Evaluation of Threaded External Skeletal Fixation Pin Insertion with and without Predrilling in Avian Bone

2019 ◽  
Vol 33 (01) ◽  
pp. 028-035
Author(s):  
Griselda Lam ◽  
Jacqueline Tai Li Nelson ◽  
Feng Wei ◽  
Sun-Young Kim
Keyword(s):  
Heat Generation ◽  
Structural Damage ◽  
Ex Vivo ◽  
Pullout Strength ◽  
Analog Scale ◽  
Significant Difference ◽  
Baseline Temperature ◽  
Vas Scores ◽  
Insertion Sites ◽  
Ex Vivo Study

Abstract Objective The aim of this study was to document the effects of positive-profile threaded external skeletal fixation (ESF) pin insertion without predrilling on heat generation, structural damage and pullout strength in avian bone than that with predrilling. Study design This study was an ex vivo study. Materials and Methods Twenty paired tibiotarsi and 40 paired humeri from 20 Mallard duck cadavers were used. Specimens were randomized to have positive-profile threaded ESF pins placed with or without predrilling insertion sites. Heat generation (maximum—baseline temperature) was measured during drilling and pin insertion with infrared thermography. Structural damage (gross trans-cortical damage and thread quality) was evaluated and scored using a visual analog scale (VAS). Mechanical testing was performed to evaluate pullout strength of inserted pins. Results VAS scores for trans-cortical surfaces were significantly higher than for cis-cortical surfaces; however, no difference was noted between predrilled and non-predrilled specimens. No significant difference in heat generation or pullout strength was noted between pins placed with and without predrilling. Conclusion Pin insertion without predrilling in avian humeri and tibiotarsi does not cause significantly more structural damage or heat generation, or reduced pullout strength, compared with predrilling. Overall, our results indicate that predrilling prior to ESF pin placement provides no obvious advantage in avian bone.

Aerosol generation through pars plana vitrectomy

2020 ◽  
pp. bjophthalmol-2020-317214
Author(s):  
Hasan Naveed ◽  
Fong May Chew ◽  
Hanbin Lee ◽  
Edward Hughes ◽  
Mayank A Nanavaty
Keyword(s):  
Pars Plana Vitrectomy ◽  
Ex Vivo ◽  
Dynamic Changes ◽  
Aerosol Generation ◽  
Significant Difference ◽  
Optical Particle Counter ◽  
Pars Plana ◽  
23 Gauge ◽  
Set Up ◽  
Ex Vivo Study

PurposeTo assess whether pars plana vitrectomy (PPV) is an aerosol-generating procedure (AGP) in an ex vivo experimental model.MethodsIn this ex vivo study on 10 porcine eyes, optical particle counter was used to measure particles ≤10 μm using cumulative mode in the six in-built channels: 0.3 μm, 0.5 μm, 1 μm, 2.5 μm, 5 μm and 10 μm aerosols during PPV. Two parts of the study were as follows: (1) to assess the pre-experimental baseline aerosol count in the theatre environment where there are dynamic changes in temperature and humidity and (2) to measure aerosol generation with 23-gauge and 25-gauge set-up. For each porcine eye, five measurements were taken for each consecutive step in the experiment including pre-PPV, during PPV, fluid–air exchange (FAX) and venting using a flute with 23-gauge set-up and a chimney with 25-gauge set-up. Therefore, a total of 200 measurements were recorded.ResultsWith 23-gauge and 25-gauge PPV, there was no significant difference in aerosol generation in all six channels comparing pre-PPV versus PPV or pre-PPV versus FAX. Venting using flute with 23-gauge PPV showed significant reduction of aerosol ≤1 μm. Air venting using chimney with 25-gauge set-up showed no significant difference in aerosol of ≤1 μm. For cumulative aerosol counts of all particles measuring ≤5 μm, compared with pre-PPV, PPV or FAX, flute venting in 23-gauge set-up showed significant reduction unlike the same comparison for chimney venting in 25-gauge set-up.ConclusionPPV and its associate steps do not generate aerosols ≤10 μm with 23-gauge and 25-gauge set-ups.

scholarly journals Ex vivo and in vivo study of Kowa HA-2 applanation tonometer in the measurement of intraocular pressure in cats

2017 ◽  
Vol 38 (6) ◽  
pp. 3647
Author(s):  
Claudia Lizandra Ricci ◽  
Rogério Giuffrida ◽  
Glaucia Prada Kanashiro ◽  
Hilidia Stephania Rufino Belezzi ◽  
Carolina De Carvalho Bacarin ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Ex Vivo ◽  
Clinical Signs ◽  
In Vivo Study ◽  
Eye Drops ◽  
Significant Difference ◽  
Applanation Tonometer ◽  
Ex Vivo Study ◽  
Healthy Eyes

The objective of this study was to evaluate the use of the Kowa HA-2 applanation tonometer in measuring intraocular pressure (IOP) in cats. Ten healthy eyes were used in an ex vivo study in which the calibration curve for manometry vs. tonometry was determined by artificially raising the IOP in 5 mmHg increments up to 60 mmHg (10-60 mmHg). Both eyes of 10 anesthetized cats were studiedin vivo to compare manometry vs. tonometry. In the ambulatory study, 78 healthy eyes, 7 eyes with glaucoma and 20 eyes with uveitis were evaluated by tonometry, which was performed with topical anesthesia and 1% fluorescein eye drops for the formation of fluorescein semicircles. The correlation coefficient (r²) between the manometer and the Kowa HA-2 tonometer was 0.993 and the linear regression equation was y = 0.0915x + 0.0878 in the ex-vivo study. In the in vivo study, the IOP values (mean±SD, in mmHg) in manometry were 15.6 ± 1.1(14.0 – 17.5) and in tonometry were 15.5 ± 1.2(13.5 – 17.2), with no significant difference (P > 0.05) between manometry and tonometry. In ambulatory study, using the Kowa HA-2 tonometer, the IOP values (mean±SD, in mmHg) were 15.0 ± 1.5 (11.8 – 18.3) for the healthy eyes, 38.4 ± 8.1(29.6 – 53.7) for glaucomatous eyes and 10.4 ± 2.0(5.3 – 12.2) for eyes with uveitis. There was a strong correlation and accuracy between the IOP values with the manometry and the Kowa HA-2 tonometer. In the ambulatorystudy the IOP values obtained with the tonometer were compatible for animals with healthy eyes and with clinical signs of glaucoma and uveitis. We conclude that the Kowa HA-2 tonometer can be used in the measurement of IOP in cats, since it is a practical and accurate method in this species.

scholarly journals Comparative Observational Study on the Effects of Intra-articular Hominis Placenta Pharmacopuncture and Acupoint Hominis Placenta Pharmacopuncture for Knee Osteoarthritis Patients

2021 ◽  
Vol 38 (1) ◽  
pp. 60-65
Author(s):  
Yeo-bin Park ◽  
Chang Beohm Ahn ◽  
Yun-Leong Park ◽  
Ji-Won Baek ◽  
Won-Ho Kong ◽  
...  
Keyword(s):  
Knee Osteoarthritis ◽  
Medical Records ◽  
Joint Space ◽  
Osteoarthritis Of The Knee ◽  
Analog Scale ◽  
Degenerative Osteoarthritis ◽  
Significant Difference ◽  
Group A ◽  
Vas Scores ◽  
Group B

The aim of this case report was to observe the effects of intra-articular hominis placenta pharmacopuncture (HPP). Based on the medical records patients who received intra-articular treatment or received acupoint pharmacopuncture treatment, a comparison was made. There were 35 patients who were hospitalized for degenerative osteoarthritis of the knee joint from the 1<sup>st</sup> October 2019 to 26<sup>th</sup> September 2020. There were 14 patients who were treated with HPP in the intra-articular joint space (Group A), and 14 patients who were treated with HPP at specific acupoints (Group B). The outcome effects were measured using the Korean Western Ontario and Mc (KWOMAC) the visual analog scale (VAS) before the first treatment, and after the fifth treatment. The KWOMAC (<i>p</i> < 0.001) and the VAS scores (<i>p</i> < 0.001) in Groups A and B significantly improved after treatment compared with before treatment. When comparing Group A improvement with Group B improvement using the KWOMAC there was no statistically significant difference however, when using the VAS scores, Group A treatment was statistically more effective compared with Group B (<i>p</i> = 0.002). This study indicated that HPP may be an effective treatment for knee osteoarthritis. Moreover, intra-articular HPP may be more effective than acupoint HPP for knee osteoarthritis.

Comparison of Chitosan-Based Liquid Scaffold and Hyaluronic Acid–Based Soft Scaffold for Treatment of Talus Osteochondral Lesions

2020 ◽  
Vol 41 (10) ◽  
pp. 1240-1248
Author(s):  
Ramazan Akmeşe ◽  
Mehmet Batu Ertan ◽  
Hakan Kocaoğlu
Keyword(s):  
Magnetic Resonance ◽  
Osteochondral Lesions ◽  
Resonance Imaging ◽  
Analog Scale ◽  
Level Of Evidence ◽  
Time Period ◽  
Significant Difference ◽  
Vas Scores ◽  
American Orthopaedic ◽  
Retrospective Comparative Study

Background: The aim of this study was to evaluate the clinical and radiologic results of 2 different scaffolds with hyaluronan or chitosan-based structure used in the treatment of talus osteochondral lesions. Methods: Eighty-one patients who underwent chondral lesion repair with hyaluronan (n = 42) or chitosan-based (n = 39) scaffold were included. American Orthopaedic Foot & Ankle Society (AOFAS) and visual analog scale (VAS) scores were evaluated within and between groups preoperatively and at the 3rd, 12th, and 24th month postoperatively. In all patients, magnetic resonance imaging was performed between the 12 and 18th month postoperatively and compared with magnetic resonance observation of cartilage repair tissue (MOCART) scoring. Results: Within-group evaluations revealed significant improvements in AOFAS and VAS scores at postoperative 3 and 12 months. The postoperative 24th-month results of AOFAS scores in any group did not differ significantly from the 12th-month results. There was no significant difference between the groups in comparison of AOFAS, VAS, and MOCART scores at any time period. Conclusion: Both scaffolds were found to be effective in cartilage healing but had no clinical or radiologic superiority to each other. This is the first study to compare the use of different cell-free scaffold types in osteochondral defects of the talus. Level of Evidence: Level III, retrospective comparative study.

The Influence of Implant Shape on Primary Stability of Implants With a Thread Cutting and Forming Design: An Ex Vivo Study

2019 ◽  
Vol 45 (3) ◽  
pp. 181-185 ◽  
Author(s):  
Cagatay Dayan ◽  
Onur Geckili ◽  
Canan Bural
Keyword(s):  
Ex Vivo ◽  
Primary Stability ◽  
Type I ◽  
Resonance Frequency Analysis ◽  
Implant Stability ◽  
Thread Cutting ◽  
Type Iii ◽  
Experienced Clinician ◽  
Significant Difference ◽  
Ex Vivo Study

The design of an implant has a great effect on primary stability. The purpose of this study was to determine the differences in primary stability between straight and tapered Neoss ProActive implants in type I and type III bones using resonance frequency analysis (RFA) and electronic percussive testing (EPT) methods. Fresh cow vertebrae and pelvis were used as models of type III and type i bone, respectively. Implants of 2 different designs—straight and tapered Neoss ProActive implants with a thread cutting and forming (TCF) design, both 3.5-mm wide and 11-mm long—were placed in both types of bone (n = 60). The primary stability of all implants was measured by an experienced clinician blinded to the study protocol using the EPT and RFA devices. No statistically significant difference was found between the implant stability quotients and the percussive test values of straight and tapered implants in either bone type. Within the limitations of this ex vivo study, it may be concluded that the shape of an implant with a TCF design does not affect primary stability.

scholarly journals Single-Needle Arthrocentesis with Upper Compartment Distension versus Conventional Two-Needle Arthrocentesis: Randomized Clinical Trial

2017 ◽  
Vol 2017 ◽  
pp. 1-5 ◽  
Author(s):  
Eduardo Grossmann ◽  
Primo Guilherme Vargas Pasqual ◽  
Rodrigo Lorenzi Poluha ◽  
Lilian Cristina Vessoni Iwaki ◽  
Liogi Iwaki Filho ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Disc Displacement ◽  
Articular Disc ◽  
Analog Scale ◽  
Significant Difference ◽  
Interincisal Distance ◽  
Vas Scores ◽  
Tmj Pain ◽  
One Year

The objective of this study was to compare single-needle arthrocentesis with distension of the upper compartment of the temporomandibular joint (TMJ) with the conventional two-needle arthrocentesis. Twenty-six patients with articular disc displacement without reduction (DDWOR) were included in the study and assigned to two groups (n=13): single-needle arthrocentesis with distension of the upper compartment of the TMJ (1N) and conventional two-needle arthrocentesis (2N). The maximum interincisal distance (MID) and TMJ pain as measured by the visual analog scale (VAS) were compared. MID and VAS data were obtained: before (T1), seven days after (T2), fifteen days after (T3), one month after (T4), three months after (T5), six months after (T6), nine months after (T7), and one year after the arthrocentesis procedures (T8). Considering each group individually, results of the VAS scores and MID measurements showed a significant difference between T1 and T2–T8 (p<0.001) in both groups. Between two groups, results show no significant differences (p>0.05). Both techniques tested were effective in reducing pain and increasing MID. Due to the advantages over the conventional two-needle arthrocentesis, single-needle arthrocentesis with distension of the upper compartment should be considered as the first treatment option for patients with painful hypomobilized TMJ of DDWOR.

scholarly journals Comparison of the amount of apically extruded debris produced by four retreatment techniques: an ex vivo study

2017 ◽  
Vol 74 (4) ◽  
pp. 309
Author(s):  
Cristiane Ferreira Alfenas ◽  
Inês de Fátima De Azevedo Jacinto Inojosa ◽  
Júlio César De Azevedo Carvalhal ◽  
Mariana Teixeira Maneschy Faria ◽  
Fernanda Freitas Lins ◽  
...  
Keyword(s):  
Root Canal ◽  
Ex Vivo ◽  
Nickel Titanium ◽  
Filling Material ◽  
Root Canal Filling ◽  
Apical Extrusion ◽  
Significant Difference ◽  
The Mean ◽  
Ex Vivo Study ◽  
One Way Anova

Objective: the aim of this study was to compare the amount of apically extruded debris during the removal of root canal filling material using nickel-titanium rotary retreatment instruments and Hedström files. Material and Methods: sixty mandibular incisors with a single canal were instrumented and obturated by cold lateral compaction. For retreatment, specimens were randomly divided into four groups (n = 15): Hedström files with or without solvent; D-RaCe system and Mtwo retreatment system. Debris extruded apically during the removal of canal filling material was collected into preweighed Eppendorf tubes. The tubes were then stored in an incubator at 70°C for 5 days. The weight of the dry extruded debris was established by subtracting the preretreatment and postretreatment weight of the Eppendorf tubes for each group. The mean weights of extruded material were analyzed by one-way ANOVA. Results: the results showed that all retreatment techniques caused apical extrusion of debris, but no statistically significant difference was observed between groups (p>0.05). Conclusion: under the conditions of this study, all retreatment techniques caused apical debris extrusion.

scholarly journals Augmented Reality Guided Osteotomy in Hallux Valgus Correction

2020 ◽  
Author(s):  
Arnd Viehöfer ◽  
Stephan Hermann Wirth ◽  
Stefan Michael Zimmermann ◽  
Laurenz Jaberg ◽  
Cyrill Dennler ◽  
...  
Keyword(s):  
Augmented Reality ◽  
Hallux Valgus ◽  
Ex Vivo ◽  
First Metatarsal ◽  
Second Metatarsal ◽  
Significant Difference ◽  
Improve Accuracy ◽  
Foot Model ◽  
Inexperienced Surgeon ◽  
Ex Vivo Study

Abstract Background An optimal osteotomy angle avoids shortening of the first metatarsal bone after hallux valgus surgery and therefore reduces the risk of transfer-metatarsalgia. The purpose of the present ex-vivo study was to investigate whether augmented reality (AR) would improve accuracy of the distal osteotomy during hallux valgus surgery. Methods Distal osteotomies of the first metatarsals were performed on a foot model by two surgeons with different levels of surgical experience each with (AR, n=15x2) or without (controls, n=15x2) overlay of a hologram depicting an angle of osteotomy perpendicular to the second metatarsal. Subsequently, the deviation of the osteotomy angle in the transverse plane was analyzed. Results Overall, the AR decreased the range of impression and the AR guided osteotomies were more accurate (4.9 ± 4.2°) compared to the freehand cuts (6.7± 6.1°) by tendency (p=0.2). However, while the inexperienced surgeon performed more accurate osteotomies with AR with a mean angle of 6.4± 3.5° compared to freehand 10.5 ± 5.5° (p=0.02), no significant difference was noticed for the experienced surgeon with an osteotomy angle of around 3° in both cases. Conclusion This pilot-study suggests that AR guided osteotomies can potentially improve accuracy during hallux valgus correction, particularly for less experienced surgeons.

scholarly journals Influence of Prior Exposure to Zidovudine on Stavudine Phosphorylation In Vivo and Ex Vivo

2001 ◽  
Vol 45 (2) ◽  
pp. 577-582 ◽  
Author(s):  
P. G. Hoggard ◽  
S. D. Sales ◽  
D. Phiboonbanakit ◽  
J. Lloyd ◽  
B. A. Maher ◽  
...  
Keyword(s):  
High Performance ◽  
Mononuclear Cells ◽  
Ex Vivo ◽  
Hiv Positive ◽  
Peripheral Blood Mononuclear ◽  
Significant Difference ◽  
Immunodeficiency Virus ◽  
Ex Vivo Study ◽  
Level 2

ABSTRACT Intracellular phosphorylation of stavudine (d4T) and zidovudine (ZDV) was investigated in peripheral blood mononuclear cells (PBMCs) isolated from ZDV-naive and ZDV-experienced human immunodeficiency virus (HIV)-positive patients. An in vivo study measured the amount of d4T triphosphate (d4TTP), while an ex vivo study assessed the capacity of cells to phosphorylate added d4T. Endogenous dTTP was also measured. d4TTP and dTTP were determined in vivo using a reverse transcriptase chain termination assay. In ex vivo studies, d4T (1 μM) was incubated in resting and phytohemagglutinin-stimulated (10 μg ml−1; 72 h) PBMCs for 24 h. After washing and methanol extraction, radiolabeled anabolites were detected by high-performance liquid chromatography. d4TTP reached its highest level 2 to 4 h after dosing (0.21 ± 0.14 pmol/106cells; n = 27 [mean ± standard deviation]). Comparison of ZDV-naive and ZDV-experienced individuals showed no significant difference in levels of d4TTP (ZDV naive, 0.23 ± 0.17 pmol/106 cells [n = 7] versus ZDV experienced, 0.20 ± 0.14 pmol/106 cells [n = 20]; P = 0.473) or the d4TTP/dTTP ratio (0.14 ± 0.12 [n = 7] and 0.10 ± 0.08 [n = 20], respectively;p = 0.391). Ex vivo data demonstrated no significant difference in the formation of d4TTP or total d4T phosphates in naive and experienced patients (0.086 ± 0.055 pmol/106cells in ZDV-naive patients [n = 17] versus 0.081 ± 0.038 pmol/106 cells in ZDV-experienced patients [n = 22]; P = 0.767). The ability of HIV-infected patients to phosphorylate d4T in vivo and ex vivo was unchanged with increasing exposure to ZDV.

Severity of Rhinosinusitis: Comparison Between Visual Analog Scale Given by Patients and Otorhinolaryngologists

2020 ◽  
Vol 34 (6) ◽  
pp. 734-741 ◽  
Author(s):  
Li Zhao ◽  
Ke Na Yu ◽  
Jian Li Tan ◽  
Hai Ling Zhang ◽  
Peng Jin ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Visual Analog Scale ◽  
Revision Surgery ◽  
Nasal Polyps ◽  
Staging System ◽  
Position Paper ◽  
Moderate Correlation ◽  
Analog Scale ◽  
Significant Difference ◽  
Vas Scores

Background Visual Analog Scale (VAS) as determined by the patient is recommended by the European Position Paper on Rhinosinusitis and Nasal Polyps 2012 in evaluation of the total severity of the chronic rhinosinusitis (CRS) patients’ symptoms. Objective To evaluate the correlation between evaluations performed by otorhinolaryngologists and CRS patients with commonly used systems. Methods Scores of VAS and Sino-Nasal Outcome Test-20 (SNOT-20) Chinese version were obtained from 110 CRS patients with nasal polyps (CRSwNPs, n = 61) and without nasal polyps (CRSsNPs, n = 49) before surgery, which were compared with scores of Lund–Kennedy endoscopic staging system, the Lund–Mackay computed tomography (CT) staging system, and VAS from 3 attending otorhinolaryngologists. Results The median VAS scores given by CRS patients (6.0; 4.25–7.5) do not correlate significantly with the VAS scores by the 3 otorhinolaryngologists (5.5; 4.83–6.5) with a correlation coefficient of .218 (−0.146 to 0.466). For CRS patients, there was only a moderate correlation between scores of VAS and the SNOT-20 ( r = .37), and no significant difference of VAS scores between CRSwNP and CRSsNP, and between unilateral and bilateral nasal polys. For otorhinolaryngologists, a higher median VAS score was found in CRSwNP (6.0; 5.17–7.0), especially in bilateral (6.0; 5.0–7.08) and revision surgery (6.08; 5.33–7.63). The VAS scores of otorhinolaryngologists correlated significantly with the Lund–Mackay CT score ( r = .7536) and Lund–Kennedy endoscopic staging ( r = .5947). Conclusions VAS scores between patients and physicians are not correlated significantly in this study, but they fall within the same therapeutic range and do not change the clinical management of the patients.

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