scholarly journals Increasing disparities between resource inputs and outcomes, as measured by certain health deliverables, in biomedical research

2015 ◽  
Vol 112 (36) ◽  
pp. 11335-11340 ◽  
Author(s):  
Anthony Bowen ◽  
Arturo Casadevall
Keyword(s):  
Biomedical Research ◽  
High Impact ◽  
National Institutes Of Health ◽  
Future Research ◽  
Scientific Journals ◽  
Scientific Enterprise ◽  
Numerical Development ◽  
Scientific Outputs ◽  
Research Questions ◽  
Research Investments

Society makes substantial investments in biomedical research, searching for ways to better human health. The product of this research is principally information published in scientific journals. Continued investment in science relies on society’s confidence in the accuracy, honesty, and utility of research results. A recent focus on productivity has dominated the competitive evaluation of scientists, creating incentives to maximize publication numbers, citation counts, and publications in high-impact journals. Some studies have also suggested a decreasing quality in the published literature. The efficiency of society’s investments in biomedical research, in terms of improved health outcomes, has not been studied. We show that biomedical research outcomes over the last five decades, as estimated by both life expectancy and New Molecular Entities approved by the Food and Drug Administration, have remained relatively constant despite rising resource inputs and scientific knowledge. Research investments by the National Institutes of Health over this time correlate with publication and author numbers but not with the numerical development of novel therapeutics. We consider several possibilities for the growing input-outcome disparity including the prior elimination of easier research questions, increasing specialization, overreliance on reductionism, a disproportionate emphasis on scientific outputs, and other negative pressures on the scientific enterprise. Monitoring the efficiency of research investments in producing positive societal outcomes may be a useful mechanism for weighing the efficacy of reforms to the scientific enterprise. Understanding the causes of the increasing input-outcome disparity in biomedical research may improve society’s confidence in science and provide support for growing future research investments.

scholarly journals Article-level assessment of influence and translation in biomedical research

2017 ◽  
Vol 28 (11) ◽  
pp. 1401-1408 ◽  
Author(s):  
George M. Santangelo
Keyword(s):  
Impact Factor ◽  
Biomedical Research ◽  
Journal Impact Factor ◽  
Relevant Literature ◽  
Scientific Progress ◽  
Careful Analysis ◽  
Data Driven ◽  
Scientific Enterprise ◽  
Research Investments ◽  
Journal Impact

Given the vast scale of the modern scientific enterprise, it can be difficult for scientists to make judgments about the work of others through careful analysis of the entirety of the relevant literature. This has led to a reliance on metrics that are mathematically flawed and insufficiently diverse to account for the variety of ways in which investigators contribute to scientific progress. An urgent, critical first step in solving this problem is replacing the Journal Impact Factor with an article-level alternative. The Relative Citation Ratio (RCR), a metric that was designed to serve in that capacity, measures the influence of each publication on its respective area of research. RCR can serve as one component of a multifaceted metric that provides an effective data-driven supplement to expert opinion. Developing validated methods that quantify scientific progress can help to optimize the management of research investments and accelerate the acquisition of knowledge that improves human health.

The Collaborative Network Approach: a model for advancing patient-centric research for Castleman disease and other rare diseases

2019 ◽  
Vol 3 (1) ◽  
pp. 97-105
Author(s):  
Mary Zuccato ◽  
Dustin Shilling ◽  
David C. Fajgenbaum
Keyword(s):  
Rare Diseases ◽  
Treatment Options ◽  
Castleman Disease ◽  
High Impact ◽  
Collaborative Network ◽  
Network Approach ◽  
Grant Applications ◽  
Research Questions ◽  
Novel Strategy ◽  
Patient Centric

Abstract There are ∼7000 rare diseases affecting 30 000 000 individuals in the U.S.A. 95% of these rare diseases do not have a single Food and Drug Administration-approved therapy. Relatively, limited progress has been made to develop new or repurpose existing therapies for these disorders, in part because traditional funding models are not as effective when applied to rare diseases. Due to the suboptimal research infrastructure and treatment options for Castleman disease, the Castleman Disease Collaborative Network (CDCN), founded in 2012, spearheaded a novel strategy for advancing biomedical research, the ‘Collaborative Network Approach’. At its heart, the Collaborative Network Approach leverages and integrates the entire community of stakeholders — patients, physicians and researchers — to identify and prioritize high-impact research questions. It then recruits the most qualified researchers to conduct these studies. In parallel, patients are empowered to fight back by supporting research through fundraising and providing their biospecimens and clinical data. This approach democratizes research, allowing the entire community to identify the most clinically relevant and pressing questions; any idea can be translated into a study rather than limiting research to the ideas proposed by researchers in grant applications. Preliminary results from the CDCN and other organizations that have followed its Collaborative Network Approach suggest that this model is generalizable across rare diseases.

TheOrvosi Hetilap (Hungarian Medical Journal)in the network of medical journals

2014 ◽  
Vol 155 (22) ◽  
pp. 876-879
Author(s):  
András Schubert
Keyword(s):  
Medical Journal ◽  
Scientific Knowledge ◽  
Knowledge Network ◽  
Scientific Journals ◽  
Scientific Enterprise ◽  
Medical Journals ◽  
The Subject

The role of networks is swiftly increasing in the production and communication of scientific knowledge. Network aspects have, therefore, an ever growing importance in the analysis of the scientific enterprise, as well. The present paper demonstrates some techniques of studying the network of scientific journals on the subject of seeking the position of Orvosi Hetilap (Hungarian Medical Journal) in the international journal network. Orv. Hetil., 2014, 155(22), 876–879.

Dysfunctional Behavior in Organizations: Insights from the Management Control Literature

2017 ◽  
Vol 37 (4) ◽  
pp. 117-141 ◽  
Author(s):  
Krista Fiolleau ◽  
Theresa Libby ◽  
Linda Thorne
Keyword(s):  
Risk Factors ◽  
Internal Control ◽  
Management Control ◽  
Future Research ◽  
Fraud Triangle ◽  
Audit Risk ◽  
Research Opportunities ◽  
Dysfunctional Behavior ◽  
Research Questions ◽  
Published Research

SUMMARY As the scope of the audit continues to broaden (Cohen, Krishnamoorthy, and Wright 2017), research questions in management control and internal control are beginning to overlap. Even so, there is little overlap between these fields in terms of published research to date. The purpose of this paper is to take a step in bridging the gap between the management control and the internal control literatures. We survey relevant findings from the extant management control literature published between 2003 and 2016 on dysfunctional behavior and the ways in which it might be mitigated. We then use the fraud triangle as an organizing framework to consider how the management control literature might help to address audit risk factors identified in SAS 99/AU SEC 316 (AICPA 2002). The outcome of our analysis is meant to identify and classify the extant management control literature of relevance to research on internal control in a manner that researchers new to the management control literature will find accessible. We conclude with a set of future research opportunities that can help to broaden the scope of current research in internal control.

scholarly journals People with amyotrophic lateral sclerosis and their caregivers: what matters most?

2021 ◽  
pp. bmjspcare-2020-002741
Author(s):  
Paola Brunori ◽  
Maria Grazia Celani ◽  
Angelo Alberto Bignamini ◽  
Marzia Carlini ◽  
Rossella Papetti ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Disease Burden ◽  
Anger Management ◽  
Care Service ◽  
Group Discussion ◽  
Future Research ◽  
Text File ◽  
Medical Issues ◽  
Research Questions ◽  
Lateral Sclerosis

ObjectivesThe aim of this study is to collect the perspectives and values of people affected by amyotrophic lateral sclerosis (ALS) and their carers to offer clinicians, researchers and policymakers aspects which are precious in prioritising future research questions and reshaping care service organisations in a participatory approach.Design and settingCohort study using ALS Umbria, the electronic database in Italy.ParticipantsEleven patients and 33 carers who agreed to participate in the study were divided into six focus groups by ‘status’ (patient or carer) and by four severity levels of ‘burden of disease’.MethodsA semiquantitative analysis was undertaken. Each recorded group discussion was transcribed into text file and independently read by two psychologists and two ALS specialists to blindly identify needs, emotions and medical issues, which are the key semantic meanings expressed. Any disagreement in interpretation was resolved through consultation among authors.ResultsCarers pronounced significantly more words related to patient’s disease burden they cared. 40% of subjects expressed the need for ‘assistance’, regardless of the disease burden. ‘Anger’ alone represented more than 1/4 of all expressed emotions and was more common in patients than in carers (73% vs 36%, p=0.077). The most frequent medical issue expressed by 1/3 of participants was ‘difficulty in communication’.ConclusionThis study has given voice to the expectations of those affected by the burden of ALS. ‘Welfare assistance’, ‘anger management’ and resolution of ‘difficulties in communication’ represent issues that need to be analysed in a common prioritised research agenda with sensible and shared outcome measures to implement patient-centred medicine.

scholarly journals Artificial intelligence in hospitals: providing a status quo of ethical considerations in academia to guide future research

AI & Society ◽  
2021 ◽  
Author(s):  
Milad Mirbabaie ◽  
Lennart Hofeditz ◽  
Nicholas R. J. Frick ◽  
Stefan Stieglitz
Keyword(s):  
Artificial Intelligence ◽  
Citation Network ◽  
Status Quo ◽  
Biomedical Ethics ◽  
Future Research ◽  
Ethical Considerations ◽  
Ethical Discourse ◽  
The Status ◽  
Clinical Environments ◽  
Research Questions

AbstractThe application of artificial intelligence (AI) in hospitals yields many advantages but also confronts healthcare with ethical questions and challenges. While various disciplines have conducted specific research on the ethical considerations of AI in hospitals, the literature still requires a holistic overview. By conducting a systematic discourse approach highlighted by expert interviews with healthcare specialists, we identified the status quo of interdisciplinary research in academia on ethical considerations and dimensions of AI in hospitals. We found 15 fundamental manuscripts by constructing a citation network for the ethical discourse, and we extracted actionable principles and their relationships. We provide an agenda to guide academia, framed under the principles of biomedical ethics. We provide an understanding of the current ethical discourse of AI in clinical environments, identify where further research is pressingly needed, and discuss additional research questions that should be addressed. We also guide practitioners to acknowledge AI-related benefits in hospitals and to understand the related ethical concerns.

scholarly journals Translating a Global Emission-Reduction Framework for Subnational Climate Action: A Case Study from the State of Georgia

2021 ◽  
Vol 67 (2) ◽  
pp. 205-227
Author(s):  
Marilyn A. Brown ◽  
Blair Beasley ◽  
Fikret Atalay ◽  
Kim M. Cobb ◽  
Puneet Dwiveldi ◽  
...  
Keyword(s):  
Carbon Footprint ◽  
Global Solutions ◽  
High Impact ◽  
Environmental Benefits ◽  
Future Research ◽  
Carbon Footprints ◽  
Carbon Reduction ◽  
Global Emission ◽  
Greenhouse Gas Reduction ◽  
Climate Action

AbstractSubnational entities are recognizing the need to systematically examine options for reducing their carbon footprints. However, few robust and comprehensive analyses are available that lay out how US states and regions can most effectively contribute. This paper describes an approach developed for Georgia—a state in the southeastern United States called “Drawdown Georgia”, our research involves (1) understanding Georgia’s baseline carbon footprint and trends, (2) identifying the universe of Georgia-specific carbon-reduction solutions that could be impactful by 2030, (3) estimating the greenhouse gas reduction potential of these high-impact 2030 solutions for Georgia, and (4) estimating associated costs and benefits while also considering how the solutions might impact societal priorities, such as economic development opportunities, public health, environmental benefits, and equity. We began by examining the global solutions identified by Project Drawdown. The resulting 20 high-impact 2030 solutions provide a strategy for reducing Georgia’s carbon footprint in the next decade using market-ready technologies and practices and including negative emission solutions. This paper describes our systematic and replicable process and ends with a discussion of its strengths, weaknesses, and planned future research.

Engaging Undergraduate Public Health Students Through a Textbook Creation Project

2020 ◽  
pp. 237337992096241
Author(s):  
Jessica Sloan Kruger ◽  
Christopher Hollister
Keyword(s):  
Public Health ◽  
Future Research ◽  
Open Educational Resource ◽  
Educational Resource ◽  
Final Version ◽  
Primary Motivation ◽  
Course Content ◽  
Health Course ◽  
Research Questions ◽  
Undergraduate Public Health

This study examines students’ perceptions of an open pedagogy experiment in which they created their own textbook for an undergraduate public health course. The lead author’s primary motivation for developing this assignment was the high cost associated with the traditional textbooks that were otherwise needed to cover the breadth of subject matter in the course. The resulting open textbook included 19 chapters, covering all the required components of the course, and the final version was published in a statewide open educational resource repository. Students provided feedback about this undertaking by way of an end-of-term survey. The results showed high percentages of students who associated the textbook creation project with greater engagement and satisfaction than the passive use of traditional textbooks. Students also reported their perception of a learning benefit related to the creation of course content. Pedagogical implications of this study are discussed, and future research questions are proposed.

scholarly journals It’s Time to Change Direction on Agility Research: a Call to Action

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Warren Young ◽  
Russell Rayner ◽  
Scott Talpey
Keyword(s):  
Ecological Validity ◽  
Primary Outcome Measure ◽  
Future Research ◽  
Call To Action ◽  
Change Of Direction ◽  
Movement Component ◽  
Research Questions ◽  
Action Coupling ◽  
Perception Action ◽  
Opinion Article

AbstractAgility is an important skill for both attackers and defenders in invasion sports such as codes of football. On the sporting field, agility requires reacting to a stimulus, often presented by an opponent’s movement, before a change of direction or speed. There is a plethora of research that examines the movement component of agility in isolation, which is described as change-of-direction (COD) ability, and this is thought to underpin agility performance. This opinion article proposes that COD ability should not be researched as the only or primary outcome measure when the objective is to inform agility performance in invasion sports. It is argued that pre-planned COD movements and tests lack ecological validity because they lack perception-action coupling and involve movement out of context from the game. The movement techniques and strength qualities required for the performance of COD tests can be quite different to those required for agility. It is suggested that COD tests can be applied to sports that involve pre-planned COD movements, but researchers should endeavour to use agility tests when studying invasion sports. Some new methods for assessing one-on-one agility contests are reported as potentially valuable for future research, and examples of research questions are provided.

scholarly journals Sustainable Waste Management Innovations in Africa: New Perspectives and Research Agenda for Improving Global Health

2021 ◽  
Vol 13 (12) ◽  
pp. 6646
Author(s):  
Frederick Ahen ◽  
Joseph Amankwah-Amoah
Keyword(s):  
Waste Management ◽  
Future Research ◽  
Limited Attention ◽  
Business Practices ◽  
Sustainable Waste Management ◽  
Production And Consumption ◽  
Incorrect Diagnosis ◽  
Critical Issues ◽  
Green Business ◽  
Research Questions

The need for green business practices and green innovations underscores a growing recognition that climate change is now an existential threat not just to population health but also to the survival of businesses that are unable to embrace green practices with a sense of urgency. This paper contributes to the literature on market violence as an inhibitor of green innovations for sustainable waste management to curb the unneeded health effects of wastes in Africa. Our purpose is to problematize received wisdom, unquestioned assumptions, and incorrect diagnosis of the sources and health consequences of various forms of wastes in Africa. Much of the discourse on this issue remains ahistorical, and that risks leaving aside a vital question of exploitative extraction. By including this ‘out-of-the-box’ explanation through major case references, we are able to shed light on the critical issues that have hitherto received limited attention, thus enabling us to propose useful research questions for future enquiries. We propose a framework that delineates the structural composition of costs imposed by market violence that ranges from extraction to e-waste disposal. We advocate for the engineering of policies that create conditions for doing more with less resources, eliminating waste, and recycling as crucial steps in creating sustainable waste management innovations. Additionally, we highlight a set of fundamental issues regarding enablers and inhibitors of sustainable innovations and policies for waste management worth considering for future research. These include programmed obsolescence, irresponsible extraction, production, and consumption, all seen through the theoretical lens of market violence.

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