scholarly journals The potential of jamu to relieve clinical symptoms and reduce the tumor size of patients with Fibro Adenoma Mammae (FAM) at Rumah Riset Jamu (RRJ) Hortus Medicus Tawangmangu : a pilot study

2021 ◽  
Vol 913 (1) ◽  
pp. 012086
Author(s):  
Z Zulkarnain ◽  
PRW Astana ◽  
A Triyono ◽  
D Ardiyanto ◽  
F Novianto ◽  
...  

Abstract Fibro Adenoma Mammae (FAM) is a benign tumor that sometimes causes clinical symptoms like pain. Not all women who suffer from FAM in Indonesia are willing to undergo surgery and choose to drink jamu. In fact, scientific evidence regarding jamu efficacy is limited. This study aims to determine the effect of jamu consumption on the size and clinical symptoms of FAM patients. A total of 26 women with FAM who came to RRJ Hortus Medicus and met the inclusion and exclusion criteria participated in this study until finish. Subjects were asked to drink boiled water of 8 plants Simplicia with a certain dose every day for 16 weeks. A breast ultrasound to determine tumor size was performed at baseline and day-112. Clinical symptoms were assessed at baseline and every 2 weeks. The result showed that the tumor average size was decreased from 13.89+ 6.47mm to 11.79+5.74mm (paired t-test p<0.001). About 88.46% of the subjects experienced a decrease in tumor size. The pain subsided and disappeared in 69.23% and 30.77% of subjects, respectively. The itching that was complained by one subject subsided since week 6. The administration of jamu for 16 weeks has the potential to reduce tumor size and clinical symptoms.

2020 ◽  
pp. 19-29
Author(s):  
Patricia Diaz Ortega ◽  
Manuel García Manero

Introduction: Symptomatic uterine fibroids can cause symptoms that can be disabling. There are many treatments, including ulipristal acetate, whose role in reducing symptoms and decreasing the size of the fibroid is well known. With this preliminary study, we also try to evaluate the correlation between myoma vascularization measured by ultrasound (Power Doppler 2D) and serum VEGF levels, before and after treatment with ulipristal acetate; in patients diagnosed with symptomatic uterine fibroids. Materials and Methods: A preliminary, prospective observational pilot study was designed. Twenty-four premenopausal women, diagnosed with symptomatic uterine fibroids, were included and all of them completed the study. Four cycles of ulipristal acetate were administered according to the dose and indications specified in the data sheet. In order to assess the influence of this treatment on the angiogenesis process of the fibroids, measurements of VEGF serum levels were made and their vascularization was assessed by means of 2D power doppler ultrasound; at the beginning and the end of treatment. In addition, several determinations of the same parameters were made throughout the successive visits. Endpoints were defined as the decrease in VEGF levels from previous levels, the decrease in myoma vascularization on ultrasound, and the reduction in myoma size. Result: 24 patients who met the inclusion criteria were enrolled (n=24). The average size of myomas was reduced from 45,08 ? 24,02mm to 29?16,96mm after treatment. The average VEGF serum level significantly decreased after the first treatment cycle (from 147,17 ? 153,51 pg/ml to 102,04 ? 186,08pg/ml). Vascularization of myomas after treatment with ulipristal acetate was analyzed, and a significantly decrease was achieved in 83,3% of cases. Conclusion: There is a correlation between myoma vascularization and treatment with Ulipristal acetate. SPRMs may provide effective treatment for women with symptomatic fibroids by two ways: supports selective progesterone receptor modulators and reduced angiogenesis. Keywords: Angiogenesis; Ulipristal Acetate; Uterine fibroids; VEGF


2018 ◽  
Vol 6 (1) ◽  
Author(s):  
Hartin Suidah ◽  
Ninik Murtiyani ◽  
Arif Susanto ◽  
Yufi Aris Lestari ◽  
Shindy Sofyaning Fitra

ABSTRAKMasih tingginya penderita hipertensi merupakan salah satu masalah yang berpengaruh terhadap gaya hidup dan sikap yang mendorong timbulnya hipertensi. Untuk menangani tekanan darah pada penderita hipertensi umumnya minum obat-obatan dari puskesmas, rutinitas ini sering tidak disukai oleh penderita. Penelitian ini bertujuan untuk mengetahui efektifitas air rebusan daun seledri terhadap perubahan tekanan darah pada lansia di Posyandu Ngudi Konco Desa Donomulyo Kecamatan Donomulyo Kabupaten Malang.Desain penelitian ini Pre-Experimental dengan rancangan One- Group Pre-Post test design. Populasi dalam penelitian ini adalah semua lansia penderita hipertensi di Posyandu Ngudi Konco Desa Donomulyo Kecamatan Donomulyo Kabupaten Malang sebanyak 30 responden. Sampel diambil dengan teknik total sampling. Variabel penelitian yaitu pemberian air rebusan daun seledri sebagai variabel independent dan tekanan darah sebagai variabel dependen. Data yang di dapat melalui lembar observasi tekanan darah kemudian di uji dengan menggunakan uji paired t Test.Hasil uji paired t Test menunjukkan bahwa p = 0,000 α= 0,05 Ho di tolak dan H1 diterima sehingga air rebusan daun seledri efektif terhadap perubahan tekanan darah pada lansia di Posyandu Ngudi Konco Desa Donomulyo Kecamatan Donomulyo Kabupaten Malang.Terdapat penurunan jumlah penderita hipertensi sebelum dan sesudah diberikan air rebusan daun seledri. Responden agar dapat meningkatkan informasi tentang pelaksanaan tekanan darah sehingga dapat mengurangi tekanan darah yang dialami dengan cara non formakologi sehingga responden tidak hanya menggantungkan pada obat-obatan farmakologi dalam menurunkan tekanan darah.Kata kunci : Air Rebusan Daun Seledri, Tekanan Darah, Lansia ABSTRACTStill high hypertension was  one of the problems that affect the lifestyle and attitudes that encourage the emergence of hypertension. To handle blood pressure in people with hypertension generally take  medication from puskesmas, this routine was often disliked by the patient. This study aims to determine the effectiveness of boiling water celery leaves on changes in blood pressure in the elderly at Posyandu Ngudi Konco Donomulyo Village Donomulyo District Malang Regency.The design of this research was  Pre-Experimental with the design of One- Group Pre-Post test design. Population in this research was all elderly patient of hypertension in Posyandu Ngudi Konco Village Donomulyo District Donomulyo Malang Regency as many as 30 respondents. Samples were taken with total sampling technique. The research variable was giving boiled water of celery leaves as independent variable and blood pressure as dependent variable. The data can be through blood pressure observation sheet then tested by using paired t test.The result of paired t - test showed that p = 0.000 α = 0.05 Ho in rejection and H1 accepted so that boiling water celery leaf effective against blood pressure changes in elderly at Posyandu Ngudi Konco Donomulyo Village Donomulyo District Malang Regency. There was a decrease in the number of hypertensive patients before and after being given boiled water of celery leaves. Respondents in order to improve information about the implementation of blood pressure so as to reduce blood pressure experienced by non-formakologi way so that respondents not only rely on pharmacological drugs in lowering blood pressure. Key Words: Water Stew of Celery leaves, Blood Pressure, Elderly


AERA Open ◽  
2021 ◽  
Vol 7 ◽  
pp. 233285842110285
Author(s):  
Tom Rosman ◽  
Samuel Merk

We investigate in-service teachers’ reasons for trust and distrust in educational research compared to research in general. Building on previous research on a so-called “smart but evil” stereotype regarding educational researchers, three sets of confirmatory hypotheses were preregistered. First, we expected that teachers would emphasize expertise—as compared with benevolence and integrity—as a stronger reason for trust in educational researchers. Moreover, we expected that this pattern would not only apply to educational researchers, but that it would generalize to researchers in general. Furthermore, we hypothesized that the pattern could also be found in the general population. Following a pilot study aiming to establish the validity of our measures (German general population sample; N = 504), hypotheses were tested in an online study with N = 414 randomly sampled German in-service teachers. Using the Bayesian informative hypothesis evaluation framework, we found empirical support for five of our six preregistered hypotheses.


2014 ◽  
Vol 35 (2) ◽  
pp. 142-149
Author(s):  
Érick Igor dos Santos

The objective of the present study was to identify scientific evidence in the literature regarding management and prevention of skin tears by nurses over the last ten years. This is an integrative review of articles found in the LILACS, SciELO, BDENF, MEDLINE, Scopus, ScienceDirect and PubMed databases, identified with the Portuguese, English and Spanish descriptors for "skin," "friction," or with the keyword "skin tears". After inclusion and exclusion criteria were applied, fifteen texts were selected. Scientific evidence demonstrated that the best management results are obtained by covering the tear with the skin flap itself, using octylcyanoacrylate or silicone-based products. Prevention consists of promoting a safe environment, through multidisciplinary work and health education. We conclude that it is the nursing staff's responsibility to avoid infection, trauma of any intensity, pain and bleeding.


2012 ◽  
Vol 7 (1) ◽  
pp. 9-16
Author(s):  
Hongjing Wang ◽  
Yuan Liang ◽  
Yanhua Li ◽  
Yingsheng Cheng ◽  
Ping Yin

2020 ◽  
Vol 10 (32) ◽  
pp. 259-268
Author(s):  
Karla Brandão de Araújo ◽  
Erika Oliveira Abinader ◽  
Anete Leda de Oliveira Martins ◽  
Gláucia Alvarenga de Araújo ◽  
Karem De Souza Brandão ◽  
...  

A Hiperbilirrubinemia neonatal é uma condição clínica caraterizada pelo acúmulo de bilirrubina no organismo do neonato podendo acarretar graves sequelas quando não tratada. Um dos meios terapêuticos consiste fototerapia, um tratamento que demanda cuidados específicos para prevenir iatrogenias. A enfermagem desempenha relevante papel nesses cuidados, pois permanece 24 horas no seguimento dos casos prevenindo complicações e contribuindo para a eficácia da terapêutica. Portanto, nesse estudo o objetivo foi investigar, através de revisão integrativa da literatura, as evidências científicas sobre os cuidados de enfermagem ao recém nascido em fototerapia. Para tal, foram pesquisadas as bases de dados: BDENF, LILACS, MEDLINE e SCIELO. Na formulação da estratégia de busca foram utilizados os descritores em saúde combinados entre si através dos operadores booleanos AND e OR. Foram encontrados quarenta artigos que após uso de critérios de inclusão e exclusão pré-definidos, permaneceram quatro que compuseram a amostra. A revisão revelou que os cuidados de enfermagem influenciam positivamente na adesão e resultado do tratamento.Descritores: Assistência de Enfermagem, Hiperbilirrubinemia Neonatal, Fototerapia. Nursing care for newborn in phototherapy, what the evidence reveals: integrative reviewAbstract: Neonatal hyperbilirubinemia is a clinical condition characterized by the accumulation of bilirubin in the neonate's organism and can cause serious sequelae when not treated. One of the therapeutic means consists of phototherapy, a treatment that requires specific care to prevent iatrogenesis. Nursing plays an important role in this care, as it remains 24 hours in the follow-up of cases, preventing complications and contributing to the effectiveness of therapy. Therefore, in this study the objective was to investigate, through an integrative literature review, the scientific evidence on nursing care for newborns undergoing phototherapy. For this, the databases were searched: BDENF, LILACS, MEDLINE and SCIELO. In the formulation of the search strategy, health descriptors combined with each other through the Boolean operators AND and OR were used. Forty articles were found that, after using pre-defined inclusion and exclusion criteria, four remained in the sample. The review revealed that nursing care positively influences adherence and treatment results.Descriptors: Nursing Care, Neonatal Hyperbilirubinemia, Phototherapy. Cuidado de enfermería para lo recién nacida en fototerapia, lo que revelan la evidencia: revisión integrativaResumen: La hiperbilirrubinemia neonatal es una condición clínica caracterizada por la acumulación de bilirrubina en el organismo del recién nacido y puede causar secuelas graves cuando no se trata. Uno de los medios terapéuticos consiste en la fototerapia, un tratamiento que requiere atención específica para prevenir la iatrogénesis. La enfermería desempeña un papel importante en esta atención, ya que permanece 24 horas en el seguimiento de los casos, previniendo complicaciones y contribuyendo a la efectividad de la terapia. Por lo tanto, en este estudio el objetivo fue investigar, a través de una revisión bibliográfica integradora, la evidencia científica sobre el cuidado de enfermería para los recién nacidos sometidos a fototerapia. Para esto, se realizaron búsquedas en las bases de datos: BDENF, LILACS, MEDLINE y SCIELO. En la formulación de la estrategia de búsqueda, se utilizaron descriptores de salud combinados entre sí a través de los operadores booleanos AND y OR. Cuarenta artículos se encontraron que, después de utilizar criterios de inclusión y exclusión predefinidos, cuatro permanecieron en la muestra. La revisión reveló que la atención de enfermería influye positivamente en la adherencia y los resultados del tratamiento.Descriptores: Cuidados de Enfermería, Hiperbilirrubinemia Neonatal, Fototerapia.


2019 ◽  
Vol 82 (20) ◽  
Author(s):  
Flávia Ribeiro do Carmo ◽  
Harriet Bárbara Maruxo ◽  
Willian Alves dos Santos

Objetiva-se identificar evidências científicas sobre a qualidade de vida em pacientes diagnosticados com insuficiênciacardíaca. Revisão integrativa realizada nas bases de dados Literatura Latino-Americana e do Caribe em Ciências da Saúde(LILACS), Base de Dados de Enfermagem (BDENF) e Sistema Online de Busca e Análise de Literatura Médica (MEDLINE)com a seguinte questão norteadora: Como a insuficiência cardíaca interfere na qualidade de vida dos pacientescardiológicos? Foi utilizada a estratégia PICO com recorte temporal de 2011 a 2016, nos idiomas português, inglês eespanhol. As informações foram tabuladas em programa Microsoft Excel® e processadas a partir de estratégia: médiaaritmética descritiva simples, frequência absoluta e relativa. Encontrou-se 712 artigos na sua totalidade, após aplicaçãodos critérios de inclusão e exclusão foram selecionados 17 artigos científicos avaliados a partir da categoria: os principaisfatores que comprometem a qualidade de vida dos pacientes com insuficiência cardíaca. Conclui-se que os pacientes cominsuficiência cardíaca apresentam intolerância à realização de atividades físicas e têm seu sono prejudicado por conta dadispneia e fadiga, sintomas que contribuem para o declínio da qualidade de vida.Palavras-chave: Insuficiência Cardíaca; Qualidade de Vida; Enfermagem. ABSTRACTThe aim is to identify scientific evidence on the quality of life in patients diagnosed with heart failure. Integrativereview carried out in the Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), Base de Dadosde Enfermagem (BDENF) e Sistema Online de Busca e Análise de Literatura Médica (MEDLINE) databases withthe question: How does heart failure interfere with the quality of life of cardiology patients? The PICO strategywith time cut from 2011 to 2016 was used in Portuguese, English and Spanish. The information was tabulated inMicrosoft Excel® program and processed from strategy: simple descriptive arithmetic mean, absolute and relativefrequency. It found 712 articles in their totality, after applying the inclusion and exclusion criteria, were selected17 scientific articles evaluated from the category: the main factors that compromise the quality of life of patientswith heart failure. It concludes that the patients with heart failure are intolerant to physical activities and sleepimpaired due to dyspnea and fatigue, such symptoms that contribute to the decline of quality of life.Keywords: Heart failure; Quality of life; Nursing.


2018 ◽  
Vol 1 (1) ◽  
pp. 123-132
Author(s):  
Gerlinde AS Metz ◽  
Bettenson D ◽  
Babatunde S ◽  
Gustafson C ◽  
Chan R

Experimental autoimmune encephalomyelitis (EAE) is a common animal model of multiple sclerosis (MS) which mimics the autoimmune, demyelinating, and inflammatory hallmarks of this human disorder. To better understand the severity of the symptoms in relation to the antigen in EAE, we explored the dose-symptom relationship between the quantity of MOG35-55 and clinical symptoms in a C57/BL6 mouse pilot study. To isolate the impact of MOG35-55 we developed an EAE model that does not require the additional application of pertussis toxin. Mice were treated with either 50µg, 100µg, or 150µg of MOG35-55 emulsified in complete Freund’s adjuvant. Following induction, the mice were assessed for clinical symptoms daily, and tested weekly for gross and fine motor impairments, mechanical allodynia, and anxiety-like behaviours. The time course of sensorimotor function loss was characterized by multiphasic disease progression. Findings also suggested an inverted U-shape dose-response relationship with a medium dosage of 100 µl MOG35-55 dosage aggravating symptom severity in induced animals. Outcomes measured by a clinical score correlated with performance on motor and nociceptive sensitivity tasks. As the disease progressed, fine and gross motor impairments and nociceptive sensitivity diminished and impairments persisted beyond 8 weeks. This study indicates that mild to moderate EAE can be induced in the absence of use of pertussis toxin. The progression suggests a spontaneously multiphasic disease course, which may have attractive implications for clinically relevant animal models.


2015 ◽  
Vol 2015 ◽  
pp. 1-4
Author(s):  
Tao Huang

Infrared thermometry was performed in 15 female asthenopia patients (average ± SD: 54.88 ± 7.30 years) prior to, during, and after stimulation using electrothermal Bian-stone at the Guangming (GB37) acupoints. The results of this controlled pilot study (control points at the Yongquan (KI1) and Tianshu (ST25) points) showed significant (P≤0.05) increases in eyes’ temperature. At the same time, no changes were found at the control points. Furthermore, after warm stimulation on Guangming (GB37) acupoints, the clinical symptoms were getting better than the control points. The symptoms’ score was decreased significantly too (P≤0.05). It was demonstrated that there is some relationship between Guangming (GB37) point and eyes, and warm stimulation on Guangming (GB37) could relief uncomfortable of asthenopia.


QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Sherine George Moftah ◽  
Essam Mohamed Hafez ◽  
Walid Dahy Zidan

Abstract Background Breast cancer is a leading cause of death and disability between women, particularly young women, in low- and average -income countries (Porter, 2018). Neoadjuvant chemotherapy (NAC) is increasingly used in management patients with locally advanced breast cancer (LABC) (Mougalian et al., 2015). Mammography and breast ultrasound are the most widest diagnostic techniques used to evaluate primary tumor size and character at the time of diagnosis and monitoring the response to NAC (Kald et al., 2015). Aim of the work The purpose of this study is to assess and evaluate the role and the accuracy of Mammography and breast ultrasound modalities in monitoring the response of the breast cancer to the neoadjuvant chemotherapy. Patients and methods Twenty three patients presenting with pathologically proven malignant mass and conducted for neoadjuvant chemotherapy with age above 40 years-old. They were referred to the radiology department (mammography unit, Ultrasound unit and MRI unit) at El Salam oncology center, during the period between December 2018 to June 2019. Once a patient satisfied the inclusion and exclusion criteria for this study, an elaborate history was taken from all the patients which was followed by a thorough clinical evaluation, in which duration of symptoms, affected side, affected breast and family history. Patients were subjected to evaluation before starting neoadjunant chemotherapy by mammography, ultrasound and MRI as well as after finishing the neoadjuvant cycles which usually was ranging 3-4 cycles. Results Total of 23 patients with breast cancer were enrolled in this study. The patients were in the age group of 41-70 years with mean age of 54 years. Majority of patients had infiltrative ductal carcinoma IDC (16 cases -69.56% and the rest of cases were infiltrative lobular carcinoma (9 cases -39.13 %). After monitoring the response of the cases to neoadjuvant chemotherapy the results showed significant regressive course to the majority of cases ( 17 cases ) (73.91%) with the rest non respondent cases divided to cases with stationary ( 3 cases ) (13.04% ) and cases with progressive course ( 3 cases ) (13.04% ). The comparison between the results of Sonomammographic assessment of the breast lesions before and after the neoadjuvant chemotherapy cycles and also to MRI show close results. There were 5 cases that showed non-respondent (including stationary course and progressive course) in both Sonomammography and MRI and only one case that was respondent according to Sonomammography and non-respondent according to MRI breast (false +e). On the other hand there were 16 cases that had showed respondent fashion in both Sonomammography and MRI. Also there was one case that had showed non-respondent course according to Sonomammography and was respondent according to MRI results (false –ve). Sonomammography sensitivity was 94.12 % and specificity was 83.33% compared to MRI results, with high accuracy value reaching to 91.30 %. Conclusion The ability of mammography and breast ultrasound to accurately measure residual tumor size following neoadjuvant chemotherapy compared to Breast MRI measurement of the residual tumor demonstrated sensitivity of 94.12 % and specificity of 83.33% with high accuracy value reaching to 91.30 %. Even that the MRI is proved to be of high accuracy in detecting residual tumor, sonomammographic imaging isa cost-effective imaging modality than the MRI with sensitivity and specificity near to that of MRI.


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