Free triiodothyronine measured in dried blood spots from normal, low-birth-weight, and hypothyroid neonates.

1988 ◽  
Vol 34 (12) ◽  
pp. 2448-2451 ◽  
Author(s):  
D Laroche ◽  
F Lemonnier ◽  
J F Viel ◽  
G Travert ◽  
Y Fernandez
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Dried Blood Spots ◽  
Serum Samples ◽  
Free Triiodothyronine ◽  
Low Birth Weight Infants ◽  
Neonatal Hypothyroidism ◽  
Blood Samples ◽  
Low Weight ◽  
The Mean

Abstract Free triiodothyronine (FT3) has rarely been studied in neonates, primarily because of obvious problems in obtaining serum samples from neonates for research purposes. We adapted an analog radioimmunoassay for measuring FT3 in dried blood samples and used it to assay 361 samples selected from those collected for the screening for neonatal hypothyroidism. The mean FT3 concentration in healthy neonates on the fourth postpartum day is 2.55 pmol per liter of whole blood (SD 0.78 pmol/L, n = 145), the same as in healthy adults. Low-birth-weight infants have a decreased concentration of FT3, and this decrease is much greater in premature neonates than in infants at low weight for gestational age. In six hypothyroid newborns, the FT3 concentration was normal or increased, clearly indicating that FT3 assay is not a diagnostic tool for hypothyroidism. FT3 was barely detectable in one case of congenital galactosemia.

scholarly journals Handling Associated with Drenching Does Not Impact Survival and General Health of Low Birth Weight Piglets

Animals ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 404
Author(s):  
Kevin Van Tichelen ◽  
Sara Prims ◽  
Miriam Ayuso ◽  
Céline Van Kerschaver ◽  
Mario Vandaele ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Significant Risk ◽  
Skin Lesions ◽  
Additional Stress ◽  
Bioactive Substances ◽  
Blood Samples ◽  
Panel Test ◽  
Esterified Fatty Acids ◽  
The Mean

The increase in litter sizes in recent years has resulted in more low birth weight (LBW) piglets, accompanied by a higher mortality. A potential intervention to overcome this is drenching bioactive substances. However, if the act of drenching provokes additional stress in LBW piglets, it might counteract the supplement’s effect and be detrimental for the piglet’s survival. To study the effect of the drenching act, piglets from 67 sows were weighed within 4 h after birth. The mean litter birth weight (MLBW) and standard deviation (SD) were calculated. LBW piglets (n = 76) were defined as weighing between (MLBW-1*SD) and (MLBW-2.5*SD). They were randomly allocated to two treatments: “sham” (conducting the act of drenching by inserting an empty 2.5 mL syringe in the mouth during 20 s, once a day, d1 till d7; n = 37) or “no treatment” (no handling; n = 39). On day 1, 3, 9, 24 and 38, piglets were weighed and scored for skin lesions. Blood samples were collected on day 9 and 38 and analyzed to determine glucose, non-esterified fatty acids (NEFA), urea, immunoglobulin G (IgG), insulin-like growth factor 1 (IGF-1) and a standard blood panel test. There was no difference between sham drenched and untreated piglets regarding any of the parameters. In conclusion, this study showed that drenching does not impose a significant risk to LBW piglets and can be applied safely during the first 7 days after birth.

Association of early postnatal growth trajectory with body composition in term low birth weight infants

2014 ◽  
Vol 5 (3) ◽  
pp. 189-196 ◽  
Author(s):  
P. Khandelwal ◽  
V. Jain ◽  
A. K. Gupta ◽  
M. Kalaivani ◽  
V. K. Paul
Keyword(s):  
Body Composition ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Postnatal Growth ◽  
Early Infancy ◽  
Low Birth Weight Infants ◽  
Z Scores ◽  
The Mean ◽  
And Gender

Growth acceleration or catch-up growth (CUG) in early infancy is a plausible risk factor for later obesity and cardiovascular disease. We postulate that this risk may be mediated by an adverse programming of body composition by CUG in early infancy. The study was aimed at evaluating the association between the pattern of gain in weight and length of term low birth weight (LBW) infants from birth to 6 months, with fat mass percent (FM%) at 6 months. Term healthy singleton LBW infants were enrolled. Baby’s weight and length z-scores were measured at birth and three follow-up visits. Body composition was measured by dual-energy absorptiometry at last visit. A total of 54 babies (28 boys) were enrolled. The mean birth weight and gestation were 2175±180 g and 37.6±0.6 weeks. Follow-up visits were at 1.4±0.0, 3.0±0.3 and 7.2±0.8 months. The proportion of babies who showed CUG [increase in weight for age z-score (∆WAZ)>0.67] from birth to 1.4, 3.0 and 7.2 months was 29.6, 26.4 and 48.5%, respectively. The mean FM% at 7.2 months was 16.6±7.8%. Infants with greater ∆WAZ from birth to 3 and 7.2 months had significantly greater FM% at 7.2 months after adjusting for current age, size and gender. Infants with early CUG (<1.4 months) had higher FM% than infants with no CUG. We conclude that earlier and greater increment in WAZ is positively associated with FM%.

Pre-discharge growth pattern of very low birth weight infants (VLBW): A 5 year single center experience

2020 ◽  
pp. 1-6
Author(s):  
S.H. Elbeely ◽  
M.A. AlQurashi
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Gestational Age ◽  
Growth Pattern ◽  
Very Low Birth Weight ◽  
Single Center ◽  
Low Birth Weight Infants ◽  
Cross Sectional ◽  
Vlbw Infants ◽  
The Mean

BACKGROUND: Very low birth weight infants born prematurely are at greater risk for growth delays that lead to Ex-utero Growth Restriction (EUGR) during vulnerable periods of organ structural and functional development. There is considerable evidence that early growth failure has adverse effects on long term neurodevelopment in children which often persists into adulthood. METHODS: This is a single-center cross-sectional study on live newborn infants with birth weight ranges from 500 to 1500 grams (VLBW) and gestational age (GA) between 24–32 weeks who were admitted to NICU at KAMC-Jeddah over a 5 year period (2009–2013). This study aims to evaluate predischarge growth pattern of VLBW infants in terms of weight, head circumference (HC) and length and to identify important variables that have influenced such growth pattern. RESULTS: Of the 135 infants included in the final analysis, 68 (50.4%) were male and 67 (49.6%) were female and the mean gestational age was 28.83±2.064 weeks and the mean birth weight 1166.74±256 grams. Ninety-two infants (68%) had discharge weight at ≤10th percentile and forty four (32%) had their weight >10th percentile. HC was the lowest affected among the anthropometric measurements with 42% ≤10th percentile. In terms of linear growth, 62% had their length ≤10th percentile. Amongst infants born ≤750 grams, 71% and 70% had HC and height at ≤10th percentile respectively, at the time of discharge. BPD was significantly associated with EUGR (p = 0.026). CONCLUSIONS: This study demonstrates that almost 2/3rd of VLBW infants born at KAMC-Jeddah with birth weight ≤750 grams were discharged home with EUGR as demonstrated by their weight, length, and HC ≤10th percentile. BPD was found to be significantly associated with EUGR amongst post-natal factors influencing EUGR.

scholarly journals Associated Factors to Immunization Timeliness and Completion in Preterm and Low Birth Weight Infants at Essos Hospital Center Yaounde

2020 ◽  
Author(s):  
Marie Kouya ◽  
Annie Carole Nga Motaze ◽  
Jeannette Epee Ngoué ◽  
Arsene Brunelle Sandie ◽  
Paul Olivier Koki Ndombo ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Very Low Birth Weight ◽  
High Rate ◽  
Routine Immunization ◽  
Low Birth Weight Infants ◽  
Cross Sectional ◽  
Immunization Practice ◽  
The Mean ◽  
Hospital Center

Abstract Introduction. Vaccination is very often delayed in premature and low birth weight infants. However, timely vaccination is even more important in the latter because of their increased susceptibility to infection.Objective. To assess immunization practice and factors associated with vaccine promptness and completeness in former preterm and low-birth-weight infants.Methods. We conducted a retrospective analytical cross-sectional study (January 2017 to February 2019). Main measurement : Promptness and completeness at each contact, Statistical analysis was performed using R software version 3.6.2, logistic regression was used to estimate the Odds Ratio (OR) and their 95% Confidence Interval (CI).Results. We recruited 310 children aged 12 to 36 months born before 37 weeks with low birth weight, 163 (52.6%) of whom were female. Two hundred and fifty-three had received the vaccines at the indicated age, with promptness rate of 81.6%, and 97.7% had completed routine immunization at 9 months. The mean age at vaccination initiation was 6 days ±11 and the mean weight at vaccination initiation was 2233g ±494. High prematurity and very low birth weight were associated with a high rate of vaccine delay: 61.5% [OR: 15.56; (CI: 3.22-118.52; p=0.002)] and 66.7% [OR: 19.19; (CI: 4.67-92.52; p<0.001)] respectively. Distance > 5 km with HEC [OR: 3.48; (CI: 1.68-7.47; p=0.001)] was associated with poor vaccination. Women in common-law unions had the lowest vaccine readiness rate (60.6%), (OR: 3.36; CI: 1.006-10.70; p=0.038). The frequency of occurrence of post immunization adverse events was 24.5%, with fever type in 94.7%.Conclusion. Nearly all premature and/or low-birth-weight children hospitalized at Essos Hospital Center had completed routine immunization at 9 months, and the majority had received the vaccines in a timely manner. Similar study is needed in rural area.

scholarly journals PENGARUH PERAWATAN METODE KANGURU TERHADAP PENINGKATAN SUHU TUBUH BAYI BERAT LAHIR RENDAH DI NICU RUMAH SAKIT GRANDMED LUBUK PAKAM TAHUN 2018

2019 ◽  
Vol 1 (2) ◽  
pp. 6-9
Author(s):  
Ika Nur Sapurtri ◽  
Dwi Handayani ◽  
Maharani Nazmi Nasution
Keyword(s):  
Birth Weight ◽  
Body Temperature ◽  
Low Birth Weight ◽  
Sampling Technique ◽  
Low Birth Weight Infants ◽  
Kangaroo Care ◽  
Low Birth Weight Babies ◽  
Before And After ◽  
Post Test ◽  
The Mean

Babies with low birth weight have a temperature that is unstable and prone to hypothermia (temperature <36,5ºC). Cold stress can increase mortality and hamper growth. The warmth of the mother's body or a known method of kangaroo care proved to be an effective heat source for infants born at term or low birth weight. This study aims to determine whether there is influence kangaroo care method to your body temperature low birth weight infants. This type of research is pre experiment with models (one group pre-post test design). The population of this research is all low birth weight babies. Sampling techniques in use purposive sampling, that the sampling technique was based on sample criteria specified by the researchers themselves. In this case the samples found as many as 22 people. Data analysis using paired sample t-test with a level of 95%. The results of this study gained an average prior to 34.7 kangaroo care method, after doing kangaroo care method 36.9. The mean before and after kangaroo care method 2.2273. Based on the analysis results showed pvalue (0.004) <α (0.05), It can be concluded no treatment effect kangaroo method to your body temperature low birth weight infants. Recommendations from this research is the kangaroo care method can be used as one LBW care that can be done by the mothers in raising and maintaining body temperature.

Nutritional Balance Studies in Very-Low-Birth-Weight Infants: Enhanced Nutrient Retention Rates by an Experimental Formula

PEDIATRICS ◽  
1980 ◽  
Vol 66 (2) ◽  
pp. 233-238
Author(s):  
Jayant P. Shenai ◽  
John W. Reynolds ◽  
S. Gorham Babson
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Very Low Birth Weight ◽  
Oral Intake ◽  
Nutrient Retention ◽  
Postnatal Growth ◽  
Retention Rates ◽  
Low Birth Weight Infants ◽  
Accretion Rates ◽  
The Mean

An experimental infant formula developed to meet the specific nutritional needs of very-low-birth-weight infants was evaluated by 96-hour balance studies in ten preterm infants (birth weight: 1,130 to 1,530 gm). The formula contained 23.2 gm/liter of protein (whey protein/casein ratio, 60:40), 44.1 gm/liter of fat (50% medium-chain triglycerides) and 85.0 gm/liter of carbohydrate (50% lactose, 50% Polycose), and provided relatively higher amounts of calcium, phosphorus, vitamin D, and electrolytes than are in human milk. All infants were fed 150 ml/kg/day (120 calories/kg/day) by intermittent gavage. Balance studies were carried out nine days following establishment of oral intake. The mean (±SEM) nutrient retention rates revealed by balance studies in these infants (calcium, 170 ± 4 mg/kg/day; phosphorus, 78 ± 3 mg/kg/day; nitrogen, 426 ± 8 mg/kg/day; sodium, 1.4 ± 0.1 mEq/kg/day) were comparable to normal fetal accretion rates. The mean (±SEM) fat absorption was 92.5 ± 0.9%. No clinical intolerances or biochemical abnormalities were observed, and adequate postnatal growth was achieved in all infants. The diet proved to be nutritionally advantageous and safe for very-low-birth-weight infants.

scholarly journals Screening Retinopathy of Prematurity in Extremely Low Birth Weight Infants in China and the Need for Earlier Screening Times

2016 ◽  
Vol 2016 ◽  
pp. 1-4 ◽  
Author(s):  
Jianxun Wang ◽  
Feng Chen ◽  
Shiping He ◽  
Daoman Xiang
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Retinopathy Of Prematurity ◽  
Age Of Onset ◽  
Screening Strategy ◽  
Extremely Low Birth Weight ◽  
Low Birth Weight Infants ◽  
Group A ◽  
The Mean

Purpose. To convey the need for a revised screening strategy for retinopathy of prematurity (ROP) for extremely low birth weight (ELBW) infants in China.Design. A retrospective longitudinal study.Methods. The medical charts of infants with a birth weight (BW) of less than 1 kg were reviewed. The infants were divided into three groups: group A, without ROP; group B, with ROP but not up to type 1 prethreshold or threshold ROP; group C, with type 1 prethreshold or threshold ROP. Data collected included gender, gestational age (GA), BW, postmenstrual age (PMA), age of onset of ROP, and age at which treatment was carried out, if required.Results. A total of 77 infants were involved. Fifty-six infants developed ROP at any stage and 38 infants developed type 1 prethreshold or threshold ROP. The mean BW and GA of infants in group A were significantly different compared with groups B and C. The mean PMA of onset of ROP in infants who developed mild ROP was 37 weeks compared with 34 weeks for infants who developed severe ROP.Conclusion. ELBW infants have a higher incidence of ROP in China which highlights the need for optimizing neonatal care for these infants. In ELBW infants, ROP tends to develop more severely when it occurs earlier. It is necessary for ELBW infants, especially for those with a BW less than 800 g or a GA less than 25 weeks, to be initially screened at an earlier time.

Characterization of the role of microRNA-517a expression in low birth weight infants

2013 ◽  
Vol 4 (6) ◽  
pp. 522-526 ◽  
Author(s):  
G. Y. Song ◽  
W. W. Song ◽  
Y. Han ◽  
D. Wang ◽  
Q. Na
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Placental Tissue ◽  
Maternal Serum ◽  
Trophoblast Invasion ◽  
Normal Birth Weight ◽  
Serum Samples ◽  
Low Birth Weight Infants ◽  
Human Trophoblast ◽  
Normal Birth

The purpose of this study was to analyze the expression of the placenta-specific microRNA miR-517a in maternal serum and in placental tissue from low birth weight newborns and try to detect the effects of miR-517a expression on invasion potential of trophoblasts. Placental tissue and maternal serum were collected from both low birth weight newborns (n = 10) and normal birth weight newborns (n = 20). Expression of miR-517a was assessed in placenta and serum samples by real-time qRT-PCR. In addition, human trophoblast HTR8/SVneo cells were transfected with a miR-517a 2′-O-methyl oligonucleotide or a negative control RNA, and invasion was measured using transwell migration assays. Expression of miR-517a was significantly increased in placentas from low birth weight newborns (61.79 ± 23.06) in comparison with those of normal birth weight newborns (5.01 ± 1.97; P < 0.05). The expression of miR-517a was also increased in maternal serum isolated from the low birth weight newborn (25.78 ± 8.69) compared with the normal birth weight newborn (3.21 ± 1.07; P < 0.05). Overexpression of miR-517a significantly inhibited invasion of HTR8/SVneo cells (P < 0.05). These data indicate that miR-517a overexpression could potentially lead to low birth weight, likely through the inhibition of trophoblast invasion.

scholarly journals Berat Lahir dan Kelangsungan Hidup Neonatal di Indonesia

2012 ◽  
Vol 7 (1) ◽  
pp. 8
Author(s):  
Demsa Simbolon
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Cumulative Probability ◽  
Low Birth Weight Infants ◽  
Normal Birth ◽  
Cohort Design ◽  
Low Weight ◽  
High Prevalence ◽  
Maternal Parity ◽  
Single Birth

Angka kematian neonatal Indonesia menduduki peringkat ke-10 tertinggi di dunia disebabkan kejadian bayi dengan berat badan lahir rendah (BBLR) yang tinggi. Penelitian ini bertujuan untuk mengetahui pengaruh berat lahir terhadap kelangsungan hidup neonatal. Penelitian dengan desain studi kohort retrospektif ini menggunakan sumber data sekunder Survei Demografi Kesehatan Indonesia tahun 2007. Sampel meliputi 11.748 bayi yang memenuhi kriteria anak terakhir lahir hidup, lahir tunggal, dan saat wawancara berumur minimal 28 hari. Probabilitas kumulatif kelangsungan hidupneonatal di Indonesia adalah 98,49% dan cenderung semakin rendah sesuai dengan berat lahir, pada neonatal dengan berat lahir rendah adalah 95,68% dan neonatal berat lahir sangat rendah adalah 89,83%. Berat lahir berinteraksi dengan paritas ibu. Artinya, pengaruh berat lahir terhadap kelangsungan hidup neonatal berbeda berdasarkan paritas ibu. Bayi BBLR dari ibu paritas multipara dan grande multipara berisiko 2,9 kali dan 3,9 kali untuk mengalami kematian pada periode neonatal dibandingkan bayi lahir dengan berat normal. Disarankan untuk melakukan intervensi dini mencegah bayi lahir BBLR dan penanganan intensif terhadap bayi lahir BBLR.Kata kunci: Berat lahir, kelangsungan hidup neonatal, paritas ibuAbstractNeonatal mortality rate in Indonesia was ranked as 10th highest in the world because of high prevalence of infants low birth weight. This research used Indonesia Demographic and Health Survey 2007 data with retrospective cohort design. The purposes of the research are to measure the probability ofneonatal survival according to birth weight and to identify effect of birth weight on neonatal survival. The number of sample is 11.748 infants with inclusion criteria born alive, single birth, and at least 28 days old when interviewed.The study found the cumulative probability of neonatal survival in Indonesia was 98,49% and getting lower according to birth weight, at neonatal with low birth weight is 95,68% and 89,83% at neonatal with very low weight. Birth weight modification related to maternal parity, so that the influence of birth weight on neonatal survival depent on the maternal parity. Low birth weight infants of multiparous and grandemultiparous maternal parity risk 2,9 and 3,9 times experienced death in the neonatal period compared with normal birth weight. Early interventions to prevent low birth weight and intensive care to infants with low birth weight are suggested.Keywords: Birth weight, neonatal survival, maternal parity

Neurodevelopmental outcome in extremely low birth weight infants in Johannesburg, South Africa

2020 ◽  
Author(s):  
Tanusha Ramdin ◽  
Yoliswa Magadla ◽  
Robin T Saggers ◽  
Aripfani Veronica Mphaphuli ◽  
Rossella M Bandini ◽  
...  
Keyword(s):  
South Africa ◽  
At Risk ◽  
Cerebral Palsy ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Subscale Score ◽  
Extremely Low Birth Weight ◽  
Low Birth Weight Infants ◽  
The Mean

Abstract Background: Improved survival in preterm infants whether due to technological progress or treatment like antenatal steroids, surfactant administration or nasal continuous positive airway pressure (NCPAP) and aggressive resuscitation have raised the question about whether the survivors would be more prone to increased morbidity and adverse neurodevelopmental disability. Methods: This was a prospective follow-up study conducted in the neonatal unit of a tertiary hospital in Johannesburg, South Africa. Bayley scales of infant and toddler development, version III, were conducted on a group of extreme low birth weight infants (ELBWI). The mean composite cognitive, language and motor sub-scales were reported. Infants were considered to be “at risk” if the composite subscale score was below 85 and “disabled” if the composite subscale score was below 70. Infants identified with cerebral palsy were also reported.Results: The mean birth weight of the study group was 858.5grams (95% CI 839.2- 877.8) and the mean gestational age was 27.5 weeks (95% CI 27.1-27.9). The majority of ELBWI enrolled in the study had at least one Bayley at a mean corrected age of 17.09 months (CI 16.04 to 18.14). The mean composite scores for cognition were 98.4 (CI 95.1-101.7), language 90.0 (CI 87.5-92.6) and motor 97.9 (CI 94.8-101.0). All mean scores fell within the normal range, but the composite language score was the lowest. The study did not diagnose cerebral palsy in any of the infants. The study found 28 (36.3%) infants to be “at risk” for neurodevelopmental delay. Significantly more males were classified as “at risk” than females (13/25 (52%) vs. 15/52 (28.8%). Late onset sepsis (sepsis18/37 (48.6%) vs. no sepsis 10/40 (25%) p=0.031) and longer duration of ventilation (median of 12 days (IQR 46) vs. median of 4.0 days (IQR 5) p=0.048) were significantly associated with an “at risk” classification. Conclusion: Rates of early neurodevelopmental impairment have altered minimally despite significant improvements in the overall survival of ELBWI. It is of paramount importance to ensure that early neurodevelopmental outcomes are accurately assessed so as to assist doctors and families in establishing a foundation for advocacy for the immediate intensive care and post discharge follow up.

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