scholarly journals Relationship Between Arterial Stiffness and Cardiovascular Risk Scores Predicted by 2 Different Models

2021 ◽  
Vol 34 (2) ◽  
pp. 226-227
Author(s):  
Ting-jun Wang ◽  
Xiao-qi Cai ◽  
Ling-yu Zhang ◽  
Yi-hua Shen ◽  
Qun-fang Xie ◽  
...  

Abstract Background To investigate the relationship between arterial stiffness and 10-year atherosclerotic cardiovascular disease (ASCVD) risk predicted by models of pooled cohort equations (PCEs) or ASCVD risk in China (China-PAR). Methods A cross-sectional clinical study was carried out, in which clinical data were collected from 1,090 subjects aged 30–75 years who were admitted to a university affiliated hospital from 2016 to 2018. Arterial stiffness was examined by carotid–femoral pulse wave velocity (cfPWV). All subjects were divided into 2 groups: normal arterial stiffness (cfPWV <10 m/second) and elevated arterial stiffness (cfPWV ≥10 m/second). Ten-year ASCVD risk was predicted by either PCE or China-PAR. Results ASCVD risks predicted by 2 models in the elevated arterial stiffness group were higher than those in the normal arterial stiffness group [PCE: 16.5% (8.6%–28.3%) vs. 6.3% (2.7%–12.3%); China-PAR: 8.8% (6.1%–12.4%) vs. 3.9% (2.1%–6.6%), both P < 0.001]. The correlation coefficient between cfPWV and ASCVD risk predicted by China-PAR was greater than that by PCE (0.573 vs. 0.503, z = 5.272, P < 0.001). Multivariate linear regression analysis showed that 10-year ASCVD risk predicted by PCE model (β = 0.475, P < 0.001) and waist circumference (β = 0.092, P = 0.001) correlated with cfPWV. However, when PCE was replaced by China-PAR, only ASCVD risk (β = 0.573, P < 0.001), not waist circumference, was associated with arterial stiffness. Receiver operation characteristic curve showed that the discrimination of 10-year ASCVD risk predicted by China-PAR for arterial stiffness was better than PCE (area under curve 0.814 vs. 0.767, z = 4.992, P < 0.001). A stratification analysis revealed that the better discrimination by China-PAR mainly came from males. Conclusions Ten-year ASCVD risks predicted by either China-PAR or PCE are associated with arterial stiffness. The association is stronger when the risk is predicted by China-PAR, especially in males.

2021 ◽  
Vol 34 (3) ◽  
pp. 299-300
Author(s):  
Ting-jun Wang ◽  
Xiao-qi Cai ◽  
Ling-yu Zhang ◽  
Yi-hua Shen ◽  
Qun-fang Xie ◽  
...  

Abstract Background To investigate the relationship between arterial stiffness and 10-year atherosclerotic cardiovascular disease (ASCVD) risk predicted by models of pooled cohort equations (PCEs) or ASCVD risk in China (China-PAR). Methods A cross-sectional clinical study was carried out, in which clinical data were collected from 1,090 subjects aged 30–75 years who were admitted to a university affiliated hospital from 2016 to 2018. Arterial stiffness was examined by carotid–femoral pulse wave velocity (cfPWV). All subjects were divided into 2 groups: normal arterial stiffness (cfPWV <10 m/second) and elevated arterial stiffness (cfPWV ≥10 m/second). Ten-year ASCVD risk was predicted by either PCE or China-PAR. Results ASCVD risks predicted by 2 models in the elevated arterial stiffness group were higher than those in the normal arterial stiffness group [PCE: 16.5% (8.6%–28.3%) vs. 6.3% (2.7%–12.3%); China-PAR: 8.8% (6.1%–12.4%) vs. 3.9% (2.1%–6.6%), both P < 0.001]. The correlation coefficient between cfPWV and ASCVD risk predicted by China-PAR was greater than that by PCE (0.573 vs. 0.503, z = 5.272, P < 0.001). Multivariate linear regression analysis showed that 10-year ASCVD risk predicted by PCE model (β = 0.475, P < 0.001) and waist circumference (β = 0.092, P = 0.001) correlated with cfPWV. However, when PCE was replaced by China-PAR, only ASCVD risk (β = 0.573, P < 0.001), not waist circumference, was associated with arterial stiffness. Receiver operation characteristic curve showed that the discrimination of 10-year ASCVD risk predicted by China-PAR for arterial stiffness was better than PCE (area under curve 0.814 vs. 0.767, z = 4.992, P < 0.001). A stratification analysis revealed that the better discrimination by China-PAR mainly came from males. Conclusions Ten-year ASCVD risks predicted by either China-PAR or PCE are associated with arterial stiffness. The association is stronger when the risk is predicted by China-PAR, especially in males.


2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Juan Yin ◽  
Minghui Li ◽  
Lingling Yu ◽  
Feng Hu ◽  
Yu Yu ◽  
...  

Abstract Background The atherogenic index of plasma (AIP) always remains in a potential association with arterial stiffness, however, this association has not been fully discovered and needs to be studied in depth in large hypertensive patient populations. The present analysis thus sought to further explore the association that exists between AIP and arterial stiffness in Chinese patients diagnosed with arterial hypertension. Methods This cross-sectional study analyzed 4744 Chinese individuals with essential hypertension. AIP was defined as the base 10 logarithm of the ratio of plasma of triglycerides to high-density lipoprotein cholesterol levels indicated in molar concentrations. Measurement of arterial stiffness was carried out via brachial-ankle pulse wave velocity (baPWV). Results Data were adjusted for potential confounding variables, and multivariate linear regression analysis revealed AIP to be positively correlated with baPWV (β = 1.34, 95% CI: 0.96 to 1.72, P < 0.001). When AIP was instead treated as a categorical variable divided into quartiles, the same relationship was observed (P for trend < 0.001). We additionally found AIP and baPWV had a stronger positive association in individuals with a body mass index (BMI) < 24 kg/m2 (P for interaction < 0.05). Conclusion AIP and arterial stiffness were positively correlated in essential hypertension patients in China, especially in those with a BMI < 24 kg/m2. Clinical trial registration ChiCTR1800017274.


Hypertension ◽  
2021 ◽  
Vol 78 (Suppl_1) ◽  
Author(s):  
Chisa Matsumoto ◽  
Hirofumi Tomiyama ◽  
Mari Matsuura ◽  
Takayuki Nakai ◽  
Daichi Chikazu ◽  
...  

Background: Frailty is associated with higher risk of cardiovascular disease (CVD) and mortality. Recently, oral hypofunction, a disease in which the oral function is complexly reduced not only by ageing but also by a variety of factors, is regarded as a major risk factor for frailty, as it develops malnutrition and sarcopenia. However, no studies have evaluated the association of oral hypofunction and arterial stiffness, a marker for CVD. Hypothesis: We hypothesized that subjects with oral hypofunction have increased arterial stiffness compared to those without oral hypofunction. Methods: Japanese subjects above 50 years old who underwent annual health checkup were enrolled in this cross-sectional study. Subjects with history of CVD and dementia were excluded. Arterial stiffness was evaluated by brachial-ancle pulse wave velocity (baPWV). Oral hypofunction was evaluated based on the guidance by the Japanese Association for Dental Science. Seven oral factors, oral hygiene, oral moisture, occlusal force, tongue-lip motor function, tongue pressure, masticatory function, and swallowing function were assessed. Oral hypofunction was diagnosed if more than 3 factors showed deterioration. The association of oral hypofunction and baPWV was evaluated by multivariate linear regression analysis adjusted for conventional CVD risk factors. We also performed subgroup analysis stratified by age. (<60, ≧60 years). Results: Among 148 subjects (mean age: 59±7 years), 34 subjects (23%) had oral hypofunction. BaPWV in subjects with oral hypofunction was significantly higher than subjects without oral hypofunction (mean baPWV: 1539±312 v.s. 1416±260cm/sec, p=0.02). However, after adjustment for CVD risk factors, oral hypofunction did not significantly associate with baPWV (β=46±49, p=0.35). On the other hand, in subgroup analysis, oral hypofunction was significantly associated with increased baPWV among subjects in subjects younger than 60 years old even after adjustment of CVD risk factors (β=135±67, p=0.046), but this association was not observed in subjects over 60s. Conclusion: Oral hypofunction was associated with increased arterial stiffness, especially in subjects younger than 60s. Further research on oral hypofunction and CVD is warranted.


2021 ◽  
Author(s):  
Juan Yin ◽  
Minghui Li ◽  
Lingling Yu ◽  
Feng Hu ◽  
Yu Yu ◽  
...  

Abstract Background: The atherogenic index of plasma (AIP) always remains in a potential association with the arterial stiffness, however, in large hypertensive patient populations, this relation is not fully discovered and needs to be studied in depth. The present analysis thus sought to further explore the association that exists between AIP and arterial stiffness in patients diagnosed with arterial hypertension in China.Methods: This cross-sectional study analyzed 4744 Chinese individuals with essential hypertension. AIP was defined as the base 10 logarithm of the ratio of plasma of triglycerides (TG) to high-density lipoprotein cholesterol (HDL-c) levels indicates as in molar concentrations. Measurement of arterial stiffness was carried out via brachial-ankle pulse wave velocity (baPWV).Results: Data were adjusted for potential confounding variables, after which a multivariate linear regression analysis revealed AIP to be positively correlated with baPWV (β = 1.34, 95% CI: 0.96 to 1.72, P < 0.001). When AIP was instead treated as a categorical variable divided into quartiles, this same relationship was observed (P for trend < 0.001). We additionally found AIP and baPWV had a stronger positive association in individuals with a body mass index (BMI) < 24 kg/m2 (P for interaction < 0.05).Conclusion: AIP and arterial stiffness were positively correlated in essential hypertension patients in China, especially in those with a BMI < 24 kg/m2.


2020 ◽  
pp. jrheum.200188
Author(s):  
Jean W. Liew ◽  
John D. Reveille ◽  
Maria Castillo ◽  
Henna Sawhney ◽  
Benjamin S. Naovarat ◽  
...  

Objective Cardiovascular (CV) morbidity and mortality are increased in axial spondyloarthritis (axSpA). We conducted a cross-sectional study evaluating the 10-year atherosclerotic cardiovascular disease (ASCVD) risk in axSpA compared to the general US population. Methods We included 211 adults, 40–75 years old with ankylosing spondylitis (AS) or nonradiographic axSpA from 2 sites, who had available data on comorbidities, medication use, blood pressure measures, and laboratory cholesterol values. General population comparators from the 2009–2014 National Health and Examination Survey (NHANES) cycles were matched 4:1 to subjects, on age, sex, and race. We estimated the prevalence ratio for a 10-year ASCVD risk score ≥ 7.5% comparing axSpA and matched NHANES comparators using conditional Poisson regression. Results Overall, subjects were 53.9 ± 11.2 years old, 69% were male, and 74% were White. The mean 10-year ASCVD risk score was 6.7 ± 6.9% for those with axSpA, and 9.0 ± 10.5% for NHANES comparators. Compared to those with axSpA, the prevalence of current smoking and diabetes was higher among NHANES comparators. The estimated prevalence ratio for a 10-year ASCVD risk score ≥ 7.5% comparing those with axSpA and their age-, sex-, and race-matched comparators was 0.96 (95% CI 0.74–1.24). Conclusion The prevalence of a 10-year ASCVD risk score ≥ 7.5% was not significantly different comparing axSpA patients and those drawn from the general population who were similar in terms of age, sex, and race. Future studies should focus on improved CV risk prediction in axSpA, because underestimation by a general population risk score may potentially explain these results.


2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
Y Iwasaki ◽  
H Tomiyama ◽  
K Shiina ◽  
C Matsumoto ◽  
K Kimura ◽  
...  

Abstract Background Heart failure (HF) is a heterogeneous condition. The reduced liver blood flow and hepatic congestion associated with HF causes liver damages leading to liver sclerosis. Fibrosis 4 score (FIB-4 score), a marker of liver sclerosis, is easily calculated from age, serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) level and blood platelet count (PLT). Liver stiffness is known to be associated with vascular damages, including arterial stiffness and central hemodynamics. These vascular damages also cause the new onset of HF. However, it remains to be clarified whether liver stiffness is a direct risk factor for HF or whether its association with HF is mediated by vascular damage. We conducted cross-sectional and prospective longitudinal studies to examine whether FIB-4 score is directly associated with the serum NT-pro-BNP levels or the association is mediated by arterial stiffness and/or abnormal central hemodynamics. Methods and results In 3,040 health Japanese subjects with serum NT-pro-BNP levels <125 pg/ml, the FIB-4 score was calculated, and the serum NT-pro-BNP levels, brachial-ankle pulse wave (baPWV) velocity, radial augmentation index (rAI), second peak of the radial pressure waveform (SBP2) and PP2 (SBP2 – diastolic blood pressure) were measured. These parameters were measured again after a 3-year interval in 2,135 subjects. Pearson's correlation analysis demonstrated that FIB-4 score was significantly correlated with baPWV, rAI, SBP2, PP2 and the log-transformed the serum NT-pro-BNP levels. Multivariate linear regression analysis demonstrated a significant cross-sectional association of the FIB-4 scores with the log-transformed the serum NT-pro-BNP levels (beta = 0.08, p<0.01), but not with the baPWV, rAI, SBP2 and PP2. The change of serum NT-pro BNP levels during the study period was significantly higher in subjects with increase of the FIB-4 score during the study period (8.2±22.5 pg/ml) than that in those with decrease/no change (5.4±22.3 pg/ml) (p<0.05). The change of FIB-4 score during the study period was significantly associated with the change of the serum NT-pro-BNP levels during the study period (beta = 0.09, p<0.01). Conclusion Liver stiffness may have a significant direct association with the development of HF from the early stage, without the mediation of arterial stiffness and/or abnormal central hemodynamics. Therefore, the FIB-4 score appears to serve as a direct risk factor for HF from the early stage, and its association with HF may not be mediated by vascular damages.


Author(s):  
Xin Chen ◽  
Chang Chu ◽  
Cornelia Doebis ◽  
Volker von Baehr ◽  
Berthold Hocher

Abstract Background Animal studies suggested that vitamin D might decrease insulin resistance. Estrogen increased insulin sensitivity and glucose tolerance in rodents. However, sex-specific association of vitamin D with insulin resistance in humans remains unclear. Objectives To investigate the sex-dependency of the association of insulin resistance and 25(OH)D in a large Caucasian population. Methods Cross-sectional study from out-patients’ blood samples with measurements of 25(OH)D and HOMA-IR drawn at exactly the same day (N=1887). This cohort was divided into three groups: i) group with vitamin D deficiency (n=1190), ii) group with vitamin D sufficiency (N=686)), iii) vitamin D excess groups (n=11), the vitamin D excess group was excluded from further analysis due to the small size. Results Analysis of the entire study population showed that serum 25-hydroxyvitamin D was inversely associated with HOMA-IR (rs=-0.19, P&lt;0.0001). When considering the vitamin D status, this association was only seen in the vitamin D deficiency group, but not in the vitamin D sufficient group. The correlation was sex-dependent: HOMA-IR was inversely correlated with vitamin D in women with vitamin D deficiency (rs=-0.26, P&lt;0.0001) but not in men with vitamin D deficiency (rs=0.01, P=0.714). After multivariate linear regression analysis considering confounding factors, this relationship was again only seen in women. Conclusion Vitamin D was inversely and independently associated with insulin resistance only in women with vitamin D deficiency. Based on our data, we suggest that in particular vitamin D deficient women might benefit from vitamin D substitution by improving insulin resistance. This, however, needs to be proven in adequately designed double-blind placebo-controlled clinical studies.


2021 ◽  
Vol 49 (8) ◽  
pp. 030006052110393
Author(s):  
Keunjae Lee ◽  
Eun-San Kim ◽  
Boyoung Jung ◽  
Sang-Won Park ◽  
In-Hyuk Ha

Objective To determine whether pain is associated with gait instability in patients with lumbar disc herniation (LDH). Methods This retrospective cross-sectional study used data from electronic medical records. Among patients with lumbar back pain caused by LDH between January 2017 and July 2019, patients that underwent gait analysis were included. LDH was diagnosed using magnetic resonance imaging. An OptoGait photoelectric cell system was used for gait evaluation. Instability was measured using a gait symmetry index. Multivariate linear regression analysis was performed to determine the association between lumbar pain and gait instability. Results A total of 29 patients (12 females [41.4%] and 17 males [58.6%]; mean ± SD age, 40.6 ± 12.0 years) with LDH were enrolled in the study. With each 1-point increase in lumbar pain on the numeric rating scale, the symmetry index of the stance phase (0.33; 95% confidence interval [CI] 0.04, 0.62), swing phase (0.78; 95% CI 0.14, 1.43) and single support (0.79; 95% CI 0.15, 1.43) increased. Conclusions Gait instability in patients with LDH may occur due to an increase in pain.


Author(s):  
Ana Cebrián-Cuenca ◽  
José Joaquín Mira ◽  
Elena Caride-Miana ◽  
Antonio Fernández-Jiménez ◽  
Domingo Orozco-Beltrán

Abstract Background: The COVID-19 pandemic is affecting people worldwide. In Spain, the first wave was especially severe. Objectives: This study aimed to identify sources and levels of distress among Spanish primary care physicians (PCPs) during the first wave of the pandemic (April 2020). Methods: A cross-sectional study was conducted using a survey that included sociodemographic data, a description of working conditions related to distress [such as gaps in training in protective measures, cleaning, and hygiene procedures in work setting, unavailability of personal protective equipments (PPEs) and COVID-19 RT-PCR test, and lack of staff due to be infected] and a validated scale, the ‘Self-applied Acute Stress Scale’ (EASE). The survey was answered by a non-probability sampling of PCPs working in family healthcare centres from different regions of Spain. Analysis of variance and multivariate linear regression analysis were performed. Results: In all, out of 518 PCP participants, 123 (23.7%) obtained high psychological distress scores. Only half of them had received information about the appropriate use of PPE. PCP characteristics associated with higher levels of distress include female gender [1.69; 95% confidence interval (CI) 0.54, 2.84]; lack of training in protective measures (1.96; 95% CI 0.94, 2.99); unavailable COVID-19 RT-PCR for health care workers after quarantine or COVID-19 treatment (−0.77 (−1.52, −0.02). Reinforcing disinfection of the work environment (P < 0.05), availability of PPEs (P < 0.05), and no healthcare professional was infected (P < 0.05) were related to the lowest distress score. Conclusions: A better understanding of the sources of distress among PCPs could prevent its effect on future outbreaks.


Med Phoenix ◽  
2020 ◽  
Vol 5 (1) ◽  
pp. 32-39
Author(s):  
Manisha Maskey ◽  
KK Dutta Gupta ◽  
Meraj Ahmed

Background: Calculating BMI in an individual is a standard anthropometric procedure to estimate overweight/obesity. But it has been observed to be a bad predictor of central obesity. On the other hand, waist circumference, in many studies, has been found to be a good predictor of central obesity but not so frequently used because of tendency to vary throughout the day. In the recent years, NC has been found to have a good correlation with both BMI and WC. The aim of this study was to find out whether neck circumference is a good predictor of Overweight/Obesity or not. Methods: This was a cross sectional study carried out among the school children, aged 12 to 15 years, in Pokhara city, Nepal. In total, 408 students, 238 males and 170 females were screened. Anthropometric markers of obesity measured: included body mass index (BMI), waist circumference (WC), and compared with neck circumference (NC) of the same subjects. Pearson’s correlation test was used to see the correlation between NC with BMI and WC, and receiver operating characteristic curve analysis was used to determine the best cut off value of neck circumference in predicting high BMI. Results: Among 408 students, 238 (58.3%) were male and 170 (41.7%) were female. Among them 37 (9.1%) were overweight and 32 (7.8%) were obese. All the anthropometric parameters were significantly higher in cases, except height in male, than in controls. NC was significantly correlated with age, BMI, and waist circumference in both boys and girls. The best cut-off value of neck circumference by ROC to identify boys with a high BMI was 29.5 with sensitivity of (76%), specificity (54%), and for girls was 28.5 with sensitivity of (97%), specificity (48%). Conclusion: Statistically significant positive correlation was found between NC with BMI and WC. The value of NC as a screening tool has been found comparably lower in compare to WC.


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