scholarly journals The pathological autopsy of coronavirus disease 2019 (COVID-2019) in China: a review

2020 ◽  
Vol 78 (3) ◽  
Author(s):  
Baoyong Zhou ◽  
Wei Zhao ◽  
Ruixi Feng ◽  
Xiaohui Zhang ◽  
Xuemei Li ◽  
...  

ABSTRACT The coronavirus disease 2019 (COVID-2019) that emerged in Wuhan, China, has rapidly spread to many countries across all six WHO regions. However, its pathobiology remains incompletely understood and many efforts are underway to study it worldwide. To clarify its pathogenesis to some extent, it will inevitably require lots of COVID-2019-associated pathological autopsies. Pathologists from all over the world have raised concerns with pathological autopsy relating to COVID-2019. The issue of whether a person died from COVID-2019 infection or not is always an ambiguous problem in some cases, and ongoing epidemiology from China may shed light on it. This review retrospectively summarizes the research status of pathological autopsy for COVID-2019 deaths in China, which will be important for the cause of death, prevention, control and clinical strategies of COVID-2019. Moreover, it points out several challenges at autopsy. We believe pathological studies from China enable to correlate clinical symptoms and pathological features of COVID-2019 for doctors and provide an insight into COVID-2019 disease.

2022 ◽  
pp. 109-126
Author(s):  
Omar El Hiba ◽  
Hicham Chatoui ◽  
Nadia Zouhairi ◽  
Lahoucine Bahi ◽  
Lhoussaine Ammouta ◽  
...  

Since December 2019, the world has been shaken by the spread of a highly pathogen virus, causing severe acute respiratory syndrome (SARS-Cov2), which emerged in Wuhan, China. SARS-Cov2 is known to cause acute pneumonia: the cardinal feature of coronavirus disease 2019 (COVID-19). Clinical features of the disease include respiratory distress, loss of spontaneous breathing, and sometimes neurologic signs such as headache and nausea and anosmia, leading to suppose a possible involvement of the nervous system as a potential target of SARS-CoV2. The chapter will shed light on the recent clinical and experimental data sustaining the involvement of the nervous system in the pathophysiology of COVID-19, based on several case reports and experimental data reporting the possible transmission of SARS-CoV2 throughout the peripheral nerves to the brain cardiorespiratory centers. Thus, understanding the role of the nervous system in the course of clinical symptoms of COVID-19 is important in determining the appropriate therapeutic approach to combat the disease.


Author(s):  
Stephen Olaide Aremu ◽  
Emmanuel Olumuyiwa Onifade ◽  
Babatunde Fatoke ◽  
Samuel Olusegun Itodo ◽  
Oluwatosin Oladipo ◽  
...  

The COVID-19 which belongs to the coronaviridae family has continued to spread in a geometric progression version. The disease that originated from Wuhan, Hubei, China has spread to all the continents of the World except Antarctica continent. As of the 5th of August, 2020 there are over 18 million reported cases of COVID-19 from 214 countries and territories of the world. More than 10 million people have recovered while approximately 696,147 people have died due to COVID-19. This review provides general information on the COVID-19 and gives deep insight into the course of the disease, interventions challenges and possible solutions in Nigeria “the giant of Africa”. Scientific databases including Science Direct, Pub Med, Elsevier, Scopus, and Nature were explored. Data has also been accessed from case reports, newspaper reports, internet data, World Health Organisation (WHO) reports, Centre of Disease Control (CDCs) and Nigerian Centre of Disease Control (NCDCs) reports. US National Library of Medicine, Clinicaltrials.gov, has been accessed to get information about ongoing clinical trials. The literature survey started in the first week of April, 2020 and was completed in the first week of August, 2020. The clinical symptoms of COVID-19 patients are generally categorized as critical, severe, moderate and mild or even asymptomatic in descending order in terms of severity. Predictions from experts in different parts of the World concerning the possible impact of the disease in Africa have been on the downside which is due to a lot of glaring factors including poor health facilities and services. 


Author(s):  
Marina M. Sodnompilova ◽  

The aim of this article is to analyze traditional somatic ideas of the Turkic-Mongolians of Inner Asia that they formed as a part of their “theories” on the origin of the world and man. Data and methods. An important part of the studies of man as a social and biological being is the investigation of the human body conceptualizations of the Turkic-Mongolian peoples. When explored, the ideas that traditional societies had on the human body and its constituent parts, such as organs, muscles, and blood may give an important clue to understanding traditional medicine methods, attitudes towards the body, and the body potentialities. In this respect, one cannot overestimate the relevance of the nomads’ folklore texts dealing with the origin of the world and man as a research source. A variety of such stories relating how man was made of clay, wood, metal, bone, and stone may shed light on the invention and development of new materials by man, as well as on the technologies they used for their processing. The study is based on a comparative historical method that helps to identify commonalities characteristic of the Turkic-Mongolian world in understanding the human body; as well as the method of cultural and historical reconstruction, which gives an insight into the logic of archaic views. Conclusions. In the somatic conceptualizations of the Turkic-Mongolians, the key and stable correspondences of the natural and the human are such series as bone – wood, flesh – clay/earth /stone form. The associations of the human body and its parts with metals manifest to a lesser degree. The processes of maturing and aging of the human body were conceptualized by traditional societies in terms of both natural and cultural phenomena, such as the life cycles of a tree and ceramics making of raw/soft clay hardened in the process of its firing.


2020 ◽  
Vol 94 (5) ◽  
pp. 966-978 ◽  
Author(s):  
Roy M. Farman ◽  
Phil R. Bell

AbstractThe Hawkesbury Sandstone (Hawkesbury Series, Sydney Basin) on the southeastern coast of New South Wales, Australia, preserves a depauperate but important vertebrate tetrapod body-fossil record from the Early and Middle Triassic. As with many fossil sites around the world, the ichnological record has helped to shed light on the paleoecology of this interval. Herein, we investigate historical reports of a trackway pertaining to a putative short-tailed reptile found at Berowra Creek in the 1940s. Reinvestigation of the surviving track-bearing slabs augmented by archival photographs of the complete trackway, suggests that these impressions, which consist primarily of didactyl tracks (plus less common monodactyl and tridactyl traces), represent the earliest example of a swimming tetrapod found in Australia. Another isolated specimen (possibly from a nearby locality at Annangrove) appears to represent similar didactyl swim traces of a second, larger individual. Although the identities of the trackmakers are unknown, the Berowra Creek individual had an estimated body length of between ~80 cm (short-coupled) and 1.35 m (long-coupled), and produced the subaqueous trackway while travelling upslope (against the current) on a sandbar within a braided river system of the Hawkesbury Sandstone. These trackways partially resemble amphibian swim traces in the so-called Batrachichnus C Lunichnium continuum, but appear to represent a unique locomotion trace. This reanalysis of the Berowra Creek trackway provides insight into the locomotion of tetrapods of the Triassic Hawkesbury Series, which remains a poorly understood aspect of their life history.


2008 ◽  
Vol 42 ◽  
pp. 5-13
Author(s):  
William McNeill ◽  

The present paper remains modest in its scope: It seeks only to undertake some exploratory and preparatory investigations with a view to addressing a more difficult and far-reaching question. The issue, in brief, is the following: In the 1920s, Heidegger engages in an incisive and comprehensive critique of techn!, which I shall render here as “production” or “productive comportment,” arguing that it furnishes the foundation and horizon for Greek ontology, and by extension for the entire Western philosophical tradition, a horizon that is problematically reductive because the ontology it gives rise to understands the Being of beings in general in terms of independent presence-at-hand, the appropriate mode of access to which is theoretical apprehension. Not only philosophy and ontology, but science and its outgrowth, modern technicity—itself a monstrous transformation of techn!—would be an almost inexorable consequence of this fateful Greek beginning. The project of a “destructuring of the history of ontology” announced in Being and Time would seek to retrieve and to open up an entirely other dimension of Being, a dimension foreclosed by the Greek beginning and yet awaiting us precisely as the unthought of that beginning and the tradition to which it gave rise. The destructuring would take as its guiding thread an understanding of the Being of Dasein—designating the being that we ourselves in each case are—as radically temporal, never simply present-at-hand, and essentially inaccessible to theoretical apprehension. Yet the critical resource for this analytic of the Being of Dasein was, for the early Heidegger, itself provided by Greek philosophy: It was Aristotle’s insight into the Being of the human being as praxis, and its authentic mode of self-disclosure, phron!sis, that led Heidegger to see the radically different kind of temporality pertaining to human existence, by contrast with the theoretically ascertained time of nature as something present-at-hand, and provided a key insight into the essence of “truth” (aletheia) as unconcealment. Aristotle’s insight into this more primordial sense of aletheia or “truth” as the knowing self-disclosure of our radically temporal Being-in-the-world as praxis, as opposed to truth conceived as a property of logos, judgment, or theoretical knowledge, was a forgotten thread of Greek philosophy that could shed light upon the limits and foundations of the theoretical tradition that dominates the subsequent history of ontology.


Author(s):  
W. L. Steffens ◽  
Nancy B. Roberts ◽  
J. M. Bowen

The canine heartworm is a common and serious nematode parasite of domestic dogs in many parts of the world. Although nematode neuroanatomy is fairly well documented, the emphasis has been on sensory anatomy and primarily in free-living soil species and ascarids. Lee and Miller reported on the muscular anatomy in the heartworm, but provided little insight into the peripheral nervous system or myoneural relationships. The classical fine-structural description of nematode muscle innervation is Rosenbluth's earlier work in Ascaris. Since the pharmacological effects of some nematacides currently being developed are neuromuscular in nature, a better understanding of heartworm myoneural anatomy, particularly in reference to the synaptic region is warranted.


2020 ◽  
Vol 29 (3S) ◽  
pp. 631-637
Author(s):  
Katja Lund ◽  
Rodrigo Ordoñez ◽  
Jens Bo Nielsen ◽  
Dorte Hammershøi

Purpose The aim of this study was to develop a tool to gain insight into the daily experiences of new hearing aid users and to shed light on aspects of aided performance that may not be unveiled through standard questionnaires. Method The tool is developed based on clinical observations, patient experiences, expert involvement, and existing validated hearing rehabilitation questionnaires. Results An online tool for collecting data related to hearing aid use was developed. The tool is based on 453 prefabricated sentences representing experiences within 13 categories related to hearing aid use. Conclusions The tool has the potential to reflect a wide range of individual experiences with hearing aid use, including auditory and nonauditory aspects. These experiences may hold important knowledge for both the patient and the professional in the hearing rehabilitation process.


2019 ◽  
Vol 58 (2) ◽  
pp. 249-259
Author(s):  
Joseph Acquisto

This essay examines a polemic between two Baudelaire critics of the 1930s, Jean Cassou and Benjamin Fondane, which centered on the relationship of poetry to progressive politics and metaphysics. I argue that a return to Baudelaire's poetry can yield insight into what seems like an impasse in Cassou and Fondane. Baudelaire provides the possibility of realigning metaphysics and politics so that poetry has the potential to become the space in which we can begin to think the two of them together, as opposed to seeing them in unresolvable tension. Or rather, the tension that Baudelaire animates between the two allows us a new way of thinking about the role of esthetics in moments of political crisis. We can in some ways see Baudelaire as responding, avant la lettre, to two of his early twentieth-century readers who correctly perceived his work as the space that breathes a new urgency into the questions of how modern poetry relates to the world from which it springs and in which it intervenes.


2018 ◽  
Vol 3 (2) ◽  
pp. 76
Author(s):  
Novi Anggun Pusvitasary

Pneumonia disease is the leading cause of death of babies in the world. The prevalence of pneumonia in infants is 18.5 / mil. Data from Samarinda City Health Office during the last 1 year there are 91 cases of pneumonia in Karang Anyar Village and 63 cases in Teluk Lerong Ulu Village. Factors causing pneumonia are toddler factors, behavioral factors, and environmental factors. The results show there is a relationship between house humidity (p value = 0,013; OR = 0,192), house dwelling density (p value = 0,024; OR = 0,214), and family member smoking behavior (p value = 0,006; OR = 10,450) with incidence of pneumonia in toddlers in the Working Area of Puskesmas Wonorejo Samarinda. There was no correlation between house temperature (p value = 0,214; OR = 0,337), house lighting (p value = 0,095; OR = 3,188) and family disease history (p value = 0,707; OR = 0,753) with Pneumonia occurrence in infant in region Work Puskesmas Wonorejo Samarinda. It was concluded that there was a relationship between house humidity, home dwelling density, and smoking behavior of family members with the incidence of pneumonia in infants. It is recommended to be able to apply housing health requirements that meet health standards to reduce the incidence of pneumonia in infants and change smoking habits.


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