scholarly journals Leucine Supplementation Increases Muscle Strength and Volume, Reduces Inflammation, and Affects Wellbeing in Adults and Adolescents with Cerebral Palsy

2020 ◽  
Vol 151 (1) ◽  
pp. 59-64 ◽  
Author(s):  
Nicola Theis ◽  
Meghan A Brown ◽  
Paula Wood ◽  
Mark Waldron
Keyword(s):  
Body Composition ◽  
Cerebral Palsy ◽  
Muscle Strength ◽  
Body Mass ◽  
Muscle Protein ◽  
Muscle Volume ◽  
Spastic Cerebral Palsy ◽  
Control Group ◽  
Leucine Supplementation ◽  
Functional Changes

ABSTRACT Background Spastic cerebral palsy (CP) is characterized by muscle weakness owing, in part, to a blunted muscle protein synthetic response. This might be normalized by long-term leucine supplementation. Objectives The study assessed the effects of 10 wk leucine supplementation in adolescents and adults with CP. Methods The study was a single-center randomized controlled trial. Twenty-four participants were randomly assigned to a control group (n = 12) or a leucine group (n = 12). l-Leucine (192 mg/kg body mass) was dissolved in water and administered daily for 10 wk. The primary outcome measures of elbow flexor muscle strength and muscle volume (measured by 3D ultrasound technique) and inflammation [C-reactive protein (CRP) concentration] were assessed before and after the 10 wk, alongside the secondary outcomes of body composition (measured by CP-specific skinfold assessment), metabolic rate (measured by indirect calorimetry), and wellbeing (measured by a self-reported daily questionnaire). Data were compared via a series of 2-factor mixed ANOVAs. Results Twenty-one participants completed the intervention (control group: n = 11, mean ± SD age: 18.3 ± 2.8 y, body mass: 48.8 ± 11.9 kg, 45% male; leucine group: n = 10, age: 18.6 ± 1.7 y, body mass: 58.3 ± 20.2 kg, 70% male). After 10 wk, there was a 25.4% increase in strength (P = 0.019) and a 3.6% increase in muscle volume (P = 0.001) in the leucine group, with no changes in the control group. This was accompanied by a 59.1% reduction in CRP (P = 0.045) and improved perceptions of wellbeing (P = 0.006) in the leucine group. No changes in metabolism or body composition were observed in either group (P > 0.05). Conclusions Improvements in muscle strength and volume with leucine supplementation might provide important functional changes for adults and adolescents with CP and could be partly explained by reduced inflammation. The improved wellbeing highlights its capacity to improve the quality of daily living. This trial was registered at clinicaltrials.gov as NCT03668548.

scholarly journals A School-Based Exercise Intervention Program Increases Muscle Strength in Prepubertal Boys

2010 ◽  
Vol 2010 ◽  
pp. 1-9 ◽  
Author(s):  
Susanna Stenevi-Lundgren ◽  
Robin M. Daly ◽  
Magnus K. Karlsson
Keyword(s):  
Body Composition ◽  
Physical Education ◽  
Muscle Strength ◽  
Body Mass ◽  
Intervention Program ◽  
Intervention Group ◽  
Knee Extensors ◽  
Control Group ◽  
School Based ◽  
Pubertal Boys

This prospective controlled intervention study over 12 months evaluated the effect of exercise on muscular function, physical ability, and body composition in pre-pubertal boys. Sixty-eight boys aged 6–8 years, involved in a general school-based exercise program of 40 min per school day (200 min/week), were compared with 46 age-matched boys who participated in the general Swedish physical education curriculum of mean 60 min/week. Baseline and annual changes of body composition were measured by dual energy X-ray absorptiometry (DXA), stature, and body mass by standard equipments, isokinetic peak torque (PT) of the knee extensors, and flexors at 60 and 180 deg/sec by computerized dynamometer (Biodex) and vertical jump height (VJH) by a computerized electronic mat. The annual gain in stature and body mass was similar between the groups whereas the increase in total body and regional lean mass (P<.001) and fat mass (P<.001) was greater in the exercise group. The one-year gain in body mass-adjusted knee extensor and flexor PT at 180 deg/sec was significantly greater in the intervention group compared with the control group (P<.01, adjusted for age at baseline andP<.001, adjusted for age and muscle strength at baseline, resp.). There was no group difference in VJH. In conclusion, the increase in school-based physical education from 60 to 200 minutes per week enhances the development of lean body mass and muscle strength in pre-pubertal boys.

Effect of muscle strength training in children and adolescents with spastic cerebral palsy: A systematic review and meta-analysis

2021 ◽  
pp. 026921552110401
Author(s):  
Javier Merino-Andrés ◽  
Agustín García de Mateos-López ◽  
Diane L Damiano ◽  
Alberto Sánchez-Sierra
Keyword(s):  
Cerebral Palsy ◽  
Muscle Strength ◽  
Strength Training ◽  
Children And Adolescents ◽  
Training Program ◽  
Meta Analysis ◽  
Spastic Cerebral Palsy ◽  
Control Group ◽  
Therapy Technique ◽  
Mean Differences

Objective: This systematic review and meta-analysis investigates the effects of strength training program in children and adolescents with cerebral palsy to improve function, activity, and participation. Data sources: Five electronic databases (MEDLINE-Pubmed, Cochrane Library, PEDro, CINAHL, and SPORTDiscus) were systematically searched for full-text articles published from inception to 30 June 2021. Review methods: Randomized controlled trials were included, who compared: (i) child population with spastic cerebral palsy population between 0 and 22 years; (ii) studies in which a muscle strength training program was performed and included dosing information; (iii) studies comparing strength training with other physical therapy technique(s) or untreated control group. Studies with similar outcomes were pooled by calculating standardized mean differences. Risk of bias was assessed with Cochrane Collaboration’s tool for assessing the risk of bias and PROSPERO’s registration number ID: CRD42020193535. Results: Twenty-seven studies, comprising 847 participants with spastic cerebral palsy. The meta-analyses demonstrated significant standardized mean differences in favor of strength training program compared to other physical therapy technique(s) or untreated control group(s) for muscle strength at the knee flexors, at the knee extensor, at the plantarflexors, maximum resistance, balance, gait speed, GMFM (global, D and E dimension) and spasticity. Conclusion: A strength training program has positive functional and activity effects on muscle strength, balance, gait speed, or gross motor function without increasing spasticity for children and adolescents with cerebral palsy in Gross Motor Function Classification System levels I, II, and III when adequate dosage and specific principles are utilized.

scholarly journals Sex differences in leptin and cardiometabolic profile after exercise intervention in physically inactive adults with primary hypertension and obesity

2021 ◽  
Vol 28 (Supplement_1) ◽  
Author(s):  
SMM Maldonado-Martin ◽  
PC Corres ◽  
AMAB Martinezaguirre-Betolaza ◽  
BJI Jurio-Iriarte ◽  
MTE Tous-Espelosin ◽  
...  
Keyword(s):  
Body Composition ◽  
Sex Differences ◽  
Aerobic Exercise ◽  
Body Mass ◽  
Primary Hypertension ◽  
Public Institution ◽  
Hypocaloric Diet ◽  
Moderate Intensity ◽  
Control Group ◽  
Physically Inactive

Abstract Funding Acknowledgements Type of funding sources: Public Institution(s). Main funding source(s): University of the Basque Country OnBehalf GIKAFIT PURPOSES. To analyse the change on leptin, body composition, blood pressure (BP), cardiorespiratory fitness (CRF) and some biochemical parameters in physically inactive women and men with primary hypertension (HTN) and obesity, and to evaluate the potential sex differences in the change after intervention. METHODS. Participants (n = 37 women, n= 40 men, 52.9 ± 6.9 yrs) from the EXERDIET-HTA study were randomized into attention control group (physical activity recommendations) or one of three supervised aerobic exercise groups [two days/week: high-volume (HV) with 45 min of moderate-intensity continuous training, HV and high-intensity interval training (HV-HIIT), and low volume-HIIT (LV-HIIT, 20 min)]. All participants received the same hypocaloric diet. All variables were assessed pre and post intervention (16 weeks). 24 h ambulatory BP monitoring was used to analyze systolic and diastolic BP. A cardiopulmonary exercise test was performed to determine peak oxygen uptake (VO2peak). RESULTS. Following the intervention, there were increments (P &lt; 0.01) in CRF by VO2peak (Women, W = 21.1 ± 3.7 vs. 24.6 ± 4.4 mL·kg-1·min-1, Men, M = 26.3 ± 6.0 vs. 33.1 ± 10.2 mL·kg-1·min-1) and decreases (P &lt; 0.05) in leptin (W = 49.5 ± 23.0 vs. 41.8 ± 19.9 ng/mL, M = 20.5 ± 14.8 vs. 12.9 ± 18.6 ng/mL), body mass (W = 84.7 ± 12.1 vs. 80.3 ± 11.5 kg, M = 97.9 ± 14.4 vs. 91.5 ± 13.3 kg), waist perimeter (W = 97.3 ± 10.7 vs. 94.3 ± 10.9 cm, M = 107.9 ± 8.7 vs. 101.5 ± 7.9 cm), fat mass (W = 42.3 ± 5.1 vs. 38.6 ± 8.4 %, M = 31.2 ± 5.0 vs. 28.0 ± 4.4 %), systolic BP (M = 136.5 ± 12.1 vs. 129.3 ± 12.5 mmHg), diastolic BP (W = 76.2 ± 8.9 vs. 74.1 ± 8.7 mmHg, M = 79.3 ± 7.2 vs. 75.0 ± 8.2 mmHg), total cholesterol (M = 216.1 ± 44.5 vs. 196.1 ± 35.0 mg/dL), insulin (W = 13.4 ± 7.9 vs. 9.4 ± 4.2 mU/L) values. There were significant between-sex differences in body mass (W=-5.2%, M=-6.5%, effect size, ES = 0.073), waist circumference (W=-3.1%, M=-5.9%, ES = 0.114), and VO2peak (W = 14.2%, M = 20.5%, ES = 0.059). CONCLUSIONS. Aerobic exercise along with hypocaloric diet is an effective non-pharmacological tool to induce beneficial changes in women and men in BP and leptin as a mediator of obesity-induced HTN, and other regulatory mechanisms such as body composition, CRF and biochemical profile. The found sex-related differences could confirm the need of individual non-pharmacological strategies.

scholarly journals Effects of whole-body vibration on quadriceps and hamstring muscle strength, endurance, and power in children with hemiparetic cerebral palsy: a randomized controlled study

2021 ◽  
Vol 26 (1) ◽  
Author(s):  
Rania G. Hegazy ◽  
Amr Almaz Abdel-aziem ◽  
Eman I. El Hadidy ◽  
Yosra M. Ali
Keyword(s):  
Cerebral Palsy ◽  
Physical Therapy ◽  
Muscle Strength ◽  
Whole Body Vibration ◽  
Whole Body ◽  
Controlled Study ◽  
Control Group ◽  
Hamstring Muscle ◽  
Post Intervention ◽  
Body Vibration

Abstract Background Hemiplegic cerebral palsy (CP) enormously affects the quadriceps and hamstring muscles. It causes weakness in the affected lower-extremity muscles in addition to muscle imbalance and inadequate power production, especially in the ankle plantar-flexor and knee extensor muscles. It also causes anomalous delayed myoelectrical action of the medial hamstring. A whole-body vibration (WBV) exercise can diminish muscle spasticity and improve walking speed, muscle strength, and gross motor function without causing unfavorable impacts in adults suffering from CP. Thus, the aim of this study is to investigate the impacts of WBV training associated with conventional physical therapy on the quadriceps and hamstring muscle strength, endurance, and power in children with hemiparetic CP. Results The post-intervention values of the quadriceps and hamstring muscle force, endurance, and power were significantly higher than the pre-intervention values for both groups (p = 0.001). The post-intervention values of the study group were significantly higher than the control group (quadriceps force, p = 0.015; hamstring force, p = 0.030; endurance, p = 0.025; power, p = 0.014). Conclusion The 8 weeks of WBV training that was added to traditional physical therapy was more successful in improving the quadriceps and hamstring muscle strength, endurance, and power in children with hemiparetic CP when compared to traditional physical therapy alone.

scholarly journals Effect of Aerobic Exercise Training and Essential Amino Acid Supplementation for 24 Weeks on Physical Function, Body Composition, and Muscle Metabolism in Healthy, Independent Older Adults: A Randomized Clinical Trial

2018 ◽  
Vol 74 (10) ◽  
pp. 1598-1604 ◽  
Author(s):  
Melissa M Markofski ◽  
Kristofer Jennings ◽  
Kyle L Timmerman ◽  
Jared M Dickinson ◽  
Christopher S Fry ◽  
...  
Keyword(s):  
Older Adults ◽  
Clinical Trial ◽  
Body Composition ◽  
Protein Synthesis ◽  
Muscle Strength ◽  
Randomized Clinical Trial ◽  
Walking Speed ◽  
Muscle Protein ◽  
Muscle Protein Synthesis ◽  
Before And After

Abstract Background Essential amino acids (EAA) and aerobic exercise (AE) acutely and independently stimulate skeletal muscle protein anabolism in older adults. Objective In this Phase 1, double-blind, placebo-controlled, randomized clinical trial, we determined if chronic EAA supplementation, AE training, or a combination of the two interventions could improve muscle mass and function by stimulating muscle protein synthesis. Methods We phone-screened 971, enrolled 109, and randomized 50 independent, low-active, nonfrail, and nondiabetic older adults (age 72 ± 1 years). We used a 2 × 2 factorial design. The interventions were: daily nutritional supplementation (15 g EAA or placebo) and physical activity (supervised AE training 3 days/week or monitored habitual activity) for 24 weeks. Muscle strength, physical function, body composition, and muscle protein synthesis were measured before and after the 24-week intervention. Results Forty-five subjects completed the 24-week intervention. VO2peak and walking speed increased (p < .05) in both AE groups, irrespective of supplementation type, but muscle strength increased only in the EAA + AE group (p < .05). EAA supplementation acutely increased (p < .05) muscle protein synthesis from basal both before and after the intervention, with a larger increase in the EAA + AE group after the intervention. Total and regional lean body mass did not change significantly with any intervention. Conclusions In nonfrail, independent, healthy older adults AE training increased walking speed and aerobic fitness, and, when combined with EAA supplementation, it also increased muscle strength and EAA-stimulated muscle protein synthesis. These increases occurred without improvements in muscle mass.

scholarly journals Development of Lower Extremity Strength in Ambulatory Children With Bilateral Spastic Cerebral Palsy in Comparison With Typically Developing Controls Using Absolute and Normalized to Body Weight Force Values

2021 ◽  
Vol 12 ◽  
Author(s):  
Nicolaos Darras ◽  
Eirini Nikaina ◽  
Magda Tziomaki ◽  
Georgios Gkrimas ◽  
Antigone Papavasiliou ◽  
...  
Keyword(s):  
Body Weight ◽  
Cerebral Palsy ◽  
Muscle Strength ◽  
Lower Limb ◽  
Age Groups ◽  
Knee Extensors ◽  
Spastic Cerebral Palsy ◽  
Typically Developing ◽  
Antagonist Muscles ◽  
Muscle Groups

This cross-sectional study aimed to examine the development of lower limb voluntary strength in 160 ambulatory patients with bilateral spastic cerebral palsy (CP) (106 diplegics/54 quadriplegics) and 86 typically developing (TD) controls, aged 7–16 years. Handheld dynamometry was used to measure isometric strength of seven muscle groups (hip adductors and abductors, hip extensors and flexors, knee extensors and flexors, and ankle dorsiflexors); absolute force (AF) values in pounds were collected, which were then normalized to body weight (NF). AF values increased with increasing age (p &lt; 0.001 for all muscle groups), whereas NF values decreased through adolescence (p &lt; 0.001 for all muscle groups except for hip abduction where p = 0.022), indicating that increases in weight through adolescence led to decreases in relative force. Both AF and NF values were significantly greater in TD subjects when compared with children with CP in all muscle and all age groups (p &lt; 0.001). Diplegics and quadriplegics demonstrated consistently lower force values than TD subjects for all muscle groups, except for the hip extensors where TD children had similar values with diplegics (p = 0.726) but higher than quadriplegics (p = 0.001). Diplegic patients also exhibited higher values than quadriplegics in all muscles, except for the knee extensors where their difference was only indicative (p = 0.056). The conversion of CP subjects' force values as a percentage of the TD subjects' mean value revealed a pattern of significant muscle strength imbalance between the CP antagonist muscles, documented from the following deficit differences for the CP muscle couples: (hip extensors 13%) / (hip flexors 32%), (adductors 27%) / (abductors 52%), and (knee extensors 37%) / (knee flexors 53%). This pattern was evident in all age groups. Similarly, significant force deficiencies were identified in GMFCS III/IV patients when compared with TD children and GMFCS I/II patients. In this study, we demonstrated that children and adolescents with bilateral CP exhibited lower strength values in lower limb muscles when compared with their TD counterparts. This difference was more prevalent in quadriplegic patients and those with a more severe impairment. An important pattern of muscle strength imbalance between the antagonist muscles of the CP subjects was revealed.

scholarly journals Changes in Ankle Range of Motion, Gait Function and Standing Balance in Children with Bilateral Spastic Cerebral Palsy after Ankle Mobilization by Manual Therapy

Children ◽  
2020 ◽  
Vol 7 (9) ◽  
pp. 142
Author(s):  
Pong Sub Youn ◽  
Kyun Hee Cho ◽  
Shin Jun Park
Keyword(s):  
Cerebral Palsy ◽  
Range Of Motion ◽  
Ankle Joint ◽  
Center Of Pressure ◽  
Standing Balance ◽  
Spastic Cerebral Palsy ◽  
Control Group ◽  
Walk Test ◽  
Joint Mobilization ◽  
Gait Function

The aim of this study was to investigate the effect of ankle joint mobilization in children with cerebral palsy (CP) to ankle range of motion (ROM), gait, and standing balance. We recruited 32 children (spastic diplegia) diagnosed with CP and categorized them in two groups: the ankle joint mobilization (n = 16) group and sham joint mobilization (n = 16) group. Thus, following a six-week ankle joint mobilization, we examined measures such as passive ROM in ankle dorsiflexion in the sitting and supine position, center of pressure (COP) displacements (sway length, area) with eyes open (EO) and closed (EC), and a gait function test (timed up and go test (TUG) and 10-m walk test). The dorsiflexion ROM, TUG, and 10-m walk test significantly increased in the mobilization group compared to the control group. Ankle joint mobilization can be regarded as a promising method to increase dorsiflexion and improve gait in CP-suffering children.

Muscle Strength, Body Composition, and Performance of an Elite Shot-Putter

2012 ◽  
Vol 7 (4) ◽  
pp. 394-396 ◽  
Author(s):  
Gerasimos Terzis ◽  
Thomas Kyriazis ◽  
Giorgos Karampatsos ◽  
Giorgos Georgiadis
Keyword(s):  
Body Composition ◽  
Muscle Strength ◽  
Lean Body Mass ◽  
Body Mass ◽  
Bench Press ◽  
Scientific Data ◽  
The Body ◽  
Mineral Density ◽  
Repetition Maximum ◽  
Shot Put

Purpose:Although muscle mass and strength are thought to be closely related to throwing performance, there are few scientific data about these parameters in elite shot-putters. The purpose of this case report was to present longitudinal data for muscle strength and body composition in relation to performance of an elite male shot-putter.Methods:A male national champion with the best rotational shot-put performance of 20.36 m (in 2010) was followed from 2003 to 2011 (current age: 29 y). Data regarding body composition (dual X-ray absorptiometry), as well as 1-repetition-maximum muscle strength (bench press, squat, snatch) and rotational shot-put performance, were collected every February for the last 9 y, 4 wk before the national indoor championship event.Results:The athlete’s personal-best performances in squat, bench press, and snatch were 175 kg, 210 kg, and 112.5 kg, respectively. His peak total lean body mass was 92.4 kg, bone mineral density 1.55 g/cm2, and lowest body fat 12.9%. His shot-put performance over these 9 years was significantly correlated with 1-repetition-maximum squat strength (r = .93, P < .01), bench press (r = .87, P < .01), and snatch (r = .92, P < .01). In contrast, shot-put performance was not significantly correlated with any of the body-composition parameters.Conclusions:The results of this case study suggest that elite rotational shot-put performance may not be directly correlated with lean body mass. Instead, it seems that it is closely related with measures of muscle strength.

Changes in ankle spasticity and strength following selective dorsal rhizotomy and physical therapy for spastic cerebral palsy

1999 ◽  
Vol 91 (5) ◽  
pp. 727-732 ◽  
Author(s):  
Jack R. Engsberg ◽  
Sandy A. Ross ◽  
Tae Sung Park
Keyword(s):  
Cerebral Palsy ◽  
Physical Therapy ◽  
Spastic Cerebral Palsy ◽  
Control Group ◽  
Selective Dorsal Rhizotomy ◽  
Content Type ◽  
Dorsal Rhizotomy ◽  
Angle Data ◽  
Work Done ◽  
Fine Print

Object. In this investigation the authors quantified changes in ankle plantarflexor spasticity and strength following selective dorsal rhizotomy (SDR) and intensive physical therapy in patients with cerebral palsy (CP).Methods. Twenty-five patients with cerebral palsy (CP group) and 12 able-bodied volunteers (AB controls) were tested with a dynamometer. For the spasticity measure, the dynamometer was used to measure the resistive torque of the plantarflexors during passive ankle dorsiflexion at five different speeds. Data were processed to yield a single value that simultaneously encompassed the three key elements associated with spasticity: velocity, resistance, and stretch. For the strength test, the dynamometer rotated the ankle from full dorsiflexion to full plantarflexion while a maximum concentric contraction of the plantarflexors was performed. Torque angle data were processed to include the work done by the patient or volunteer on the machine. Plantarflexor spasticity values for the CP group were significantly greater than similar values for the AB control group prior to surgery but not significantly different after surgery. Plantarflexor strength values of the CP group were significantly less than those of the AB control group pre- and postsurgery. Postsurgery strength values did not change relative to presurgery values.Conclusions. The spasticity results of the present investigation agreed with those of previous studies indicating a reduction in spasticity for the CP group. The strength results did not agree with the findings of most previous related literature, which indicated that a decrease in strength should have occurred. The strength results agreed with a previous investigation in which knee flexor strength was objectively examined, indicating that strength did not decrease as a consequence of an SDR. The methods of this investigation could be used to improve SDR patient selection.

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