The depression phenotype in a European population-based study

Abstract Introduction Depression is a growing public health concern and associated with a number of co-morbidities including diabetes mellitus. The aim was to estimate the prevalence of depression at a population level across different glycaemic statuses while establishing phenotypic characteristics of this sub-population. Methods A national representative cross-sectional study was conducted in Malta (2014-6). Participants were categorized into different sub-populations according to their glycaemic status. Depression prevalence rates and bio-socio-economic characteristics for each sub-population were established. Multiple regression analyses performed to identify links between glycaemic status and depression. Results Depression was prevalent in 17.15% of our study population (CI 95%: 16.01 - 18.36) with a female predominance. The normoglycaemic sub-population had the highest depression rates. Persons with known diabetes had a higher probability of having a history of depression (OR:2.36 CI 95%:1.12 - 4.96), as well as with being of female gender, having lower educational status, smoking tobacco and having established cardiovascular disease. Conclusions Depression was highly prevalent among the normoglycaemic population. Primary care physicians should implement a depression screening tool as part of their routine health check-ups, with special attention to those with cardiovascular co-morbidities and low socioeconomic status. Key messages Depression prevalent mostly in the normoglycemic population. Screening for depression should be part of routine health check-ups.

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Are normoglycaemic individuals at risk of depression? The depression-dysglycaemic phenotype from a European population-based cross-sectional study

10.21203/rs.2.19240/v1 ◽

2019 ◽

Author(s):

Sarah Cuschieri ◽

Julian Mamo

Keyword(s):

Communicable Disease ◽

Population Level ◽

Female Gender ◽

Educational Status ◽

Population Based ◽

Cross Sectional Study ◽

Health Concern ◽

Sectional Study ◽

Cross Sectional ◽

History Of

Abstract Background Depression is an ever more common chronic non communicable disease and its control constitutes a growing public health concern given its links with a number of co-morbidities, including diabetes mellitus. The study aimed to estimate the prevalence of depression at a population level across groups of different glycaemic status, whilst establishing its socioeconomic phenotypic characteristics.Methods A nationally representative cross-sectional study was conducted in Malta between 2014 and 2016. Participants were categorized into different sub-populations according to their glycaemic status. Depression prevalence rates and socio-economic characteristics for each sub-population were established. Multiple regression analysis was performed to identify links with depression.Results Depression was prevalent in 17.15% (CI 95%: 16.01 – 18.36) with a female predominance. The normoglycaemic sub-population had the highest depression rates. However, persons with known diabetes had a higher probability of having a history of depression (OR:2.36 CI 95%:1.12 – 4.96), as well as with being of the female gender, having lower educational status, having a history of smoking tobacco and having established cardiovascular disease.Conclusions Depression was highly prevalent among the normoglycaemic population especially as age progress. Physicians in primary care should implement a depression screening tool as part of their routine health check-ups, with special attention to those with cardiovascular co-morbidities and any signs of psycho-socio-economic burden.

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Association of Conventional Cardiovascular Risk Factors with Carotid Atherosclerosis Prevalence in General Population

Rational Pharmacotherapy in Cardiology ◽

10.20996/1819-6446-2018-14-4-552-557 ◽

2018 ◽

Vol 14 (4) ◽

pp. 552-557

Author(s):

V. S. Kaveshnikov ◽

V. N. Serebryakova ◽

I. A. Trubacheva ◽

S. A. Shalnova

Keyword(s):

Risk Factors ◽

Regression Analysis ◽

Carotid Atherosclerosis ◽

Population Level ◽

Educational Status ◽

Population Based ◽

High Density Lipoproteins ◽

Ultrasound Screening ◽

Cross Sectional ◽

Working Age

Material and methods. In the cross-sectional population-based study of general unorganized population of Tomsk aged 25-64 years ultrasound screening examination of the carotid arteries was done for detection of atherosclerotic plaques (plaque). As potential plaque determinants the following factors were studied: age, gender, smoking, low and high density lipoproteins (LDL-C and HDL-C), triglycerides, arterial hypertension, body mass index (BMI), low educational status (LES), high-sensitive C-reactive protein, glucose, diabetes mellitus, antihypertensive and hypolipidemic therapy. Study of relationships was carried out with logistic regression analysis. The error probability of less than 5% was considered statistically significant.Results. In the crude analysis most of the determinants under study showed statistically significant relationship with plaque presence. After adjustment for age and sex, LDL-C, smoking and LES were associated with CAS prevalence. In multivariable regression analysis 9 risk factors appeared to be independently associated with plaque presence, wherein age, male sex, LDL-C, BMI and HDL-C were the most significant. In the participants of 50 years and older the smoking effect was the next in significance after LDL-C.Conclusion. The results obtained focus attention on the comparative value of the major atherogenic risk factors and suggest that currently effective and timely control of LDL-C is of primary importance for prevention of carotid atherosclerosis in the general working-age population. As well the findings of the study evidence that at the population level smoking is still one of the leading atherogenic risk factors.

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Psychotic symptoms associate inversely with social support, social autonomy and psychosocial functioning: A community-based study

International Journal of Social Psychiatry ◽

10.1177/00207640211011198 ◽

2021 ◽

pp. 002076402110111

Author(s):

Margarita Guerrero-Jiménez ◽

Blanca Gutiérrez ◽

Jorge A Cervilla

Keyword(s):

Social Support ◽

Psychosocial Functioning ◽

Female Gender ◽

Population Based ◽

Cross Sectional Study ◽

European Population ◽

Psychotic Symptoms ◽

Cross Sectional ◽

Multi Stage ◽

Social Autonomy

Background: Population-based studies exploring psychotic symptoms (PS) show that their prevalence in the community is higher than previously thought. Psychosocial functioning and social support are poorer among people presenting clinical and subclinical PS. Aims: We aimed to estimate the prevalence rate of PS in Andalusia and to explore the association between PS and psychosocial functioning, social support and social autonomy in a Southern European population. Material and methods: This is a cross-sectional study. We undertook multi-stage sampling using different standard stratification techniques. Out of 5496 households approached, we interviewed 4507 (83.7%) randomly selected participants living in the autonomous region of Andalusia (Southern Spain). The Spanish version of the MINI International Neuropsychiatric Interview was used to elicit PS. We also gathered information on socio-demographic factors, suicidality risk, psychosocial functioning, social support and social autonomy. Results: The overall prevalence of PS was 6.7% (95% CI: 5.99–6.45). PS were associated with lower age (OR 0.975; 95% CI (0.967–0.983); p < .0001), female gender (OR = 1.346; 95% CI (1.05–1.07) p = .018), not living in a rural area (OR = 0.677; 95% CI (0.50–0.90) p = 0.009), lower social support (OR = 0.898; 95% CI (0.85–0.94) p < .0001), lower scores on social autonomy (OR = 0.889; 95% CI (0.79–1.00) p = .050), having an increased suicidality risk score (OR = 1.038; 95% CI (1.005–1.07); p = .023) and having lower scores on psychosocial functioning (OR = 0.956; 95% CI (0.95–0.96); p < 0.0001). Conclusions: Social outcomes seem to be strongly inversely associated with PS in spite of presumed higher levels of social support among Southern European cultures.

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Adolescent Suicidality as Seen in Rural Northeastern Uganda

Crisis ◽

10.1027/0227-5910/a000059 ◽

2011 ◽

Vol 32 (1) ◽

pp. 43-51 ◽

Cited By ~ 17

Author(s):

Eugene Kinyanda ◽

Ruth Kizza ◽

Jonathan Levin ◽

Sheila Ndyanabangi ◽

Catherine Abbo

Keyword(s):

Low Socioeconomic Status ◽

Sub Saharan Africa ◽

Psychosocial Risk ◽

Psychiatric Nurses ◽

Health Concern ◽

Cross Sectional ◽

Childhood Experiences ◽

Low Socioeconomic ◽

Dsm Iv ◽

Sub Saharan

Background: Suicidal behavior in adolescence is a public health concern and has serious consequences for adolescents and their families. There is, however, a paucity of data on this subject from sub-Saharan Africa, hence the need for this study. Aims: A cross-sectional multistage survey to investigate adolescent suicidality among other things was undertaken in rural northeastern Uganda. Methods: A structured protocol administered by trained psychiatric nurses collected information on sociodemographics, mental disorders (DSM-IV criteria), and psychological and psychosocial risk factors for children aged 3–19 years (N = 1492). For the purposes of this paper, an analysis of a subsample of adolescents (aged 10–19 years; n = 897) was undertaken. Results: Lifetime suicidality in this study was 6.1% (95% CI, 4.6%–7.9%). Conclusions: Factors significantly associated with suicidality included mental disorder, the ecological factor district of residence, factors suggestive of low socioeconomic status, and disadvantaged childhood experiences.

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Modeling Hearing Loss Progression and Asymmetry in the Older Old: A National Population-Based Survey

Innovation in Aging ◽

10.1093/geroni/igaa057.693 ◽

2020 ◽

Vol 4 (Supplement_1) ◽

pp. 214-215

Author(s):

Rahul Sharma ◽

Anil Lalwani ◽

Justin Golub

Keyword(s):

Hearing Loss ◽

Pure Tone ◽

Population Level ◽

Population Based ◽

National Database ◽

Cross Sectional ◽

Adult Lifespan ◽

Pure Tone Average ◽

Age Related ◽

Public Datasets

Abstract The progression and asymmetry of age-related hearing loss has not been well characterized in those 80 years of age and older because public datasets mask upper extremes of age to protect anonymity. We aimed to model the progression and asymmetry of hearing loss in the older old using a representative, national database. This was a cross-sectional, multicentered US epidemiologic analysis using the National Health and Nutrition Examination Study (NHANES) 2005-2006, 2009-2010, and 2011-2012 cycles. Subjects included non-institutionalized, civilian adults 80 years and older (n=621). Federal security clearance was granted to access publicly-restricted age data. Outcome measures included pure-tone average air conduction thresholds and the 4-frequency pure tone average (PTA). 621 subjects were 80 years old or older (mean=84.2 years, range=80-104 years), representing 10,600,197 Americans. Hearing loss exhibited constant acceleration across the adult lifespan at a rate of 0.0052 dB/year2 (95% CI = 0.0049, 0.0055). Compounded over a lifetime, the velocity of hearing loss would increase five-fold, from 0.2 dB loss/year at age 20 to 1 dB loss/year at age 100. This model predicted mean PTA within 2 dB of accuracy for most ages between 20 and 100 years. There was no change in the asymmetry of hearing loss with increasing age over 80 years (linear regression coefficient of asymmetry over age=0.07 (95% CI=-0.01, 0.24). In conclusion, hearing loss steadily and predictably accelerates across the adult lifespan to at least age 100, becoming near-universal. These population-level statistics will guide treatment and policy recommendations for hearing health in the older old.

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MS prevalence in New Zealand, an ethnically and latitudinally diverse country

Multiple Sclerosis Journal ◽

10.1177/1352458510379614 ◽

2010 ◽

Vol 16 (12) ◽

pp. 1422-1431 ◽

Cited By ~ 54

Author(s):

Bruce V Taylor ◽

John F Pearson ◽

Glynnis Clarke ◽

Deborah F Mason ◽

David A Abernethy ◽

...

Keyword(s):

New Zealand ◽

Environmental Factors ◽

Latitudinal Gradient ◽

Population Level ◽

Cross Sectional Study ◽

European Population ◽

Multiple Sources ◽

Cross Sectional ◽

The North ◽

Mcdonald Criteria

Background: The prevalence of multiple sclerosis (MS) is not uniform, with a latitudinal gradient of prevalence present in most studies. Understanding the drivers of this gradient may allow a better understanding of the environmental factors involved in MS pathogenesis. Method: The New Zealand national MS prevalence study (NZMSPS) is a cross-sectional study of people with definite MS (DMS) (McDonald criteria 2005) resident in New Zealand on census night, 7 March 2006, utilizing multiple sources of notification. Capture—recapture analysis (CRA) was used to estimate missing cases. Results: Of 2917 people with DMS identified, the crude prevalence was 72.4 per 100,000 population, and 73.1 per 100,000 when age-standardized to the European population. CRA estimated that 96.7% of cases were identified. A latitudinal gradient was seen with MS prevalence increasing three-fold from the North (35°S) to the South (48°S). The gradient was non-uniform; females with relapsing—remitting/secondary-progressive (RRMS/SPMS) disease have a gradient 11 times greater than males with primary-progressive MS ( p < 1 × 10-7). DMS was significantly less common among those of Māori ethnicity. Conclusions: This study confirms the presence of a robust latitudinal gradient of MS prevalence in New Zealand. This gradient is largely driven by European females with the RRMS/SPMS phenotype. These results indicate that the environmental factors that underlie the latitudinal gradient act differentially by gender, ethnicity and MS phenotype. A better understanding of these factors may allow more targeted MS therapies aimed at modifiable environmental triggers at the population level.

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Concerns in the Norwegian Population during the Initial Lockdown Due to the COVID-19 Pandemic

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18116119 ◽

2021 ◽

Vol 18 (11) ◽

pp. 6119

Author(s):

Inger Schou-Bredal ◽

Laila Skogstad ◽

Tine K. Grimholt ◽

Tore Bonsaksen ◽

Øivind Ekeberg ◽

...

Keyword(s):

Online Survey ◽

Female Gender ◽

Population Based ◽

Snowball Sampling ◽

Financial Loss ◽

Next Of Kin ◽

Cross Sectional ◽

Norwegian Population ◽

Gender And Age ◽

Response Alternatives

Although concern affects one’s welfare or happiness, few studies to date have focused on peoples’ concerns during the initial COVID-19 lockdown. The aim of the study was to explore concerns in the Norwegian populations according to gender and age, and identify which concerns were most prominent during the lockdown. A population-based cross-sectional online survey using snowball-sampling strategies was conducted, to which 4527 adults (≥18 years) responded. Questions related to concerns had response alternatives yes or no. In addition, they were asked which concern was most prominent. Nearly all the 4527 respondents (92%) reported that they were concerned: 60.9% were generally concerned about the pandemic, 83.9% were concerned about family and friends, 21.8% had financial concerns, and 25.3% expected financial loss. More women were concerned about family and friends than males, (85.2% vs. 76.2%, p < 0.001), whereas more men expected financial loss (30.4% vs. 24.4%y, p = 0.001). Younger adults (<50 years) had more financial concerns than older adults (25.9% vs. 10.5%, p < 0.001). Being concerned about family and friends was the most prominent concern and was associated with; lower age (OR 0.79), female gender (OR 1.59), and being next of kin (2.42). The most prominent concern for adults 70 years or older was being infected by COVID-19. In conclusion, women and younger individuals were most concerned. While adults under 70 years of age were most concerned about family and friends and adults 70 years or older were most concerned about being infected by COVID-19.

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Use, awareness and willingness to self-test for HIV: An analysis of cross-sectional population-based surveys in Malawi and Zimbabwe

10.21203/rs.3.rs-15570/v2 ◽

2020 ◽

Author(s):

Cheryl Case Johnson ◽

Melissa Neuman ◽

Peter MacPherson ◽

Augustine Choko ◽

Caitlin Quinn ◽

...

Keyword(s):

Sexual Risk ◽

Large Scale ◽

Scale Up ◽

Population Level ◽

Sociodemographic Factors ◽

Population Based ◽

African Countries ◽

Cross Sectional ◽

Self Test ◽

Result Analysis

Abstract Background Many southern African countries are nearing the global goal to diagnose 90% of people with HIV by 2020. In 2016, 84% and 86% of people with HIV knew their status in Malawi and Zimbabwe respectively. Despite this progress, gaps remain, particularly among men (≥25 years). We investigated awareness, use and willingness to HIV self-test (HIVST) prior to large scale implementation and explored sociodemographic associations. Methods We pooled responses from two of the first cross-sectional Demographic Health Surveys to include HIVST questions: Malawi and Zimbabwe in 2015-16. Sociodemographic factors and sexual risk behaviours associated with previously testing for HIV, and awareness, past use and future willingness to self-test were investigated using univariable and multivariable logistic regression, adjusting for the sample design and limiting analysis to participants with completed questionnaire and a valid HIV result. Analysis of willingness to self-test was restricted to Zimbabwean men, as Malawians and women were not asked this question. Results Of 31 385 individuals, the proportion never-tested was higher for men (31.2%) than women (16.5%), p<0.001. For men, having ever tested increased with age. Past use and awareness of HIVST was very low, 1.2% and 12.6% respectively. Awareness was lower among women than men (9.1% vs 15.3%, adjusted odds ratio (aOR)=1.55; 95% confidence interval [CI]: 1.37-1.75), and at younger ages, and lower education and literacy levels. Willingness to self-test among Zimbabwean men was high (84.5%), with having previously tested for HIV, high sexual risk, and being ≥25 years associated with greater willingness. Wealthier men had greater awareness of HIVST than poorer men (p<0.001). Men at higher HIV-related sexual risk, compared to men at lower HIV-related sexual risk, had the greatest willingness to self-test (aOR=3.74; 95%CI: 1.39-10.03, p<0.009).Conclusions In 2015-16 many Malawian and Zimbabwean men had never tested for HIV. Despite low awareness and minimal HIVST experience at that time, willingness to self-test was high among Zimbabwean men, especially in older men with moderate to high HIV-related sexual risk. These data provide a valuable baseline against which to investigate population-level uptake of HIVST as programmes scale-up. Programmes introducing, or planning to introduce HIVST, should consider including questions in population-based surveys.

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Prevalence of falls in elderly in Brazil: a countrywide analysis

Cadernos de Saúde Pública ◽

10.1590/s0102-311x2011000900015 ◽

2011 ◽

Vol 27 (9) ◽

pp. 1819-1826 ◽

Cited By ~ 69

Author(s):

Fernando Vinholes Siqueira ◽

Luiz Augusto Facchini ◽

Denise Silva da Silveira ◽

Roberto Xavier Piccini ◽

Elaine Tomasi ◽

...

Keyword(s):

Low Socioeconomic Status ◽

Urban Areas ◽

Female Gender ◽

The Elderly ◽

Cross Sectional Study ◽

Cross Sectional ◽

Low Socioeconomic ◽

The North ◽

High Prevalence ◽

Falls In Elderly

We conducted a cross-sectional study of a sample of 6,616 elderly living in urban areas of 100 municipalities in 23 Brazilian states, who responded to questions on the occurrence of falls in the 12 months prior to the interview, and occurrence of fractures due to the falls. The prevalence of falls among the elderly was 27.6% (95%CI: 26.5-28.7). Among those reporting falls, 11% had suffered fractures as a result. Of the elderly, 36% had received guidance about the precautions necessary to prevent falls, and about 1% had required surgery. Falls were associated with female gender, older age, low socioeconomic status, obesity and sedentary lifestyles. The prevalence of falls differed significantly between the North and other regions of Brazil. The study shows a high prevalence of falls, and underlines the need for preventive strategies targeting modifiable risk factors.

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Relationship between dental fluorosis and quality of life: a population based study

Brazilian Oral Research ◽

10.1590/s1806-83242005000200014 ◽

2005 ◽

Vol 19 (2) ◽

pp. 150-155 ◽

Cited By ~ 23

Author(s):

Edgard Michel-Crosato ◽

Maria Gabriela Haye Biazevic ◽

Edgard Crosato

Keyword(s):

Quality Of Life ◽

Water Supply ◽

Dental Fluorosis ◽

Female Gender ◽

Population Based ◽

Daily Activities ◽

Cross Sectional ◽

Significance Level ◽

The Impact

The aim of this study was to verify the prevalence of dental fluorosis in schoolchildren aged 6 to 15 and its possible association with the impacts on their daily activities. This study is observational, cross-sectional and analytical. A total of 513 schoolchildren from the city of Pinheiro Preto, SC, took part in this study. The children were examined by three calibrated dentists, after obtaining a kappa > 0.80. To assess the prevalence of fluorosis, clinical examinations were performed according to the methodology set forth by the 4th edition of the WHO. To assess the impact of fluorosis on their daily activities, a modified OIDP (Oral Impacts on Daily Performance) was adopted. The statistical analysis used was the Chi-squared test with a 5% significance level. Of the total number of children examined, 262 (51.1%) were of the female gender and 251 (48.9%) were of the male gender. In regard to the prevalence of fluorosis, 94 (18.3%) of the children presented this condition, while 419 children (81.7%) presented a normal condition. In regard to the severity of fluorosis, few children presented severe alterations. No association was found between dental fluorosis and gender (p = 0.646), between fluorosis and socioeconomic status (p = 0.848) or between fluorosis and access to public water supply system (p = 0.198). The activities that most affected children's daily performance were: oral hygiene (40.9%) and food intake or enjoying food (40.4%). None of the daily activities could be associated with the occurrence of dental fluorosis. The prevalence of dental fluorosis was consonant with the standards found for locations with optimum fluoride content in the water supply. The questionable and very slight levels of fluorosis were the most frequently found, without influence in the quality of life of the schoolchildren participating in the study.

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