The relationship between maternal and umbilical cord adropin levels with the presence and severity of preeclampsia

AbstractAim:To investigate both maternal and umbilical cord adropin levels in patients with preeclampsia and the possible relations with its severity and perinatal outcomes.Materials and methods:In this study, a total of 38 preeclamptic and 40 age-matched healthy pregnant women between January and June 2016 were included. Serum and cord adropin levels were measured using an enzyme-linked immunosorbent assay (ELISA).Results:The maternal and umbilical cord adropin levels were significantly lower in the preeclamptic group compared to controls [71.19±22.21 vs. 100.76±27.02 ng/L and 92.39 (59.77:129.89) vs. 106.20 (74.42:208.02) ng/L, P<0.001, respectively]. While maternal adropin levels were significantly lower in the severe preeclampsia group as compared to the mild preeclamptic group [66.45 (21.49:98.02) vs. 76.17 (58.06:109.58), P=0.007], umbilical cord adropin levels did not differ between each group [91.32 (59.77:113.34) vs. 92.87 (63.12:129.89), P=0.750]. Maternal adropin level was negatively correlated with systolic and diastolic blood pressures (r=−0.60, P<0.001 and r=−0.58, P<0.001, respectively) and positively correlated with platelet count (r=0.27, P=0.016). Moreover, umbilical cord adropin levels were weakly correlated with gestational age at delivery (r=0.28, P=0.012) and birth weight (r=0.28, P=0.014).Conclusion:The present study is the first to demonstrate a significant association between maternal and umbilical adropin levels and the presence and severity of preeclampsia. Adropin might be a useful parameter for predicting the presence and severity of preeclampsia.

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Reduced Growth in Non-Small for Gestational Age Fetuses from 35 Weeks of Gestation to Birth and Perinatal Outcomes

Fetal Diagnosis and Therapy ◽

10.1159/000519639 ◽

2021 ◽

pp. 1-10

Author(s):

Peña Dieste Pérez ◽

Luis M. Esteban ◽

Ricardo Savirón-Cornudella ◽

Faustino R. Pérez-López ◽

Sergio Castán-Mateo ◽

...

Keyword(s):

Gestational Age ◽

Small For Gestational Age ◽

Perinatal Outcomes ◽

Entire Study ◽

Birth Weight Percentile ◽

Gestational Age At Delivery ◽

Study Population ◽

The Difference ◽

Relationship Of ◽

The Relationship

Objective: This study aimed to assess reduced fetal growth between 35 weeks of gestation and birth in non-small for gestational age fetuses associated with adverse perinatal outcomes (APOs). Material and Method: It is a retrospective cohort study of 9,164 non-small for gestational age fetuses estimated by ultrasound at 35 weeks. The difference between the birth weight percentile and the estimated percentile weight (EPW) at 35 weeks of gestation was calculated, and we studied the relationship of this difference with the appearance of APO. APOs were defined as cesarean or instrumental delivery rates for nonreassuring fetal status, 5-min Apgar score <7, arterial cord blood pH <7.10, and stillbirth. Fetuses that exhibited a percentile decrease between both moments were classified into 6 categories according to the amount of percentile decrease (0.01–10.0, 10.01–20.0, 20.01–30.0, 30.01–40.0, 40.01–50.0, and >50.0 percentiles). It was evaluated whether the appearance of APO was related to the amount of this percentile decrease. Relative risk (RR) was calculated in these subgroups to predict APOs in general and for each APO in particular. Receiver operating characteristic and area under curves (AUC) for the difference in the percentile was calculated, used as a continuous parameter in the entire study population. Results: The median gestational age at delivery in uncomplicated pregnancies was 40.0 (39.1–40.7) and in pregnancies with APOs 40.3 (49.4–41.0), p < 0.001. The prevalence of APOs was greater in the group of fetuses with a decrease in percentile (7.6%) compared to those with increased percentile (4.8%) (p < 0.001). The RR was 1.63 (95% CI: 1.365–1.944, p < 0.001). Although the differences were significant in all decreased percentile groups, RRs were significantly higher when decreased growth values were >40 points (RR: 2.036, 95% CI: 1.581–2.623, p < 0.001). The estimated value of the AUC for percentile decrease was 0.58 (0.56–0.61, p < 0.001). Conclusion: Fetuses with a decrease in the EPW between the ultrasound at 35 weeks of gestation and birth have a higher risk of APOs, being double in fetuses with a decrease of >40 percentile points.

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Micronutrient intake and fundal height determine birth weight

International Journal of Public Health Science (IJPHS) ◽

10.11591/ijphs.v8i1.16311 ◽

2019 ◽

Vol 8 (1) ◽

pp. 93

Author(s):

Faradina Aghadiati ◽

Diffah Hanim ◽

Yulia Lanti Retno Dewi

Keyword(s):

Folic Acid ◽

Birth Weight ◽

Pregnant Women ◽

Gestational Age ◽

Significant Relationship ◽

Cross Sectional ◽

Normal Birth ◽

Micronutrient Intake ◽

Term Newborns ◽

The Relationship

The birth weight (BW) are utilized as indicators of the healthy and term newborns. Factor that affects the weight of a newborn are micronutrient intake and fundal height. Folic acid and iron (Fe) were associated with newborn birth weight. Fundal height in centimeters (cm) is the same as the gestational age of the week, the fundal height that is not in accordance with the gestational age is leading to stunted fetal growth. The purpose of this study was to analyze the relationship between intake of folic acid, iron (Fe) and fundal height with newborn birth weight. This research method was an analytic observational using a cross-sectional approach. The sample in this study were 114 pregnant women living in Yogyakarta. Statistical test results proved a significant relationship between the intake of folic acid and iron (Fe) with the newborn birth weight (p < 0.05). There was a significant relationship between the fundal height with the newborn birth weight (p < 0.05). The concludes of this study, pregnant women with adequate folic acid intake, adequate iron intake and normal fundal height tended to give birth newborns with normal birth weight.

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Perinatal Outcomes of Babies Born with Fresh or Frozen-Thawed Testicular Sperm in Patients with Azoospermia

Gynecology & Reproductive Health ◽

10.33425/2639-9342.1153 ◽

2021 ◽

Vol 5 (3) ◽

Author(s):

Mehmet AK ◽

Nur Dokuzeylul Gungor

Keyword(s):

Birth Weight ◽

Live Birth ◽

Gestational Age ◽

Neonatal Death ◽

Perinatal Outcomes ◽

Pregnancy Rates ◽

Clinical Pregnancy ◽

Testicular Sperm ◽

Significant Difference ◽

Gestational Age At Delivery

Aim: To compare the perinatal outcomes of pregnancies obtained with fresh or frozen-thawed sperm in patients who underwent surgical sperm extraction for the diagnosis of azoospermia. Materials and Methods: In this retrospective study, data were collected on couples who conceived following Intracytoplasmic Sperm Injection using surgically retrieved fresh or frozen-thawed sperm. Participants were divided into two equal groups as follows. Group 1 (n = 100) consisted of patients who underwent ICSI and subsequent embryo transfer using fresh testicular sperm and Group 2 (n = 100) consisted of patients who underwent ICSI by using frozen-thawed testicular sperm. Perinatal outcome was compared according to the use of fresh or frozen-thawed sperm. Primary outcome measures included clinical pregancy, miscarriage, live birth, congenital abnormality, birthweight, gestational age at delivery, stillbirth and neonatal death. Results: Live birth and clinical pregnancy rates were found to be significantly higher in patients who underwent ICSI/ET with frozen-thawed testicular sperm compared to fresh sperm group. The miscarriage rates were significantly lower in the frozen-thawed sperm group compared to the fresh testicular sperm group. Clinical pregnancy was detected in 18 cases, while no pregnancy was detected in 82 cases undergoing ICSI with fresh sperm. In the group where ICSI/ET was applied with frozen sperm, clinical pregnancy was detected in 51 cases, whereas pregnancy was not detected in 49 cases. In the frozen sperm group, in addition to C/S and multiple pregnancy rates, the number of babies with a birth weight below 2500 g was significantly higher than in the fresh sperm group. There was no significant difference between the groups in terms of minor and major congenital anomalies, birth weight, gestational age at delivery, stillbirth and neonatal death. Conclusion: Using fresh or frozen testicular sperm does not have a significant effect on perintal outcome in patients with azoospermia.

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The Correlation Between Bronchopulmonary Dysplasia and Platelet Metabolism in Preterm Infants

Frontiers in Pediatrics ◽

10.3389/fped.2021.670469 ◽

2021 ◽

Vol 9 ◽

Author(s):

Longli Yan ◽

Zhuxiao Ren ◽

Jianlan Wang ◽

Xin Xia ◽

Liling Yang ◽

...

Keyword(s):

Platelet Count ◽

Birth Weight ◽

Preterm Infants ◽

Bronchopulmonary Dysplasia ◽

Premature Infants ◽

Gestational Age ◽

Admission Diagnosis ◽

Control Group ◽

The Relationship

Background: Platelets play an important role in the formation of pulmonary blood vessels, and thrombocytopenia is common in patients with pulmonary diseases. However, a few studies have reported on the role of platelets in bronchopulmonary dysplasia.Objective: The objective of the study was to explore the relationship between platelet metabolism and bronchopulmonary dysplasia in premature infants.Methods: A prospective case-control study was performed in a cohort of premature infants (born with a gestational age <32 weeks and a birth weight <1,500 g) from June 1, 2017 to June 1, 2018. Subjects were stratified into two groups according to the diagnostic of bronchopulmonary dysplasia: with bronchopulmonary dysplasia (BPD group) and without bronchopulmonary dysplasia (control group). Platelet count, circulating megakaryocyte count (MK), platelet-activating markers (CD62P and CD63), and thrombopoietin (TPO) were recorded and compared in two groups 28 days after birth; then serial thrombopoietin levels and concomitant platelet counts were measured in infants with BPD.Results: A total of 252 premature infants were included in this study. Forty-eight premature infants developed BPD, 48 premature infants without BPD in the control group who were matched against the study infants for gestational age, birth weight, and admission diagnosis at the age of postnatal day 28. Compared with the controls, infants with BPD had significantly lower peripheral platelet count [BPD vs. controls: 180.3 (24.2) × 109/L vs. 345.6 (28.5) × 109/L, p = 0.001]. Circulating MK count in the BPD group was significantly more abundant than that in the control group [BPD vs. controls: 30.7 (4.5)/ml vs. 13.3 (2.6)/ml, p = 0.025]. The level of CD62p, CD63, and TPO in BPD group was significantly higher than the control group [29.7 (3.1%) vs. 14.5 (2.5%), 15.4 (2.0%) vs. 5.8 (1.7%), 301.4 (25.9) pg/ml vs. 120.4 (14.2) pg/ml, all p < 0.05]. Furthermore, the concentration of TPO was negatively correlated with platelet count in BPD group with thrombocytopenia.Conclusions: Our findings suggest that platelet metabolism is involved in the development of BPD in preterm infants. The possible mechanism might be through increased platelet activation and promoted TPO production by feedback.

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Customized versus Population-Based Birth Weight References for Predicting Fetal and Neonatal Undernutrition

Fetal Diagnosis and Therapy ◽

10.1159/000433428 ◽

2015 ◽

Vol 39 (3) ◽

pp. 198-208 ◽

Cited By ~ 2

Author(s):

Juan Jesús Fernández-Alba ◽

Carmen González-Macías ◽

Raquel León del Pino ◽

Fabiana Prado Fernandes ◽

Carolina Lagares Franco ◽

...

Keyword(s):

Birth Weight ◽

Pregnant Women ◽

Gestational Age ◽

Predictive Value ◽

Population Based ◽

Maternal Weight ◽

Gestational Age At Delivery ◽

Preterm Babies ◽

And Gender ◽

Singleton Pregnancies

Objectives: The aim of our study was to construct a model of customized birth weight curves based on a Spanish population and to compare the ability of this customized model to our population-based chart to predict a neonatal ponderal index (PI) <10th percentile. Methods: We developed a model that can predict the 10th percentile for a fetus according to gestational age and gender as well as maternal weight, height, and age. We compared the ability of this customized model to that of our own population-based model to predict a neonatal PI <10th percentile. Data from a large database were used (32,854 live newborns, from 1993 through 2012). Only singleton pregnancies with a gestational age at delivery of 32-42 weeks were included. Results: In the entire pregnant population, the customized method was superior to the population-based method for detecting newborns with a PI <10th percentile (sensitivity: 55 vs. 40.96%; specificity: 99.6 vs. 91.23%; positive predictive value: 11.49 vs. 9.55%, and negative predictive value: 98.84 vs. 98.55%, respectively). In pregnant women with a BMI >90th percentile, the sensitivity was 75%, compared to 50% in the population-based method. In pregnant women with a height >90th percentile, the sensitivity was almost as high as in the population-based method (61.53 vs. 33.33%). Conclusion: The customized birth weight curve is superior to the population-based method for the detection of newborns with a PI <10th percentile. This is especially the case in women in the higher scales of height and weight as well as in preterm babies.

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Development of Symphysio Fundal Height Curve

Bangladesh Journal of Obstetrics & Gynaecology ◽

10.3329/bjog.v32i1.56729 ◽

2017 ◽

Vol 32 (1) ◽

pp. 20-24

Author(s):

Chowdhury Taslima Nasrein ◽

Ferdousi Begum ◽

Jaglul Haider Khan ◽

Novera Islam ◽

Zahangir Alam

Keyword(s):

Birth Weight ◽

Low Birth Weight ◽

Pregnant Women ◽

Gestational Age ◽

Cross Sectional ◽

Medical College ◽

Gestation Age ◽

The Mean ◽

Relationship Of ◽

The Relationship

Objective: To Develop a symphysio fundal height(SFH) curve of pregnant women from 20 weeks of pregnancy onwards; and to find out the relationship of fundal height with different variables. Methodology: A cross-sectional hospital based study was conducted from 1st january 2010 to 31st December 2010 on 159 patients with gestation age less than 20 weeks at entry in the OPD of Department of Obstetric and Gynaecology, Shaheed Suhrawardy Medical College & Hospital, Shere-e Bangla Nagar, Dhaka,Bangladesh. All the patients were followed up till delivery. Results: The measurements of SFH obtained on the basis of 10, 50th and 90th percentiles and the rate of growth of SFH was approximately 5 mm per week from 24 weeks to 36 weeks and thereafter it was 5-6 mm per week till 40 weeks.Patients with higher socioeconomic class had higher symphysio fundal height.SFH is less in younger subjects. SFH increases with increased height,weight,gestational age,gravidity of mothers and birth weight of the baby.Multiparous was predominant and more than one third (34.6%) of the study patients height belonged to 1.51 - 1.60 meters. The mean±SD gestational age was 39.2±1.4 weeks with range from 28 to 41 weeks. Low birth weight was found 17.0% and the mean±SD birth weight was 2.8±0.4 kg with range from 1.9 to 3.8 kg. Bangladesh J Obstet Gynaecol, 2017; Vol. 32(1): 20-24

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Prevalence of maternal periodontitis and its association with preterm and low birth weight infants: a hospital-based study

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20191530 ◽

2019 ◽

Vol 8 (5) ◽

pp. 1767

Author(s):

Priyanka S. ◽

Sowmya Koteshwara ◽

Anitha Subappa

Keyword(s):

Birth Weight ◽

Low Birth Weight ◽

Pregnant Women ◽

Gestational Age ◽

Tertiary Care ◽

Care Hospital ◽

Low Birth Weight Infants ◽

Mortality And Morbidity ◽

Severe Periodontitis ◽

Gestational Age At Delivery

Background: Preterm deliveries and low birth are important causes of infant mortality and morbidity. The aim of this study was to evaluate the association between maternal periodontitis and preterm and low birth weight at delivery and to correlate the severity of periodontitis with obstetric outcome.Methods: This was a prospective observational study conducted in Outpatient Department of Tertiary Care Hospital. Pregnant women who had regular antenatal checkup at were screened clinically for periodontitis. Those who were diagnosed with periodontitis and satisfied the inclusion and exclusion criteria were considered as cases (n=45) and equal number of pregnant women without periodontal disease (n=45) were included in the study as controls. These patients were followed up and gestational age at delivery and baby’s birth weight was noted and correlated to the maternal periodontal status.Results: The prevalence of maternal periodontitis was found to be 11.4%. Mean age, socioeconomic status and educational status was comparable. 33.3%, 40% of the cases v/s 17.8%, 24.4% of controls had preterm deliveries and LBW infants respectively. 26.8% of cases with mild periodontitis and all cases of moderate and severe periodontitis had preterm birth. Additionally, 34.1% of cases with mild periodontitis and all cases with moderate and severe periodontitis had low birth weight infants (p=0.02).Conclusions: Maternal periodontitis is found to be associated with preterm and low birth weight deliveries. The severity of periodontitis is inversely related to gestational age at delivery and birth weight of infant. Thus, periodontitis is suggested to be a modifiable risk factor for preterm and low birth deliveries.

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Exclusive and Dual Cigarette and Hookah Smoking Is Associated with Adverse Perinatal Outcomes among Pregnant Women in Cairo, Egypt

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph182412974 ◽

2021 ◽

Vol 18 (24) ◽

pp. 12974

Author(s):

Omar El-Shahawy ◽

Kareem Labib ◽

Elizabeth Stevens ◽

Linda G. Kahn ◽

Wagida Anwar ◽

...

Keyword(s):

Birth Weight ◽

Pregnant Women ◽

Tobacco Use ◽

Perinatal Outcomes ◽

Prenatal Smoking ◽

Childbearing Age ◽

Low Birth Weight Babies ◽

Hookah Smoking ◽

Gestational Age At Delivery ◽

Exhaled Carbon Monoxide

This study assessed the prevalence of prenatal smoking, factors associated with prenatal smoking, and its association with birth outcomes in a sample of pregnant women in Egypt. Pregnant women were recruited during their last trimester from antenatal clinics in Cairo from June 2015 to May 2016. Participants completed an interviewer-administered survey that assessed tobacco use and attitudes, and exhaled carbon monoxide (CO) was measured. Gestational age at delivery and offspring birth weight were collected via a postnatal phone interview. Two hundred pregnant women ages 16–37 years participated. More than a quarter (29.0%) of women reported smoking (cigarettes, hookah, or both) during their current pregnancy, and hookah was more popular than cigarettes. Most women who smoked prior to their current pregnancy either maintained their current smoking habits (46.6%) or switched from dual to hookah-only smoking (46.6%). Current smokers during pregnancy had a higher mean (±SD) exhaled CO level (2.97 ± 1.45 vs. 0.25 ± 0.60 ppm, p < 0.001) and had babies with a lower mean birth weight (2583 ± 300 vs. 2991 ± 478 g, p < 0.001) than non-smokers. Smokers during pregnancy had greater odds of premature birth and/or low birth weight babies compared to non-smokers. Dual cigarette-hookah smokers had the highest risk. Additional focused programs are required to prevent women of childbearing age from initiating tobacco use and empower women to stop tobacco use during the preconception and gestational periods.

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Perinatal Outcome in Assisted Reproductive Pregnancies: Comparative Analysis of Reduced versus Unreduced Gestation

International Journal of Reproductive Medicine ◽

10.1155/2016/7504609 ◽

2016 ◽

Vol 2016 ◽

pp. 1-6 ◽

Cited By ~ 1

Author(s):

Shilpa Bhandari ◽

Pallavi Agrawal ◽

Ishita Ganguly ◽

Aparna Singh ◽

Nitika Gupta

Keyword(s):

Birth Weight ◽

Live Birth ◽

Gestational Age ◽

Birth Rate ◽

Perinatal Outcomes ◽

Live Birth Rate ◽

Multiple Gestation ◽

Fetal Reduction ◽

Gestation Age ◽

Gestational Age At Delivery

Objectives. This study aims to evaluate perinatal outcomes such as gestational age at delivery and live birth rate in singleton and twin gestation with or without fetal reduction. Method. A retrospective analysis was done on patients which were divided into reduced and unreduced groups on the basis of order of reduction of one or more fetuses between 6 and 13 weeks of gestation. Patients records were studied to note gestational age at delivery/abortion, birth weight, and neonatal outcome. Result. The cohort included a total of 292 patients: 102 singletons and 190 twins. 52 pregnancies were reduced in singleton cohort and 68 were reduced in twin cohort. No statistical difference was observed in live birth rate, gestational age at delivery, and birth weight and significant higher incidence of IUGR was observed in reduced and unreduced twin gestation. In singleton pregnancies however preterm delivery rate increased with fetal reduction. Conclusion. Although reduction does not reduce the live birth rate, it does reduce gestation age of delivery and birth weight of newborn. This effect is more apparent when multiple gestation is reduced to singleton.

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HPV Prevalence and its Association with Perinatal Outcomes among Singleton Mothers: Analysis of Pregnancy Risk Assessment and Monitoring System (PRAMS) Data, 2004-2011

Current Women s Health Reviews ◽

10.2174/1573404814666180517085022 ◽

2019 ◽

Vol 15 (2) ◽

pp. 143-149 ◽

Cited By ~ 1

Author(s):

Harpriya Kaur ◽

Delf Schmidt-Grimminger ◽

Baojiang Chen ◽

K.M. Monirul Islam ◽

Steven W. Remmenga ◽

...

Keyword(s):

Birth Weight ◽

Low Birth Weight ◽

Pregnant Women ◽

Monitoring System ◽

Large Population ◽

Perinatal Outcomes ◽

Hpv Infection ◽

Adverse Outcomes ◽

P Value ◽

Pregnancy Risk

Background: Pregnancy may increase the risk of Human Papillomavirus (HPV) infection because of pregnancy induced immune suppression. The objective of this study was to use a large population-based dataset to estimate the prevalence of HPV infection and its association with adverse outcomes among pregnant women. Methods: We analyzed Pregnancy Risk Monitoring System data from 2004-2011 (N=26,085) to estimate the self-reported HPV infection. Survey logistic procedures were used to examine the relationship between HPV infection and adverse perinatal outcomes. Results: Approximately 1.4% of women were estimated to have HPV infection during their pregnancy. The prevalence of adverse outcomes in this sample was preterm birth (8.4%), preeclampsia (7.5%), low birth weight (6.3%) and premature rupture of membranes (2.8%). Compared to women without HPV infection, HPV infection positive women were much more likely to have had other infections such as chlamydia (9.23% vs. 2.12%, p-value <.0001), Group B Strep (21.7% vs. 10.04%, p-value <.0001), and herpes (7.17% vs. 1.07%, p-value <.0001). After adjusting for other risk factors including other infections, HPV infection was significantly associated with low birth weight (OR: 1.94, 95% CI: 1.14-3.30). Conclusion: The study indicated a potential association between HPV infection and low birth weight. Because pregnant women with HPV infection are at higher risk of other infections, future research may focus on the roles of co-infection in the development of adverse perinatal effects.

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