Airway Clearance and Mucoactive Therapies

2021 ◽  
Vol 42 (04) ◽  
pp. 616-622
Author(s):  
Gerard Muñoz Castro ◽  
Ana Balañá Corberó
Keyword(s):  
Respiratory System ◽  
Mucociliary Clearance ◽  
Defense System ◽  
Defense Systems ◽  
Airway Clearance ◽  
Respiratory Physiotherapy

AbstractThe respiratory system is constantly exposed to external pathogens but has different and effective defense systems. The pathophysiology of bronchiectasis affects the defense system considerably in that alterations occur in the airway that reduce its effectiveness in mucociliary clearance and the greater presence of mucins leads to the accumulation of more adherent and viscous mucus. One of the pillars of treatment of this disease should be improvement of mucociliary clearance and a decrease in the adherence and viscosity of the mucus. To this end, the mobilization of secretions must be increased through effective respiratory physiotherapy techniques, which can be manual and/or instrumental. The properties of mucus can be modified to improve its mobilization through the use of a mucoactive agent. Despite the increase in the number and quality of studies, the evidence for these treatments remains scarce, although their application is recommended in all guidelines.

scholarly journals Effect of Methyl Jasmonate, Cytokinin, and Lavender Oil on Antioxidant Enzyme System of Apricot Fruit (Prunus armeniaca L.)

2021 ◽  
Vol 13 (15) ◽  
pp. 8565
Author(s):  
Seyda Cavusoglu ◽  
Nurettin Yilmaz ◽  
Firat Islek ◽  
Onur Tekin ◽  
Halil Ibrahim Sagbas ◽  
...  
Keyword(s):  
Enzyme Activity ◽  
Methyl Jasmonate ◽  
Prunus Armeniaca ◽  
Lavender Oil ◽  
Defense Systems ◽  
Antioxidant Enzyme System ◽  
Prunus Armeniaca L ◽  
Antioxidant Defense Systems ◽  
And Storage

Various treatments are carried out in order to extend both the shelf life and storage life of fresh fruit and vegetables after harvest and among them non-toxic for humans, environmentally and economically friendly alternative treatments are gained more importance. In the current study, methyl jasmonate (MeJA), cytokinin, and lavender oil which are eco-friendly and safe for human health were applied on apricot fruit. The treated fruit were stored at 0 °C and 90–95% relative humidity for 25 days and catalase (CAT), superoxide dismutase (SOD), and ascorbate peroxidase (APX) enzyme activities and lipid peroxidation of apricots after treatments were studied. According to the findings obtained from the study, it was observed that 5 ppm cytokinin and 1000 ppm lavender oil treatments of apricot fruit gave better APX and CAT enzyme activity, respectively. In addition, better SOD enzyme activity in fruit was obtained with MeJA+lavender oil treatments. As a result, it can be emphasized that the product quality of apricot fruit is preserved as both the eco-friendly application of MeJA, cytokinin, and lavender oil separately from each other and the treatment of combinations between these compounds activate the enzymatic antioxidant defense systems of apricot fruit after harvest.

Sinonasal effects of external dacryocystorhinostomy

2021 ◽  
pp. 1-4
Author(s):  
H Eyigor ◽  
E A Cetinkaya ◽  
D T Coban ◽  
G Ozturk ◽  
Ö Erdem
Keyword(s):  
Mucociliary Clearance ◽  
Nasal Symptom ◽  
Ciliary Activity ◽  
Test Results ◽  
Saccharine Test ◽  
Significant Difference ◽  
Symptom Scores ◽  
Endoscopic Score ◽  
External Dacryocystorhinostomy

Abstract Objective External dacryocystorhinostomy is thought to cause mucociliary dysfunction by damaging the mucosa, in turn affecting ciliary activity and mucus quality. This study investigated the effect of external dacryocystorhinostomy on sinonasal function. Methods Patients scheduled for unilateral external dacryocystorhinostomy who underwent endoscopic nasal examination and paranasal sinus computed tomography were included in this study. A saccharine test was performed on the planned surgical side and the mucociliary clearance time was determined. The sinonasal quality of life was measured in all patients, pre-operatively and at six months post-operatively, using the Sino-Nasal Outcome Test-22. The Lund–Kennedy endoscopic score was also determined in all patients, both pre- and post-operatively. Results The study comprised 28 patients (22 females and 6 males). A statistically significant difference was found between the pre- and post-operative saccharine test results (p = 0.006), but not between the pre- and post-operative Sino-Nasal Outcome Test-22 scores (p > 0.05). Conclusion This study is one of only a few to investigate the effect of external dacryocystorhinostomy on sinonasal function. The results showed that external dacryocystorhinostomy impairs mucociliary clearance. The surgical procedure is well tolerated and does not significantly change nasal symptom scores.

scholarly journals Cause-and-effect relationships between air pollution and health conditions in population

2020 ◽  
Vol 5 (4) ◽  
pp. 230-234
Author(s):  
I. I. Berezin ◽  
Yu. Yu. Eliseev ◽  
A. K. Sergeev
Keyword(s):  
Air Pollution ◽  
Allergic Rhinitis ◽  
Bronchial Asthma ◽  
Respiratory System ◽  
Air Pollutants ◽  
Preventive Measures ◽  
Industrial City ◽  
Cause And Effect ◽  
The Impact

Objectives to reveal cause-and-effect relationships in the system "air pollution morbidity of the population" in a large industrial city. Material and methods.The dynamics of the pollutants concentration, such as formaldehyde and benzopyrene, through the period of 20152017 was analyzed in relation to the indicators of the morbidity of the respiratory system in the population of Samara. In particular, the study focused on the ratio of allergic rhinitis and asthma cases and the concentration of the formaldehyde and benzopyrene. Results.The incidence of respiratory diseases and the general morbidity increased both among children (by 46.7%) and adults (by 11.4%). There was the causal correlation between the effect of benzopyrene on the development of allergic rhinitis and bronchial asthma in children(r = 0.57 and r = 0.76) and in adults (r = 0.45 and r = 0.51) in Samara. The significant differences between the level of the pollutants and the frequency of the respiratory system diseases were registered in children and adults in different areas of Samara. Discussion.As a result of the increase of the maximum allowable concentration (MAC) of formaldehyde in atmospheric air, this pollutant has now ceased to be a priority. The revealed negative correlations point to the absence of an adverse effect of formaldehyde on the development of allergic rhinitis and bronchial asthma in both children and adults in Samara. Conclusion.According to the results of the study, the preventive measures aimed at reducing the impact of main air pollutants on the health of children and adults in Samara were suggested. Their implementation is possible by the immediate informing of the executive authorities to ensure they can make timely management decisions to improve the quality of the environment.

scholarly journals Importance of military vacation facilities for the quality of life of the defense system members

Vojno delo ◽  
2017 ◽  
Vol 69 (4) ◽  
pp. 134-145
Author(s):  
Mihajlo Ranisavljevic ◽  
Slavisa Arsic ◽  
Miljojko Janosevic
Keyword(s):  
Quality Of Life ◽  
Defense System

A Longitudinal Study of Cellular Changes in Experimental Otitis Media

1979 ◽  
Vol 87 (5) ◽  
pp. 685-700 ◽  
Author(s):  
Marcos V. Goycoolea ◽  
Michael M. Paparella ◽  
Anna Mary Carpenter ◽  
S. K. Juhn
Keyword(s):  
Longitudinal Study ◽  
Otitis Media ◽  
Experimental Animal ◽  
Middle Ear ◽  
Defense System ◽  
Tube Obstruction ◽  
Defense Systems ◽  
Cellular Changes ◽  
Staining Techniques ◽  
The Continuum

A longitudinal sequential study of otitis media in an experimental animal (cat) using eustachian tube obstruction was done. Fifty animals were used. The continuum of mucoperiosteal changes from one day to six months after obstruction revealed gradual changes that were similar for each animal. Stages were defined, and by using different staining techniques, including immunocytochemistry, an overall middle ear defense system was postulated and documented. Nonspecific as well as specific defense systems, including localized immunity, were described. Effusions were studied in a continuum, and their pathogenesis was discussed.

Superimposed Oscillations Enhance the Clearance of Mucus Simulant at Low Air Flows in a Rigid Tracheal Model

2002 ◽  
Author(s):  
Peter E. Krumpe ◽  
Cahit A. Evrensel ◽  
Amgad A. Hassan
Keyword(s):  
Pulmonary Disease ◽  
Mucociliary Clearance ◽  
Healthy People ◽  
Pulmonary Diseases ◽  
Flow Rates ◽  
Airway Clearance ◽  
Clearance Mechanism ◽  
Primary Means ◽  
Air Flows ◽  
Expiratory Flow Rates

Clearance of mucus by the beating action of cilia is the primary means of removing inhaled particulates and airway debris from airways in healthy people. However many pulmonary diseases are associated with impaired mucociliary clearance mechanisms. For these patients, cough is the default airway clearance mechanism. Unfortunately most pulmonary disease patients can only produce low expiratory flow rates and have difficulty coughing for this reason.

scholarly journals 0960 Perception of Sleep Importance in Children With Cystic Fibrosis

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A364-A365
Author(s):  
K Reiling ◽  
A Patel
Keyword(s):  
Cystic Fibrosis ◽  
Lung Function ◽  
Sleep Problems ◽  
Pulmonary Function Tests ◽  
Poor Sleep ◽  
Airway Clearance ◽  
The Mean ◽  
Nocturnal Cough ◽  
Perception Of Sleep

Abstract Introduction Children with cystic fibrosis (CF) are known to have poor sleep efficiency and increased nighttime awakenings secondary to factors such as nocturnal cough and time spent on therapies for airway clearance. Studies have shown that children with poor lung function have a higher Pediatric Daytime Sleepiness Score (PDSS). An increase in sleep disturbance has been associated with poorer perceived health in children with CF. There have been limited studies to date that report the perception of sleep importance in CF patients. We aim to characterize the perception of sleep importance in children with CF as measured through a self-reported questionnaire and identify barriers to sleep. Methods After IRB approval, subjects with CF aged 3-17 years were prospectively recruited from routine pulmonology clinic visits (n=28, 17 male). A questionnaire was provided consisting of 35 questions regarding sleep practices, perception of sleep importance, and PDSS. Recent pulmonary function tests (PFTs) were also collected. Results The mean PDSS was 11.3, with a range of 4 to 24. The questionnaire responses were as follows: 82% of participants reported sleep as “very important” overall, 92% reported sleep being “very important” for health, and 75% reported sleep being “very important” for lung function. In addition, 39% reported airway clearance as part of their nighttime routine and 89% reported utilizing electronic screens 2 hours prior to bed. The most frequent barriers to sleep identified were technology and bedtime resistance (14% each), and homework, excitability, and vest/airway treatments (11% each). 86% of participants had at least one symptom of disordered sleep. Conclusion Screening for sleep problems in the CF population may be beneficial and may contribute to improved quality of life. Further recruitment is ongoing. Support  

Research on Multi-Core Network Equipment Virus Defense System

2015 ◽  
Vol 738-739 ◽  
pp. 1197-1200
Author(s):  
Yan Wen Xu ◽  
Feng Dong
Keyword(s):  
Information Network ◽  
Enterprise Networks ◽  
Core Network ◽  
Defense System ◽  
Business Systems ◽  
Enterprise Information ◽  
Defense Systems ◽  
Network Equipment ◽  
Security Infrastructure ◽  
Network Server

With the arrival of the wave of information technology, the business activities of a variety of business systems via the network to complete. But the virus to exploit system vulnerabilities to sneak into the enterprise information network server, the enterprise network into a leak and suffered the double threat of external hackers. Leverage existing security infrastructure, enterprise networks, statistical analysis of all possible virus invasion point, combined with a good virus defense technology layers protection system vulnerabilities, the formation of a whole network antivirus, coordinated operations, a unified management modernization virus defense systems.

Metabolic and musculoskeletal effects of cystic fibrosis

2015 ◽  
Author(s):  
Uta Hill ◽  
Jane Ashbrook ◽  
Charles Haworth
Keyword(s):  
Quality Of Life ◽  
Bone Mineral Density ◽  
Urinary Incontinence ◽  
Bone Mineral ◽  
Negative Impact ◽  
Fragility Fractures ◽  
Pulmonary Complications ◽  
Mineral Density ◽  
Airway Clearance

This chapter provides a comprehensive update on the prevention, recognition, and treatment of low bone mineral density in people with CF. As life expectancy improves, the extra-pulmonary complications of CF are becoming increasingly important to quality of life. Up to 25 per cent of CF patients have reduced bone mineral density in adulthood, leading to the development of fragility fractures which cause pain, thereby interfering with airway clearance and predisposing to pulmonary infection. Osteoporosis can be a relative contraindication for lung transplantation. Other important musculoskeletal issues including CF arthropathy, growth, and urinary incontinence are covered. CF arthropathy is a non-erosive episodic sero-negative arthritis, often difficult to treat and which may require specialist input. Urinary incontinence is common girls and women with CF and has a negative impact on quality of life and ability to complete therapies. The pathophysiology and management of urinary incontinence are discussed.

Is Wikipedia a reliable learning resource for medical students? Evaluating respiratory topics

2015 ◽  
Vol 39 (1) ◽  
pp. 5-14 ◽  
Author(s):  
Samy A. Azer
Keyword(s):  
Medical Students ◽  
Respiratory System ◽  
Strong Correlation ◽  
Grade Level ◽  
Signs And Symptoms ◽  
Learning Resources ◽  
Learning Resource ◽  
Prevention And Treatment ◽  
The Mean

The aim of the present study was to critically evaluate the accuracy and readability of English Wikipedia articles on the respiratory system and its disorders and whether they can be a suitable resource for medical students. On April 27, 2014, English Wikipedia was searched for articles on respiratory topics. Using a modified DISCERN instrument, articles were independently scored by three assessors. The scoring targeted content accuracy, frequency of updating, and quality of references. The readability of articles was measured using two other instruments. The mean DISCERN score for the 40 articles identified was 26.4 ± 6.3. Most articles covered causes, signs and symptoms, prevention, and treatment. However, several knowledge deficiencies in the pathogenesis of diseases, investigations needed, and treatment were observed. The total number of references for the 40 articles was 1,654, and the references varied from 0 to 168 references, but several problems were identified in the list of references and citations made. The readability of articles was in the range of 9.4 ± 1.8 to 22.6 ± 10.7 using the Flesch-Kincaid Grade Level instrument and 10.0 ± 2.6 to 19.6 ± 8.3 using the Readability Coleman-Liau index. A strong correlation was found between the two instruments ( r2= 0.744, P < 0.001). The agreement between the assessors had mean κ scores in the range of 0.712–0.857. In conclusion, despite the effort placed in creating Wikipedia respiratory articles by anonymous volunteers (wikipedians), most articles had knowledge deficiencies, were not accurate, and were not suitable for medical students as learning resources.

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