scholarly journals The Impact of Moderate or High-Intensity Combined Exercise on Systemic Inflammation Among Older Persons With and Without HIV

2020 ◽  
Author(s):  
Kristine M Erlandson ◽  
Melissa P Wilson ◽  
Samantha MaWhinney ◽  
Eric Rapaport ◽  
Jay Liu ◽  
...  
Keyword(s):  
High Intensity ◽  
High Intensity Exercise ◽  
Moderate Intensity ◽  
Moderate Intensity Exercise ◽  
Beneficial Effects ◽  
Markers Of Inflammation ◽  
Tnf Α ◽  
Hiv Serostatus ◽  
Soluble Tnf Receptor ◽  
The Impact

Abstract Background We investigated whether higher-intensity exercise provided greater decrease in markers of inflammation, and whether responses differed by HIV serostatus. Methods People with HIV (PWH; n = 32) and controls (n = 37) aged 50–75 years completed 12 weeks moderate-intensity exercise, then were randomized to moderate- or high-intensity exercise for 12 additional weeks (n = 27 and 29, respectively). Inflammation biomarkers were measured at 0, 12, 24 weeks. Mixed and multiple regression models were adjusted for baseline inflammation, age, and body mass index. Results Baseline tumor necrosis factor-α (TNF-α), soluble TNF receptor 2 (sTNFR2), and soluble CD14 (sCD14) were significantly higher among PWH than controls (P < .04). From week 0–12, changes in interleukin-6 (IL-6), TNF-α, and sTNFR1 were not significantly different by HIV serostatus. We found no significant interaction between HIV serostatus/exercise intensity on week 12–24 changes in IL-6, TNF-α, and sTNFR1. Among high-intensity exercisers, PWH and controls had significant increases in sCD14 (P ≤ .003), controls significant increases in IL-10 (P = .01), and PWH nonsignificant decrease in highly sensitive C-reactive protein (P = .07). Other markers were not significantly different by serostatus or intensity. Conclusions Moderate and high-intensity exercise elicited similar effects on inflammation among PWH and controls, with additional beneficial effects seen among high-intensity exercisers. Increase in sCD14 and attenuated IL-10 increase (PWH only) merit further study. Clinical Trials Registration NCT02404792.

Abstract 14433: High Intensity Exercise Training Safely Increases Cardiorespiratory Fitness in Patients With Hypertrophic Cardiomyopathy

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Katrin A Dias ◽  
James P Macnamara ◽  
Christopher M Hearon ◽  
Mitchel Samels ◽  
Aslan Turer ◽  
...  
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Cardiorespiratory Fitness ◽  
High Intensity ◽  
Training Session ◽  
Interval Training ◽  
High Intensity Exercise ◽  
Moderate Intensity ◽  
Moderate Intensity Exercise ◽  
Wide Complex Tachycardia ◽  
High Intensity Interval

Introduction: Patients with hypertrophic cardiomyopathy (HCM) are excluded from high intensity activities due to perceived fear of sudden cardiac death. Observational data from athletes with HCM suggest that engaging in high intensity exercise (HIE) may be safe and is associated with higher cardiorespiratory fitness. Whether HIE can safely elicit a superior increase in fitness compared to moderate intensity exercise in patients with HCM is unclear. Methods: Nine HCM patients (49 ± 7 years, 3 female) were assessed for maximal oxygen uptake (VO 2 max, Douglas Bag method), cardiac output (Q c , acetylene rebreathing), and peripheral oxygen extraction (av-O 2 diff, Fick equation) before randomization and after 5 months of MIE or HIE training. Patients completed 3-4 sessions of MIE each week, while the HIE group also incorporated 1-2 supervised high intensity interval training sessions/week from month 3 onwards. Arrhythmias were monitored via pre-existing implantable cardiac defibrillators or implantable loop recorders placed prior to training. Results: Five months of MIE increased absolute VO 2 max by 3% and relative VO 2 max by 4%, while HIE consistently increased absolute VO 2 max by 6% and relative VO 2 max by 5% (Figure). Maximal Q c did not change after MIE but increased in all HIE patients (+1.2L/min, 95% CI -1.4 to 3.9), while maximal av-O 2 diff remained stable in both groups. Training compliance was 84 ± 15% in HIE and 93 ± 11% in MIE. There were no serious exercise-related adverse events in either group though two HIE subjects had arrhythmias at rest: 1) 14-beat run of wide complex tachycardia of uncertain mechanism given underlying conduction disease prior to a training session, and 2) 11 beats of non-sustained ventricular tachycardia prior to post exercise testing. Conclusions: Preliminary findings show that five months of HIE safely and consistently increased cardiorespiratory fitness in patients with HCM, though overall the improvements were comparable to MIE.

Effects of high-intensity interval exercise versus continuous moderate-intensity exercise on postprandial glycemic control assessed by continuous glucose monitoring in obese adults

2014 ◽  
Vol 39 (7) ◽  
pp. 835-841 ◽  
Author(s):  
Jonathan P. Little ◽  
Mary E. Jung ◽  
Amy E. Wright ◽  
Wendi Wright ◽  
Ralph J.F. Manders
Keyword(s):  
Continuous Glucose Monitoring ◽  
High Intensity ◽  
Glucose Monitoring ◽  
Area Under The Curve ◽  
Postprandial Glucose ◽  
Moderate Intensity ◽  
Moderate Intensity Exercise ◽  
Obese Adults ◽  
High Intensity Interval ◽  
The Impact

The purpose of this study was to examine the impact of acute high-intensity interval training (HIIT) compared with continuous moderate-intensity (CMI) exercise on postprandial hyperglycemia in overweight or obese adults. Ten inactive, overweight or obese adults (41 ± 11 yrs, BMI = 36 ± 7 kg/m2) performed an acute bout of HIIT (10 × 1 min at approximately 90% peak heart rate (HRpeak) with 1-min recovery periods) or matched work CMI (30 min at approximately 65% HRpeak) in a randomized, counterbalanced fashion. Exercise was performed 2 h after breakfast, and glucose control was assessed by continuous glucose monitoring under standardized dietary conditions over 24 h. Postprandial glucose (PPG) responses to lunch, dinner, and the following day’s breakfast were analyzed and compared with a no-exercise control day. Exercise did not affect the PPG responses to lunch, but performing both HIIT and CMI in the morning significantly reduced the PPG incremental area under the curve (AUC) following dinner when compared with control (HIIT = 110 ± 35, CMI = 125 ± 34, control = 162 ± 46 mmol/L × 2 h, p < 0.05). The PPG AUC (HIIT = 125 ± 53, CMI = 186 ± 55, control = 194 ± 96 mmol/L × 2 h) and the PPG spike (HIIT = Δ2.1 ± 0.9, CMI = Δ3.0 ± 0.9, control = Δ3.0 ± 1.5 mmol/l) following breakfast on the following day were significantly lower following HIIT compared with both CMI and control (p < 0.05). Absolute AUC and absolute glucose spikes were not different between HIIT, CMI, or control for any meal (p > 0.05 for all). We conclude that a single session of HIIT has greater and more lasting effects on reducing incremental PPG when compared with CMI.

scholarly journals Moderate Intensity Treadmill Running Relieves Motion-Induced Post-Traumatic Osteoarthritis Mice by up-Regulating the Expression of lncRNA H19

2021 ◽  
Author(s):  
Xuchang Zhou ◽  
Hong Cao ◽  
Miao Wang ◽  
Jun Zou ◽  
wei wu
Keyword(s):  
Knee Joint ◽  
High Intensity ◽  
High Intensity Exercise ◽  
Treadmill Running ◽  
Moderate Intensity ◽  
Control Group ◽  
Mrna Levels ◽  
Knee Cartilage ◽  
Moderate Intensity Exercise ◽  
Post Traumatic

Abstract Background The purpose of this study was to explore whether moderate-intensity exercise can alleviate motion-induced post-traumatic osteoarthritis (PTOA) and the expression change of lncRNA H19 during this progression.Methods Twenty-week-old male C57BL/6 mice were randomly divided into five groups: model control group (CM group, n = 6), treadmill model group (M group, n = 6), rehabilitation control group (CK group, n = 6), treadmill model + rehabilitation training group (K group, n = 6) and treadmill model + rest group (J group, n = 6). Paraffin sections were used to observe the pathological changes in the mouse knee joint in each group. A micro-CT was used to scan the knee joint to obtain the morphological indexes of tibial plateau bone. Real-time PCR was used to detect the mRNA levels of inflammatory factors, synthetic and catabolic factors in cartilage. Results After high-intensity exercise for four weeks, the inflammation and catabolism of the mouse knee cartilage were enhanced, and the anabolism was weakened. Further study showed that these results were partially reversed after four-week moderate-intensity training. The results of hematoxylin-eosin staining confirmed this finding. Meanwhile, high-intensity exercise reduced the expression of lncRNA H19 in cartilage, while the expression of lncRNA H19 increased after four weeks of moderate-intensity exercise.Conclusion High-intensity treadmill running can cause injury to the knee cartilage in C57BL/6 mice which leads to PTOA and an decrease of lncRNA H19 expression in cartilage. Moderate-intensity exercise can relieve PTOA and partially reverse lncRNA H19 expression.

scholarly journals Moderate-intensity exercise with blood flow restriction on cardiopulmonary kinetics and efficiency during a subsequent high-intensity exercise in young women

Medicine ◽  
2021 ◽  
Vol 100 (31) ◽  
pp. e25368
Author(s):  
Robson F. Borges ◽  
Gaspar R. Chiappa ◽  
Paulo T. Muller ◽  
Alexandra Correa Gervazoni Balbuena de Lima ◽  
Lawrence Patrick Cahalin ◽  
...  
Keyword(s):  
Blood Flow ◽  
Young Women ◽  
High Intensity ◽  
High Intensity Exercise ◽  
Blood Flow Restriction ◽  
Moderate Intensity ◽  
Moderate Intensity Exercise ◽  
Flow Restriction

scholarly journals The effect of moderate versus high intensity exercise on heart rate variability in sedentary office workers

2021 ◽  
Vol 16 (1) ◽  
pp. 16-23
Author(s):  
Vibha Gangwar ◽  
Manish Kumar Verma ◽  
Ritesh Singh Gangwar ◽  
Nitin Ashok John ◽  
Rajani Bala Jasrotia
Keyword(s):  
Heart Rate ◽  
Exercise Training ◽  
High Intensity ◽  
High Intensity Exercise ◽  
Office Workers ◽  
Moderate Intensity ◽  
Moderate Intensity Exercise ◽  
Group I ◽  
Before And After ◽  
Group Ii

Background: Sedentary behavior is one of the leading modifiable risk factors for cardiovascular disease and all-cause mortality. Physical exercise exerts beneficial physiological effects on cardiovascular fitness. Different grades of physical exercise have different effects on cardiovascular health. Objective: To compare the effect of moderate and high intensity exercise training on heart rate variability (HRV) in sedentary office workers. Methods: This study was conducted on 40 healthy sedentary volunteers aged between 20-40 years of both the genders. Participants were distributed into two groups of 20 subjects each. Subjects of group I and group II performed moderate intensity and high intensity exercise respectively on bicycle ergometer for 12 weeks. Their 5- minute ECG recording was done by three channel physiograph, and frequency domain indices of HRV and heart rate (HR) were analyzed and compared before and after exercise training. Their blood pressure was also recorded and compared before and after exercise training. Independent sample t-test and paired sample ttest were used for statistical analysis. Results: HF, systolic and diastolic blood pressure reduced significantly after exercise in group II (p=0.015, 0.005, and 0.015 respectively) while HR and LF/HF ratio reduced in both group I and group II (p=0.000 for HR, and 0.034, 0.001 for LF/HF). The decrease in HR was greater after high intensity exercise than moderate intensity exercise (p= 0.025). Conclusion: Parasympathetic activity improves after moderate and high intensity exercise but improvement is more after high intensity exercise training. Therefore, high intensity exercise training is more beneficial than moderate intensity exercise training. J Bngladesh Soc Physiol 2021;16(1): 16-23

Intensity Matters: High-intensity Interval Exercise Enhances Motor Cortex Plasticity More Than Moderate Exercise

2019 ◽  
Vol 30 (1) ◽  
pp. 101-112 ◽  
Author(s):  
Sophie C Andrews ◽  
Dylan Curtin ◽  
Ziarih Hawi ◽  
Jaeger Wongtrakun ◽  
Julie C Stout ◽  
...  
Keyword(s):  
Motor Cortex ◽  
High Intensity ◽  
Therapeutic Potential ◽  
Intracortical Inhibition ◽  
High Intensity Exercise ◽  
Moderate Intensity ◽  
Moderate Intensity Exercise ◽  
Exercise Interventions ◽  
Interval Exercise ◽  
High Intensity Interval

Abstract A single bout of cardiovascular exercise can enhance plasticity in human cortex; however, the intensity required for optimal enhancement is debated. We investigated the effect of exercise intensity on motor cortex synaptic plasticity, using transcranial magnetic stimulation. Twenty healthy adults (Mage = 35.10 ± 13.25 years) completed three sessions. Measures of cortico-motor excitability (CME) and inhibition were obtained before and after a 20-min bout of either high-intensity interval exercise, moderate-intensity continuous exercise, or rest, and again after intermittent theta burst stimulation (iTBS). Results showed that high-intensity interval exercise enhanced iTBS plasticity more than rest, evidenced by increased CME and intracortical facilitation, and reduced intracortical inhibition. In comparison, the effect of moderate-intensity exercise was intermediate between high-intensity exercise and rest. Importantly, analysis of each participant’s plasticity response profile indicated that high-intensity exercise increased the likelihood of a facilitatory response to iTBS. We also established that the brain-derived neurotrophic factor Val66Met polymorphism attenuated plasticity responses following high-intensity exercise. These findings suggest that high-intensity interval exercise should be considered not only when planning exercise interventions designed to enhance neuroplasticity, but also to maximize the therapeutic potential of non-invasive brain stimulation. Additionally, genetic profiling may enhance efficacy of exercise interventions for brain health.

The Acute Effect of High-Intensity Exercise on Executive Function: A Meta-Analysis

2019 ◽  
Vol 14 (5) ◽  
pp. 734-764 ◽  
Author(s):  
David Moreau ◽  
Edward Chou
Keyword(s):  
Executive Function ◽  
High Intensity ◽  
Brain Function ◽  
Meta Analysis ◽  
Significant Proportion ◽  
Acute Effect ◽  
High Intensity Exercise ◽  
Moderate Intensity ◽  
Moderate Intensity Exercise ◽  
Cardiovascular Exercise

High-intensity exercise has recently emerged as a potent alternative to aerobic regimens, with ramifications for health and brain function. As part of this trend, single sessions of intense exercise have been proposed as powerful, noninvasive means for transiently enhancing cognition. However, findings in this field remain mixed, and a thorough synthesis of the evidence is lacking. Here, we synthesized the literature in a meta-analysis of the acute effect of high-intensity exercise on executive function. We included a total of 1,177 participants and 147 effect sizes across 28 studies and found a small facilitating effect ( d = 0.24) of high-intensity exercise on executive function. However, this effect was significant only compared with rest ( d = 0.34); it was not significant when high-intensity exercise was compared with low-to-moderate intensity exercise ( d = 0.07). This suggests that intense and moderate exercise affect executive function in a comparable manner. We tested a number of moderators that together explained a significant proportion of the between-studies variance. Overall, our findings indicate that high-intensity cardiovascular exercise might be a viable alternative for eliciting acute cognitive gains. We discuss the potential of this line of research, identify a number of challenges and limitations it faces, and propose applications to individuals, society, and policies.

scholarly journals Exercise training modalities in chronic heart failure: does high intensity aerobic interval training make the difference?

2016 ◽  
Vol 86 (1-2) ◽  
Author(s):  
Francesco Giallauria ◽  
Neil Andrew Smart ◽  
Antonio Cittadini ◽  
Carlo Vigorito
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Exercise Training ◽  
Exercise Capacity ◽  
High Intensity ◽  
Moderate Intensity ◽  
Exercise Session ◽  
Moderate Intensity Exercise ◽  
Training Modalities ◽  
The Impact

Exercise training (ET) is strongly recommended in patients with chronic heart failure (CHF). Moderate-intensity aerobic continuous ET is the best established training modality in CHF patients. In the last decade, however, high-intensity interval exercise training (HIIT) has aroused considerable interest in cardiac rehabilitation community. Basically, HIIT consists of repeated bouts of high-intensity exercise alternated with recovery periods. In CHF patients, HIIT exerts larger improvements in exercise capacity compared to moderate-continuous ET. These results are intriguing, mostly considering that better functional capacity translates into an improvement of symptoms and quality of life. Notably, HIIT did not reveal major safety issues; although CHF patients should be clinically stable, have had recent exposure to at least regular moderate-intensity exercise, and appropriate supervision and monitoring during and after the exercise session are mandatory. The impact of HIIT on cardiac dimensions and function and on endothelial function remains uncertain. HIIT should not replace other training modalities in heart failure but should rather complement them. Combining and tailoring different ET modalities according to each patient’s baseline clinical characteristics (i.e. exercise capacity, personal needs, preferences and goals) seem the most astute approach to exercise prescription.

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