Effects of hydrated sodium calcium aluminosilicate on growth performance, fatty liver, intestine morphology, and serum parameters of overfed geese

2018 ◽  
Vol 58 (10) ◽  
pp. 1876 ◽  
Author(s):  
Junwang Tang ◽  
Maxue Lu ◽  
Qianqian Fang ◽  
Feizhen Lu ◽  
Rongyi Shao ◽  
...  
Keyword(s):  
Treatment Group ◽  
Fatty Liver ◽  
Liver Weight ◽  
Villus Height ◽  
Very Low Density Lipoproteins ◽  
Serum Parameters ◽  
Crypt Depth ◽  
Sodium Calcium ◽  
Calcium Aluminosilicate ◽  
Landes Geese

In geese, overfeeding induces hepatic steatosis and makes the liver functions enhanced. Aluminosilicate absorbs toxins created by moulds in animal feeds and enhances nutrient absorption. In the present study, the effects of hydrated sodium calcium aluminosilicate (Improved HSCAS, Jumpstar) on the growth performance, fatty liver, serum parameters, and intestinal morphology of overfed Landes geese were evaluated. The study included two Control groups, a non-overfed Control (Control I) and an overfed Control (Control II), as well as a treatment group. The results showed that compared with the Control I group, liver weight, relative liver weight, abdominal fat weight, intestinal fat weight, villus height, total cholesterol, very low density lipoproteins, lipoprotein lipase, aspartate aminotransferase, IgM, and IgG in the HSCAS treatment group all significantly increased (P < 0.05) at Days 10 and 20. The villus height/crypt depth, triglycerides, cholinesterase, alanine aminotransferase, and serum IgA levels were higher than those in the Control I (P < 0.05) after 20 days of overfeeding. Compared with the Control II group, the relative abdominal fat weight, relative intestinal fat weight, and crypt depth in the HSCAS treatment group were significantly increased (P < 0.05) after 10 days of overfeeding, whereas villus height/crypt depth decreased (P < 0.05). Relative liver weight and IgA were higher in HACAS group after 20 days’ overfeeding (P < 0.05). HSCAS treatment also led to higher cholinesterase, very low density lipoproteins and decreased lipase, alanine aminotransferase (P > 0.05), and decreased aspartate aminotransferase levels than those in the Control II group (P < 0.05). In conclusion, HSCAS treatment had a beneficial effect on fatty liver production, intestinal development, and serum parameters in overfed Landes geese, which could enhance the health status of these geese.

scholarly journals Mitigation Effects of Bentonite and Yeast Cell Wall Binders on AFB1, DON, and OTA Induced Changes in Laying Hen Performance, Egg Quality, and Health

Toxins ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 156
Author(s):  
Ling Zhao ◽  
Yue Feng ◽  
Jing-Tao Wei ◽  
Meng-Xiang Zhu ◽  
Lei Zhang ◽  
...  
Keyword(s):  
Laying Hens ◽  
Egg Quality ◽  
Dietary Supplementation ◽  
Basal Diet ◽  
Liver Weight ◽  
Laying Hen ◽  
Egg Laying ◽  
Villus Height ◽  
Crypt Depth ◽  
Induced Changes

The objective of this study was to evaluate the efficacy of mycotoxin binders in reducing the adverse effects of co-occurring dietary aflatoxin B1 (AFB1), deoxynivalenol (DON) and ochratoxin A (OTA) on laying hens. Three hundred and sixty 26-week-old Roman laying hens were randomly allocated into four experimental groups with 10 replicates of nine birds each. The four groups received either a basal diet (BD; Control), a BD supplemented with 0.15 mg/kg AFB1 + 1.5 mg/kg DON + 0.12 mg/kg OTA (Toxins), a BD + Toxins with Toxo-HP binder (Toxins + HP), or a BD + Toxins with TOXO XL binder (Toxins + XL) for 12 weeks. Compared to the control, dietary supplementation of mycotoxins decreased (P < 0.10) total feed intake, total egg weight, and egg-laying rate, but increased feed/egg ratio by 2.5–6.1% and mortality during various experimental periods. These alterations induced by mycotoxins were alleviated by supplementation with both TOXO HP and XL binders (P < 0.10). Furthermore, dietary mycotoxins reduced (P < 0.05) eggshell strength by 12.3% and caused an accumulation of 249 μg/kg of DON in eggs at week 12, while dietary supplementation with TOXO HP or XL mitigated DON-induced changes on eggshell strength and prevented accumulation of DON in eggs (P < 0.05). Moreover, dietary mycotoxins increased relative liver weight, but decreased spleen and proventriculus relative weights by 11.6–22.4% (P < 0.05). Mycotoxin exposure also increased alanine aminotransferase activity and reduced immunoglobulin (Ig) A, IgM, and IgG concentrations in serum by 9.2–26.1% (P < 0.05). Additionally, mycotoxin exposure induced histopathological damage and reduced villus height, villus height/crypt depth, and crypt depth in duodenum, jejunum and (or) ileum (P < 0.05). Notably, most of these histological changes were mitigated by supplementation with both TOXO HP and XL (P < 0.05). In conclusion, the present study demonstrated that the mycotoxin binders TOXO HP and XL can help to mitigate the combined effects of AFB1, DON, and OTA on laying hen performance, egg quality, and health.

scholarly journals A Serum Metabolic Profiling Analysis During the Formation of Fatty Liver in Landes Geese via GC-TOF/MS

2020 ◽  
Vol 11 ◽  
Author(s):  
Yujie Gong ◽  
Wentao Lyu ◽  
Xingfen Shi ◽  
Xiaoting Zou ◽  
Lizhi Lu ◽  
...  
Keyword(s):  
Fatty Liver ◽  
Metabolic Pathways ◽  
Liver Steatosis ◽  
Liver Weight ◽  
The Body ◽  
Flight Mass Spectrometry ◽  
Similar Weight ◽  
Underlying Mechanisms ◽  
Landes Geese ◽  
Tof Ms

During the process of fatty liver production by overfeeding, the levels of endogenous metabolites in the serum of geese would change dramatically. This study investigated the effects of overfeeding on serum metabolism of Landes geese and the underlying mechanisms using a metabolomics approach. Sixty Landes geese of the same age were randomly divided into the following three groups with 20 replicates in each group: D0 group (free from gavage); D7 group (overfeeding for 7 days); D25 group (overfeeding for 25 days). At the end of the experiment, 10 geese of similar weight from each group were selected for slaughter and sampling. The results showed that overfeeding significantly increased the body weight and the liver weight of geese. Serum enzymatic activities and serum lipid levels were significantly enhanced following overfeeding. Gas chromatography time-of-flight/mass spectrometry (GC-TOF/MS) was employed to explore the serum metabolic patterns, and to identify potential contributors to the formation of fatty liver and the correlated metabolic pathways. Relative to overfeeding for 7 days, a large number of endogenous molecules in serum of geese overfed for 25 days were altered. Continuous elevated levels of pyruvic acid, alanine, proline and beta-glycerophosphoric acid and reduced lactic acid level were observed in the serum of overfed geese. Pathway exploration found that the most of significantly different metabolites were involved in amino acids, carbohydrate and lipid metabolism. The present study exhibited the efficient capability of Landes geese to produce fatty liver, identified potential biomarkers and disturbed metabolic pathways in liver steatosis. These findings might reveal the underlying mechanisms of fatty liver formation and provide some theoretical basis for the diagnosis and treatment of liver diseases.

scholarly journals A Serum Metabolic Profiling Analysis During the Formation of Fatty Liver in Landes Geese via Gc-tof/ms

2020 ◽  
Author(s):  
Yujie Gong ◽  
Wentao Lyu ◽  
Xingfen Shi ◽  
Xiaoting Zou ◽  
Lizhi Lu ◽  
...  
Keyword(s):  
Fatty Liver ◽  
Metabolic Pathways ◽  
Liver Weight ◽  
The Body ◽  
Metabolic Profiling Analysis ◽  
Underlying Mechanisms ◽  
Endogenous Metabolites ◽  
Landes Geese ◽  
Profiling Analysis ◽  
Tof Ms

Abstract Background:During the process of fatty liver production by overfeeding, the levels of endogenous metabolites in the serumof geese would change dramatically. This study investigated the effects of overfeeding on serum metabolism of Landes geese and the underlying mechanisms using a metabolomics approach.Results:Sixty Landes geese of the same age were randomly divided into the following 3 groups: D0 group (free from gavage); D7 group (overfeeding for 7 days); D25 group (overfeeding for 25 days). The results showed that overfeeding significantly increased the body weight and the liver weight of geese. Serum enzymatic activities and serum lipid levels were significantly enhanced following overfeeding.Gas chromatography time-of-flight/massspectrometry (GC-TOF/MS) was employed to explore the serum metabolic patterns, and to identify potential contributors to the formation of fatty liver and the correlatedmetabolic pathways. A large number of endogenous molecules in serum were altered, especially at the late stage of overfeeding (7 days to 25 days). Continuous elevated levels of pyruvic acid, alanine, proline and beta-glycerophosphoric acid and reduced lactic acid level were observed in the serum of overfed geese. Pathway exploration found that the most of significantly different metabolites were involved in various amino acids metabolism, carbohydrate metabolismand lipid metabolism.Conclusions: These findings pinpoint specific metabolite changes and identify potential biomarkers for early diagnosis of fatty liver disease, as well as provide insights into the perturbation of metabolic pathways involved in fatty liver formation.

scholarly journals Non-Alcoholic Fatty Liver in Patients with Chylomicronemia

2021 ◽  
Vol 10 (4) ◽  
pp. 669
Author(s):  
Mélanie Maltais ◽  
Diane Brisson ◽  
Daniel Gaudet
Keyword(s):  
Acute Pancreatitis ◽  
Fatty Liver ◽  
Transient Elastography ◽  
Very Low Density Lipoproteins ◽  
Alcoholic Fatty Liver ◽  
The Metabolic Syndrome ◽  
Increased Risk ◽  
Main Driver ◽  
Liver Ultrasonography

Non-alcoholic fatty liver disease (NAFLD) is frequent in patients with features of the metabolic syndrome (MetS), obesity, or type 2 diabetes. Lipoprotein lipase (LPL) is the main driver of triglyceride (TG) hydrolysis in chylomicrons and very-low density lipoproteins (VLDL). In some patients with MetS, dysfunction of this pathway can lead to plasma TG values > 10 mmol/L (multifactorial chylomicronemia or MCS). Chylomicronemia also characterizes LPL deficiency (LPLD), a rare autosomal recessive disease called familial chylomicronemia syndrome (FCS), which is associated with an increased risk of recurrent pancreatitis. This study aims to investigate the expression of NAFLD, as assessed by transient elastography, in MCS and FCS subjects. Data were obtained from 38 subjects with chylomicronemia; 19 genetically confirmed FCS and 19 sex- and age-matched MCS. All participants underwent liver ultrasonography and stiffness measurement after a 4-h fast using transient elastography (FibroScan®, Echosens, Waltham, MA, USA). NAFLD (controlled attenuation parameter (CAP) > 280 dB/m) was observed in 42.1% of FCS and 73.7% of MCS subjects (p = 0.05). FCS subjects had lower body mass index (BMI) than MCS. Only 25% of FCS subjects with NAFLD had a BMI ≥ 30 compared to 64.3% in MCS (p = 0.004). In FCS, NAFLD occurred even in the presence of very low (≤18 kg/m2) BMI. In both FCS and MCS, CAP was negatively associated with acute pancreatitis risk. In this study, NAFLD was commonly observed in both FCS and MCS subjects and occurred independently of the BMI and fasting glucose values in FCS; NAFLD was associated with a lower occurrence of acute pancreatitis episodes.

scholarly journals Effects of Dietary β-Mannanase Supplementation on Growth Performance, Apparent Total Tract Digestibility, Intestinal Integrity, and Immune Responses in Weaning Pigs

Animals ◽  
2020 ◽  
Vol 10 (4) ◽  
pp. 703
Author(s):  
Jae-Cheol Jang ◽  
Kwang Kim ◽  
Young Jang ◽  
Yoo Kim
Keyword(s):  
Oxidative Stress ◽  
Body Weight ◽  
Growth Performance ◽  
Basal Diet ◽  
Villus Height ◽  
Crypt Depth ◽  
Intestinal Integrity ◽  
Weaning Pigs ◽  
Dietary Treatments ◽  
And Oxidative Stress

The experiment aimed to investigate the effects of dietary β-mannanase supplementation on growth performance, apparent total tract digestibility (ATTD) of nutrients, intestinal integrity, and the immunological and oxidative stress parameters in weaning pigs. A total of 64 newly weaning pigs (initial body weight: 6.96 ± 0.70 kg) were allotted to two dietary treatments in eight replicates per treatment with four pigs per pen based on body weight and sex. Dietary treatments were 1.) CON (control: corn-soybean meal based basal diet) and 2.) β-mannanase (basal diet +0.06% β-mannanase). The β-mannanase supplementation did not affect growth performance, concentrations of acute phase protein, superoxide dismutase and glutathione peroxidase. However, the pigs fed the β-mannanase-supplemented diet had greater ATTD of ether extract, jejunum villus height, and villus height-to-crypt depth ratio, and lower crypt depth compared with those fed the CON diet (p < 0.05). The pigs fed the β-mannanase-supplemented diet tended to have the lower count of E. coli in cecum than those fed the CON diet (p = 0.08). In conclusion, dietary β-mannanase supplementation did not affect growth performance, immune response and oxidative stress of weaning pigs, whereas it increased fat digestibility and had positive effects on intestinal integrity and cecum microflora by reducing the count of E.coli.

scholarly journals Diminution of Aflatoxicosis in Growing Chickens by the Dietary Addition of a Hydrated, Sodium Calcium Aluminosilicate

1990 ◽  
Vol 69 (5) ◽  
pp. 727-735 ◽  
Author(s):  
L.F. KUBENA ◽  
R.B. HARVEY ◽  
T.D. PHILLIPS ◽  
D.E. CORRIER ◽  
W.E. HUFF
Keyword(s):  
Sodium Calcium ◽  
Calcium Aluminosilicate

scholarly journals Hydrated Sodium Calcium Aluminosilicate: Effects on Zinc, Manganese, Vitamin A, and Riboflavin Utilization

1990 ◽  
Vol 69 (8) ◽  
pp. 1364-1370 ◽  
Author(s):  
T.K. CHUNG ◽  
J.W. EKDMAN ◽  
D.H. BAKER
Keyword(s):  
Vitamin A ◽  
Sodium Calcium ◽  
Calcium Aluminosilicate

scholarly journals 362 Effect of a modified hydrated sodium calcium aluminosilicate adsorbent on the growth performance, nutrients digestibility, and digestive tract morphology of chicks challenged with T-2 toxin

2019 ◽  
Vol 97 (Supplement_3) ◽  
pp. 129-130
Author(s):  
Kun-Tan Wu ◽  
Lv-hui Sun ◽  
Jin-Tao Wei ◽  
Ni-Ya Zhang
Keyword(s):  
Growth Performance ◽  
Digestive Tract ◽  
Body Weight Gain ◽  
Development Program ◽  
Dietary Supplementation ◽  
Lymphoid Cells ◽  
Control Group ◽  
Sodium Calcium ◽  
Calcium Aluminosilicate ◽  
Nutrients Digestibility

Abstract The objective of this study was to evaluate the modified hydrated sodium calcium aluminosilicate (HSCAS) adsorbent ability to reduce the toxicity of T-2 toxin in broilers. 96 one-day-old male broilers were randomly allocated to 4 experimental groups with 4 replicates of 6 birds each. The four groups 1–4 were received the basal diet (BD), BD plus 6.0 mg/kg T-2 toxin, BD plus 6.0 mg/kg T-2 toxin with 0.05% modified HSCAS adsorbent, BD plus 0.05% modified HSCAS adsorbent, respectively, for 2 weeks. The growth performance, nutrients digestibility, and digestive tract histopathology were analyzed. Compared with the control group, dietary supplementation of T-2 toxin decreased (P &lt; 0.05) body weight gain, feed intake and feed conversion by 11.4–31.8% during d 1–7, d 8–14 and d 1–14. Dietary supplementation of T-2 toxin also decreased (P &lt; 0.05) the apparent metabolic rate of crude protein, calcium, and total phosphorus by 14.9–16.1% during d 8–14. These alterations induced by T-2 toxin were mitigated or prevented (P &lt; 0.05) by the supplementation of the modified HSCAS adsorbent. Meanwhile, dietary modified HSCAS adsorbent supplementation also prevented (P &lt; 0.05) T-2 toxin-induced morphological changes and damage, such as severe degeneration and desquamation of the villous epithelial cells, congestion in intestinal lamina propria, and edema and thicken in the serosa with infiltration of numerous lymphoid cells, in the gizzard, duodenum, jejunum, and ileum of broilers. Notably, dietary supplementation of the modified HSCAS adsorbent alone did not affect (P &gt; 0.05) any of those parameters. In conclusion, these findings indicate this novel HSCAS could be used as a promising adsorbent for protecting against T-2 toxin-induced toxicity in chicks (This work was supported in part by the National Key Research and Development Program of China, Projects 2018YFD0500601 and 2016YFD0501207).

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