Relationship of Coagulation Test Abnormalities to Tumour Burden and Postoperative DVT in Resected Colorectal Cancer

2002 ◽  
Vol 87 (03) ◽  
pp. 402-408 ◽  
Author(s):  
O. Thorlacius-Ussing ◽  
L. H. Iversen

SummaryIn a prospective study, coagulation test results were compared in 137 patients with colorectal cancer (CRC) and 39 subjects with benign colorectal diseases. Prothrombin fragment 1+2 (F1+2), thrombinantithrombin complex (TAT), and soluble fibrin (SF) were measured in plasma before and after surgery. CRC patients presented with significantly higher values of F1+2 and TAT than controls. Patients with localised CRC had elevated values of F1+2 and TAT, whereas patients with advanced CRC also had elevated SF values. TAT and SF levels correlated with tumour spread, and normal values virtually excluded advanced cancer. Postoperative deep venous thrombosis (DVT) was diagnosed by phlebography in 20% of the CRC patients. Preoperative values of the markers did not predict postoperative DVT, but postoperative values did.

2016 ◽  
Vol 4 (7) ◽  
pp. 59
Author(s):  
Syahruddin Syahruddin ◽  
Idiannor Mahyudin ◽  
Emmy Sri Mahreda

Fish landing base (PPI) is a container that can support development and the development of a better fishery.Accordence with the increasing number of fishing vessels that enter the  territory  Kotabaru, either the ships  from itself or the ships that come from the outside area.  Making  the  existence  of  the PPI  Saijaan Kotabaru  a  medium  which  accommodates  fishery  activities  to  make  a   direct   relevance  relationship  of  upriver  and  downstream activities. This research was conducted: identifying facilities, conditions  and function of the PPI Saijaan Kotabaru; Analyzing changes in the income of entrepreneur fishery before and after the PPI Saijaan Kotabaru in District Stagen Kotabaru; Formulating a strategy of economic development of the PPI  Saijaan  Kotabaru as an area of fisheries.Analysis  Technique of  the  research  uses  qualitative  and  quantitative  method  with descriptive approach. The results obtained that the basic, functional and additional facilities of  the PPI Saijaan Kotabaru have been fulfilled by 90 % and have not been  fulfilled  by 10 % thatneed to be developed. Condition and function facilities of  the PPI Saijaan Kotabaru, is only 90 % facilities are function optimally and 10 % is  not function optimally.Wilcoxon  test results  in Statistics  Test, shows that value of Wilcoxon test p-value is  0.003 (< 0.05),then Ho is rejected and H1 is accepted, meaning that there is a very significant difference from the increased income of entrepreneur fishery after the construction of  the PPI Saijaan  Kotabaru as well. The results of the value to external factors (EFAS) is = 2.85, while  for  internal factors (IFAS) is = 2.55. So the value of EFAS >IFAS value, then a qualitative activity and capacity of existing facilities of the PPI Saijaan Kotabaru still very likely to be developed. 


2011 ◽  
Vol 90-93 ◽  
pp. 584-587
Author(s):  
Tong Hui Qian ◽  
Wen Cai Xia ◽  
Fang Chen ◽  
Hong Xing Ding

Through analysis of model test results, some of the basic sliding piles features of the frame anti-slide pile can be obtained. Under the thrust of landslide, a complex parabola and line function could be used to describe the relationship of load and lateral displacement of pile head. At the same time, there was a big crack in front of the pile. It was shown by monitoring the soil pressure that pushing force acting on the back frame pile was trapezoidal distribution and on the leading frame pile was parabola distribution. The soil pressure value was larger at back piles central and around sliding surface and smaller at the head of piles. the landslide thrust acting on the back piles more larger than the front row piles, the central of piles’ maximum soil pressure minimum 1:3 ratio of the middle pile at the before and after row, the ratio between the changes with the load. Frame pile of the inflection point after another figure appeared, at the top of the link beam and ring beam structure of the entire framework of the pile Showed a synergistic effect of spatial, compare to other forms of single row of piles and others forms, it can significantly reduce the size, to achieve the economic security landslide treatment goal, there is wide application prospect.


2018 ◽  
Vol 56 (3) ◽  
pp. 454-462 ◽  
Author(s):  
Ana Mlinaric ◽  
Marija Milos ◽  
Désirée Coen Herak ◽  
Mirjana Fucek ◽  
Vladimira Rimac ◽  
...  

AbstractBackground:The need to satisfy high-throughput demands for laboratory tests continues to be a challenge. Therefore, we aimed to automate postanalytical phase in hematology and coagulation laboratory by autovalidation of complete blood count (CBC) and routine coagulation test results (prothrombin time [PT], international normalized ratio [PT-INR], activated partial thromboplastin time [APTT], fibrinogen, antithrombin activity [AT] and thrombin time [TT]). Work efficacy and turnaround time (TAT) before and after implementation of automated solutions will be compared.Methods:Ordering panels tailored to specific patient populations were implemented. Rerun and reflex testing rules were set in the respective analyzers’ software (Coulter DxH Connectivity 1601, Beckman Coulter, FL, USA; AutoAssistant, Siemens Healthcare Diagnostics, Germany), and sample status information was transferred into the laboratory information system. To evaluate if the automation improved TAT and efficacy, data from manually verified results in September and October of 2015 were compared with the corresponding period in 2016 when autovalidation was implemented.Results:Autovalidation rates of 63% for CBC and 65% for routine coagulation test results were achieved. At the TAT of 120 min, the percentage of reported results increased substantially for all analyzed tests, being above 90% for CBC, PT, PT-INR and fibrinogen and 89% for APTT. This output was achieved with three laboratory technicians less compared with the period when the postanalytical phase was not automated.Conclusions:Automation allowed optimized laboratory workflow for specific patient populations, thereby ensuring standardized results reporting. Autovalidation of test results proved to be an efficient tool for improvement of laboratory work efficacy and TAT.


2008 ◽  
Vol 26 (6) ◽  
pp. 948-954 ◽  
Author(s):  
Donald W. Hadley ◽  
Jean F. Jenkins ◽  
Seth M. Steinberg ◽  
David Liewehr ◽  
Stephanie Moller ◽  
...  

Purpose Lynch syndrome poses multiple cancer risks, yet attention has focused on screening for colorectal cancer. Estimated risks for endometrial cancer equal risks for colorectal cancer. This study (1) evaluated women's perceived risks for cancers, (2) compared endometrial cancer screening and colonoscopy, and (3) identified predictors of screening before and after genetic testing. Patients and Methods Sixty-five adult women at 50% risk for carrying a cancer-predisposing mutation, without a history of endometrial cancer or hysterectomy, participated in genetic counseling and received unequivocal genetic test results for Lynch syndrome. Participants completed questionnaires before and after receipt of genetic results. Results Pretest, perceived risks for colon cancer were significantly higher than for extracolonic cancers (P < .0001). Use of colonoscopy was significantly higher (P = .006) than endometrial cancer screening. Post-test, carriers demonstrated a significant (P < .0001) increase in their perceived risk for extracolonic cancers and increased both colonoscopy (P = .79) and endometrial cancer screening (P = .11). Mutation status, age, perceived likelihood of carrying a mutation, and communication of test results to their physician independently predicted cancer screening at follow-up. Conclusion Women in families with Lynch syndrome are less aware of their risks for extracolonic cancers and undergo endometrial cancer screening significantly less often than colonoscopy before genetic counseling. Given the significantly increased risks for endometrial and ovarian cancers and the mortality associated with ovarian cancer, additional efforts to inform families of cancer risks and screening recommendations seem prudent. Physicians play a critical role in ensuring appropriate cancer screening in women with Lynch syndrome.


2020 ◽  
Vol 1 (2) ◽  
pp. 117-121
Author(s):  
Oleeviya Joseph ◽  
◽  
Sajeev Cherian Jacob ◽  
Venkataramana Kalikivayi ◽  
◽  
...  

AIM: To analyse visual modifications such as amplitude of accommodation, near point of convergence (NPC) reopsis and near phoria associated with asthenopic symptoms after 3D viewing at varying distances. METHODS: A prospective study. Thirty young adults were randomly selected. Each individual was exposed to 3D viewing thrice in a day for a fixed distance and the distance was varied on three consecutive days. Same video of equal duration and different screen sizes were used for every distance. Cyclic 3D mode of K-multimedia player was used for projecting the 3D video. Different variables like stereopsis, amplitude of accommodation, near point of accommodation, near phoria and asthenopic symptoms were recorded immediately after 3D video viewing. Stereopsis was measured with “Toegepast Natuurwetenschappelijk Onderzoek” or “Netherlands Organisation for Applied Scientific Research” (TNO test), amplitude of accommodation and NPC were measured using Royal Air Force (RAF) ruler, near phoria was measured using prism bar and a closed ended sample questionnaire was used to know the occurrence of asthenopic symptoms. Statistical analyses were performed using descriptive statistics, paired t-test etc. Qualitative data was analyzed using Chi-square test. RESULTS: For every distance of 40 cm, 3 m and 6 m, amplitude of accommodation was significantly reduced by 0.66 D, 1.12 D and 1.44 D. NPC got significantly receded by 0.63 cm, 0.93 cm and 1.23 cm, and the near phoria was significantly increased by 0.87, and 2.2 prism dioptres (PD) base-in respectively. It was found that most of the subjects got pain around the eyes; headache and irritation for each viewing distance. This study also revealed that 3D video viewing in theaters may increase the symptoms of headache, watering and irritation. Symptoms like headache, watering, fatigue, irritation and nausea may increase considerably at home environment and symptoms such as headache and watering may cause significant discomfort by 3D viewing using a laptop. CONCLUSION: There was a significant difference in amplitude of accommodation, NPC, near phoria and asthenopic symptoms before and after viewing a 3D video and also at three viewing distances. There was a predominant occurrence of asthenopic symptoms after 3D video viewing at different distances.


Author(s):  
Kathleen B. Reuter

The reaction rate and efficiency of piperazine to 1,4-diazabicyclo-octane (DABCO) depends on the Si/Al ratio of the MFI topology catalysts. The Al was shown to be the active site, however, in the Si/Al range of 30-200 the reaction rate increases as the Si/Al ratio increases. The objective of this work was to determine the location and concentration of Al to explain this inverse relationship of Al content with reaction rate.Two silicalite catalysts in the form of 1/16 inch SiO2/Al2O3 bonded extrudates were examined: catalyst A with a Si/Al of 83; and catalyst B, the acid/phosphate Al extracted form of catalyst A, with a Si/Al of 175. Five extrudates from each catalyst were fractured in the transverse direction and particles were obtained from the fracture surfaces near the center of the extrudate diameter. Particles were also obtained from the outside surfaces of five extrudates.


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