scholarly journals Sugar-Sweetened Beverages, Fruit Juice, and Low-Calorie Beverages, and All-Cause Mortality Risk Among Dutch Adults: The Lifelines Cohort Study Within the SWEET Project

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 1066-1066
Author(s):  
Novita Naomi ◽  
Elske Brouwer-Brolsma ◽  
Marion Buso ◽  
Sabita Soedamah-Muthu ◽  
Johanna Geleijnse ◽  
...  

Abstract Objectives To examine prospective associations between intakes of sugar-sweetened beverages (SSB), fruit juice, and low-calorie beverages (LCB), and all-cause mortality among Dutch adults participating in the Lifelines Cohort Study. Methods A total of 118,439 participants aged 45 ± 13 years (60% women) were included in a prospective cohort analysis. Dietary intake at baseline was assessed using an extensive semi-quantitative food frequency questionnaire (FFQ). Uni- and multivariate Cox proportional hazard regression analyses, including substitution analyses, were performed adjusted for demographics, self-reported diseases and lifestyle, and dietary factors. The association was modelled continuously in each 1 glass (or 150 mL)/day intake increment and in four categories of each beverages intake (no intake, ≤2 glass/week, >2--<7 glass/week, and ≥1 glass/day). Results Of the total participants, 63% were SSB consumers, 76% were fruit juice consumers, and 56% were LCB consumers. The median intake among consumers was 0.4 [0.2–1.0] glass/day for SSB, 0.3 [0.1–0.7] glass/day for fruit juice, and 0.5 [1.2–1.1] glass/day for LCB. During a follow-up period of 8.3 [7.5–9.3] y, 2,023 (1.8%) deaths were recorded. Compared to no intake, ≥1 glass SSB/day was associated with a higher risk of mortality (HR 1.24, 95% CI 1.05, 1.46), whereas LCB intake was not associated with all-cause mortality risk. Theoretical replacement of 1 glass/day of SSB with the same amount of LCB was associated with a lower risk of all-cause mortality (HR 0.90, 95% CI 0.83, 0.98). Finally, compared to no intake, moderate fruit juice intake (≤2 glass/week and >2--<7 glass/week) was inversely associated with all-cause mortality (HR 0.80, 95% CI 0.72, 0.90 and HR 0.85, 95% CI 0.76, 0.95 respectively). Conclusions SSB intake was associated with a higher risk of all-cause mortality in the general Dutch adult population, whereas moderate fruit juice intake showed the opposite. Replacing SSB with LCB was associated with a lower risk of all-cause mortality Funding Sources This EU-project under the acronym “SWEET” has received funding from the European Union's Horizon 2020 research and innovation programme. The material presented and views expressed here are the responsibility of the author(s) only. The EU Commission takes no responsibility for any use made of the information set out.

2019 ◽  
Vol 149 (11) ◽  
pp. 1985-1993 ◽  
Author(s):  
Fumiaki Imamura ◽  
Matthias B Schulze ◽  
Stephen J Sharp ◽  
Marcela Guevara ◽  
Dora Romaguera ◽  
...  

ABSTRACT Introduction Beverage consumption is a modifiable risk factor for type 2 diabetes (T2D), but there is insufficient evidence to inform the suitability of substituting 1 type of beverage for another. Objective The aim of this study was to estimate the risk of T2D when consumption of sugar-sweetened beverages (SSBs) was replaced with consumption of fruit juice, milk, coffee, or tea. Methods In the European Prospective Investigation into Cancer and Nutrition (EPIC)–InterAct case–cohort study of 8 European countries (n = 27,662, with 12,333 cases of incident T2D, 1992–2007), beverage consumption was estimated at baseline by dietary questionnaires. Using Prentice-weighted Cox regression adjusting for other beverages and potential confounders, we estimated associations of substituting 1 type of beverage for another on incident T2D. Results Mean ± SD of estimated consumption of SSB was 55 ± 105 g/d. Means ± SDs for the other beverages were as follows: fruit juice, 59 ± 101 g/d; milk, 209 ± 203 g/d; coffee, 381 ± 372 g/d; and tea, 152 ± 282 g/d. Substituting coffee for SSBs by 250 g/d was associated with a 21% lower incidence of T2D (95% CI: 12%, 29%). The rate difference was −12.0 (95% CI: −20.0, −5.0) per 10,000 person-years among adults consuming SSBs ≥250 g/d (absolute rate = 48.3/10,000). Substituting tea for SSBs was estimated to lower T2D incidence by 22% (95% CI: 15%, 28%) or −11.0 (95% CI: −20.0, −2.6) per 10,000 person-years, whereas substituting fruit juice or milk was estimated not to alter T2D risk significantly. Conclusions These findings indicate a potential benefit of substituting coffee or tea for SSBs for the primary prevention of T2D and may help formulate public health recommendations on beverage consumption in different populations.


2021 ◽  
pp. 1-11
Author(s):  
Floor R Scheffers ◽  
Jolanda MA Boer ◽  
Alet H Wijga ◽  
Yvonne T van der Schouw ◽  
Henriëtte A Smit ◽  
...  

Abstract Objective: Dietary guidelines on pure fruit juice differ between countries regarding the question whether pure fruit juice (without added sugars) is an acceptable substitute for fruit or should be avoided because of its comparable sugar content with that of sugar-sweetened beverages (SSB). We modelled whether substituting pure fruit juice for fruit or SSB was associated with cardiometabolic risk. Design: Prospective cohort study. Setting: Based on a validated FFQ at baseline, we calculated the relative contribution of pure fruit juice to total consumption of fruit and pure fruit juice ( ${{{\rm{pure}}\;{\rm{fruit}}\;{\rm{juice}}\;\;\left( {{\rm{g}}/{\rm{day}}} \right)} \over {{\rm{fruit}}\; + \;{\rm{pure}}\;{\rm{fruit}}\;{\rm{juice}}\;\left( {{\rm{g}}/{\rm{day}}} \right)}}$ ) and to total consumption of SSB and pure fruit juice ( ${{{\rm{pure}}\;{\rm{fruit}}\;{\rm{juice}}\;\;\left( {{\rm{g}}/{\rm{day}}} \right)} \over {{\rm{SSBs}}\; + \;{\rm{pure}}\;{\rm{fruit}}\;{\rm{juice}}\;\left( {{\rm{g}}/{\rm{day}}} \right)}}$ ). In multivariate analyses (Cox regression), we assessed associations with incidence of type 2 diabetes, CVD, CHD and stroke after an average follow-up of 14·6 years. Participants: About 35 000 participants from the EPIC-NL study, aged 20–70 years at enrolment. Results: Substitution of pure fruit juice for SSB was associated with lower risk of all endpoints. For type 2 diabetes and CHD, for example, drinking 75–100 % (as compared with 0–<25 %) of total SSB + pure fruit juice as pure fruit juice showed hazard ratio (95 % CI) of 0·74 (95 % CI 0·64, 0·85) and 0·85 (95 % CI 0·76, 0·96), respectively. Substitution of pure fruit juice for fruit was not associated with the risk of type 2 diabetes, CVD, CHD and stroke. Conclusions: Substituting pure fruit juice for SSB was associated with lower cardiometabolic risk, whereas substituting pure fruit juice for fruit was not associated with cardiometabolic risk.


2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Djibril M. Ba ◽  
Xiang Gao ◽  
Joshua Muscat ◽  
Laila Al-Shaar ◽  
Vernon Chinchilli ◽  
...  

Abstract Background Whether mushroom consumption, which is rich in several bioactive compounds, including the crucial antioxidants ergothioneine and glutathione, is inversely associated with low all-cause and cause-specific mortality remains uncertain. This study aimed to prospectively investigate the association between mushroom consumption and all-cause and cause-specific mortality risk. Methods Longitudinal analyses of participants from the Third National Health and Nutrition Examination Survey (NHANES III) extant data (1988–1994). Mushroom intake was assessed by a single 24-h dietary recall using the US Department of Agriculture food codes for recipe foods. All-cause and cause-specific mortality were assessed in all participants linked to the National Death Index mortality data (1988–2015). We used Cox proportional hazards regression models to calculate multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (95% CIs) for all-cause and cause-specific mortality. Results Among 15,546 participants included in the current analysis, the mean (SE) age was  44.3 (0.5) years. During a mean (SD) follow-up duration of 19.5 (7.4) years , a total of 5826 deaths were documented. Participants who reported consuming mushrooms had lower risk of all-cause mortality compared with those without mushroom intake (adjusted hazard ratio (HR) = 0.84; 95% CI: 0.73–0.98) after adjusting for demographic, major lifestyle factors, overall diet quality, and other dietary factors including total energy. When cause-specific mortality was examined, we did not observe any statistically significant associations with mushroom consumption. Consuming 1-serving of mushrooms per day instead of 1-serving of processed or red meats was associated with lower risk of all-cause mortality (adjusted HR = 0.65; 95% CI: 0.50–0.84). We also observed a dose-response relationship between higher mushroom consumption and lower risk of all-cause mortality (P-trend = 0.03). Conclusion Mushroom consumption was associated with a lower risk of total mortality in this nationally representative sample of US adults.


Stroke ◽  
2021 ◽  
Vol 52 (Suppl_1) ◽  
Author(s):  
Dong Hoon Shin ◽  
Jaehun Jung ◽  
Gi Hwan Bae

Background: Atrial fibrillation (AF) should be treated with anticoagulants to prevent stroke and systemic embolism. Resuming anticoagulation after intracerebral hemorrhage (ICH) poses a clinical conundrum. The absence of evidence-based guidelines to address this issue has led to wide variations in restarting anticoagulation after ICH. This study aimed to evaluate the risks and benefits of anticoagulation therapy on all-cause mortality, severe thromboembolism, and severe hemorrhage and compare the effect of novel direct oral anticoagulants (NOACs) with warfarin on post-ICH mortality in patients with AF. Methods: This retrospective cohort study was performed using health insurance claim data obtained between 2002 and 2017 from individuals with newly developed ICH with comorbid AF. We excluded participants aged < 40 years and those with traumatic ICH, subdural hemorrhage, or subarachnoid hemorrhage. The primary endpoint was all-cause mortality, and the secondary endpoints were severe thrombotic and hemorrhagic events. Anticoagulants, antiplatelet agents, and non-users were analyzed for survival with propensity score matching. Results: Among 6735 participants, 1743 (25.9%) and 1690 (25.1%) used anticoagulants and antiplatelet agents, respectively. Anticoagulant (HR, 0.321; 95% CI, 0.264-0.390; P < 0.0001) or antiplatelet users (HR, 0.393; 95% CI, 0.330-0.468; P < 0.0001) had a lower risk of all-cause mortality than non-users. However, there was no difference between the two drug users (HR, 1.183; 95% CI, 0.94-1.487; P = 0.152; reference: anticoagulant). The risk of acute thrombotic events, although not hemorrhagic events, was significantly lower in anticoagulant users than in antiplatelet users. In addition, anticoagulation between 6 to 8 weeks post-ICH showed a tendency of the lowest risk of death. Further, NOACs were associated with a lower risk of all-cause mortality than warfarin. Conclusions: Our results showed that in patients with AF, resuming anticoagulants between 6 and 8 weeks after ICH improved all-cause mortality, severe thromboembolism, and severe hemorrhage. Further, compared with warfarin, NOAC had additional benefits.


Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
Josiemer Mattei ◽  
Vasanti Malik ◽  
Frank B Hu ◽  
Hannia Campos

Introduction: Consumption of sugar sweetened beverages (SSB) has been consistently associated with metabolic syndrome (MetS), while results on the role of fruit juice intake are conflicting. Hispanics consume both SSB and traditional fruit-based beverages; however, studies conducted on such ethnic group are scarce. Given the high prevalence of MetS among Hispanics, describing putative contributors to this condition is essential in proposing approaches that may successfully reduce its prevalence and avoid further complications. Hypothesis: We assessed the hypothesis that substituting fruit-based beverages traditionally consumed by Hispanics for SSB may be associated with lower odds of MetS. Methods: To determine the cross-sectional association between beverages consumed by Hispanics, and MetS and its components, data were analyzed in 1,872 Costa Rican adults who served as controls of a population-based case-control study of coronary heart disease. Multivariate adjusted means were calculated for components of MetS by servings (never, <1/week, 2–6/week, ≥1/day) of two traditional fruit-based beverages (‘fresco’ and homemade fruit juice, separately) and two SSB (instant drinks and regular sodas, separately and combined). Prevalence ratio (PR) of MetS was calculated for each beverage, and odds ratio (OR) was calculated by substituting one serving of homemade fruit juice or water for one of SSB. Results: Significant positive trends were observed for increasing servings of instant drinks and combined SSB with plasma triglyceride and waist circumference, and for regular soda with waist circumference (all P -trend<0.001). Increasing servings of homemade fruit juice were associated positively with HDL-C ( P -trend=0.033). Consuming ≥1 serving/day of instant drinks was associated with higher PR of MetS (1.42, 95%CI: 1.11, 1.83) compared to no consumption; similar results were obtained for combined SSB. Substituting one serving of homemade fruit juice for instant drink was associated with 29% (95% CI=7, 47%) lower odds of MetS, and for regular soda with 30% (1, 50%) lower odds. Substituting water for combined SSB was marginally significant (OR=0.86 (0.74, 1.00). Conclusion: In conclusion, reducing consumption of SSB and substituting them with homemade fruit juices in moderation, may be a culturally-appropriate approach to lower metabolic syndrome among Hispanics. Our study provides the groundwork for interventions on beverage intake that aim to prevent MetS and type 2 diabetes in Hispanic ethnic subgroups, and may support current public health efforts on limiting availability and intake of SSB, while substituting with a healthy beverage.


BMJ Open ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. e039239
Author(s):  
Ying Yue Huang ◽  
Chao Qiang Jiang ◽  
Lin Xu ◽  
Wei Sen Zhang ◽  
Feng Zhu ◽  
...  

ObjectiveTo examine the associations of change in body mass index (BMI) and waist circumference (WC) over an average of 4 years with subsequent mortality risk in middle-aged to older Chinese.DesignProspective cohort study based on the Guangzhou Biobank Cohort Study.SettingCommunity-based sample.Participants17 773 participants (12 956 women and 4817 men) aged 50+ years.Primary and secondary outcome measuresPrimary outcome measure was all-cause mortality. Secondary outcome measures were cardiovascular disease (CVD) and cancer mortality. Causes of death were obtained via record linkage, and coded according to the International Classification of Diseases (tenth revision).Results1424 deaths (53.4% women) occurred in the 17 773 participants (mean age 61.2, SD 6.8 years) during an average follow-up of 7.8 (SD=1.5) years, and 97.7% of participants did not have an intention of weight loss . Compared with participants with stable BMI, participants with BMI loss (>5%), but not gain, had a higher risk of all-cause mortality (HR=1.49, 95% CI 1.31 to 1.71), which was greatest in those who were underweight (HR=2.45, 95% CI 1.31 to 4.59). Similar patterns were found for WC. In contrast, for participants with a BMI of ≥27.5 kg/m2, BMI gain, versus stable BMI, was associated with 89% higher risk of all-cause mortality (HR=1.89, 95% CI 1.25 to 2.88), 72% higher risk of CVD mortality (HR=1.72, 95% CI 0.80 to 3.72) and 2.27-fold risk of cancer mortality (HR=2.27, 95% CI 1.26 to 4.10).ConclusionIn older people, unintentional BMI/WC loss, especially in those who were underweight was associated with higher mortality risk. However, BMI gain in those with obesity showed excess risks of all-cause and cancer mortality, but not CVD mortality. Frequent monitoring of changes in body size can be used as an early warning for timely clinical investigations and interventions and is important to inform appropriate health management in older Chinese.


2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 676-676
Author(s):  
Yan-Bo Zhang ◽  
Yi-Wen Jiang ◽  
An Pan

Abstract Objectives We aimed to investigate the associations of dietary intakes of sugar-sweetened beverages (SSB) and artificially sweetened beverages (ASB) with mortality. Methods Adults without cancer aged 20 years or older from the National Health and Nutrition Examination Survey 1999–2014 were followed up to December 31, 2015. Beverage intake was assessed by 24-hour dietary recall interviews (a single recall in 5109 participants and an average of two recalls in 19,914 participants). Multivariable Cox proportional hazards models were used to evaluate the associations of SSB and ASB intake with all-cause and cause-specific mortality. Pubmed, Embase, Web of Science, Cochrane, ProQuest, ClinicalTrials.gov, and International Clinical Trials Registry Platform were searched for related cohort studies. Random-effects models were used to pool the estimates, and dose-response analyses were conducted using the 2-stage generalized least-squares trend program. Results After a median follow-up of 6.8 years, 2365 deaths were identified in 25,023 participants. Each additional serving of daily SSB intake was associated with an HR (95% CI) of 1.06 (1.02–1.11), 1.13 (1.03–1.24), and 1.06 (1.00–1.11) for mortality from all-cause, heart diseases, and other causes. Each additional serving of daily ASB intake was associated with an HR (95% CI) of 0.96 (0.92–1.00), 0.90 (0.82–0.98), and 0.97 (0.92–1.02) for mortality from all-cause, heart diseases, and other causes. No significant associations were found with cancer mortality. We identified 23,631 citations and included 12 studies (including 13 cohorts) in meta-analyses. It was shown that each additional serving of daily SSB intake was associated with an HR (95% CI) of 1.08 (1.05–1.11, ten cohorts with 388,548 participants) for all-cause mortality and 1.10 (1.06–1.14, five cohorts with 255,584 participants) for cardiovascular mortality. No significant association was found between ASB intake and mortality in the meta-analysis. Conclusions Higher SSB intake was associated with a higher risk of all-cause mortality and cardiovascular mortality, while the association between ASB intake and mortality needed further investigation. Funding Sources National Key Research and Development Program of China, National Nature Science Foundation of China, and Hubei Province Science Fund for Distinguished Young Scholars.


2020 ◽  
Vol 79 (OCE2) ◽  
Author(s):  
Paloma Flores Barrantes ◽  
Alicia Larruy ◽  
Maria Luisa Miguel-Berges ◽  
Pilar De Miguel-Etayo ◽  
Iris Iglesia-Altaba ◽  
...  

AbstractIntroduction: Dietary habits are established from a very young age. Parental role modeling is an important factor influencing the eating behavior of their children. Drinking behavior may have an impact in the development of childhood obesity. This study aimed to explore the correlations of core drinking beverages between parents and their children.Materials and Methods: The present study included children of 3.5–5.5 years and their parents from the (Multifactorial evidence-based approach using behavioral models in understanding and promoting fun, healthy food, play and policy for the prevention of obesity in early childhood) ToyBox study. The study was a kindergarten-based family-involved intervention, in preschool children from six European countries: Belgium, Bulgaria, Germany, Greece, Poland, and Spain. For this study, we analyzed data from the baseline cross-sectional survey.Data on consumption frequency of water, homemade or fresh fruit juice, prepacked fruit juice, light beverages and sugared sweetened beverages consumption from parents and their children was obtained via a validated food frequency questionnaire. Parents were given examples of serving sizes and asked about how to self-report their usual consumption per day or week. Beverage consumption of children was reported by their parents and information about frequency and portion sizes was collected. Body weight and height of children was measured and classified according to the International Obesity Task Force (IOTF). Bivariate correlations were performed to analyze beverage consumption (servings per day) in children and their parents.Results: The studied sample included 5266 pairs of children (49.2% girls) and parents (91.7% women) that were included in the analysis.Girls presented higher correlations in water (r2 = 0,317) and sugar sweetened beverages (r2 = 0,302), whereas boys, presented slightly higher correlations of light soft drinks (r2 = 0,273), pure fruit juices (r2 = 0,308) and prepacked fruit juices (r2 = 0,324), all of them at < 0.01 level of significance. Considering boys and girls together, a slightly higher significant correlation coefficients were found between children-parents’ dyads with overweight/obesity compared to normal weight children-parentś for sugar sweetened beverages (r2 = 0,303) and light soft drinks (r2 = 0,396).Discussion: Beverage consumption of children and their parents were found to be moderately correlated. Overweight children seem to have better correlations with their parents in relation of sugar sweetened beverages and light soft drinks. Parents should encourage a healthy beverage consumption for their own health and most important, because there are key role models to their children.


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