Comparison Of Mean Platelet Survival Time In A Non-Radioisotope Method Calculatend With New Model With Mean Survival Time In CR-51 Methods

1981 ◽  
Author(s):  
T Tsukada ◽  
T Tango
Keyword(s):  
Linear Regression ◽  
Survival Time ◽  
The Other ◽  
Gamma Model ◽  
Radioisotope Method ◽  
Mean Survival Time ◽  
Normal Platelet ◽  
Other Hand ◽  
Platelet Survival ◽  
The Difference

Platelet survival time using non-radioisotope method measuring malondialdehyde(MDA) generation stimulated by arachidonate prior to and after intake of aspirin(ASA) and Cr-51 method was measured simultaneously in 18 cases with ITP. In cases with normal platelet survival time MDA generation curve showed linear or the letter-S pattern. On the other hand, all cases with shorter survival time had MDA generation curve with letter-S pattern. To describe the S pattern of MDA generation curve following model was devised on the assumption : 1) ASA inhibits MDA generation in megakaryocytes so that newly produced platelets show impaired MDA generation, 2) ability of MDA generation in platelets exposed to ASA recovers during circulating.where a is the disappearance time of inhibiting effect of ASA on megakaryocyte MDA generation and b is the time necessary for recovery of MDA generation in platelets exposed to ASA. Mean survival time(MST) is calculated by l/λ.The difference of MST between non-radioisotope method and Cr-51 method( gamma model) in 11 cases with MST of less than 4 days in Cr-51 method were 2.9 ± 0.4 days in platelet survival time (PST) at which MDA generation attained to pre-ASA levels, 2.7 ± 0.4 days in MST calculated with linear regression of MDA generation curve and 1.8 ± 0.4(SEM) days in MST calculated by the above model. On the other hand, in cases with MST of more than 4 days in Cr-51 method the difference of MST in both methods were 1.4 ± 0.3(SEM) days in PST, 0.6 ± 0.2 days in linear regression and 0.6 ± 0.2 days when MST was calculated with the above formula.These results suggest that the model reported is so far the better fitting model for the MDA generation curve in cases with normal and shortened platelet survival.

scholarly journals ML-23 The outcome of malignant lymphoma of the central nervous system in a single institution

2020 ◽  
Vol 2 (Supplement_3) ◽  
pp. ii18-ii18
Author(s):  
Kiyonori Kuwahara ◽  
Shigeo Ohba ◽  
Kazuyasu Matsumura ◽  
Saeko Higashiguchi ◽  
Daijiro Kojima ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Adverse Events ◽  
Malignant Lymphoma ◽  
Survival Time ◽  
Progression Free Survival ◽  
Treatment Method ◽  
The Other ◽  
High Dose ◽  
Other Hand

Abstract Background: Although high dose-methotrexate therapy has been performed for primary central nervous system malignant lymphoma (PCNSL), R-MPV (rituximab, methotrexate (MTX), procarbazine and vincristine) therapy is currently the first line therapy for (PCNSL) in our hospital. This study examines the results of R-MPV therapy comparing with past treatment. Method/Subjects: Thirty-seven patients treated at our hospital from 2009 to 2020 were included. Overall survival time, progression free survival time, and toxicities were evaluated. Results: The average age of patients was 65.7 years. Patients included 21 males and 16 females. Thirty-six patients were diagnosed DLBCL by resected brain tumor tissues, and one was diagnosed DLBCL by vitreous biopsy. As initial treatment, rituximab±HD-MTX therapy (R±MTX group) was performed in 20 cases, HD-MTX therapy plus radiation (R±MTX+RT group) was performed in 12 cases, and RMPV therapy was performed in 5 cases (R-MPV group). Median OS of all cases was 69 months and median PFS was 38 months. Median OS was 69 months in R±MTX group and could not be calculated in R±MTX+RT, and R-MPV groups. Median PFS was 16 months and 56 months in R±MTX group and R±MTX+RT, respectively, and could not be calculated in the R-MPV group. Although the R-MPV group had a short follow-up period, the results were considered to be comparable to those of the R±MTX+RT group. On the other hand, grade 3/4 adverse events occurred in 50%, 25%, and 100%, respectively. Conclusion: R-MPV therapy may delay the timing of radiation and reduce the amount of radiation. On the other hand, the frequency of adverse events is high, and more strict management of treatment is required.

scholarly journals Another Name for Liberty: Revelation, ‘Objectivity,’ and Intellectual Freedom in Barth and Marion

Open Theology ◽  
2019 ◽  
Vol 5 (1) ◽  
pp. 430-450
Author(s):  
Kristóf Oltvai
Keyword(s):  
A Priori ◽  
The Other ◽  
Christian Theology ◽  
Intellectual Freedom ◽  
Specific Kind ◽  
Absolute Truth ◽  
Saturated Phenomenon ◽  
Other Hand ◽  
The Difference ◽  
The Relationship

Abstract Karl Barth’s and Jean-Luc Marion’s theories of revelation, though prominent and popular, are often criticized by both theologians and philosophers for effacing the human subject’s epistemic integrity. I argue here that, in fact, both Barth and Marion appeal to revelation in an attempt to respond to a tendency within philosophy to coerce thought. Philosophy, when it claims to be able to access a universal, absolute truth within history, degenerates into ideology. By making conceptually possible some ‚evental’ phenomena that always evade a priori epistemic conditions, Barth’s and Marion’s theories of revelation relativize all philosophical knowledge, rendering any ideological claim to absolute truth impossible. The difference between their two theories, then, lies in how they understand the relationship between philosophy and theology. For Barth, philosophy’s attempts to make itself absolute is a produce of sinful human vanity; its corrective is thus an authentic revealed theology, which Barth articulates in Christian, dogmatic terms. Marion, on the other hand, equipped with Heidegger’s critique of ontotheology, highlights one specific kind of philosophizing—metaphysics—as generative of ideology. To counter metaphysics, Marion draws heavily on Barth’s account of revelation but secularizes it, reinterpreting the ‚event’ as the saturated phenomenon. Revelation’s unpredictability is thus preserved within Marion’s philosophy, but is no longer restricted to the appearing of God. Both understandings of revelation achieve the same epistemological result, however. Reality can never be rendered transparent to thought; within history, all truth is provisional. A concept of revelation drawn originally from Christian theology thus, counterintuitively, is what secures philosophy’s right to challenge and critique the pre-given, a hermeneutic freedom I suggest is the meaning of sola scriptura.

Markedness and Perspective in the Interpretation of the Active and Passive Voice

1974 ◽  
Vol 26 (2) ◽  
pp. 189-195 ◽  
Author(s):  
Irene Klenbort ◽  
Moshe Anisfeld
Keyword(s):  
Information Content ◽  
Focal Point ◽  
The Other ◽  
Clear Pattern ◽  
Passive Voice ◽  
Other Hand ◽  
Logical Subject ◽  
The Difference

The subjects were presented with active and passive sentences. For each sentence, they had to choose between two alternative implications. The pattern of choices indicates that in the passive the logical subject was interpreted by the subjects as the focal point of the information asserted by the sentence and as the carrier of overall responsibility for the sentential proposition. In contrast to the passive, there was no clear pattern of preferences for the active. The difference between the two voices was attributed to their markedness asymmetry, the passive being marked and the active unmarked. It is concluded that the active offers a neutral structure for conveying information; a structure available for use when one does not want to superimpose on the information content any stylistic or connotational implications. The passive, on the other hand, suggests special connotations in addition to the basic message.

Scenarios as Tools of the Scientific Imagination: The Case of Climate Projections

2021 ◽  
Vol 29 (1) ◽  
pp. 36-61
Author(s):  
Michael Poznic ◽  
Rafaela Hillerbrand
Keyword(s):  
Scientific Community ◽  
Climate Science ◽  
The Other ◽  
Climate Projections ◽  
Public Realm ◽  
The Public ◽  
Other Hand ◽  
The Difference ◽  
The One ◽  
Scientific Imagination

Climatologists have recently introduced a distinction between projections as scenario-based model results on the one hand and predictions on the other hand. The interpretation and usage of both terms is, however, not univocal. It is stated that the ambiguities of the interpretations may cause problems in the communication of climate science within the scientific community and to the public realm. This paper suggests an account of scenarios as props in games of make-belive. With this account, we explain the difference between projections that should be make-believed and other model results that should be believed.

Prevalence and Causal Factors of Playing-Related Musculoskeletal Disorders of the Upper Extremity and Trunk among Japanese Pianists and Piano Students

2006 ◽  
Vol 21 (3) ◽  
pp. 112-117
Author(s):  
Shinichi Furuya ◽  
Hidehiro Nakahara ◽  
Tomoko Aoki ◽  
Hiroshi Kinoshita
Keyword(s):  
Musculoskeletal Disorders ◽  
Age Groups ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Daily Practice ◽  
The Other ◽  
Causal Factors ◽  
Western Countries ◽  
Other Hand ◽  
The Difference

The purpose of this study was to investigate the prevalence of playing-related musculoskeletal disorders (PRMDs) among Japanese female classical pianists of different age groups. The causal factors for PRMDs also were examined. A group of 203 senior pianists, including piano teachers and students with piano majors at high schools and colleges, were surveyed using questionnaires. Results showed that 77% of these pianists suffered from PRMDs in at least one of their body portions. This value was larger than those reported in Western countries. Forty-four percent of these were serious enough to warrant medical treatment, which was a lower rate than reported in Western countries. The difference in these numbers may reflect the current state of understanding of PRMDs among Japanese pianists and their educators. The prevalence of PRMDs was found to be age-dependent. In the student groups, the finger/hand had the highest rate of PRMDs, followed by the forearm and shoulder. The senior group, on the other hand, had the highest PRMD incidence at the neck/trunk, followed by the forearm and hand/finger. Care may need to be exercised for these differences. The results also indicated that prolonged daily practice (>4 hours), playing chords forcefully, eagerness about practice, and nervous traits were found to contribute to the development of PRMDs in these pianists. Hand size was, on the other hand, not a significant risk factor of PRMDs.

Distinction between Dolus and Culpa with reference to Arson in Zakon Sudnyj LJudem, the Vinodol Law and the Statute of Senj

De Jure ◽  
2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Daniel Haman ◽  
◽  
◽  
Keyword(s):  
Criminal Law ◽  
The Other ◽  
Legal Documents ◽  
The Third ◽  
Other Hand ◽  
Criminal Offenses ◽  
The World ◽  
The Difference ◽  
Different Levels ◽  
Better Than

The difference between intent (dolus) and negligence (culpa) was rarely emphasized in codified medieval laws and regulations. When compared to the legal statements related to intent, negligence was mentioned even more rarely. However, there are some laws that distinguished between the two concepts in terms of some specific crimes, such as arson. This paper draws attention to three medieval Slavic legal documents – the Zakon Sudnyj LJudem (ZSLJ), the Vinodol Law and the Statute of Senj. They are compared with reference to regulations regarding arson, with the focus being on arson as a crime committed intentionally or out of negligence. The ZSLJ as the oldest known Slavic law in the world shows some similarities with other medieval Slavic legal codes, especially in the field of criminal law, since most of the ZSLJ’s articles are related to criminal law. On the other hand, the Vinodol Law is the oldest preserved Croatian law and it is among the oldest Slavic codes in the world. It was written in 1288 in the Croatian Glagolitic script and in the Croatian Chakavian dialect. The third document – the Statute of Senj – regulated legal matters in the Croatian littoral town of Senj. It was written in 1388 – exactly a century after the Vinodol Law was proclaimed. When comparing the Vinodol Law and the Statute of Senj with the Zakon Sudnyj LJudem, there are clear differences and similarities, particularly in the field of criminal law. Within the framework of criminal offenses, the act of arson is important for making a distinction between intent and negligence. While the ZSLJ regulates different levels of guilt, the Vinodol Law makes no difference between dolus and culpa. On the other hand, the Statute of Senj strictly refers to negligence as a punishable crime. Even though the ZSLJ is almost half a millennium older than the Statute of Senj and around 400 years older than the Vinodol Law, this paper proves that the ZSLJ defines the guilt and the punishment for arson much better than the other two laws.

Reading Identity, Reading Essence: A Strategic Essentialist Approach to Mulk Raj Anand’s Untouchable

2021 ◽  
Vol 2 (4) ◽  
pp. 91-101
Author(s):  
Saleha Ilhaam
Keyword(s):  
Present Article ◽  
Human Existence ◽  
The Other ◽  
Political Strategy ◽  
Other Hand ◽  
Strategic Essentialism ◽  
Reading Identity ◽  
The Difference ◽  
The Individual ◽  
Individual Self

The term strategic essentialism, coined by Spivak, is generally understood as “a political strategy whereby differences (within Group) are temporarily downplayed, and unity assumed for the sake of achieving political goals.” On the other hand, essentialism focuses that everything in this world has an intrinsic and immutable essence of its own. The adaption of a particular “nature” of one group of people by way of sexism, culturalization, and ethnification is strongly linked to the idea of essentialism. Mulk Raj Anand’s Bakha is dictated as an outcast by the institutionalized hierarchy of caste practice. He is essentialized as an untouchable by attributing to him the characteristic of dirt and filth. However, unlike other untouchables, Bakha can apprehend the difference between the cultured and uncultured, dirt and cleanliness. Via an analysis of Anand’s “Untouchable,” the present article aims to bring to the forefront the horrid destruction of the individual self that stems from misrepresentations of personality. Through strategic essentialism, it unravels Bakha’s contrasting nature as opposed to his pariah class, defied by his remarkable inner character and etiquette. The term condemns the essentialist categories of human existence. It has been applied to decontextualize and deconstruct the inaccurately essentialized identity of Bakha, which has made him a part of the group he does not actually belong to.

scholarly journals PENGETAHUAN PERPAJAKAN, SOSIALISASI PERPAJAKAN, DAN PELAYANAN FISKUS TERHADAP KEPATUHAN WAJIB PAJAK

2017 ◽  
Vol 9 (2) ◽  
pp. 55-65
Author(s):  
Meiska Lianty ◽  
Dini Wahjoe Hapsari ◽  
Kurnia K
Keyword(s):  
Linear Regression ◽  
Multiple Linear Regression ◽  
Sampling Technique ◽  
The Other ◽  
Analysis Method ◽  
Other Hand ◽  
Whole Number ◽  
Convenience Sampling ◽  
Positive Effect

This study aims to discover how the effect of the tax knowledge, tax socialization, and tax authorities service, either simultaneously or partially, on the taxpayers compliance in KPP Pratama Bandung Bojonagara. The research samples are the whole number of the non-employee individual taxpayers in the amount of 100 people. The sampling technique is convenience sampling and the analysis method is using multiple linear regression. Simultaneously, the tax knowledge, the tax socialization, and the tax authorities service significantly affect the taxpayers compliance in KPP Pratama Bandung Bojonagara. Partially, the result shows that both the tax knowledge and the tax authorities service significantly have positive effect and are directly proportional on the taxpayers compliance. On the other hand, the tax socialization has no significant effect on the taxpayers compliance in KPP Pratama Bandung Bojonagara.

scholarly journals HYDRODYNAMIC AND BOUSSINESQ WAVE MODELING FOR THE N219 AMPHIBIOUS AIRCRAFT SEAPLANE DOCK DEVELOPMENT PLAN IN PANJANG ISLAND

2021 ◽  
Vol 15 (2) ◽  
Author(s):  
Hanah Khoirunnisa ◽  
Mardi Wibowo ◽  
Wahyu Hendriyono ◽  
Khusnul Setia Wardani
Keyword(s):  
Flight Test ◽  
The Other ◽  
Waveform Modeling ◽  
Significant Wave ◽  
Other Hand ◽  
Wave Heights ◽  
Significant Wave Heights ◽  
Wave Conditions ◽  
The Difference ◽  
Mike 21

The flight test of N219 Amphibious aircraft will be targeted in 2003/2024. For flight tests, these aircraft need a seaplane dock. One of the potential locations for the seaplane dock is Panjang Island at Seribu Islands. This study aims to know the characteristic of hydrodynamic and wave conditions and to determine whether Panjang Island is suitable for the seaplane dock. This study uses a modeling method with MIKE 21 FM HD-SW module and MIKE 21 Boussinesq Wave (BW)  module. The bathymetry data were obtained from the Indonesian Navy Hydrographic and Oceanographic Center (Pushidrosal), tide data is generated from Tide Model Driver (TMD), wave and wind data from ECMWF. The result of surface elevation validation between hydrodynamic modeling and TMD is 92%. During the west monsoon and spring conditions, the difference in the largest and lowest current velocity is quite large (0.018-0.199 m/s), on the other hand, when the tides are in neap conditions (0.008-0.144 m/s). Meanwhile, during the east monsoon and spring conditions, the difference in the largest and lowest current velocities is quite large (0.02-0.193 m/s), on the other hand, when the tides are in neap conditions (0.008-0.146 m/s). The maximum wave height resulting from the 50-year return period waveform modeling between 1.139 - 1.474 m. Meanwhile, the significant wave heights between 0.679 - 0.741 with a significant wave period of 13.45 seconds. In general, the current and wave conditions of the two locations are suitable for the construction of the seaplane dock, except that the dominant wave heights are still above the requirements.

scholarly journals Euripidés Médeiájának magyar fordításairól

2017 ◽  
Vol 56 (1-4) ◽  
Author(s):  
Anikó Polgár
Keyword(s):  
20Th Century ◽  
The Other ◽  
Professional Background ◽  
The Third ◽  
Other Hand ◽  
Final Goal ◽  
The Difference ◽  
Textual Strategies

This study is dealing with two Hungarian translations of Euripides’ Medea. The translation made by Grácia Kerényi was produced in the second half of the 20th century, whereas the version by Zsuzsa Rakovszky was published at the beginning of the 21st. The difference between the translations regarding their textual strategies, the professional background of the translators and the final goal of the works is abysmal. Grácia Kerényi was an expert of ancient literatures, her translation was published in the official and renowned collection of Euripides’ work, Zsuzsa Rakovszky on the other hand translates predominantly from English, and her version was inspired by the request of the theatre. The study contains three parts: in the first the author analyses Kerényi’s Medea in the context of the philological reconstruction, in the second, the author examines the same text modified and revised by Fruzsina Magyar, who was the dramatic advisor of the theatre performance in Szolnok, and the third part reflects on the problems of validity, poetical force and immediacy in the translation of Zsuzsa Rakovszky.

Sign in / Sign up

Export Citation Format

Share Document