SARS-CoV-2 Antibody Response among Women Infected during Pregnancy

2021 ◽  
Author(s):  
Ayisha Buckley ◽  
Ariana Mills ◽  
Keisha Paul ◽  
Samantha Raymond ◽  
Damondara R. Mendu ◽  
...  
Keyword(s):  
Antibody Response ◽  
Health System ◽  
Pregnant Women ◽  
Antibody Titer ◽  
Gestational Age ◽  
Antibody Test ◽  
Mount Sinai Hospital ◽  
World Health ◽  
Enzyme Linked Immunosorbent Assay ◽  
Mount Sinai

Objectives Novel coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) virus has been declared a pandemic by the World Health Organization as of March 11, 2020. Pregnant women naturally have a reduced immune system due to immunological changes and decreased lung capacity due to respiratory adaptations, making them more susceptible to coronavirus complications. Within the Mount Sinai Health system, more than 15,000 deliveries are performed annually. We began to care for pregnant women with known COVID-19 infections in late March of 2020. In early April 2020, a policy was implemented to perform universal COVID-19 testing for all women planning to deliver within the Mount Sinai Health system. We examined the antibody response of postpartum women who delivered at Mount Sinai Hospital with a SARS-CoV-2 infection between the study intervals during March 15, 2020, through April 30, 2020. Study Design This was a prospective observational study examining the immune response of pregnant women who delivered at Mount Sinai Hospital with a polymerase chain reaction (PCR)-confirmed SARS-CoV-2 infection. Women with a SARS-CoV-2 infection were contacted via phone to discuss participation in the study. Patients who consented were scheduled for a phlebotomy visit to assess their antibody titer levels to COVID-19. The COVID-19 enzyme-linked immunosorbent assay (ELISA) immunoglobulin (Ig)-G antibody test was used to evaluate the patients' antibody titers. The assay detects IgG antibodies for the detection of IgG seroconversion in patients following a known recent SARS-CoV-2 infection. Results A total of 120 patients were identified with a documented SARS-CoV-2 infection who delivered within the prespecified time frame. Of those patients, 25 women agreed to participate and were included. Of them, 64.00% were Caucasian with a mean age of 35 years. The mean body mass index (BMI) was 30 kg/m2 and the majority of patients had commercial insurance (88.00%). The majority of women were asymptomatic for COVID-19 at the time of admission (80.00%) and the average gestational age of delivery and diagnosis of COVID-19 was 39 weeks' gestation. The later the gestational age at the time of diagnosis, the lower the antibody titer response. When examining the interval from diagnosis to antibody titer analysis, patients with the highest titers (2,880) tended to have a shorter interval between their COVID-19 diagnosis and the time at which the titer level was drawn. Patients with symptoms on admission had similar antibody titer levels when compared with women who were asymptomatic. Conclusion The antibody response among women infected with COVID-19 during pregnancy appears to be greater when the patients are diagnosed at an earlier gestational age. Key Points

scholarly journals Apelin 13 and Blood Pressure, Is there any Association in Pre-eclampsia? - A Case-control Study

2021 ◽  
Author(s):  
Rajeev Gandham ◽  
CD Dayanand ◽  
SR Sheela
Keyword(s):  
Blood Pressure ◽  
Pregnant Women ◽  
Gestational Age ◽  
Case Control Study ◽  
Case Control ◽  
Maternal Serum ◽  
Research Centre ◽  
Categorical Variables ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Study

Introduction: Pre-eclampsia is a pregnancy specific disorder, characterised by the onset of hypertension and proteinuria. Pre-eclampsia is the leading cause of maternal, perinatal morbidity and mortality. The exact cause of pre-eclampsia is not known clearly and needs to be explored. Aim: To evaluate the maternal serum apelin 13 levels among pre-eclampsia and healthy pregnant women and also, to find the association between apelin 13 and blood pressure. Materials and Methods: A case-control study was conducted between Department of Biochemistry and Department of Obstetrics and Gynaecology, RL Jalappa Hospital and Research Centre, Kolar, Karnataka, India. After approval from the Institutional Ethics Committee and written informed consent from study subjects, a total of 270 pregnant women were recruited for this study. Among them, 135 pre-eclamptic women were considered as cases and 135 normotensive healthy pregnant women served as controls. According to the pre-eclampsia severity, cases were grouped into mild (n=47) and severe pre-eclampsia (n=88). Blood samples were collected from all the study subjects and was analysed for apelin 13 by Enzyme Linked Immunosorbent Assay (ELISA) method. Maternal and foetal adverse outcomes were recorded. Results were expressed as mean±Standard Deviation (SD). Categorical variables were expressed in percentages. Spearman’s correlation was applied and p<0.05 was considered significant. Results: The mean gestational age was 36.66±3.69 weeks which was, significantly low in pre-eclamptic women compared with healthy pregnant women. BMI (26.94±3.81 kg/m2), systolic (157.82±15.14 mmHg), diastolic (101.68±11.02 mmHg) and Mean Arterial Pressure (MAP) (120.20±11.12 mmHg), pulse rate (88.14±5.82 bpm), Aspartate Transaminase (AST) (25.25±12.49 IU/L) and Alanine Transaminase (ALT) (19.01±10.95 IU/L) were significantly increased in pre-eclamptic women when compared with control group. Mean maternal serum apelin 13 (341.44±218.63 pg/mL) concentrations were significantly lower in pre-eclampsia compared with healthy pregnant women. Maternal serum apelin 13 concentrations were negatively correlated with Systolic Blood Pressure (SBP) (r = -0.196), Diastolic Blood Pressure (DBP) (r = -0.172) and MAP (r =-0.204). Adverse maternal outcomes such as epigastric pain 75 (55.55%), oedema 62 (45.92%) and persistent headache 35 (25.92%) were higher in pre-eclamptic group. Additionally, adverse foetal outcomes were more in pre-eclamptic cases including significantly decreased birth weight (2.40±0.65), babies requiring Neonatal Intensive Care Unit (NICU) admission were 54 (40%), preterm birth (≤37 wks) in 50 (37.03%), Respiratory Distress Syndrome (RDS) 31 (22.96%), Small for Gestational Age (SGA) in 4 (2.96%) and Intra Uterine Death (IUD) in 11 (8.14%) babies. Conclusion: It was concluded from the present study that there was low maternal serum apelin 13 concentrations in pre-eclampsia and had negative correlation with blood pressure, suggesting its potential role in the pathophysiology of pre-eclampsia.

scholarly journals Detection of avian reovirus antibodies in layer birds of small scale commercial farms in Dinajpur district of Bangladesh

2016 ◽  
Vol 1 (3) ◽  
pp. 612-621 ◽  
Author(s):  
Abdus Salam ◽  
Md Atiqul Haque ◽  
Md Mostafizer Rahman ◽  
Mir Rowshan Akter ◽  
Farzana Afroz
Keyword(s):  
Antibody Titer ◽  
Specific Antibody ◽  
Age Groups ◽  
Antibody Test ◽  
Enzyme Linked Immunosorbent Assay ◽  
Small Scale ◽  
Avian Reovirus ◽  
Serum Samples ◽  
Aged Group ◽  
Test Kit

The present study was conducted on layer birds of different age groups to determine specific antibody titer level against avian reovirus (ARV) by indirect enzyme linked immunosorbent assay (iELISA) at Dinajpur district of Bangladesh. This study showed that ARV specific antibody positive cases were 84 out of 90 blood serum samples and the highest antibody titer was 26120 and lowest antibody titer was 288. The total 93.33% sera samples were showed positive result. The study showed that 100% sera sample were positive against ARV at 6 weeks of aged group and the highest, lowest and mean antibody titer were 13917, 4895 and 10269 respectively. On the other hand 88.88% sera sample were positive against ARV at 10 weeks of aged group and the highest, lowest and mean antibody titer were 9779, 288 and 5689.89 respectively. The sera sample collected from 14 weeks of aged group showed 88.88% positive and the highest, lowest and mean antibody titer were 11727, 871 and 5250 respectively. The sera sample collected from 18 weeks of aged group showed 88.88% positive against ARV and the highest, lowest and mean antibody titer were 24440, 1234 and 12648.89 respectively. The sera sample collected from 22 weeks of aged group were 100% positive against ARV and the highest, lowest and mean antibody titer were 26120, 1752 and 11373.89 respectively. The sera sample collected from 26 weeks of aged group showed 100% positive against ARV and the highest, lowest and mean antibody titer were 8566, 1630 and 4327.44 respectively. The sera sample collected from 30 weeks of aged group showed 100% positive against ARV and the highest, lowest and mean antibody titer were 13431, 1989 and 5890.56 respectively. The sera sample collected from 40 weeks of aged group showed 77.77% positive against ARV and the highest, lowest and mean antibody titer were 14618, 433 and 5103.22 respectively. The sera sample collected from 48 weeks of aged group showed 88.88% positive against ARV and the highest, lowest and mean antibody titer were 14553, 957 and 7436.5 respectively. In conclusion it is evident that avian reovirus-specific antibody was successfully detected through commercially available avian reovirus antibody test kit (ELISA kit) and the virus induced a significant antibody titer indicating the affecting virus was absolutely ARV.Asian J. Med. Biol. Res. December 2015, 1(3): 612-621

scholarly journals ANTINUCLEAR ANTIBODIES IN PATIENTS WITH UNEXPLAINED RECURRENT ABORTIONS

2017 ◽  
Vol 10 (8) ◽  
pp. 256 ◽  
Author(s):  
Anupriya Asaithambi ◽  
Manjula Gunasekaran ◽  
Manivelan S ◽  
Palaniappan Nainar
Keyword(s):  
Pregnant Women ◽  
Antinuclear Antibodies ◽  
Antibody Test ◽  
Enzyme Linked Immunosorbent Assay ◽  
Cell Substrate ◽  
Simple Alternative ◽  
History Of ◽  
Recurrent Abortions ◽  
Control Study ◽  
Indirect Fluorescence Antibody

Objective:This study aims to determine the prevalence of antinuclear antibodies in pregnant women with bad obstetric history (BOH) against healthy multigravid women in and around Tirunelveli districtMethods: This is a case-control study comprising 60 antenatal women with BOH against 60 multiparous pregnant women with no history of abortions. Antinuclear antibodies (ANA) were detected using indirect immunofluorescence with Hep-2 cell substrate, and enzyme-linked immunosorbent assay (ELISA).Results: Among BOH cases 19 (82.6%), 18 (78.26%) were positive by ELISA and indirect fluorescence antibody test (IFAT) method, respectively. Among controls, 4(17.39%) and 5(21.73%) individuals were positive by ELISA and IFAT methods, respectively. Of the 18 positives, homogenous pattern was most common followed by anticentromere pattern, fine speckled and coarse speckled patternConclusion: IFAT is considered to be gold standard in the diagnosis of autoimmune disorders, but ELISA appears to be a suitable simple alternative for testing rheumatological disorders.

scholarly journals Factors for late initiation of antenatal care in Dar es Salaam, Tanzania: A qualitative study

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Saidi Mgata ◽  
Stephen Oswald Maluka
Keyword(s):  
Health Care ◽  
Antenatal Care ◽  
Health System ◽  
Pregnant Women ◽  
Health Care Workers ◽  
Cultural Beliefs ◽  
Dar Es Salaam ◽  
World Health ◽  
Health Providers ◽  
Care Workers

Abstract Background Antenatal care (ANC) provided by a trained health care provider is important for monitoring pregnancy thereby reducing potential risks for the mother and child during pregnancy and delivery. The World Health Organization (WHO) recommends at least four ANC visits to all pregnant women. While the proportion of women who attend at least one ANC in low-income countries is high, most pregnant women start their first ANC attendance very late. In Tanzania only 24% of pregnant women start their first ANC attendance before the fourth month of pregnancy. While factors for the utilization of antenatal care in general have been widely studied, there is paucity of studies on the factors affecting timing of the first ANC attendance. This study aimed to understand individual, community, and health system factors that lead to the delay in seeking ANC services among pregnant women in Ilala Municipal in Dar es Salaam region, Tanzania. Methods A qualitative exploratory study, using in-depth interviews with 20 pregnant women and five health care workers was conducted in three different health facilities in Dar es Salaam Tanzania. Thematic analysis approach was used to analyse the data. Results Individual perceptions of antenatal care, past experience with pregnancy, fear of pregnancy disclosure, and socio-cultural beliefs were the key individual and social factors for late ANC attendance. Shortage of trained health care workers, lack of spouse’s escort and health providers’ disrespect to pregnant women were the main health system barriers to early ANC attendance. Conclusions This study concludes that community members should be sensitized about the importance of early ANC attendance. Additionally, while spouse’s escort policy is important for promoting PMTCT, the interpretation of the policy should not solely be left to the health providers. District and regional health officials should provide correct interpretation of this policy.

scholarly journals The evaluation of factors affecting antibody response after administration of the BNT162b2 vaccine: a prospective study in Japan

PeerJ ◽  
2021 ◽  
Vol 9 ◽  
pp. e12316
Author(s):  
Toshiya Mitsunaga ◽  
Yuhei Ohtaki ◽  
Yutaka Seki ◽  
Masakata Yoshioka ◽  
Hiroshi Mori ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Regression Analysis ◽  
Antibody Response ◽  
Prospective Study ◽  
Antibody Titer ◽  
Logistic Regression Analysis ◽  
Multivariate Logistic Regression Analysis ◽  
Antibody Test ◽  
Antibody Responses ◽  
Multivariate Logistic Regression

The aim of this study was to evaluate the antibody reaction after administration of the BNT162b2 vaccine, and to reveal the factors that affect antibody production. This prospective study was carried out in the Association of EISEIKAI Medical and Healthcare Corporation Minamitama Hospital, in Tokyo, Japan, from April 15, 2021 to June 09, 2021. All our hospital’s workers who were administered the BNT162b2 vaccine as part of a routine program were included in this study. We calculated the anti-SARS-CoV-2 spike-specific antibody titter (1) before vaccination, (2) 7 to 20 days after the first vaccination, and (3) A total of 7 to 20 days after the second vaccination. The low-antibody titer group (LABG) was defined as the group having less than 25 percentiles of antibody titer. Univariate and Multivariate logistic regression analysis were performed to ascertain the effects of factors on the likelihood of LABG. A total of 374 participants were eventually included in our study, and they were divided into 94 LABG and 280 non-LABG. All samples showed significant antibody elevation in the second antibody test, with a mean value of 3,476 U/mL. When comparing the LABG and non-LABG groups, the median age, blood sugar, and HbA1c were significantly higher in the LABG group. The rates of participants with low BMI (<18.5) and high BMI (>30) were significantly higher in the LABG group. The proportion of chronic lung disease, hypertension, diabetes, dyslipidemia, autoimmune disease, and cancer were significantly higher in the LABG group. Although there was no significant difference confirmed with respect to the exercise hours per day, the proportion of participants that did not perform outdoor exercises was significantly higher in the LABG group. The time interval between the second vaccination and the second antibody test, and between the first and the second vaccination was significantly longer in the non-LABG group. In the multivariate logistic regression analysis, older than 60 years, the past history of hypertension, HbA1c higher than 6.5%, and lack of outdoor exercises were significant suppressors of antibody responses, whereas the length of days from the first to the second vaccination longer than 25 days promoted a significant antibody response. Again, our single-center study demonstrates that older than 60 years, hypertension, HbA1c higher than 6.5%, and lack of outdoor exercises were significant suppressors of antibody responses, whereas the length of days from the first to the second vaccination longer than 25 days promoted a significant antibody response. Evidence from multi-center studies is needed to develop further vaccination strategies.

scholarly journals Reinventing the Pregnancy Wheel to Improve Pregnancy Dating and Antenatal Care Visits: A Pilot Randomized Trial in Malawi

2021 ◽  
Vol 10 (1) ◽  
pp. 139-145
Author(s):  
Mary Stokes ◽  
Amber Olson ◽  
Mtisunge Chan'gombe ◽  
Bakari Rajab ◽  
Isabel Janmey ◽  
...  
Keyword(s):  
Global Health ◽  
Antenatal Care ◽  
Pregnant Women ◽  
Randomized Trial ◽  
Gestational Age ◽  
Age Dating ◽  
World Health ◽  
Secondary Outcome ◽  
Time Of Presentation ◽  
Antenatal Visits

Background and Objectives: The purpose of this study was to evaluate the feasibility of a customized, culturally sensitive pregnancy wheel given to pregnant women to improve gestational age dating accuracy at the time of delivery and to improve antenatal care attendance. Methods: This was a pilot randomized trial involving pregnant women presenting to a regional hospital in Lilongwe, Malawi. The primary outcome was accuracy of gestational age at the time of presentation to the hospital in labor. The secondary outcome was the number of antenatal visits. Results: At final analysis, 14 subjects were included in the pregnancy wheel (intervention) arm and 11 in the standard care arm. Fifty percent (n=7) of women in the intervention arm were accurately dated at the time of presentation for delivery, compared to only 9% (n=1) in the standard antenatal care arm (p=0.04). There was not a significant difference in the number of antenatal visits between the two study arms. No patients met the World Health Organization’s recommended eight antenatal care visits for prenatal care. Conclusion and Global Health Implications: The customized pregnancy wheel given to patients could improve gestational age dating accuracy, and as a result, clinical decision making. However, the barriers to greater antenatal care access are more complex and likely require a more complex solution. Significant attrition in this pilot trial limited statistical power, suggesting the need for future larger interventions. Accurate gestational dating requires access to ultrasonography and early antenatal care initiation, both of which are inadequate in Malawi. Although the customized pregnancy wheel did not improve antenatal care attendance, it improved gestational age dating accuracy in a pilot study at a central hospital in Lilongwe, Malawi.   Copyright © 2021 Stokes et al. Published by Global Health and Education Projects, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in this journal, is properly cited.

scholarly journals False negative HIV antibody test in HIV infected children who receive early antiretroviral treatment in a resource-limited setting

2012 ◽  
Vol 4 (1) ◽  
pp. 6 ◽  
Author(s):  
Gerardo Alvarez-Uria ◽  
Praveen K. Naik ◽  
Manoranjan Midde ◽  
Shanmugamari Kannan ◽  
Raghuprakash Reddy
Keyword(s):  
False Negative ◽  
Rapid Test ◽  
Antibody Test ◽  
Rural Setting ◽  
World Health ◽  
Enzyme Linked Immunosorbent Assay ◽  
Resource Limited ◽  
One Year ◽  
Health Organization ◽  
Early Antiretroviral Treatment

<p>With the implementation of 2010 World Health Organization guidelines, the number of infants from developing countries who will initiate antiretroviral therapy (ART) will increase considerably. In this study we describe the HIV antibody tests of 14 HIV infected children who initiated ART at age less than one year in a rural setting of India. The HIV rapid test was negative in seven and indeterminate in two cases, whereas the HIV enzyme-linked immunosorbent assay (ELISA) antibody test was negative in three and indeterminate in one case. In one child who had both negative HIV rapid test and ELISA initially, HIV serology turned positive after having a virological failure to ART, suggesting the possibility of utilizing HIV serology for monitoring ART effectiveness in children who experience HIV seroreversion. In conclusion, HIV seroreversion of children with early initiation of ART is common and should be considered for avoiding misdiagnosis of HIV infection.</p><p> </p>

scholarly journals Health system, socio-cultural, economic, environmental and individual factors influencing bed net use in the prevention of malaria in pregnancy in two Ghanaian regions

2019 ◽  
Vol 18 (1) ◽  
Author(s):  
Matilda Aberese-Ako ◽  
Pascal Magnussen ◽  
Gifty D. Ampofo ◽  
Harry Tagbor
Keyword(s):  
Health System ◽  
Pregnant Women ◽  
Cultural Context ◽  
Ethnographic Study ◽  
Malaria In Pregnancy ◽  
World Health ◽  
Individual Factors ◽  
Cultural Economic ◽  
Llin Use ◽  
In Pregnancy

Abstract Background Improving maternal health remains a priority to the Ghanaian government. Consequently, it has implemented the World Health Organization recommendation of distributing free long-lasting insecticidal nets (LLINs) to pregnant women—one of the effective strategies to combating malaria in pregnancy. However, the burden of negative outcomes of malaria in pregnancy such as low birth weight and miscarriages is still high. This may be related to the health system, socio-cultural and economic dynamics that influence LLIN use, but their role is not well understood. This ethnographic study sought to understand health system, socio-cultural, economic and environmental dynamics in utilization of LLINs among pregnant women in two Ghanaian regions. Methods An ethnographic study design was used. In-depth interviews and conversations were conducted among health workers, pregnant women and opinion leaders. Observations were conducted in 12 communities and eight health facilities. Ethical clearance was obtained from the University of Health and Allied Sciences’ Research Ethics Committee. Nvivo 11 was used to support data coding. Data were triangulated and analysed using a thematic approach. Results Findings suggest health system, socio-cultural, economic, environmental and individual factors influenced LLIN use. Health facility readiness in stocking LLINs influenced ownership and use. Receiving appropriate information from health providers and encouragement from public officials improved LLIN use. Women with a history of LLIN use prior to becoming pregnant and women who had young children remained consistent users. Experiencing irritating effects of LLINs and preference for traditional methods to wade off mosquitoes, reduced LLIN use. Pregnant women whose household and family members used LLINs were influenced positively to use them. Gender power relations between husbands and wives influenced women’s use of LLINs. The type of housing and weather conditions contributed to inconsistent use. Staying out late for business purposes and to converse, exposed pregnant women to mosquito bites. Conclusion Giving out LLINs at facility level should be accompanied with comprehensive information, which is relevant to the socio-cultural context that women live in. Mass distribution should factor in individual and public information to promote community acceptance and proper use of ITNs. Facilities should be encouraged to constantly maintain LLINs stock in order to ensure that ANC registrants receive LLINs for use.

scholarly journals KARAKTERISTIK IBU HAMIL YANG MENGALAMI HIPEREMESIS GRAVIDARUM

2019 ◽  
Vol 8 (2) ◽  
Author(s):  
Yuni Kurniati Yuni Kurniati
Keyword(s):  
High Risk ◽  
Pregnant Women ◽  
World Health Organization ◽  
Gestational Age ◽  
Health Workers ◽  
Low Risk ◽  
World Health ◽  
Pregnancy History ◽  
Risk Parity ◽  
Health Organization

Kematian maternal menurut World Health Organization (WHO) mencapai 585.000 jiwa setiap tahun. Faktor predisposisi yang menyebabkan hiperemesis gravidarum antara lain paritas, usia kehamilan, riwayat kehamilan, umur ibu, pekerjaan, pendidikan, riwayat penyakit ibu, psikologis, pengetahuan, dan sosial budaya. Tujuan penelitian ini untuk mengetahui karakteristik ibu hamil yang mengalami hiperemesis gravidarum di Rumah Sakit Bhayangkara Palembang tahun 2017. Dengan menggunakan metode deskriptif yaitu untuk mendeskripsikan variabel paritas, usia kehamilan, riwayat kehamilan, umur ibu, pekerjaan, dan pendidikan ibu hamil yang mengalami hiperemesis gravidarum di Rumah Sakit Bhayangkara Palembang tahun 2017. Populasi dalam penelitian ini adalah semua ibu hamil yang mengalami hiperemesis gravidarum yang pernah dirawat di Rumah Sakit Bhayangkara Palembang tahun 2017 yang berjumlah 17 orang. Sampel penelitian diambil dengan menggunakan metode Porpusive Sampling. Hasil penelitian menunjukkan paritas resiko tinggi lebih sedikit (11,8%) dibandingkan paritas resiko rendah (88,2%). Usia kehamilan Trimester I lebih banyak (82,4%) dibandingkan Trimester II (17,6%). Ibu dengan molahidatidosa dan gemeli lebih sedikit (23,5%) dibandingkan dengan ibu yang tidak pernah mengalami molahidatidosa dan gemeli (76,5%). Umur resiko tinggi lebih sedikit (29,4%) dibandingkan dengan resiko rendah (70,6%). Ibu yang bekerja lebih sedikit (41,2%) dibandingkan dengan yang tidak bekerja (58,8%). Ibu yang berpendidikan tinggi lebih banyak (64,7%) dibandingkan dengan yang berpendidikan rendah (35,3%). Diharapkan kepada petugas kesehatan  dapat memberikan informasi dan penyuluhan tentang hiperemesis gravidarum dan bagi peneliti selanjutnya agar meneliti dengan metode yang berbeda serta sampel yang lebih banyak.   ABSTRACT Maternal mortality according to the World Health Organization (WHO) reach 585,000 inhabitants every year. Predisposing factors that cause hiperemesis gravidarum, among others, gestational age, parity, maternal age, pregnancy history, employment history, education, maternal diseases, psychological, social, and cultural knowledge. The purpose of this research is to know the characteristics of pregnant women who experience hiperemesis gravidarum Bhayangkara Hospital in Palembang year 2017. By using descriptive method to describe the variable parity, gestational age, pregnancy history, age, occupation, and education of pregnant women who experience hiperemesis gravidarum Bhayangkara Hospital in Palembang year 2017. The population in this research is all the pregnant women who experience hiperemesis gravidarum ever hospitalized Bhayangkara Palembang 2017 year totalling 17 people. Research samples taken using Porpusive method of Sampling. The results showed fewer high risk parity (11.8%) than low risk parity (88.2%). Pregnancy Trimester I more (82.4%) than a Trimester II (17.6%). Mom with molahidatidosa and fewer gemeli (23.5%) compared with mothers who've never experienced molahidatidosa and gemeli (76.5%). High risk age less (29.4%) compared to the low risk (70.6%). Mothers work less (41.2%) compared to not working (58.8%). Mothers who are highly educated more (64.7%) compared to the low educated (35.3%). Expected to health workers can provide information and guidance about the hiperemesis gravidarum and for subsequent researchers in order to examine different methods and samples more.

The relationship between maternal and umbilical cord adropin levels with the presence and severity of preeclampsia

2017 ◽  
Vol 45 (7) ◽  
Author(s):  
Burcu Dincgez Cakmak ◽  
Betul Dundar ◽  
Abdullah Serdar Acikgoz ◽  
Gulten Ozgen ◽  
Tayfur Cift ◽  
...  
Keyword(s):  
Platelet Count ◽  
Birth Weight ◽  
Pregnant Women ◽  
Umbilical Cord ◽  
Gestational Age ◽  
Perinatal Outcomes ◽  
Enzyme Linked Immunosorbent Assay ◽  
Gestational Age At Delivery ◽  
Blood Pressures ◽  
The Relationship

AbstractAim:To investigate both maternal and umbilical cord adropin levels in patients with preeclampsia and the possible relations with its severity and perinatal outcomes.Materials and methods:In this study, a total of 38 preeclamptic and 40 age-matched healthy pregnant women between January and June 2016 were included. Serum and cord adropin levels were measured using an enzyme-linked immunosorbent assay (ELISA).Results:The maternal and umbilical cord adropin levels were significantly lower in the preeclamptic group compared to controls [71.19±22.21 vs. 100.76±27.02 ng/L and 92.39 (59.77:129.89) vs. 106.20 (74.42:208.02) ng/L, P<0.001, respectively]. While maternal adropin levels were significantly lower in the severe preeclampsia group as compared to the mild preeclamptic group [66.45 (21.49:98.02) vs. 76.17 (58.06:109.58), P=0.007], umbilical cord adropin levels did not differ between each group [91.32 (59.77:113.34) vs. 92.87 (63.12:129.89), P=0.750]. Maternal adropin level was negatively correlated with systolic and diastolic blood pressures (r=−0.60, P<0.001 and r=−0.58, P<0.001, respectively) and positively correlated with platelet count (r=0.27, P=0.016). Moreover, umbilical cord adropin levels were weakly correlated with gestational age at delivery (r=0.28, P=0.012) and birth weight (r=0.28, P=0.014).Conclusion:The present study is the first to demonstrate a significant association between maternal and umbilical adropin levels and the presence and severity of preeclampsia. Adropin might be a useful parameter for predicting the presence and severity of preeclampsia.

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