scholarly journals Cachexia in Cancer Patients: Systematic Literature Review

2020 ◽  
Vol 06 (03) ◽  
pp. 107-115
Author(s):  
Timotius I. Hariyanto ◽  
Andree Kurniawan
Keyword(s):  
Body Composition ◽  
Body Weight ◽  
Cancer Patients ◽  
Comprehensive Evaluation ◽  
Current Evidence ◽  
Dietary Modification ◽  
Neoplastic Disease ◽  
International Consensus ◽  
Before And After ◽  
Negative Impacts

Abstract Introduction Cachexia in cancer patients, especially in advanced stage, is recently known as an emerging problem. Cachexia occurs in about half of all patients with neoplastic disease. The diagnosis of cachexia needs comprehensive evaluation of body weight and body composition for several months. Cachexia will give negative impacts such as increased mortality, chemotoxicity, and decreased quality of life. Here, we review the current evidence describing the definition, stages, mechanisms, diagnosis and treatment of cachexia in cancer patients. Methods We identified 75 studies and/or review articles evaluating cachexia and weight loss in cancer patients by searching PubMed and EMBASE databases. Results Cachexia is reported across all stages and types of cancers. The most recent definition of cachexia is reported in a 2011 paper by International Consensus. The mechanism of cachexia in cancer is complex and involved many factors which elaborate together to produce cachexia. The diagnostic evaluation and cut-off measurement of cachexia, especially in cancer varied across studies. The loss of weight that happens during chemotherapy will make a poor prognosis. Cachexia can worsen chemotherapy toxicity. Combination of dietary modification and exercise with supplementation of medication that control appetite and inflammation are important in the management of cachexia in cancer patients. Conclusion Patients with cancer are the population at risk for developing cachexia before and after chemotherapy. Cachexia diagnosis needs evaluation of body weight and body composition. Nonpharmacological treatments, such as dietary modification and physical exercise, are the best strategy to reduce cachexia in cancer patients.

scholarly journals Sarcopenia in Cancer Patients

2019 ◽  
Vol 13 (3) ◽  
pp. 96 ◽  
Author(s):  
Andree Kurniawan
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Cancer Patients ◽  
Muscle Mass ◽  
Current Evidence ◽  
Clinical Settings ◽  
Before And After ◽  
Impact Risk ◽  
Negative Impacts ◽  
And Function

Introduction: Sarcopenia in cancer patients, especially in advanced stage, recently known as an emerging problem. Firstly, sarcopenia is found in elderly patients. The diagnosis of sarcopenia needs evaluation of muscle composition and function and physical activity. Sarcopenia will give negative impacts such as increased mortality, chemo-toxicity, and decreased quality of life. Here, we review the current evidence describing the definition, impact, risk factors, mechanisms, diagnosis and treatment of sarcopenia in cancer patients.Method: We identified 48 studies and/or review articles evaluating sarcopenia in cancer patients by searching PubMed and EMBASE databases. Results: Sarcopenia is reported across all stages and types of cancers. There is a new definition of sarcopenia that is reported in 2019 paper. The risk factors or causes of sarcopenia in cancer are complex depending on the clinical settings of each patient. SARC-F questionnaire can be used to screen cancer patients in clinical settings. The diagnostic evaluation and cut-off measurement of sarcopenia especially in cancer varied across studies. The loss of muscle mass that happens during chemotherapy will make a poor prognosis. Sarcopenia can worsen chemotherapy toxicity. Combination exercise with adequate dietary supplementation, adequate energy, and protein are important in the management of sarcopenia in cancer patients.Conclusions: Patients with cancer belong to a population at risk of developing sarcopenia before and after chemotherapy. Sarcopenia diagnosis needs the evaluation of muscle mass and muscle strength or physical performance. Physical activity exercise is the best strategy to reduce sarcopenia in cancer patients.

scholarly journals Influence of ADRB2 Gln27Glu and ADRB3 Trp64Arg polymorphisms on body weight and body composition changes after a controlled weight-loss intervention

2016 ◽  
Vol 41 (3) ◽  
pp. 307-314 ◽  
Author(s):  
Barbara Szendrei ◽  
Domingo González-Lamuño ◽  
Teresa Amigo ◽  
Guan Wang ◽  
Yannis Pitsiladis ◽  
...  
Keyword(s):  
Weight Loss ◽  
Body Composition ◽  
Body Weight ◽  
Fat Mass ◽  
Current Evidence ◽  
Fat Percentage ◽  
Endurance Strength ◽  
Diet And Exercise ◽  
Before And After ◽  
Physical Activity Recommendations

The β-2 and β-3 adrenergic receptors (ADRB2 and ADRB3) are thought to play a role in energy expenditure and lipolysis. However, the effects of the ADRB2 glutamine (Gln) 27 glutamic acid (glutamate) (Glu) and ADRB3 tryptophan (Trp) 64 arginine (Arg) polymorphisms on weight loss remain controversial. The aim of this study was to investigate the effect of these polymorphisms on changes in weight and body composition during a controlled weight-loss program. One hundred seventy-three healthy overweight and obese participants (91 women, 82 men) aged 18–50 years participated in a 22-week-long intervention based on a hypocaloric diet and exercise. They were randomly assigned to 1 of 4 groups: strength, endurance, strength and endurance combined, and physical activity recommendations only. Body weight, body mass index (BMI), and body composition variables were assessed before and after the intervention. Genetic analysis was carried out according to standard protocols. No effect of the ADRB2 gene was shown on final weight, BMI, or body composition, although in the supervised male group, Glu27 carriers tended to have greater weight (p = 0.019, 2.5 kg) and BMI (p = 0.019, 0.88 kg/m2) reductions than did noncarriers. There seems to be an individual effect of the ADRB3 polymorphism on fat mass (p = 0.004) and fat percentage (p = 0.036), in addition to an interaction with exercise for fat mass (p = 0.038). After the intervention, carriers of the Arg64 allele had a greater fat mass and fat percentage than did noncarriers (p = 0.004, 2.8 kg). In conclusion, the ADRB2 Gln27Glu and ADRB3 Trp64Arg polymorphisms may influence weight loss and body composition, although the current evidence is weak; however, further studies are necessary to clarify their roles.

The Effects of Tribulus Terrestris on Body Composition and Exercise Performance in Resistance-Trained Males

2000 ◽  
Vol 10 (2) ◽  
pp. 208-215 ◽  
Author(s):  
Jose Antonio ◽  
John Uelmen ◽  
Ramsey Rodriguez ◽  
Conrad Earnest
Keyword(s):  
Body Composition ◽  
Body Weight ◽  
Dietary Intake ◽  
Exercise Performance ◽  
Bench Press ◽  
Mood States ◽  
Tribulus Terrestris ◽  
Weight Percentage ◽  
Leg Press ◽  
Before And After

The purpose of this study was to determine the effects of the herbal preparation Tribulus terrestris (tribulus) on body composition and exercise performance in resistance-trained males. Fifteen subjects were randomly assigned to a placebo or tribulus (3.21 mg per kg body weight daily) group. Body weight, body composition, maximal strength, dietary intake, and mood states were determined before and after an 8-week exercise (periodized resistance training) and supplementation period. There were no changes in body weight, percentage fat, total body water, dietary intake, or mood states in either group. Muscle endurance (determined by the maximal number of repetitions at 100—200% of body weight) increased for the bench and leg press exercises in the placebo group (p < .05; bench press ±28.4%. leg press ±28.6%), while the tribulus group experienced an increase in leg press strength only (bench press ±3.1 %, not significant; leg press ±28.6%, p < .05). Supplementation with tribulus does not enhance body composition or exercise performance in resistance-trained males.

Effect of Two Different Weight-Loss Rates on Body Composition and Strength and Power-Related Performance in Elite Athletes

2011 ◽  
Vol 21 (2) ◽  
pp. 97-104 ◽  
Author(s):  
Ina Garthe ◽  
Truls Raastad ◽  
Per Egil Refsnes ◽  
Anu Koivisto ◽  
Jorunn Sundgot-Borgen
Keyword(s):  
Weight Loss ◽  
Body Composition ◽  
Body Weight ◽  
Elite Athletes ◽  
Countermovement Jump ◽  
Repetition Maximum ◽  
Before And After ◽  
The Mean ◽  
And Performance ◽  
Better Than

When weight loss (WL) is necessary, athletes are advised to accomplish it gradually, at a rate of 0.5–1 kg/wk. However, it is possible that losing 0.5 kg/wk is better than 1 kg/wk in terms of preserving lean body mass (LBM) and performance. The aim of this study was to compare changes in body composition, strength, and power during a weekly body-weight (BW) loss of 0.7% slow reduction (SR) vs. 1.4% fast reduction (FR). We hypothesized that the faster WL regimen would result in more detrimental effects on both LBM and strength-related performance. Twenty-four athletes were randomized to SR (n = 13, 24 ± 3 yr, 71.9 ± 12.7 kg) or FR (n = 11, 22 ± 5 yr, 74.8 ± 11.7 kg). They followed energy-restricted diets promoting the predetermined weekly WL. All athletes included 4 resistance-training sessions/wk in their usual training regimen. The mean times spent in intervention for SR and FR were 8.5 ± 2.2 and 5.3 ± 0.9 wk, respectively (p < .001). BW, body composition (DEXA), 1-repetition-maximum (1RM) tests, 40-m sprint, and countermovement jump were measured before and after intervention. Energy intake was reduced by 19% ± 2% and 30% ± 4% in SR and FR, respectively (p = .003). BW and fat mass decreased in both SR and FR by 5.6% ± 0.8% and 5.5% ± 0.7% (0.7% ± 0.8% vs. 1.0% ± 0.4%/wk) and 31% ± 3% and 21 ± 4%, respectively. LBM increased in SR by 2.1% ± 0.4% (p < .001), whereas it was unchanged in FR (–0.2% ± 0.7%), with significant differences between groups (p < .01). In conclusion, data from this study suggest that athletes who want to gain LBM and increase 1RM strength during a WL period combined with strength training should aim for a weekly BW loss of 0.7%.

Assessment of body composition measure of bioelectrical impedance in patients operated for pancreatic, gastric and colorectal cancer

2020 ◽  
Vol 92 (1) ◽  
pp. 1-5
Author(s):  
Przemysław Dzierżek ◽  
Krzysztof Kurnol ◽  
Wojciech Hap ◽  
Ewelina Frejlich ◽  
Agata Diakun ◽  
...  
Keyword(s):  
Weight Loss ◽  
Body Composition ◽  
Body Weight ◽  
Bioelectrical Impedance ◽  
The Body ◽  
Intracellular Water ◽  
University Hospital ◽  
Major Surgery ◽  
Average Weight ◽  
Neoplastic Disease

Introduction An adequate level of nutrition is important in the period of reconvalescence in patients undergoing major surgery, in particular due to neoplastic disease. Bioelectrical impedance (BIA - Bioelectrical Impedance Analysis) is a widely used technique for assessing body composition. BIA measurement is easy, fast, cheap and repeatable. Material and methods The body composition of 56 patients (25 women and 31 men) was assessed with bioelectrical impedance analysys. All patients was hospitalized and operated in the Department of General and Oncological Surgery, Wrocław Clinical University Hospital in 2017-2018. Results The average weight loss on the 4th postoperative day is 1.32%, and at discharge from hospital 4.23% of body weight in relation to body weight at admission to the ward. The percentage of fat tissue (FM-Fatt Mass) in patients admitted to the ward is above the normal range. The change in body weight composition in hospitalized patients is mainly related to the amount of adipose tissue and the amount of extra- and intracellular water (ECW-Extracellular Water, ICW-Intracellular Water). Conclusions Bioelectrical impedance can be an easy and effective method to assess body composition and its change in patients undergoing major surgery. Patients operated on due to pancreatic cancer lose the highest percentage of body weight until discharge from the ward in relation to body weight at the time of admission to the ward from the analyzed groups. Weight loss mainly occurs as fat loss (FM).

scholarly journals Role of Physical Activity and Exercise in Treating Patients with Overweight and Obesity

2018 ◽  
Vol 64 (1) ◽  
pp. 99-107 ◽  
Author(s):  
John M Jakicic ◽  
Renee J Rogers ◽  
Kelliann K Davis ◽  
Katherine A Collins
Keyword(s):  
Physical Activity ◽  
Weight Loss ◽  
Body Weight ◽  
Weight Gain ◽  
Overweight And Obesity ◽  
Current Evidence ◽  
Dietary Modification ◽  
Weight Regulation ◽  
Body Weight Regulation ◽  
Lifestyle Behavior

Abstract BACKGROUND Overweight and obesity are significant public health concerns that are linked to numerous negative health consequences. Physical activity is an important lifestyle behavior that contributes to body weight regulation. CONTENT Physical activity is inversely associated with weight gain and the incidence of obesity. Physical activity also contributes to additional weight loss when coupled with dietary modification, and it can result in modest weight loss when not coupled with dietary modification. Moreover, physical activity is associated with improved long-term weight loss and prevention of weight gain following initial weight loss. Current evidence supports that physical activity should be moderate to vigorous in intensity to influence body weight regulation. There is also a growing body of evidence that physical activity can be accumulated throughout the day in shorter periods of time rather than being performed during a structured and longer period, and that physical activity performed in this manner can be important for body weight regulation. SUMMARY The literature supports the inclusion of physical activity as an important lifestyle behavior for regulating body weight. There are multiple intervention approaches that may be effective for enhancing physical activity engagement within the context of weight control.

Changes of weight and body composition after gastrectomy in the elderly gastric cancer patients.

2016 ◽  
Vol 34 (4_suppl) ◽  
pp. 89-89 ◽  
Author(s):  
Kenki Segami ◽  
Toru Aoyama ◽  
Yukio Maezawa ◽  
Kazuki Kano ◽  
Tsutomu Sato ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Body Composition ◽  
Body Weight ◽  
Adjuvant Chemotherapy ◽  
Cancer Patients ◽  
Lean Body Mass ◽  
Body Mass ◽  
The Elderly ◽  
Significant Difference ◽  
Gastric Cancer Patients

89 Background: Body weight, especially lean body mass, significantly reduces after gastrectomy for gastric cancer due to surgical invasion, reduced food intake, or decreased mobility, which could decrease quality of life and toxicity / compliance of adjuvant chemotherapy. These risks might be high especially in the elderly gastric cancer patients. However, it remains unclear whether changes of weight and body composition are different between the elderly and the non-elderly. Methods: This retrospective study examined patients who underwent curative surgery for gastric cancer between June 2010 and March 2014. Body weight and composition were evaluated by a bioelectrical impedance analyzer within 1 week before surgery (first measurement), at 1 week after surgery (second measurement), at 1 month after surgery (third measurement), and at 3 months after surgery (forth measurement). Patients were classified to the elderly (> 75 years) and the non-elderly ( < 75 years). Results: Four-hundred forty three patients (100 for the elderly and 343 for the non-elderly) were entered in the present study. Patients backgrounds, surgical factors, clinicopathological factors, surgical complications and adjuvant chemotherapy were not significantly different between the two groups. %Body weight loss until 1week, 1month, 3 months after surgery, defined as the proportion of the difference between 1st measurement and each measurement after surgery against 1st measurement, was 3.3%, 6.6%, and 9.7%, respectively in the elderly and 3.7%, 5.4%, and 8.2%, respectively in the non-elderly with significant difference (p = 0.05, 0.01, and 0.01, respectively). %Lean body mass loss until 1 week, 1 month, 3 months after surgery was 3.2%, 5.6%, and 6.1%, respectively in the elderly and 3.2%, 4.5%, and 4.2%, respectively in the non-elderly with p value of 0.36, 0.08, and 0.01, respectively. %Fat loss was not significantly different between the two groups at any time. Conclusions: Decreases in body weight and lean body mass after gastrectomy were more serious in the elderly patients as compared with the non-elderly. Surgical indication for the elderly must be carefully determined considering the risk and the benefit.

Effect of whey protein isolate supplementation on body composition, muscle strength, and treatment tolerance in malnourished advanced cancer patients undergoing chemotherapy.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. 11598-11598
Author(s):  
Paolo Pedrazzoli ◽  
Emanuele Cereda ◽  
Silvia Cappello ◽  
Luca Arcaini ◽  
Valeria Borioli ◽  
...  
Keyword(s):  
Body Composition ◽  
Body Weight ◽  
Muscle Strength ◽  
Cancer Patients ◽  
Whey Protein ◽  
Advanced Cancer ◽  
Primary Endpoint ◽  
Protein Isolate ◽  
Advanced Cancer Patients ◽  
Nutritional Counseling

11598 Background: Malnutrition is frequent in cancer pts, particularly in advanced disease, which requires appropriate multidisciplinary interventions. We evaluated the benefit of whey protein isolate (WPI) supplementation in addition to nutritional counseling in malnourished cancer pts undergoing chemotherapy (CT). Methods: In a single-center, randomized, pragmatic, parallel-group controlled trial (ClinicalTrials.gov: NCT02065726), 166 malnourished advanced cancer pts undergoing CT were randomly assigned to receive nutritional counseling with (N=82) or without (N=84) WPI supplementation (20 grams/daily) for 3 months. Primary endpoint was the change in phase angle (PhA). Secondary endpoints included changes in standardized PhA (SPA), fat-free mass index (FFMI), body weight, muscle strength, quality of life and CT toxicity. Results: In pts with the primary endpoint assessed (modified intention-to-treat population), counseling plus WPI (N=66) resulted in improved PhA compared to nutritional counseling alone (N=69): mean difference, 0.48° [95%CI, 0.05 to 0.90] (P=0.027). Imputation of missing outcomes yielded consistent findings. WPI supplementation resulted also in improved SPA (P=0.021), FFMI (P=0.041), body weight (P=0.023), muscle strength (P<0.001) and in reduced risk of CT toxicity, particularly of severe (grade ≥3) events (Table). Conclusions: In malnourished advanced cancer patients undergoing CT and receiving nutritional counseling, 3-month supplementation with WPI resulted in improved body composition, muscle strength, body weight and reduced CT toxicity. Further trials in newly diagnosed specific cancer types are warranted. Clinical trial information: NCT02065726. [Table: see text]

scholarly journals Insulin Therapy and Body Weight, Body Composition and Muscular Strength in Patients with Type 2 Diabetes Mellitus

2010 ◽  
Vol 2010 ◽  
pp. 1-4 ◽  
Author(s):  
H. Gin ◽  
V. Rigalleau ◽  
C. Perlemoine
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Body Composition ◽  
Body Weight ◽  
Insulin Therapy ◽  
Fat Mass ◽  
Fat Free Mass ◽  
Before And After

Aims.To determine the progression of body weight (BW) and body composition (BC) in patients with type 2 diabetes mellitus (T2D) on insulin therapy and the consequences on muscle strength (MS) as a reflect of free fat mass increases.Research design and methods.We analysed BC using air displacement plethysmography and MS by hand grip dynamometry in 40 T2D before and after three (M3) and six months (M6) of insulin therapy.Results.at baseline HbA1c was 9.76±1.6% and BW was stable with fat mass (FM) 28±10.7 kg; and fat free mass (FFM) 52.4±11 kg; at M6, HbA1c improved to 7.56±0.8%; insulin doses tended to increase. BW gain at M6 was+3.2±4.2 kg and with an increase of only 25% by M3; it was composed of FM, whereas FFM was unchanged. MS did not increase on insulin therapy.Conclusions.In T2D, BW gain was composed exclusively of FM with no improvement in MS.

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