scholarly journals Evaluation of an Experimentally Designed Molecular Imprinted Polyurethane Foam Performance for Extraction of Alprazolam

2019 ◽  
Vol 57 (7) ◽  
pp. 662-670
Author(s):  
Zeynab Tavakoli ◽  
Majid Soleimani ◽  
Mir Mohammad Alavi Nikje
Keyword(s):  
Polyurethane Foam ◽  
High Efficiency ◽  
Solid Phase ◽  
Selective Adsorption ◽  
Selective Extraction ◽  
Extraction Methods ◽  
Effective Parameters ◽  
Rigid Foam ◽  
Adsorption Processes ◽  
Central Composite

Abstract Industrial polyurethane rigid foam (PUF) was selected as a substrate for selective solid phase extraction of Alprazolam. Effective parameters for raising selectivity of the PUF were evaluated. Synthetic molecularly imprinted polyurethane foam (MIPUF) was tracked as selective adsorbent and its characteristic was pondered by analytical methods. Optimization was done by central composite design (CCD) to have high efficiency of the polymer adsorption. Two different extraction methods were compared in the selective adsorption processes using MIPUF and NIPUF, batch system and continuous (cartridge) system. Results of the adsorption of alprazolam on the MIPUF had 39% more recovery than NIPUF (reference polymer). Then, the proposed method suggests a selective extraction of mentioned analyte from urine and tablets as complex matrixes.

scholarly journals Molecularly Imprinted Polymers as Solid-Phase Microextraction Fibers for the Isolation of Selected Antibiotics from Human Plasma

Materials ◽  
2021 ◽  
Vol 14 (17) ◽  
pp. 4886
Author(s):  
Małgorzata Szultka-Młyńska ◽  
Daria Janiszewska ◽  
Bogusław Buszewski
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Solid Phase Microextraction ◽  
High Performance ◽  
Solid Phase ◽  
Selective Extraction ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Antibiotic Drugs ◽  
Central Composite ◽  
As Solid Phase

The aim of this study was to examine the synthesis of novel molecularly imprinted polymer (MIP)-coated polythiophene and poly(3-methylthiophene) solid-phase microextraction fibers using the direct electropolymerization method. Synthesized SPME fibers were characterized with the use of various physicochemical instrumental techniques. MIP-SPME coatings were successfully applied to carry out the selective extraction of selected antibiotic drugs (amoxicillin, cefotaxime, metronidazole) and their metabolites (amoxycilloic acid, amoxicillin diketopiperazine, desacetyl cefotaxime, 3-desacetyl cefotaxime lactone, hydroxymetronidazole). Solid-phase microextraction parameters for the simultaneous determination and identification of target compounds were optimized using the central composite design (CCD), and they accounted for 5–15 min for desorption time, 3–10 for the pH of the desorption solvent, and 30–100 μL for the volume of the desorption solvent. High-performance liquid chromatography and mass spectrometry (MS) detectors such as quadrupole time-of-flight (Q-TOF MS) and triple quadrupole (QqQ MS) were applied to determine and to identify selected antibiotic drugs and their metabolites. The MIP-coated SPME are suitable for the selective extraction of target compounds in biological samples from patients in intensive care units.

scholarly journals Growing Trends in the Efficient and Selective Extraction of Compounds in Complex Matrices Using Molecularly Imprinted Polymers and Their Relevance to Toxicological Analysis

2020 ◽  
Author(s):  
Haley A Mulder ◽  
Matthew S Halquist
Keyword(s):  
Sample Preparation ◽  
Molecularly Imprinted Polymers ◽  
Drugs Of Abuse ◽  
Matrix Effects ◽  
Solid Phase ◽  
Selective Extraction ◽  
Extraction Methods ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Key Steps

Abstract In the world of forensic and clinical toxicology, proper sample preparation is one of the key steps in identification and quantification of drugs of abuse. Traditional extraction methods such as solid-phase extraction and liquid−liquid extraction are often laborious and nonselective for the target analytes being measured. Molecularly imprinted polymers (MIPs) can be synthesized for sample extraction and their versatility allows the polymer to be employed in off-line, benchtop extractions or on/in-line instrument extractions, offering a faster and more selective sample preparation without the risk of interfering matrix effects. This review details the synthesis and applications of MIP materials for the extraction of drug compounds from biological matrices in publications from 1994 to today.

Selective Extraction of Lithium from a Spent Lithium Iron Phosphate Battery by Mechanochemical Solid-phase Oxidation

2021 ◽  
Author(s):  
Kang Liu ◽  
Lili Liu ◽  
Quanyin Tan ◽  
Jinhui Li
Keyword(s):  
Cathode Materials ◽  
Lithium Iron Phosphate ◽  
Solid Phase ◽  
Iron Phosphate ◽  
Selective Extraction ◽  
Green Process ◽  
Rapid Extraction ◽  
Phase Oxidation

This study proposes a green process for selective and rapid extraction of lithium from the cathode materials of spent lithium iron phosphate (LiFePO4) batteries via mechanochemical solid-phase oxidation. The advantages...

Selective electromembrane extraction and sensitive colorimetric detection of copper(II)

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Wajid Ali Khan ◽  
Muhammad Balal Arain ◽  
Hashmat Bibi ◽  
Mustafa Tuzen ◽  
Nasrullah Shah ◽  
...  
Keyword(s):  
Applied Voltage ◽  
Colorimetric Detection ◽  
Environmental Water ◽  
Selective Extraction ◽  
Effective Parameters ◽  
Relative Standard ◽  
Electromembrane Extraction ◽  
Optimized Conditions ◽  
Donor Phase

AbstractIn this study, an extremely effective electromembrane extraction (EME) method was developed for the selective extraction of Cu(II) followed by Red-Green-Blue (RGB) detection. The effective parameters optimized for the extraction efficiency of EME include applied voltage, extraction time, supported liquid membrane (SLM) composition, pH of acceptor/donor phases, and stirring rate. Under optimized conditions, Cu(II) was extracted from a 3 mL aqueous donor phase to 8 µL of 100 mM HCl acceptor solution through 1-octanol SLM using an applied voltage of 50 V for 15 min. The proposed method provides a working range of 0.1–0.75 µg·mL−1 with 0.03 µg·mL−1 limit for detection. Finally, the developed technique was applied to different environmental water samples for monitoring environmental pollution. Obtained relative recoveries were within the range of 93–106%. The relative standard deviation (RSD) and enhancement factor (EF) were found to be ≤4.8% and 100 respectively. We hope that this method can be introduced for quantitative determination of Cu(II) as a fast, simple, portable, inexpensive, effective, and precise procedure.

Optimization of processing parameters to control Maillard browning in ready-to-eat processed potatoes

2021 ◽  
pp. 108201322098429
Author(s):  
Revenli Fernanda do Nascimento ◽  
Maria Helene Giovanetti Canteri ◽  
Sabrina Ávila Rodrigues ◽  
Juliana Vitória Messias Bittencourt
Keyword(s):  
Processing Parameters ◽  
B Value ◽  
Effective Parameters ◽  
Browning Index ◽  
Index Reduction ◽  
L Value ◽  
Processed Potatoes ◽  
Maillard Browning ◽  
Central Composite

Relationship among pH, aw and Maillard browning was investigated in processed potatoes ready-to-eat during cooking and sterilization in autoclave to prevent their colors changes. Central composite rotational design was used for optimization of color (L*, a* and b*), browning index and intermediate compounds index. Reduction in the L* value and increase in the a*, b* value and browning index, indicators for Maillard browning of the processed potatoes were mitigated at pH 4.0–5.0 and aw 0.96–1.00 and accelerated at pH less than 3.0 or more than 7.0 and aw less than 0.84. Formation of intermediate compounds was intensified at pH 5.0 and aw 0.99 and mitigated at pH 7.0 and aw 0.84. Adjustment of the pH to 5.0 and keeping aw at to 0.99 were the most effective parameters of to control Maillard browning in processed potatoes ready-to-eat.

scholarly journals Extraction and Analysis of Tetrahydrocannabinol, A Cannabis Compound in Oral Fluid

2016 ◽  
Vol 9 (1) ◽  
pp. 30
Author(s):  
Wei Zhang ◽  
Jun Wang ◽  
Zhiyuan Mi ◽  
Jiangtao Su ◽  
Xiangyu You ◽  
...  
Keyword(s):  
Drug Testing ◽  
Oral Fluid ◽  
Solid Phase ◽  
Extraction Methods ◽  
Liquid Extraction ◽  
Phase Extraction ◽  
Advantages And Disadvantages ◽  
Liquid Liquid Extraction ◽  
The Common ◽  
Common Target

Although misuse and abuse of Cannabis is well known, the health benefits have been proved by various biomedical studies. Tetrahydrocannabinol (THC) is the major active substance in leaves of Cannabis, which is the common target for drug testing. In field drug testing, oral fluid (OF) has its unique advantages over other specimens such as blood, urine, and hair. Thus the study of THC in OF is gaining popularity in Cannabis research. In this review, extraction methods are introduced in three categories, which are Liquid-Liquid Extraction (LLE), Solid Phase Extraction (SPE), and Supercritical Fluid Extraction (SFE). Examples of application with each method will be covered. Advantages and disadvantages of these methods will be compared. In addition, methods in analysis following extraction will be briefly discussed.

scholarly journals Effective Thermal Conductivity of Open Cell Polyurethane Foam Based on the Fractal Theory

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Kan Ankang ◽  
Han Houde
Keyword(s):  
Thermal Conductivity ◽  
Fractal Dimension ◽  
Effective Thermal Conductivity ◽  
Polyurethane Foam ◽  
Solid Phase ◽  
Fractal Theory ◽  
Heat Radiation ◽  
Total Thermal Conductivity ◽  
Equivalent Thermal Conductivity ◽  
Open Cell

Based on the fractal theory, the geometric structure inside an open cell polyurethane foam, which is widely used as adiabatic material, is illustrated. A simplified cell fractal model is created. In the model, the method of calculating the equivalent thermal conductivity of the porous foam is described and the fractal dimension is calculated. The mathematical formulas for the fractal equivalent thermal conductivity combined with gas and solid phase, for heat radiation equivalent thermal conductivity and for the total thermal conductivity, are deduced. However, the total effective heat flux is the summation of the heat conduction by the solid phase and the gas in pores, the radiation, and the convection between gas and solid phase. Fractal mathematical equation of effective thermal conductivity is derived with fractal dimension and vacancy porosity in the cell body. The calculated results have good agreement with the experimental data, and the difference is less than 5%. The main influencing factors are summarized. The research work is useful for the enhancement of adiabatic performance of foam materials and development of new materials.

High-Efficiency On-Line Solid-Phase Extraction Coupling to 15−150-μm-i.d. Column Liquid Chromatography for Proteomic Analysis

2003 ◽  
Vol 75 (14) ◽  
pp. 3596-3605 ◽  
Author(s):  
Yufeng Shen ◽  
Ronald J. Moore ◽  
Rui Zhao ◽  
Josip Blonder ◽  
Deanna L. Auberry ◽  
...  
Keyword(s):  
Column Liquid Chromatography ◽  
Liquid Chromatography ◽  
Solid Phase Extraction ◽  
Proteomic Analysis ◽  
High Efficiency ◽  
Solid Phase ◽  
Phase Extraction ◽  
On Line

Why do zeolites induce an unprecedented electronic state on exchanged metal ions?

2017 ◽  
Vol 19 (36) ◽  
pp. 25105-25114 ◽  
Author(s):  
Akira Oda ◽  
Takahiro Ohkubo ◽  
Takashi Yumura ◽  
Hisayoshi Kobayashi ◽  
Yasushige Kuroda
Keyword(s):  
Metal Ions ◽  
Electronic State ◽  
Base Metal ◽  
Metal Ion ◽  
High Efficiency ◽  
Lewis Base ◽  
Mfi Zeolite ◽  
Adsorption Processes ◽  
Exact Position

Understanding the exact position and the detailed role of the Al array in zeolites is essential for elucidating the origin of unique properties and for designing zeolite materials with high efficiency in catalytic and adsorption processes. In this work, we advanced pivotal roles of Lewis base–metal ion bifunctionality caused by Al atoms arrayed circumferentially in the MFI-zeolite pores.

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