scholarly journals Anti-meningococcal B vaccination in Italian adolescents: a cost-effective health opportunity

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
D Panatto ◽  
P Landa ◽  
D Amicizia ◽  
P L Lai ◽  
E Lecini ◽  
...  
Keyword(s):  
Large Scale ◽  
Public Health Problem ◽  
Vaccination Strategy ◽  
Cost Effective ◽  
Dose Schedule ◽  
Developed Countries ◽  
Invasive Disease ◽  
International Setting ◽  
The Impact

Abstract Background Invasive disease due to Neisseria meningitidis (Nm) is a serious public health problem even in developed countries, owing to its high lethality rate (8-15%) and the invalidating sequelae suffered by many (up to 60%) survivors. As the microorganism is transmitted via the airborne route, the only available weapon in the fight against Nm invasive disease is vaccination. Our aim was to carry out an HTA to evaluate the costs and benefits of anti-meningococcal B (MenB) vaccination with Trumenba® in adolescents in Italy, while also considering the impact of this new vaccination strategy on organizational and ethics aspects. Methods A lifetime Markov model was developed. MenB vaccination with the two-dose schedule of Trumenba® in adolescents was compared with 'non-vaccination'. Two perspectives were considered: the National Health Service (NHS) and society. Three disease phases were defined: acute, post-acute and long-term. Epidemiological, economic and health utilities data were taken from Italian and international literature. The analysis was conducted by means of Microsoft Excel 2010®. Results Our study indicated that vaccinating adolescents (11th year of life) with Trumenba® was cost-effective with an ICER = € 7,912/QALY from the NHS perspective and € 7,758/QALY from the perspective of society. Vaccinating adolescents reduces the number of cases of disease due to meningococcus B in one of the periods of highest incidence of the disease, resulting in significant economic and health savings. Conclusions This is the first study to evaluate the overall impact of free MenB vaccination in adolescents both in Italy and in the international setting. Although cases of invasive disease due to meningococcus B are few, if the overall impact of the disease is adequately considered, it becomes clear that including anti-meningococcal B vaccination into the immunization program for adolescents is strongly recommended from the health and economic standpoints. Key messages Free, large-scale MenB vaccination is key to strengthening the global fight against invasive meningococcal disease. Anti-meningococcal B vaccination in adolescents is a cost-effective health opportunity.

scholarly journals Nearly zero energy renovation concepts for apartment buildings

2020 ◽  
Vol 172 ◽  
pp. 18009
Author(s):  
Kalle Kuusk ◽  
Jens Naumann ◽  
Annina Gritzki ◽  
Clemens Felsmann ◽  
Michele De Carli ◽  
...  
Keyword(s):  
Large Scale ◽  
Cost Effective ◽  
Energy Performance ◽  
Building Envelope ◽  
Energy Calculation ◽  
Zero Energy ◽  
Apartment Buildings ◽  
Effective Manner ◽  
The Impact

Revised EPBD directive has set ambitious targets for renovation. It is stated that Member States shall establish a long-term strategy facilitating the cost-effective transformation of existing buildings into nearly-zero energy buildings. The long-term strategy should set out a roadmap with a view to the long-term 2050 goal of reducing greenhouse gas emissions in the European Union. This creates the need for cost-efficient renovation solutions which can be implemented in large scale. The impact assessment shows that roughly a doubled renovation rate of 3 % would be needed to accomplish the energy efficiency ambitions in a cost-effective manner. The objective of this study is to specify renovation concepts with adequate heating and ventilation, based on Estonian and German apartment buildings and corresponding local solutions. Energy performance and sizing analyses were conducted for selected multifamily apartment buildings typical for 1960-70es with three different renovation concepts. Energy calculations were conducted with national energy calculation methods and national energy requirements for major renovation. In the renovation, the building envelope insulation, air tightness, and heating and ventilation systems were improved so that the renovated building complies with national nearly zero-energy requirement for major renovation.

A Perspective On The Impact of COVID-19 Pandemic in Basic Science Research and its Future implications

Coronaviruses ◽  
2020 ◽  
Vol 01 ◽  
Author(s):  
Yam Nath Paudel ◽  
Efthalia Angelopoulou ◽  
Bhupendra Raj Giri ◽  
Christina Piperi ◽  
Iekhsan Othman ◽  
...  
Keyword(s):  
Basic Science ◽  
Large Scale ◽  
Preventive Measure ◽  
Science Research ◽  
Research Institutes ◽  
Basic Science Research ◽  
Long Term Consequences ◽  
Long Term Impact ◽  
The Impact

: COVID-19 has emerged as a devastating pandemic of the century that the current generations have ever experienced. The COVID-19 pandemic has infected more than 12 million people around the globe and 0.5 million people have succumbed to death. Due to the lack of effective vaccines against the COVID-19, several nations throughout the globe has imposed a lock-down as a preventive measure to lower the spread of COVID-19 infection. As a result of lock-down most of the universities and research institutes has witnessed a long pause in basic science research ever. Much has been talked about the long-term impact of COVID-19 in economy, tourism, public health, small and large-scale business of several kind. However, the long-term implication of these research lab shutdown and its impact in the basic science research has not been much focused. Herein, we provide a perspective that portrays a common problem of all the basic science researchers throughout the globe and its long-term consequences.

scholarly journals Changes in historical typhoid transmission across 16 U.S. cities, 1889-1931: Quantifying the impact of investments in water and sewer infrastructures

2019 ◽  
Author(s):  
Maile T. Phillips ◽  
Katharine A. Owers ◽  
Bryan T. Grenfell ◽  
Virginia E. Pitzer
Keyword(s):  
Late Summer ◽  
Water Source ◽  
Developed Countries ◽  
The United States ◽  
Water And Sanitation ◽  
Sewer Systems ◽  
Early Fall ◽  
Sanitation Systems ◽  
The Impact

ABSTRACTBackgroundInvestments in water and sanitation systems are believed to have led to the decline in typhoid fever in developed countries, such that most cases now occur in regions lacking adequate clean water and sanitation. Exploring seasonal and long-term patterns in historical typhoid mortality in the United States can offer deeper understanding of disease drivers.MethodsWe fit modified Time-series Susceptible-Infectious-Recovered models to city-level weekly mortality counts to estimate seasonal and long-term typhoid transmission. We examined seasonal transmission separately by city and aggregated by water source. We fit regression models to measure associations between long-term transmission and financial investments in water and sewer systems.ResultsTyphoid transmission peaked in late summer/early fall. Seasonality varied by water source, with the greatest variation occurring in cities with reservoirs. Historical $1 per capita ($25.80 in 2017) investments in construction and operation of water and sewer systems were associated with 8-53% decreases in typhoid transmission, while $1 increases in total value or debt accrued to maintain them were associated with 4-7% decreases.ConclusionOur findings aid in the understanding of typhoid transmission dynamics and potential impacts of water and sanitation improvements, and can inform cost-effectiveness analyses of interventions to reduce the typhoid burden.

Numerical Modelling of a District Scale Groundwater Heat Pump Operation: Case Study from Colchester, UK

2021 ◽  
Author(s):  
Taha Sezer ◽  
Abubakar Kawuwa Sani ◽  
Rao Martand Singh ◽  
David P. Boon
Keyword(s):  
Large Scale ◽  
District Level ◽  
Thermal Plume ◽  
Injection Wells ◽  
Term Operation ◽  
Heating And Cooling ◽  
Groundwater Heat Pump ◽  
The Impact

<p>Groundwater heat pumps (GWHP) are an environmentally friendly and highly efficient low carbon heating technology that can benefit from low-temperature groundwater sources lying in the shallow depths to provide heating and cooling to buildings. However, the utilisation of groundwater for heating and cooling, especially in large scale (district level), can create a thermal plume around injection wells. If a plume reaches the production well this may result in a decrease in the system performance or even failure in the long-term operation. This research aims to investigate the impact of GWHP usage in district-level heating by using a numerical approach and considering a GWHP system being constructed in Colchester, UK as a case study, which will be the largest GWHP system in the UK. Transient 3D simulations have been performed pre-construction to investigate the long-term effect of injecting water at 5°C, into a chalk bedrock aquifer. Modelling suggests a thermal plume develops but does not reach the production wells after 10 years of operation. The model result can be attributed to the low hydraulic gradient, assumed lack of interconnecting fractures, and large (>500m) spacing between the production and injection wells. Model validation may be possible after a period operational monitoring.</p>

Food Insecurity and Mortality in American Adults: Results From the NHANES-Linked Mortality Study

2020 ◽  
pp. 152483992094592 ◽  
Author(s):  
Srikanta Banerjee ◽  
Tim Radak ◽  
Jagdish Khubchandani ◽  
Patrick Dunn
Keyword(s):  
Health Risk ◽  
Food Insecurity ◽  
Public Health Problem ◽  
The United States ◽  
Mortality Data ◽  
Long Term Outcomes ◽  
Interdisciplinary Approaches ◽  
The Impact

Food insecurity is a significant public health problem in the United States leading to substantial social, economic, and health care–related burdens. While studies continue to estimate the prevalence of food insecurity, the long-term outcomes are not extensively explored. The purpose of this study was to assess the impact of food insecurity on mortality. We analyzed data on adults (≥ 20 years) from the 1999–2010 National Health and Nutrition Examination Survey, with mortality data obtained through 2015. Among the total study participants (n = 25,247), 17.6% reported food insecurity. Food-insecure individuals were more likely to be younger in age, minorities, poorer, with lesser education, obese, smokers, and with diabetes compared to food-secure counterparts. During a 10.2-year follow-up, among the food insecure, 821 individuals died (11%). The hazard ratio (HR) for mortality among the food insecure compared with the food secure, with adjustment for age and gender only, was 1.58; 95% confidence interval [CI: 1.25, 2.01]. The adjusted HRs for all-cause mortality, HR = 1.46, CI [1.23, 1.72], p < .001, and cardiovascular mortality, HR = 1.75, CI [1.19, 2.57], p < .01, were statistically significantly higher among food-insecure individuals, after adjustment for multiple demographic and health risk factors. Individuals who are food-insecure have a significantly higher probability of death from any cause or cardiovascular disease in long-term follow-up. Comprehensive and interdisciplinary approaches to reducing food insecurity–related disparities and health risks should be implemented. Including food insecurity in health risk assessments and addressing food insecurity as a determinant of long-term outcomes may contribute to lower premature death rates.

scholarly journals Dengue Situation in Bangladesh: An Epidemiological Shift in terms of Morbidity and Mortality

2019 ◽  
Vol 2019 ◽  
pp. 1-12 ◽  
Author(s):  
Pulak Mutsuddy ◽  
Sanya Tahmina Jhora ◽  
Abul Khair Mohammad Shamsuzzaman ◽  
S. M. Golam Kaisar ◽  
Md Nasir Ahmed Khan
Keyword(s):  
Large Scale ◽  
Monsoon Season ◽  
Public Health Problem ◽  
Cost Effective ◽  
Time Frame ◽  
Morbidity And Mortality ◽  
Effective Vaccine ◽  
Vector Borne Diseases ◽  
Research Organizations ◽  
Post Monsoon Season

The escalating dengue situation in Bangladesh has been emerging as a serious public health problem in terms of morbidity and mortality. Results of analysis of 40,476 cases of Bangladesh occurring during 2000–2017 indicated that 49.73% of the dengue cases occurred during the monsoon season (May–August) and 49.22% during the post-monsoon season (September–December). However, data also showed that, since 2014, these trends have been changing, and dengue cases have been reported during the pre-monsoon season. During 2015–2017, in the pre-monsoon season, the dengue cases were reported to be more than seven times higher compared to the previous 14 years. The findings closely correlate with those of the pre-monsoon Aedes vector survey which revealed the presence of high density of larva and pupa of the dengue vectors in the environment all the year round. In our study, climate changes, such as average rainfall, humidity, and temperature, after 2014, and rapid unplanned urbanization were the strong predictors of an imbalance in the existing ecology that has led to increase in dengue cases in 2016 and the emergence of the chikungunya virus for the first time in Bangladesh in 2017. Although 2018 dengue data are relevant but not included in this study due to study time frame, it is interesting to report an increase in the number of dengue cases in pre (2016) and post (2018, which is highest within 18 years) chikungunya outbreak, which favors the study hypothesis. Despite the efforts to control dengue, based primarily on the vector control and case management, the burden and costs of the disease and similar vector-borne diseases will continue to grow in future in our country. Developing a cost-effective vaccine against all the 4 strains of dengue remains a challenge. The CDC, in collaboration with other research organizations, may come forward to initiate and coordinate a large-scale randomized clinical trial of an effective dengue vaccine in Bangladesh.

scholarly journals Impact of national interventions to promote responsible antibiotic use: a systematic review

2019 ◽  
Vol 75 (1) ◽  
pp. 14-29 ◽  
Author(s):  
Jane Mingjie Lim ◽  
Shweta Rajkumar Singh ◽  
Minh Cam Duong ◽  
Helena Legido-Quigley ◽  
Li Yang Hsu ◽  
...  
Keyword(s):  
Systematic Review ◽  
National Level ◽  
Public Health Problem ◽  
Antibiotic Use ◽  
Antibiotic Consumption ◽  
Middle Income ◽  
Middle Income Countries ◽  
Policy Interventions ◽  
The Impact

Abstract Background Global recognition of antimicrobial resistance (AMR) as an urgent public health problem has galvanized national and international efforts. Chief among these are interventions to curb the overuse and misuse of antibiotics. However, the impact of these initiatives is not fully understood, making it difficult to assess the expected effectiveness and sustainability of further policy interventions. We conducted a systematic review to summarize existing evidence for the impact of nationally enforced interventions to reduce inappropriate antibiotic use in humans. Methods We searched seven databases and examined reference lists of retrieved articles. To be included, articles had to evaluate the impact of national responsible use initiatives. We excluded studies that only described policy implementations. Results We identified 34 articles detailing interventions in 21 high- and upper-middle-income countries. Interventions addressing inappropriate antibiotic access included antibiotic committees, clinical guidelines and prescribing restrictions. There was consistent evidence that these were effective at reducing antibiotic consumption and prescription. Interventions targeting inappropriate antibiotic demand consisted of education campaigns for healthcare professionals and the general public. Evidence for this was mixed, with several studies showing no impact on overall antibiotic consumption. Conclusions National-level interventions to reduce inappropriate access to antibiotics can be effective. However, evidence is limited to high- and upper-middle-income countries, and more evidence is needed on the long-term sustained impact of interventions. There should also be a simultaneous push towards standardized outcome measures to enable comparisons of interventions in different settings.

scholarly journals Argan Oil, Functional Food, and the Sustainable Development of the Argan Forest

2008 ◽  
Vol 3 (2) ◽  
pp. 1934578X0800300 ◽  
Author(s):  
Zoubida Charrouf ◽  
Dominique Guillaume
Keyword(s):  
Functional Food ◽  
Large Scale ◽  
Economic Value ◽  
Developed Countries ◽  
Scale Production ◽  
The Sustainable Development ◽  
Argan Oil ◽  
Large Scale Production ◽  
Argan Tree

For years, in southwestern Morocco, the decline of the argan forest has been accompanied by the concomitant desert encroachment. Preservation of this forest by increasing the economic value of argan tree was proposed twenty years ago, but successful large scale production of certified, high quality argan oil, an edible oil introduced as a functional food, has only been recently achieved. Argan oil is now marketed in most developed countries, despite its elevated price, and protection of the argan forest is now seriously being considered. The aim of this work is to present the recent progress made in argan oil production, the ways explored to commercialize the oil extraction by-products, and recent attempts to use other argan tree parts as part of a long term aim to preserve the argan forest.

scholarly journals Nonlinear Creep Model of Deep Gangue Backfilling Material and Time-Dependent Characteristics of Roof Deformation in Backfilling Mining

Geofluids ◽  
2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Peng Huang ◽  
Jixiong Zhang ◽  
Qi Zhang ◽  
Ntigurirwa Jean Damascene ◽  
Yuming Guo
Keyword(s):  
Large Scale ◽  
High Stress ◽  
Viscoelastic Model ◽  
Creep Model ◽  
Mine Pressure ◽  
Nonlinear Creep ◽  
Viscoelastic Foundation ◽  
The Impact ◽  
Roof Deformation

With the gradual increase in mining depth of coal resource exploitation, deep backfilling mining has effectively solved the impact of strong deep mine pressure and strong mining disturbances. However, after deep backfilling mining, the backfilling material is subjected to high stress for a long time, and its viscoelasticity has a significant impact on the roof control effect. This paper uses a large-scale bulk confinement test device to analyze the viscoelastic properties of gangue, establishes a high-precision fractional viscoelastic creep model, and identifies the gangue parameters. The established fractional viscoelastic model was used as the foundation model of the beam, and the roof model based on the fractional viscoelastic foundation was solved. The top deformation characteristics of elastic foundation and fractional foundation were compared and analyzed, and the time effect, viscoelastic effect, and order effect of the fractional order viscoelastic foundation beam were discussed. The results show that the viscosity of gangue increased under the action of deep high stress. As time increased, the roof deformation also increased. In order to more effectively control the long-term deformation of the roof, the viscosity coefficient of the backfilling material should be greater than 20 MPa. This research provides relevant guidance for the requirements of backfilling materials for deep backfilling mining and the prediction of long-term dynamic deformation of the roof in underground excavations.

scholarly journals Places of living and places of dying: the case for preventing suicide in residential long-term care

2020 ◽  
pp. 1-16
Author(s):  
Briony Jain ◽  
Viktoryia Kalesnikava ◽  
Joseph E. Ibrahim ◽  
Briana Mezuk
Keyword(s):  
Older Adults ◽  
Suicide Prevention ◽  
Residential Care ◽  
Long Term Care ◽  
Public Health Problem ◽  
Future Research ◽  
Term Care ◽  
The Impact ◽  
Residential Long Term Care

Abstract This commentary addresses the increasing public health problem of suicide in later life and presents the case for preventing suicide in residential long-term care settings. We do so by examining this issue from the perspective of three levels of stakeholders – societal, organisational and individual – considering the relevant context, barriers and implications of each. We begin by discussing contemporary societal perspectives of ageing; the potential impact of ageism on prevention of late-life suicide; and the roles of gender and masculinity. This is followed by a historical analysis of the origin of residential long-term care; current organisational challenges; and person-centred care as a suicide prevention strategy. Finally, we consider suicide in long-term care from the perspective of individuals, including the experience of older adults living in residential care settings; the impact of suicide on residential care health professionals and other staff; and the impact of suicide bereavement on family, friends and other residents. We conclude with recommendations for policy reform and future research. This commentary aims to confront the often unspoken bias associated with preventing suicide among older adults, particularly those living with complex medical conditions, and invoke an open dialogue about suicide prevention in this population and setting.

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