scholarly journals Transforming task representations to perform novel tasks

2020 ◽  
Vol 117 (52) ◽  
pp. 32970-32981
Author(s):  
Andrew K. Lampinen ◽  
James L. McClelland

An important aspect of intelligence is the ability to adapt to a novel task without any direct experience (zero shot), based on its relationship to previous tasks. Humans can exhibit this cognitive flexibility. By contrast, models that achieve superhuman performance in specific tasks often fail to adapt to even slight task alterations. To address this, we propose a general computational framework for adapting to novel tasks based on their relationship to prior tasks. We begin by learning vector representations of tasks. To adapt to new tasks, we propose metamappings, higher-order tasks that transform basic task representations. We demonstrate the effectiveness of this framework across a wide variety of tasks and computational paradigms, ranging from regression to image classification and reinforcement learning. We compare to both human adaptability and language-based approaches to zero-shot learning. Across these domains, metamapping is successful, often achieving 80 to 90% performance, without any data, on a novel task, even when the new task directly contradicts prior experience. We further show that metamapping can not only generalize to new tasks via learned relationships, but can also generalize using novel relationships unseen during training. Finally, using metamapping as a starting point can dramatically accelerate later learning on a new task and reduce learning time and cumulative error substantially. Our results provide insight into a possible computational basis of intelligent adaptability and offer a possible framework for modeling cognitive flexibility and building more flexible artificial intelligence systems.

2018 ◽  
Vol 6 (2) ◽  
pp. 99-115
Author(s):  
Borislav Marušić ◽  
Sanda Katavić-Čaušić

Abstract The aim of this paper is to research the word class adjective in one sequence of the ESP: Business English, more precisely English business magazines online. It is an empirical study on the corpus taken from a variety of business magazines online. The empirical analysis allows a comprehensive insight into the word class adjective in this variety of Business English and makes its contribution to English syntax, semantics and word formation. The syntactic part analyses the adjective position in the sentence. The semantic part of the study identifies the most common adjectives that appear in English business magazines online. Most of the analysis is devoted to the word formation of the adjectives found in the corpus. The corpus is analysed in such a way that it enables its division into compounds, derivatives and conversions. The results obtained in this way will give a comprehensive picture of the word class adjective in this type of Business English and can act as a starting point for further research of the word class adjective.


Author(s):  
Paul N. Watton ◽  
Marc Homer ◽  
Justin Penrose ◽  
Harry Thompson ◽  
Haoyu Chen ◽  
...  

Intracranial aneurysms appear as sac-like outpouchings of the cerebral vasculature wall; inflated by the pressure of the blood that fills them. They are relatively common and affect up to 5% of the adult population. Fortunately, most remain asymptomatic. However, there is a small but inherent risk of rupture: 0.1% to 1% of detected aneurysms rupture every year. If rupture does occur there is a 30% to 50% chance of fatality. Consequently, if an aneurysm is detected, clinical intervention may be deemed appropriate. Therapy is currently aimed at pre-rupture detection and preventative treatment. However, interventional procedures are not without risk to the patient. The improvement and optimization of interventional techniques is an important concern for patient welfare and is necessary for rationalisation of healthcare priorities. Hence there is a need to develop methodologies to assist in identifying those ICAs most at risk of rupture. We focus on the mathematical modelling and computational simulation of ICA evolution. Models must take into consideration: (i) the biomechanics of the arterial wall; (ii) the biology of the arterial wall and (iii) the complex interplay between (i) and (ii), i.e. the mechanobiology of the arterial wall. The ultimate ambition of such models is to aid clinical diagnosis on a patient-specific basis. However, due to the significant biological complexity coupled with limited histological information such models are still in their relative infancy. Current research focuses on simulating the evolution of an ICA with an aim to yield insight into the growth and remodelling (G&R) processes that give rise to inception, enlargement, stabilisation and rupture. We present a novel Fluid-Structure-Growth computational framework for modelling aneurysm evolution.


2005 ◽  
Vol 14 (1) ◽  
pp. 141-162
Author(s):  
Clare Spencer

This essay presents a comparative study of the sociological assumptions implicit, and to some extent explicit, in the work of two famous architects, Charles Rennie Mackintosh and Le Corbusier. The inhabitant implied through the architectural practice of Le Corbusier resembles Elias's homo clausus (closed person), the mode of self experience viewed by Elias as the dominant one in Western society and one which sees the individual person as a ‘thinking subject’ and the starting point of knowledge. Mackintosh's designs, in contrast, imply individual people closer to Elias‘s homines aperti, social beings who are shaped through social interaction and interdependence. This paper demonstrates how, as well as fulfilling social, cultural and political needs, architecture carries, within in its designs, certain assumptions about how people and how they do, and should, live. The adoption of an Eliasian perspective provides an interesting insight into how these assumptions can shape self-experience and social interaction in the buildings of each architect.


2017 ◽  
Vol 7 (3) ◽  
pp. 147
Author(s):  
Yvonne Sedelmaier ◽  
Dieter Landes

Good requirements are commonly viewed as a key success factor for IT (and non-IT) projects, but still there seems to be insufficient insight into which competences requirements engineers need to have these days. Digitalization is likely to pose new challenges to requirements engineering. Chances are that digitalization will change the competences that are necessary for successful requirements engineering. This paper proposes a research design that will be used for clarifying which competences requirements engineers need nowadays and how these competences change due to digitalization. To that end, qualitative and quantitative research methods will be combined for developing a comprehensive competence profile for requirements engineering on a scientific basis. The resulting competence profile constitutes a starting point for devising competence-oriented learning settings. Thus, our research contributes to a better understanding of competences for requirements engineering and improves education of future requirements engineers, in particular for coping with challenges posed by digitalization.


Ars Adriatica ◽  
2017 ◽  
Vol 7 (1) ◽  
pp. 379
Author(s):  
Blaženka Perica

The collection of texts Image and Anti-Image – Julije Knifer and the Problem of Representation is based on multi- and transdisciplinary research conducted by Croatian and international critics and theoreticians. They have investigated the contemporary sensibility for the questions of image and pictoriality by referring to a common starting point: the oeuvre of one of the most important Croatian artists – Julije Knifer. In their analysis of Knifer’s paintings since the early 1960s, which revolve around a single motif – the “meander” – which the artist has repeated and varied throughout his artistic career, the authors have followed the changing reception of his work from the supremacy of the high modernist image concept, such as postulated in Greenberg’s formalistic theory, until today, when theoretical proposals have become essentially different. In his introduction to the project, editor Krešimir Purgar has stressed the importance of new perspectives that Knifer’s work may offer if viewed in the context of new disciplines such as visual studies and image science. The 21 articles, grouped into five thematic sections, aim at clarifying and expanding the references of Knifer’s “meander” by taking diverse informative and original approaches that have this recent image theory as their starting point. In the context of Croatian scholarly output, this publication is notable for having accomplished a rare blend between monographic material and a series of interdisciplinary, scholarly-theoretical studies based on extremely varied perspectives, resulting in a valuable comparative miscellany, a contribution both to the actualisation and new positioning of Knifer’s art and to our insight into various analytic and interpretative approaches related to the present state of art theory. Such an approach assigns a special place to the image, to pictoriality and visuality. The theoretical perspectives of image science and the heterogeneous, plural strategies of research developed within the new image studies (image science, visual studies) assimilate and expand rather than replace the previously accepted methods, common in traditional theoretical approaches to the discipline of art history.


2021 ◽  
Author(s):  
Scott B Biering ◽  
Francielle Tramontini Gomes de Sousa ◽  
Laurentia V. Tjang ◽  
Felix Pahmeier ◽  
Richard Ruan ◽  
...  

Severe COVID-19 is associated with epithelial and endothelial barrier dysfunction within the lung as well as in distal organs. While it is appreciated that an exaggerated inflammatory response is associated with barrier dysfunction, the triggers of this pathology are unclear. Here, we report that cell-intrinsic interactions between the Spike (S) glycoprotein of SARS-CoV-2 and epithelial/endothelial cells are sufficient to trigger barrier dysfunction in vitro and vascular leak in vivo, independently of viral replication and the ACE2 receptor. We identify an S-triggered transcriptional response associated with extracellular matrix reorganization and TGF-β signaling. Using genetic knockouts and specific inhibitors, we demonstrate that glycosaminoglycans, integrins, and the TGF-β signaling axis are required for S-mediated barrier dysfunction. Our findings suggest that S interactions with barrier cells are a contributing factor to COVID-19 disease severity and offer mechanistic insight into SARS-CoV-2 triggered vascular leak, providing a starting point for development of therapies targeting COVID-19 pathogenesis.


2011 ◽  
Vol 1 (2) ◽  
pp. 35-44
Author(s):  
Hanne Nørreklit

The purpose of this article is to establish the symbolic forms that are presently used in selected mainstream management models and to assess whether the connection between leadership and individual human reality would be improved if the management models were fundamentally inspired by those used by a successful manager and artist.The theoretical starting point of this article is Cassirer’s (Cassirer 1999) philosophy of symbolic forms. A symbolic form is “a way of having a life world” (own translation) (Cassirer 1999). In a symbolic form, a person discovers and unfolds an ability to build his own universe as an ideal universe which enables the person to “understand and interpret, to articulate and organize, synthesize and universalize his human experience” (Cassirer 1962: 221). Symbolic forms such as art, science, myth and religion thus have common features and structures in their basic function of creating common human existence. When the symbolic form is science, ideals of objectivity and precision in the description of phenomena and their relations dominate man’s formation of his universe. In art, man unfolds an ability to be subjective and create empathetic insight into matters and their diversity (Cassirer 1962). Where science as symbolic form conceptualizes objects, art teaches us empathetic insight. The symbolic forms of art and science perceive a phenomenon differently. For example, science will perhaps see a constellation as a trigonometric function, whereas it may be considered by art as a “Hogarthian shape of beauty” (own translation) (Cassirer 1999: 62). Like the symbolic form of art, the symbolic form of myth builds on emotional sympathy, but differs by believing in the existence of the constellation. It is used to create a natural or magical unity of life. Monotheistic religions also include ideas of striving for a sense of unity, but here the idea is to achieve a universal, ethical sense of unity in an individualized society. Thus the symbolic form of religion helps the individual to choose between right and wrong.With this in mind, we examine the use of symbolic forms embedded in selected mainstream management models. Subsequently, we study the symbolic forms embedded in the management discourse as the concept is unfolded by the successful Artistic Director of the Royal Danish Opera, Kasper Holten, when he talks about management, with a view to determining the extent to which this practice differs from the symbolic forms embedded in the mainstream management models. The analysis shows that mainstream management models are primarily rooted in the symbolic form of science, although they tend to gradually include the symbolic form of religion or the symbolic form of myth. Generally speaking, the mainstream management models tend to exercise power over the individual’s emphatic insight and autonomous reflection and thereby constrain the scope for human creativity and individuality. Distinctively, Kasper Holten’s management discourse integrates the symbolic forms of art and science. With art as the dominant symbolic form, Kasper rejects new public management’s perception about opera and the management of art while at the same time – through discourses that bind to the individuality of the network of players – forming personal and social identities which come together to realize a world of existential ideas about operas in general as well as opera in particular.The article is relevant because it provides insight into the ways in which management models, through the use of myth and science as symbolic forms, exercise influence on human existence and interaction and thereby influence the scope for human freedom and exercise of power and also because it provides insight into the features and structures concerning human existence and co-existence from which mainstream management models cut themselves off by not using art as a form of consciousness. The constructive aspect is a parallel outline of features and structures in a new management discourse which are better suited for postmodern society.


Life ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 1037
Author(s):  
Jorge González-Bacerio ◽  
Irina Arocha ◽  
Mirtha Elisa Aguado ◽  
Yanira Méndez ◽  
Sabrina Marsiccobetre ◽  
...  

Chagas disease, caused by the kinetoplastid parasite Trypanosoma cruzi, is a human tropical illness mainly present in Latin America. The therapies available against this disease are far from ideal. Proteases from pathogenic protozoan have been considered as good drug target candidates. T. cruzi acidic M17 leucyl-aminopeptidase (TcLAP) mediates the major parasite’s leucyl-aminopeptidase activity and is expressed in all parasite stages. Here, we report the inhibition of TcLAP (IC50 = 66.0 ± 13.5 µM) by the bestatin-like peptidomimetic KBE009. This molecule also inhibited the proliferation of T. cruzi epimastigotes in vitro (EC50 = 28.1 ± 1.9 µM) and showed selectivity for the parasite over human dermal fibroblasts (selectivity index: 4.9). Further insight into the specific effect of KBE009 on T. cruzi was provided by docking simulation using the crystal structure of TcLAP and a modeled human orthologous, hLAP3. The TcLAP-KBE009 complex is more stable than its hLAP3 counterpart. KBE009 adopted a better geometrical shape to fit into the active site of TcLAP than that of hLAP3. The drug-likeness and lead-likeness in silico parameters of KBE009 are satisfactory. Altogether, our results provide an initial insight into KBE009 as a promising starting point compound for the rational design of drugs through further optimization.


Nuncius ◽  
2016 ◽  
Vol 31 (3) ◽  
pp. 584-609
Author(s):  
Simona Valeriani

This article takes as a starting point amateur architects in 17th-century England. It considers architectural writings including Henry Wotton’s Elements of Architecture (1624), Sir Balthasar Gerbier’s Councel and Advice to All Builders (1663) as well as Sir Roger Pratt’s and Sir Roger North’s notes on architecture and several building manuals. It enquires into the different kinds of knowledge and professional figures associated with architecture in the period. The paper scrutinizes how being a lover of architecture influenced the actors’ approach to other branches of knowledge such as garden design and agriculture. Did being an amateur shape the way in which one went about apparently more trivial aspects of life such as managing one’s estate? Comparing Roger Pratt’s unpublished notes with other contemporary sources on agriculture and estate management, it provides an insight into distinctive ways in which “amateurs” approached the subject.


Author(s):  
Anca-Georgiana Andrei

Abstract In recent years, more precisely from 1989 on, which was considered by a lot of experts the beginning of the second stage of globalization, nation branding campaigns have started to be launched in more and more countries in order to help developing nations image and reputation and to provide a competitive edge on economic, social and even political areas. Simon Anholt and Wally Olins are the two authors who studied the most nation branding phenomenon and came up with theories which were applied often by professionals when elaborating nation branding campaigns for different states. Nadia Kaneva, Keith Dinnie, Melissa Aronczyk, Luminita Nicolescu and Alina Dolea have also focused their researches on this theme and manage to contribute with new and interesting ideas to the field. This paper provides insight into the most important nation branding campaigns made by Romania starting from 1989 until present. Through a comparative analysis of those campaigns the paper tries to identify which was their impact on Romania’s image or reputation. How was Romania perceived (from the image perspective) before 1989 at international level? Did the image change after 1989? And what was the impact of the most important branding nation campaigns implemented after 1989 in the image of Romania and implicit in economy? These are the main questions this paper tries to answer. At the same time, the study also explores briefly the concept of globalization, nation branding, national image and national reputation. The conclusions of the paper will provide in the end a general background of all studied nation branding campaigns which will include the similarities and differences between them, but also both strong and weak points. Its aim is to contribute, among other existing papers, as a starting point for researchers or professionals who want to elaborate nation branding strategies for Romania or other countries.


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