Changes in lipid metabolism in genetically different types of calves during chronic hyperthermia

1973 ◽  
Vol 30 (2) ◽  
pp. 211-220 ◽  
Author(s):  
J. C. O'Kelly
Keyword(s):  
Fatty Acids ◽  
Lipid Metabolism ◽  
Body Temperature ◽  
Rectal Temperature ◽  
Plasma Cholesterol ◽  
Plasma Concentrations ◽  
Water Metabolism ◽  
Control Groups ◽  
Normal Body Temperature ◽  
Bull Calves

1. The effects of chronically raised body temperature on lipid metabolism were studied in groups of 3-month-old British (Shorthorn × Hereford) and Zebu (Africander × British) bull calves. Calves in control groups at ambient temperature were pair-fed to calves housed in a climate room.2. In control groups, concentrations of plasma cholesterol and phospholipid were significantly higher and the excretion of fatty acids 14:0, 16:0 and 18:0 was lower in the Zebu than in the British calves.3. In the climate room the constant daily environmental temperature required to maintain an increase in rectal temperature of 1·3° was 33° for British and 38° for Zebu calves. Changes in respiration rate, water metabolism and nitrogen metabolism associated with hyperthermia were similar in both breeds.4. Hyperthermia in all animals was associated with lowered plasma concentrations of cholesterol and phospholipid and increases in the ratio of free to total cholesterol. It was without effect on the circulating concentrations of non-esterified fatty acids and about twice the amount of fat was excreted without change in its fatty acid composition.5. The results showed that, when control of normal body temperature was lost, increased rectal temperature led to similar metabolic changes in animals of both breeds.

scholarly journals Human thermoregulatory responses during serial cold-water immersions

1998 ◽  
Vol 85 (1) ◽  
pp. 204-209 ◽  
Author(s):  
John W. Castellani ◽  
Andrew J. Young ◽  
Michael N. Sawka ◽  
Kent B. Pandolf
Keyword(s):  
Body Temperature ◽  
Rectal Temperature ◽  
Heat Production ◽  
Alternative Explanation ◽  
Cold Water ◽  
Metabolic Heat Production ◽  
Normal Body Temperature ◽  
Repeat Trial ◽  
Metabolic Heat ◽  
Made In

This study examined whether serial cold-water immersions over a 10-h period would lead to fatigue of shivering and vasoconstriction. Eight men were immersed (2 h) in 20°C water three times (0700, 1100, and 1500) in 1 day (Repeat). This trial was compared with single immersions (Control) conducted at the same times of day. Before Repeat exposures at 1100 and 1500, rewarming was employed to standardize initial rectal temperature. The following observations were made in the Repeat relative to the Control trial: 1) rectal temperature was lower and heat debt was higher ( P < 0.05) at 1100; 2) metabolic heat production was lower ( P < 0.05) at 1100 and 1500; 3) subjects perceived the Repeat trial as warmer at 1100. These data suggest that repeated cold exposures may impair the ability to maintain normal body temperature because of a blunting of metabolic heat production, perhaps reflecting a fatigue mechanism. An alternative explanation is that shivering habituation develops rapidly during serially repeated cold exposures.

Influence of monensin on some metabolic responses of cattle fed a restricted intake of lucerne hay during heat exposure

1991 ◽  
Vol 31 (3) ◽  
pp. 301
Author(s):  
JC O'Kelly
Keyword(s):  
Body Temperature ◽  
Thyroid Hormones ◽  
Plasma Concentrations ◽  
Heat Exposure ◽  
Ruminal Fermentation ◽  
Free T4 ◽  
Metabolic Derangement ◽  
Normal Body Temperature ◽  
Ruminal Fluid ◽  
Brahman Steers

The effects of monensin supplement (33 mg/kg feed) on ruminal fermentation and body metabolism were studied in Brahman steers fed 5 kg lucerne hay daily at thermoneutral temperature (24�C) and after heat exposure [I day at 31�C (acute) or 5 days at 37�C (chronic)]. At 24�C, monensin lowered the concentrations of ammonia and protozoa in ruminal fluid and increased the plasma concentration of cholesterol but did not affect the circulating levels of urea, glucose, insulin, thyroxine (T4), triiodothyronine (T3), free T4 and free T3. Acute heat exposure lowered the plasma concentrations of thyroid hormones. Chronic heat exposure increased body temperature, the rate of dry matter digestion in the rumen and urinary nitrogen and allantoin excretion and lowered the plasma concentrations of cholesterol and differentially lowered the concentrations of the thyroid hormones. An increase in the concentration of ammonia in ruminal fluid was the only response to monensin at elevated body temperature that was uncharacteristic of its effects at normal body temperature. The results indicate that a monensin treatment of 33 mg/kg feed does not have any adverse effects on steers suffering metabolic derangement during hyperthermia.

Food restriction increases torpor and improves brown adipose tissue thermogenesis in ob/ob mice

1985 ◽  
Vol 248 (5) ◽  
pp. E531-E539 ◽  
Author(s):  
J. Himms-Hagen
Keyword(s):  
Adipose Tissue ◽  
Body Temperature ◽  
Brown Adipose Tissue ◽  
Rectal Temperature ◽  
Food Restriction ◽  
Normal Body Temperature ◽  
Cold Intolerance ◽  
Brown Adipose ◽  
Brown Adipose Tissue Thermogenesis ◽  
Ad Libitum

Restricting the food intake of the genetically obese (ob/ob) mouse is known to ameliorate its cold intolerance. Cold intolerance of the ob/ob mouse is associated with defective thermogenesis in its brown adipose tissue. The objective of the experiments was to find out whether food restriction could increase the thermogenic function of brown adipose tissue of the ob/ob mouse. Obese and lean mice were fed a restricted amount of chow in one meal per day for 3-7 mo. Both lean and ob/ob mice were torpid (rectal temperature of approximately 32 degrees C) in the early morning and aroused spontaneously to a normal body temperature before the anticipated meal time. Obese mice were also torpid during the dark phase, whereas lean mice were active and had a normal body temperature at this time. Brown adipose tissue was in a thermogenically inactive state (low level of mitochondrial GDP binding) in torpid lean and ob/ob mice but became thermogenically active (increase in mitochondrial GDP binding) during stimulated arousal when body temperature increased by 6-7 degrees C in 15-30 min. Ad libitum-fed ob/ob mice had a normal diurnal rhythm in a rectal temperature that was at a lower level than in lean ad libitum-fed mice. They did not raise their rectal temperatures when stimulated and no activation of brown adipose tissue thermogenesis occurred under these conditions. Food restriction increased the capacity of both lean and ob/ob mice to raise their metabolic rate in response to injection of noradrenaline, indicating an increased capacity for thermogenesis in their brown adipose tissue.(ABSTRACT TRUNCATED AT 250 WORDS)

Use of plasma hormone and metabolite levels to predict breeding value of young bulls for butterfat production

1984 ◽  
Vol 39 (3) ◽  
pp. 335-344 ◽  
Author(s):  
K. Sejrsen ◽  
F. Larsen ◽  
B. B. Andersen
Keyword(s):  
Fatty Acids ◽  
Free Fatty Acids ◽  
Plasma Levels ◽  
Selection Criteria ◽  
Plasma Concentrations ◽  
Indirect Selection ◽  
Breeding Value ◽  
Regression Analyses ◽  
Bull Calves ◽  
Ad Libitum

ABSTRACTThe purpose of the experiment was to investigate the possibility of using concentrations of hormones and metabolites in plasma of potential breeding bulls early in life as indirect selection criteria for butterfat production. Sixteen Red Danish bull calves were included in the experiment, 10 were offspring of parents selected for high butterfat production for two or three generations, and six were from parents selected for low butterfat yield. The average estimated relative breeding values of the calves in the two groups were 111 and 91.At 3·5 and 7 months of age blood samples were collected every 6 h during 2 days of ad libitum feeding, 5 days of fasting and 2 days of refeeding. The samples were analysed for glucose, urea, free fatty acids, insulin and thyroxine. At 3·5 months plasma concentrations of free fatty acids were significantly correlated with breeding value under all feeding conditions examined. The increase in plasma glucose during refeeding at both ages was positively related to breeding value. Plasma insulin during the 1st day of fasting was positively correlated with genetic merit at 3·5 months of age and negatively correlated at 7 months. Plasma thyroxine was negatively correlated with breeding value at both ages, but the correlation was only significant at 7 months. Multiple regression analyses showed that a large part of the variation in breeding value for butterfat production could be described by plasma levels of hormones and metabolites when more than one variable was included in the model. With six variables in the model 0·67 and 0·73 of the variation could be accounted for at 3·5 and 7 months of age respectively.The results of the experiment have to be considered with caution because only one sire was used per group, the parents were preselected, and the number of animals was small. The results, however, do indicate that plasma levels of hormones and metabolites in the early life of potential breeding bulls, measured after suitable physiological challenges, may be useful as selection criteria for butterfat production of their offspring.

Human circadian rhythms in temperature, trace metals, and blood variables

1988 ◽  
Vol 65 (4) ◽  
pp. 1840-1846 ◽  
Author(s):  
W. E. Scales ◽  
A. J. Vander ◽  
M. B. Brown ◽  
M. J. Kluger
Keyword(s):  
Trace Metals ◽  
Body Temperature ◽  
Circadian Rhythms ◽  
Rectal Temperature ◽  
Plasma Concentrations ◽  
Indirect Evidence ◽  
Iron And Zinc ◽  
Leukocyte Counts ◽  
Leukocyte Populations ◽  
Blood Variables

The literature supports the concept that circadian changes in body temperature reflect changes in the thermoregulatory set point. We were interested in studying the relationship between the circadian rhythm in body temperature and 24-h variations in plasma concentrations of iron, zinc, circulating leukocyte counts, and plasma interleukin 1 (IL-1) activity. Eight healthy men were studied for two separate 48-h sessions. Rectal temperature, plasma iron and zinc concentrations, plasma IL-1 activity, circulating leukocyte counts, and several other blood variables were monitored. Circadian rhythms in temperature, trace metals, and various leukocyte populations were demonstrated. The 24-h pattern of changes in plasma concentrations of iron and zinc approximate an inverse relationship with rectal temperature. Although we were unable to detect any IL-1 activity in human plasma collected at 4-h intervals, the daily changes in plasma trace metal concentrations and the variations in leukocyte populations may provide indirect evidence for a daily variation in local (e.g., in liver) or central nervous system release of IL-1.

Effects of Hypoxia on the Course of Induced Fever in Dogs and Monkeys

1958 ◽  
Vol 195 (3) ◽  
pp. 601-613 ◽  
Author(s):  
W. G. Kubicek ◽  
W. D. Anderson ◽  
W. F. Geber
Keyword(s):  
Body Temperature ◽  
Blood Sugar ◽  
Pulse Rate ◽  
Rectal Temperature ◽  
Tissue Damage ◽  
Relative Number ◽  
Plasma Creatinine ◽  
Normal Body Temperature ◽  
Febrile Condition ◽  
Main Effects

Data were obtained in regard to rectal temperature, inspired pO2, circulation, metabolic rate and hematology. Fevers ranged from 39°C to 45°C and inspired pO2 from 25 mm Hg to 83 mm Hg during hypoxia. In control experiments on dogs with normal body temperature hypoxia resulted in a fall in body temperature, blood O2 and CO2 content, while pulse rate, blood sugar, plasma creatinine and hematocrit increased. The main effects of induced fever in these animals breathing air were an increase in pulse rate, plasma creatinine, blood pH, blood O2 content, hematocrit, O2 consumption rate and CO2 production. Blood sugar usually decreased. Blood pressure either remained essentially constant or fell during the most rigorous experiments. Total leucocyte counts indicated a trend toward an increase and differential counts indicated a rise in the proportion of segment nuclears and a fall in the relative number of lymphocytes. Hypoxia superimposed upon fever resulted in an increase in rectal temperature in 31%, a decrease in 20% and no change in 49% of the experiments, indicating that under certain conditions hypoxia can aggravate a febrile condition by further elevating body temperature. Fever produced observable tissue damage in the heart, intestine, kidney and liver. No tissue damage could be found in the brain or skeletal muscle. In three experiments cardiac index reached a maximum at approximately 43°C rectal temperature and then fell as the temperature was increased.

The Effect of n-3 Fatty Acids on Lipids and Haemostasis in Patients with Type lla and Type IV Hyperlipidaemia

1989 ◽  
Vol 62 (02) ◽  
pp. 797-801 ◽  
Author(s):  
E Berg Schmidt ◽  
E Ernst ◽  
K Varming ◽  
J O Pedersen ◽  
J Dyerberg
Keyword(s):  
Fatty Acids ◽  
Plasma Lipids ◽  
Plasma Cholesterol ◽  
Hdl Cholesterol ◽  
Apolipoprotein A1 ◽  
Type Iv ◽  
Before And After ◽  
Von Willebrand ◽  
Willebrand Factor ◽  
Factor Antigen

SummaryPlasma lipids and haemostasis were investigated in 17 patients with hyperlipidaemia before and after 6 weeks supplementation with 6 g n-3 fatty acids. Nine of the patients had type IIa and 8 had type IV hyperlipidaemia. No effect on plasma cholesterol, LDL- or HDL-cholesterol were seen, but plasma triglycerides decreased after n-3 supplementation. Apolipoprotein B increased and apolipoprotein A1 decreased after the oil supplement. The bleeding time was prolonged, but platelet aggregation was unaltered by n-3 fatty acids. Protein C activity increased in type II a and decreased in type IV after the supplement. Fibrinolysis was markedly depressed while von Willebrand factor antigen was reduced after intake of n-3 fatty acids.

Effects of ageing and exogenous melatonin on pituitary responsiveness to GnRH in rats

Reproduction ◽  
2000 ◽  
pp. 151-156 ◽  
Author(s):  
E Diaz ◽  
D Pazo ◽  
AI Esquifino ◽  
B Diaz
Keyword(s):  
Body Weight ◽  
Reproductive System ◽  
Plasma Concentrations ◽  
Pituitary Hormones ◽  
Female Rats ◽  
Control Groups ◽  
Melatonin Treatment ◽  
Exogenous Melatonin ◽  
Reproductive Axis ◽  
Effect Of Age

The effect of age and melatonin on the activity of the neuroendocrine reproductive system was studied in young cyclic (3-5 months-old), and old acyclic (23-25 month-old) female rats. Pituitary responsiveness to a bolus of GnRH (50 ng per 100 g body weight) was assessed at both reproductive stages in control and melatonin-treated (150 micrograms melatonin per 100 g body weight each day for 1 month) groups. After this experiment, female rats were treated for another month to study the influence of ageing and melatonin on the reproductive axis. Plasma LH, FSH, prolactin, oestradiol and progesterone were measured. A positive LH response to GnRH was observed in both control groups (cyclic and acyclic). However, a response of greater magnitude was observed in old acyclic rats. Melatonin treatment reduced this increased response in acyclic rats and produced a pituitary responsiveness similar to that of young cyclic rats. FSH secretion was independent of GnRH administration in all groups, indicating desynchronization between LH and FSH secretion in response to GnRH in young animals and during senescence. No effect on prolactin was observed. Significantly higher LH (3009.11 +/- 1275.08 pg ml(-1); P < 0.05) and FSH concentrations (5879.28 +/- 1631.68 pg ml(-1); P < 0.01) were seen in acyclic control rats. After melatonin treatment, LH (811.11 +/- 89.71 pg ml(-1)) and FSH concentrations (2070 +/- 301.62 pg ml(-1)) decreased to amounts similar to those observed in young cyclic rats. However, plasma concentrations of oestradiol and progesterone were not reduced. In conclusion, the results of the present study indicate that, during ageing, the effect of melatonin is exerted primarily at the hypothalamo-pituitary axis rather than on the ovary. Melatonin restored the basal concentrations of pituitary hormones and pituitary responsiveness to similar values to those observed in young rats.

The correlation between lipid metabolism disorders and the prostate cancer

2020 ◽  
Vol 27 ◽  
Author(s):  
Justyna Dłubek ◽  
Jacek Rysz ◽  
Zbigniew Jabłonowski ◽  
Anna Gluba-Brzózka ◽  
Beata Franczyk
Keyword(s):  
Prostate Cancer ◽  
Fatty Acids ◽  
Lipid Metabolism ◽  
Cancer Progression ◽  
De Novo ◽  
Prostate Gland ◽  
Hdl Cholesterol ◽  
Atp Citrate Lyase ◽  
Male Population ◽  
Lipid Metabolism Disorders

: Prostate cancer is second most common cancer affecting male population all over the world. The existence of a correlation between lipid metabolism disorders and cancer of the prostate gland has been widely known for a long time. According to hypotheses, cholesterol may contribute to prostate cancer progression as a result of its participation as a signalling molecule in prostate growth and differentiation via numerous biologic mechanisms including Akt signalling and de novo steroidogenesis. The results of some studies suggest that increased cholesterol levels may be associated with higher risk of more aggressive course of disease. The aforementioned alterations in the synthesis of fatty acids are a unique feature of cancer and, therefore, it constitutes an attractive target for therapeutic intervention in the treatment of prostate cancer. Pharmacological or gene therapy aimed to reduce the activity of enzymes involved in de novo synthesis of fatty acids, FASN, ACLY (ATP citrate lyase) or SCD-1 (stearoyl-CoA desaturase) in particular, may result in cells growth arrest. Nevertheless, not all cancers are unequivocally associated with hypocholesterolaemia. It cannot be ruled out that the relationship between prostate cancer and lipid disorders is not a direct quantitative correlation between carcinogenesis and the amount of the circulating cholesterol. Perhaps the correspondence is more sophisticated and connected to the distribution of cholesterol fractions, or even sub-fractions of e.g. HDL cholesterol.

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