant differences in waist circumference and high-density lipoprotein cholesterol between the two groups. This intervention can lower the indicators and prevalence of metabolic syndrome. Exercise and diet interventions could promote further metabolic changes.

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Reactivity features of cytokines and vasculoendothelial growth factor in patients with chronic cerebral ischemia and metabolic syndrome

Psychiatry Neurology and Medical Psychology ◽

10.26565/2312-5675-2019-12-04 ◽

2019 ◽

Keyword(s):

Metabolic Syndrome ◽

Cerebral Ischemia ◽

Growth Factor ◽

Waist Circumference ◽

Interleukin 6 ◽

Interleukin 10 ◽

Low Density Lipoproteins ◽

Low Density ◽

Chronic Cerebral Ischemia ◽

Very Low Density Lipoproteins

The purpose of the research is to determine the correlation between cytokines (interleukin-6, interleukin-10), vasculoendothelial growth factor, biochemical and anthropometric parameters in patients with chronic cerebral ischemia and metabolic syndrome. We examined 77 patients with chronic cerebral ischemia divided into 2 groups: with metabolic syndrome and without metabolic syndrome. In addition to neuroimaging, anthropometric and biochemical research we determined serum concentrations of interleukin-6, interleukin-10 and vasculoendothelial growth factor. It was found that patients with chronic cerebral ischemia and metabolic syndrome had significantly higher concentrations of interleukin-6, vasculoendothelial growth factor, indicators of weight, body mass index, waist circumference, glucose concentration, triglycerides, very low density lipoproteins, and high density lipoproteins was lower compared with the group without metabolic syndrome. During the comparing process of the biomarkers concentrations depending on gender, it was found that in patients with chronic cerebral ischemia and metabolic syndrome, the concentration of interleukin-6 was significantly higher in women than in men. Examination of all patients with chronic cerebral ischemia showed a direct correlation between the concentrations of interleukin-6 and glucose, the concentrations of interleukin-6 and weight, the concentrations of interleukin-6 and the waist circumference and between the concentration of vasculoendothelial growth factor and the waist circumference, in the group with metabolic syndrome - between the concentrations of interleukin-6 and interleukin-10, and in the group without metabolic syndrome - between the waist circumference and the atherogenic coefficient, between the concentrations of low density lipoproteins and β-lipoproteids, between the concentrations of low density lipoproteins and very low density lipoproteins. Thereby, metabolic syndrome is an additional complicating factor that comprehensively affects the reactivity of cytokines and vasculoendothelial growth factor in the pathogenesis of chronic cerebral ischemia.

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The thickness of the epicardial fat is the "visit card" of metabolic syndrome

Obesity and metabolism ◽

10.14341/omet9295 ◽

2018 ◽

Vol 15 (2) ◽

pp. 29-34

Author(s):

Oxana M. Drapkina ◽

Ruslan N. Shepel ◽

Tatiana A. Deeva

Keyword(s):

Metabolic Syndrome ◽

Waist Circumference ◽

Blood Plasma ◽

Transthoracic Echocardiography ◽

Left Ventricular ◽

Epicardial Fat ◽

Control Group ◽

Caspase 8 ◽

Plasma Leptin

Aims. On the basis of echocardiography to evaluate the thickness of epicardial fat (TEF) in patients with metabolic syndrome (MS) and to establish a connection with the main indicators of laboratory and instrumental methods of research. Materials and methods. The study included 76 patients, 43 patients with MS and 33 without MS. The average age of patients in the MS group at the time of inclusion in the study was 62.710.3 years in the control group (without MS) 6014.7 years. All patients underwent a comprehensive examination that included the collection of complaints, study of history, physical examination, anthropometric measurements, laboratory (including the study of the levels of caspase 8, leptin in blood plasma enzyme-linked immunosorbent assay using kits Platinum ELISA) and instrumental examination (echocardiography, ultrasound examination of organs of small pelvis). TEF was determined using transthoracic echocardiography on the machine Acuson Sequoia 512. Results. According transthoracic echocardiography was significantly higher in the group of patients with MS and was 4.671.7 mm, as compared to 2.661.15 mm in the control group (p0.001). Identified moderate and strong correlation between TEF and weight of the patients, waist circumference, ratio of waist circumference to hip circumference, body mass index, glucose levels in the blood plasma, the presence of diabetes mellitus type 2, ultrasonic signs of steatosis of the liver and pancreas, increased aminotransferases, the level of caspase-8 concentration in plasma leptin. Patients the MS group with increased TEF increases the risk of developing hypertension, ischemic heart disease, left ventricular hypertrophy, diastolic dysfunction of the left ventricle type 2, level of caspase-8 and concentration in plasma leptin. Conclusion. Based on the obtained data, the measurement of TEF is justified in patients with MS in everyday clinical practice. The correlations between the TEF and the clinical and metabolic parameters of the CVD and MS make it possible to consider the TEF as a new marker of the risk of developing MS and cardiovascular diseases.

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The thickness of the epicardial fat is the "visit card" of metabolic syndrome

Obesity and metabolism ◽

10.14341/omet2018229-34 ◽

2018 ◽

Vol 15 (2) ◽

pp. 29-34

Author(s):

Oxana M Drapkina ◽

Ruslan N Shepel ◽

Tatiana A Deeva

Keyword(s):

Metabolic Syndrome ◽

Waist Circumference ◽

Blood Plasma ◽

Transthoracic Echocardiography ◽

Left Ventricular ◽

Epicardial Fat ◽

Control Group ◽

Caspase 8 ◽

Plasma Leptin

AIMS. On the basis of echocardiography to evaluate the thickness of epicardial fat (TEF) in patients with metabolic syndrome (MS) and to establish a connection with the main indicators of laboratory and instrumental methods of research. MATERIALS AND METHODS. The study included 76 patients, 43 patients with MS and 33 without MS. The average age of patients in the MS group at the time of inclusion in the study was 62.7±10.3 years in the control group (without MS) – 60±14.7 years. All patients underwent a comprehensive examination that included the collection of complaints, study of history, physical examination, anthropometric measurements, laboratory (including the study of the levels of caspase – 8, leptin in blood plasma enzyme-linked immunosorbent assay using kits «Platinum ELISA») and instrumental examination (echocardiography, ultrasound examination of organs of small pelvis). TEF was determined using transthoracic echocardiography on the machine Acuson Sequoia 512. RESULTS. According transthoracic echocardiography was significantly higher in the group of patients with MS and was 4.67±1.7 mm, as compared to 2.66±1.15 mm in the control group (p<0.001). Identified moderate and strong correlation between TEF and weight of the patients, waist circumference, ratio of waist circumference to hip circumference, body mass index, glucose levels in the blood plasma, the presence of diabetes mellitus type 2, ultrasonic signs of steatosis of the liver and pancreas, increased aminotransferases, the level of caspase-8 concentration in plasma leptin. Patients the MS group with increased TEF increases the risk of developing hypertension, ischemic heart disease, left ventricular hypertrophy, diastolic dysfunction of the left ventricle type 2, level of caspase-8 and concentration in plasma leptin. CONCLUSION. Based on the obtained data, the measurement of TEF is justified in patients with MS in everyday clinical practice. The correlations between the TEF and the clinical and metabolic parameters of the CVD and MS make it possible to consider the TEF as a new marker of the risk of developing MS and cardiovascular diseases.

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Role of vascular endothelial growth factor in the pathogenesis of hepatic steatosis and dyslipidemia

ZHurnal «Patologicheskaia fiziologiia i eksperimental`naia terapiia» ◽

10.25557/0031-2991.2020.04.31-36 ◽

2020 ◽

pp. 31-36

Author(s):

И.Л. Гуляева ◽

И.А. Булатова ◽

Л.Д. Пестренин

Keyword(s):

Metabolic Syndrome ◽

Fatty Liver ◽

Hepatic Steatosis ◽

Low Density Lipoproteins ◽

Control Group ◽

Low Density ◽

Very Low Density Lipoproteins ◽

Fatty Liver Index ◽

Nonalcoholic Hepatic Steatosis ◽

Hepatic Steatosis Index

Цель исследования - изучение роли васкулоэндотелиального фактора роста в патогенезе неалкогольного стеатоза печени и дислипидемии при метаболическом синдроме. Методика. Обследовано 35 пациентов с неалкогольным стеатозом печени, в том числе 22 женщины и 13 мужчин. Группу контроля составили 12 сопоставимых по полу и возрасту лиц без патологии печени и признаков метаболического синдрома. Наличие жирового гепатоза подтверждали методом ультразвукового исследования. У пациентов с патологией печени рассчитывали индексы-предикторы стеатоза: Fatty Liver Index (FLI) и Hepatic Steatosis Index (HSI). У всех участников исследования определяли уровни провоспалительных цитокинов и васкулоэндотелиального фактора роста (ВЭФР), оценивали также липидный спектр крови и функциональные печеночные пробы. Результаты. У пациентов со стеатозом печени наблюдалось значимое увеличение уровней провоспалительных цитокинов, ВЭФР, общего холестерина и липопротеинов низкой и очень низкой плотности. Индекс атерогенности также был значимо выше, чем в контрольной группе. Концентрация ВЭФР положительно коррелировала с показателями окружности талии, тимоловой пробы, уровнями общего холестерина, липопротеинов низкой плотности и индексом атерогенности. Чувствительность FLI составила 91,4%, HSI - 97,1%. При этом, значения FLI и HSI значимо коррелировали с уровнем ВЭФР. Заключение. Полученные данные позволяют предположить, что ВЭФР, один из основных маркеров эндотелиальной дисфункции, может играть немаловажную роль в патогенезе неалкогольного стеатоза печени и дислипидемии у пациентов с метаболическомим синдромом The aim of the study was to assess the role of vascular endothelial growth factor (VEGF) in the pathogenesis of nonalcoholic hepatic steatosis and dyslipidemia in patients with signs of metabolic syndrome. Methods. 35 patients with nonalcoholic fatty liver disease, including 22 women and 13 men, were evaluated. The sex- and age-matched control group consisted of 12 people without liver pathology and metabolic syndrome criteria. Presence of hepatic steatosis was confirmed by an ultrasound examination. The Fatty Liver Index (FLI) and the Hepatic Steatosis Index (HSI) were calculated for patients with hepatic steatosis. Concentrations of proinflammatory cytokines and VEGF were measured for all participants. Also, blood biochemistry, including the lipid profile and liver function tests, was analyzed. Results. In patients with hepatic steatosis, levels of proinflammatory cytokines and VEGF were significantly increased. Also, concentrations of total cholesterol, low-density lipoproteins, and very low-density lipoproteins were higher in patients with the liver pathology than in the control group. Atherogenic coefficient was increased in hepatic steatosis. Significant correlations were observed between VEGF and waist circumference, thymol test, total cholesterol, low-density lipoproteins, very low-density lipoproteins, and atherogenic coefficient. Sensitivity of FLI and HIS was 91.4% and 97.1%, respectively. Also, FLI significantly correlated with HSI and VEGF level. Conclusion. The study suggested that VEGF, of the main markers of endothelial dysfunction, plays an important role in the pathogenesis of nonalcoholic hepatic steatosis and dyslipidemia in patients with signs of metabolic syndrome.

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An investigation of the association between lipoxin A4 levels and metabolic syndrome parameters in patients with metabolic syndrome

10.51271/kmj-0023 ◽

2021 ◽

pp. 105-109

Keyword(s):

Blood Pressure ◽

Metabolic Syndrome ◽

Waist Circumference ◽

Density Lipoprotein ◽

Public Health Problem ◽

Serum Levels ◽

Enzyme Linked Immunosorbent Assay ◽

Lipoxin A4 ◽

Male Patients ◽

Age And Sex

Aim: Metabolic syndrome (MS) is a significant public health problem and has the potential to increase the risk of developing cardiovascular diseases (CVD), the risk of type 2 Diabetes Mellitus (T2DM), the risk of stroke and the risk of a heart attack. MS has recently been considered an inflammatory disease. Lipoxins (LXs) are, on the other hand, bioactive lipid molecules synthesized from arachidonic acid (AA) and show potent anti-inflammatory and pro-resolving activities in vivo and in vitro conditions. In this study, we aimed to evaluate serum levels of LXA4 in MS patients and explore the relationship of serum LXA4 levels with MS components [waist circumference, blood pressure, serum high-density lipoprotein (HDL), and triglyceride (TG) levels]. Material and Method: In this study, the sample was composed of 39 patients diagnosed with MS and 32 healthy age- and sex-matched individuals. We measured serum LXA4 levels adopting the enzyme-linked immunosorbent assay (ELISA) method with “Human Lipoxin A4 ELISA Kit”. While collecting the blood samples from the subjects, we noted their ages, sex, physical examination findings, and anthropometric measurements [height, weight, waist circumference, and body mass index (BMI)]. Additionally, we obtained their serum TG, low-density lipoprotein (LDL), HDL, glucose, and cholesterol levels. Results: While we could not find any significant differences between the groups by age and sex (p>0.05), the groups significantly differed by weight, waist circumference, BMI, systolic blood pressure, diastolic blood pressure, TG, HDL, and FBG (p<0.05 for TG; p<0.001 for others). Moreover, serum levels of LXA4 significantly differed between the groups (p<0.05). Within-group comparisons showed that while serum levels of LXA4 significantly differed between male subjects (p=0.01), it was not the case for females (p>0.05). In both groups, there were negative correlations between serum LXA4 levels and waist circumference (r=-0.368 p=0.02). Yet, we found such an association only among male patients (r=-0.516 p=0.02). Conclusion: Overall, we found serum LXA4 levels to be significantly low in MS patients (p<0.05). Yet, it still needs to be elucidated whether this impairment is a cause or a result of MS. Finally, we discovered this impairment and its significant correlations with some MS parameters to be only in male patients, suggesting that serum LXA4 levels may vary by sex in MS patients.

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Enumeration of Circulating Platelet-Derived Microparticles Clearly Separates PV and ET From Secondary Polycythemia or Thrombocytosis

Blood ◽

10.1182/blood.v118.21.1745.1745 ◽

2011 ◽

Vol 118 (21) ◽

pp. 1745-1745

Author(s):

Agnés Charpentier ◽

Stéphanie Devaux ◽

Véronique Tintillier-Colin ◽

Matthieu Wemeau ◽

Judith Bruge-Debreu ◽

...

Keyword(s):

Conflicts Of Interest ◽

Myeloproliferative Neoplasms ◽

Annexin V ◽

Threshold Value ◽

Normal Subjects ◽

Control Group ◽

Newly Diagnosed ◽

Testing Procedures ◽

Healthy Donors ◽

Age And Sex

Abstract Abstract 1745 Rationale: The diagnosis of Polycythemia Vera (PV) and Essential Thrombocytemia (ET) relies on a set of criteria gathered in the 2008 WHO classification; however, it may occasionnaly be difficult, especially in the absence of molecular markers such as Jak2V617→F or Mpl mutations. Having previously reported a significant increase in circulating platelets microparticles (PMP) in patients bearing Myeloproliferative neoplasms versus healthy donors (V.Tintillier-Colin, ASH Annual Meeting 2009, Abstr. 1906), our purpose has been to assess the usefulness of blood PMP count as an additional criteria in dubious cases of ET and PV. Patients and methods: We performed PMP counts in 100 newly diagnosed and still untreated patients (55 ET and 45 PV in accordance to WHO criteria), 40 secondary or reactive states (erythrocytosis and thrombocytosis, 20 cases each) and 75 controls matched for age and sex. The PMP were characterized by their size and co-expression of Annexin V and CD41; their concentration was measured on plasma extracts using the FC500 flow-cytometer (Beckman-Coulter™). Pre-analytical and testing procedures complied with the recommendations of the ISTH Standardization Sub-committee with each test performed in duplicate. Results: The 3 groups were homogeneous regarding age and sex-ratio. Mean platelet counts were 703.109/l in the TE group, 652.109/l in the cohort with secondary thrombocytosis and 247.109/l in the control group. Mean Hb level was 18.0g/dl in the PV group, 18.1g/dl in the secondary erythrocytosis group and 15g/dl in controls. The median value of PMP concentration is much higher (p < 0.05, Krusall-Wallis test) in the TE group (5900/μl) than in the reactive thombocytosis group (1283/μl), this latter being no different from the control group (996/μl). In the ET group, PMP count is similarly increased whether patients beared Jak2V617→F mutation or not. Using the ROC statistical method, we defined a threshold value of 3400 PMP/μl able to discriminate ET from reactive thrombocytosis with 93% specificity and 67% sensitivity. Similarly, the median value of PMP count was neatly higher in the PV group (3258/μl) than in secondary erythocytosis (671/μl) and healthy controls (996/μl) (p < 10−5, Krusall-Wallis test). The ROC method fixed a 1300/μl threshold separating PV from secondary erythrocytosis with 89% sensibility and 63% specificity. Conclusion: We report an evaluation of the blood PMP count in a quite large series of newly diagnosed untreated ET and PV patients compared to patients with secondary thrombocytosis or erythrocytosis and healthy volunteers; this study emphasizes the interest of the circulating PMP count in order to differentiate MPN neoplasms from normal subjects as well as patients with reactive conditions. This test, quick, reproducible and cheap, especially shows its value as an additional diagnostic criteria in ET or PV when clonal markers are lacking. Disclosures: No relevant conflicts of interest to declare.

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Increased BMI and Waist Circumference are Related to Increased DNA Damage in Women with Overweight and Metabolic Syndrome

Asian Journal of Advanced Research and Reports ◽

10.9734/ajarr/2020/v13i230306 ◽

2020 ◽

pp. 43-52

Author(s):

Lidiana de Camargo Talon ◽

Ana Paula Costa Rodrigues Ferraz ◽

Damiana Tortolero Pierine ◽

Igor Otávio Minatel ◽

Jéssica Leite Garcia ◽

...

Keyword(s):

Metabolic Syndrome ◽

Waist Circumference ◽

Medical School ◽

The Body ◽

Control Group ◽

Omega 3 ◽

Cross Sectional ◽

Dietary Antioxidant ◽

Group 2 ◽

Endocrinology Clinic

Aims: To test if the level of oxidative stress is different in women with overweight and with metabolic syndrome. Study Design: Cross- sectional. Place and Duration of Study: Endocrinology Clinic of the Botucatu Medical School- UNESP, between March 2013 and March 2014. Methodology: Eighty women (31.15 ± 7.91 years old) attended at the Endocrinology Clinic of the Botucatu Medical School- UNESP composed this study. According to the body mass index (BMI) they were divided in 3 groups: Group 1 (G1, n=36 eutrophic); Group 2 (G2, n=21 overweight) and Group 3 (G3, n=23 women with MS-Metabolic syndrome). It was evaluated: dietary intake of macro and micronutrients dietary; antioxidant capacity (HAC) of plasma and levels of malondialdehyde (MDA); carotenoids, retinol and α-tocopherol in peripheral lymphocytes and the comet assay. Results: Damage to DNA, oxidized purines and the levels of MDA didn’t differ between women with overweight and with metabolic syndrome but they are higher than those in the control group. Correlation was positive for BMI and waist circumference (WC) with damage to DNA. Linear regression showed that higher consumption of protein and sodium is related to damage to DNA and both carotenoids and omega- 3 are protectors. Conclusion: Damage to DNA occurs independent of overweight or obesity and WC could be a predictor for damage to DNA.

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