scholarly journals Timing- and Dose-Specific Associations of Prenatal Smoke Exposure With Newborn DNA Methylation

2020 ◽  
Vol 22 (10) ◽  
pp. 1917-1922
Author(s):  
Giulietta S Monasso ◽  
Vincent W V Jaddoe ◽  
Johan C de Jongste ◽  
Liesbeth Duijts ◽  
Janine F Felix
Keyword(s):  
Dna Methylation ◽  
Early Pregnancy ◽  
Maternal Smoking ◽  
Third Trimester ◽  
Smoking During Pregnancy ◽  
The Third ◽  
Quitting Smoking ◽  
Maternal Smoking During Pregnancy ◽  
Paternal Smoking ◽  
In Pregnancy

Abstract Introduction Fetal changes in DNA methylation may underlie associations of maternal smoking during pregnancy with adverse outcomes in children. We examined critical periods and doses of maternal smoking during pregnancy in relation to newborn DNA methylation, and associations of paternal smoking with newborn DNA methylation. Aims and Methods This study was embedded in the Generation R Study, a population-based prospective cohort study from early pregnancy onwards. We assessed parental smoking during pregnancy using questionnaires. We analyzed associations of prenatal smoke exposure with newborn DNA methylation at 5915 known maternal smoking-related cytosine-phosphate-guanine sites (CpGs) in 1261 newborns using linear regression. Associations with false discovery rate-corrected p-values < .05 were taken forward. Results Sustained maternal smoking was associated with newborn DNA methylation at 1391 CpGs, compared with never smoking. Neither quitting smoking early in pregnancy nor former smoking was associated with DNA methylation, compared with never smoking. Among sustained smokers, smoking ≥5, compared with <5, cigarettes/d was associated with DNA methylation at seven CpGs. Paternal smoking was not associated with DNA methylation, independent of maternal smoking status. Conclusions Our results suggest that CpGs associated with sustained maternal smoking are not associated with maternal smoking earlier in pregnancy or with paternal smoking. Some of these CpGs show dose–response relationships with sustained maternal smoking. The third trimester may comprise a critical period for associations of smoking with newborn DNA methylation, or sustained smoking may reflect higher cumulative doses. Alternatively, maternal smoking limited to early pregnancy and paternal smoking may be associated with DNA methylation at specific other CpGs not studied here. Implications Our results suggest that quitting maternal smoking before the third trimester of pregnancy, and possibly lowering smoking dose, may prevent differential DNA methylation in the newborns at CpGs associated with sustained smoking. If the relevance of DNA methylation for clinical outcomes is established, these results may help in counseling parents-to-be about quitting smoking.

Abstract P007: Maternal Heavy Smoking during Pregnancy in Association with Higher Risk of Gestational Diabetes in the Offspring

Circulation ◽  
2015 ◽  
Vol 131 (suppl_1) ◽  
Author(s):  
Wei Bao ◽  
Karin B Michels ◽  
Deirdre K Tobias ◽  
Shanshan Li ◽  
Jorge E Chavarro ◽  
...  
Keyword(s):  
Gestational Diabetes ◽  
Maternal Smoking ◽  
Adult Life ◽  
Perinatal Outcomes ◽  
Joint Effect ◽  
Health Study ◽  
Heavy Smoking ◽  
Smoking During Pregnancy ◽  
Maternal Smoking During Pregnancy ◽  
Paternal Smoking

Introduction: Maternal smoking during pregnancy is an established risk factor for adverse perinatal outcomes. However, data on the intergenerational impact of maternal smoking during pregnancy on offspring’s long-term risk of adulthood disease are limited. Hypothesis: We assessed the hypothesis that maternal smoking during pregnancy may be associated with risk of gestational diabetes mellitus (GDM) in the offspring. Methods: The analytical population was composed of 10138 parous women in the Nurses' Health Study II cohort whose mothers participated in the Nurses’ Mothers’ Cohort Study; 819 of the nurses developed GDM. Data on maternal and paternal smoking during pregnancy and associated covariates were recalled by the nurses’ mothers. GDM diagnosis was self-reported by nurse participants and was validated by medical record review in a previous study. We used logistic regression models to estimate the odds ratios (ORs) and 95% confidence intervals (CIs). Results: We observed a significant association between maternal heavy smoking during pregnancy and risk of GDM in the offspring. The multivariable-adjusted ORs (95% CIs) of GDM among women whose mothers did not smoke during pregnancy, continued smoking 1-14, 15-24, and ≥ 25 cigarettes/day were 1.00 (reference), 1.13 (0.91-1.42), 1.17 (0.88-1.55), and 1.74 (1.03-2.95) (P for trend = 0.04), respectively. Further adjustment for the nurses’ birth weight, adult life variables and body mass index during various periods of life only slightly changed the association. No significant association was observed between paternal smoking during the pregnancy period and the risk of GDM. We further examined the joint effect of both maternal and paternal smoking during pregnancy on the risk of GDM. The nurses whose parents both smoked during pregnancy ≥ 15 cigarettes/day had an OR (95% CI) of 1.25 (0.94-1.66), compared with those whose parents did not smoke during pregnancy or smoked < 15 cigarettes/day. In an analysis on the joint effect of maternal smoking during pregnancy and the nurse’s smoking during adulthood, we found that the nurses who ever smoked during adulthood and their mothers ever smoked during the pregnancy with them had a significantly higher risk of GDM (OR 1.40, 95% CI 1.08-1.81), compared to the nurses neither themselves nor the mothers smoked. Conclusions: In conclusion, maternal heavy smoking (≥ 25 cigarettes/day) during pregnancy is significantly associated with higher risk of gestational diabetes in the offspring. Further studies are warranted to confirm our findings and to elucidate the underlying mechanisms.

scholarly journals Maternal smoking during pregnancy is associated with mitochondrial DNA methylation

2016 ◽  
Vol 2 (3) ◽  
pp. dvw020 ◽  
Author(s):  
David A. Armstrong ◽  
Benjamin B. Green ◽  
Bailey A. Blair ◽  
Dylan J. Guerin ◽  
Julia F. Litzky ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Mitochondrial Dna ◽  
Maternal Smoking ◽  
Smoking During Pregnancy ◽  
Maternal Smoking During Pregnancy

scholarly journals DNA methylation mediates the effect of maternal smoking during pregnancy on birthweight of the offspring

2015 ◽  
Vol 44 (4) ◽  
pp. 1224-1237 ◽  
Author(s):  
Leanne K Küpers ◽  
Xiaojing Xu ◽  
Soesma A Jankipersadsing ◽  
Ahmad Vaez ◽  
Sacha la Bastide-van Gemert ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Maternal Smoking ◽  
Smoking During Pregnancy ◽  
Maternal Smoking During Pregnancy

scholarly journals Decreased head circumference at birth associated with maternal tobacco smoke exposure during pregnancy on the Japanese prospective birth cohort study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Tadashi Shiohama ◽  
Aya Hisada ◽  
Midori Yamamoto ◽  
Kenichi Sakurai ◽  
Rieko Takatani ◽  
...  
Keyword(s):  
Cohort Study ◽  
Tobacco Smoke ◽  
Maternal Smoking ◽  
Tobacco Smoke Exposure ◽  
Smoking During Pregnancy ◽  
Quitting Smoking ◽  
Maternal Smoking During Pregnancy ◽  
Exposure During Pregnancy ◽  
Smoking Group ◽  
The Impact

AbstractMaternal tobacco smoke exposure during pregnancy impairs fetal body size, including head circumference (HC) at birth; however, the mechanism still remains unclear. This analysis using a large prospective cohort study evaluated the impact of maternal tobacco exposure on their offspring’s HC and the relationship with placental weight ratio (PWR) and placental abnormalities. Parents-children pairs (n = 84,856) were included from the 104,065 records of the Japan Environmental and Children’s Study. Maternal perinatal clinical and social information by self-administered questionnaires, offspring’s body size, and placental information were collected. Data were analyzed with binominal logistic regression analysis and path analysis. Logistic regression showed significantly elevated adjusted odds ratio (aOR) (1.653, 95% CI 1.387–1.969) for the impact of maternal smoking during pregnancy on their offspring’s smaller HC at birth. Maternal exposure to environmental tobacco smoke in the non-smoking group did not increase aOR for the smaller HC. Path analysis showed that maternal smoking during pregnancy decreased the offspring’s HC directly, but not indirectly via PWR or placental abnormalities. The quitting smoking during pregnancy group did not increase aOR for the smaller HC than the non-smoking group, suggesting that quitting smoking may reduce their offspring’s neurological impairment even after pregnancy.

scholarly journals Placental DNA methylation signatures of maternal smoking during pregnancy and potential impacts on fetal growth

2019 ◽  
Author(s):  
Todd M. Everson ◽  
Marta Vives-Usano ◽  
Emie Seyve ◽  
Andres Cardenas ◽  
Marina Lacasaña ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Birth Outcomes ◽  
Fetal Growth ◽  
Maternal Smoking ◽  
Meta Analysis ◽  
Growth Factor Signaling ◽  
Hormone Activity ◽  
Smoking During Pregnancy ◽  
Placental Function ◽  
Maternal Smoking During Pregnancy

AbstractMaternal smoking during pregnancy (MSDP) contributes to poor birth outcomes, in part through disrupted placental functions, which may be reflected in the placental epigenome. We meta-analyzed the associations between MSDP and placental DNA methylation (DNAm) and between DNAm and birth outcomes within the Pregnancy And Childhood Epigenetics (PACE) consortium (7 studies, N=1700, 344 with any MSDP). We identified 1224 CpGs that were associated with MSDP, of which 341 associated with birth outcomes and 141 associated with gene expression. Only 6 of these CpGs were consistent with the findings from a prior meta-analysis of cord blood DNAm, demonstrating substantial tissue-specific responses to MSDP. The placental MSDP associated CpGs were enriched for growth-factor signaling, hormone activity, inflammation, and vascularization, which play important roles in placental function. We demonstrate links between placental DNAm, MSDP and poor birth outcomes, which may better inform the mechanisms through which MSDP impacts placental function and fetal growth.

Maternal Smoking During Pregnancy and ADHD: Results From a Systematic Review and Meta-Analysis of Prospective Cohort Studies

2017 ◽  
Vol 24 (12) ◽  
pp. 1637-1647 ◽  
Author(s):  
Yan He ◽  
Jian Chen ◽  
Li-Hua Zhu ◽  
Ling-Ling Hua ◽  
Fang-Fang Ke
Keyword(s):  
Cohort Studies ◽  
Prospective Cohort ◽  
Maternal Smoking ◽  
Meta Analysis ◽  
Smoking During Pregnancy ◽  
Prospective Cohort Studies ◽  
Relative Risks ◽  
Increased Risk ◽  
Quitting Smoking ◽  
Maternal Smoking During Pregnancy

Objective: Findings on maternal smoking during pregnancy and ADHD risk in children are inconsistent. A meta-analysis was performed to summarize effects of exposure to maternal smoking during pregnancy on ADHD risk in children. Method: We conducted a systematic literature search to select articles up to June 2016. Only prospective cohort studies were included. Summary relative risks (RRs) with 95% confidence intervals (CIs) were calculated. Results: Pooled RR estimates based on 12 cohort studies including 17,304 pregnant women suggested that maternal smoking during pregnancy was associated with an increased risk of ADHD (pooled RR = 1.58, 95% CI = [1.33, 1.88]). Conclusion: Results from this study indicate that maternal smoking during pregnancy is related to an increased risk of ADHD in children. There is an urgent need to increase maternal awareness of smoking risk and quitting smoking to mitigate the ADHD risk in children.

scholarly journals Identification of DNA Methylation Changes in Newborns Related to Maternal Smoking during Pregnancy

2014 ◽  
Vol 122 (10) ◽  
pp. 1147-1153 ◽  
Author(s):  
Christina A. Markunas ◽  
Zongli Xu ◽  
Sophia Harlid ◽  
Paul A. Wade ◽  
Rolv T. Lie ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Maternal Smoking ◽  
Smoking During Pregnancy ◽  
Maternal Smoking During Pregnancy

scholarly journals Association of early and late maternal smoking during pregnancy with offspring body mass index at 4 to 5 years of age

2015 ◽  
Vol 6 (6) ◽  
pp. 485-492 ◽  
Author(s):  
L. E. Grzeskowiak ◽  
N. A. Hodyl ◽  
M. J. Stark ◽  
J. L. Morrison ◽  
V. L. Clifton
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Maternal Smoking ◽  
South Australia ◽  
First Trimester ◽  
Z Score ◽  
Smoking During Pregnancy ◽  
Smoking In Pregnancy ◽  
Quitting Smoking ◽  
Maternal Smoking During Pregnancy

The objective was to investigate the association between early and late maternal smoking during pregnancy on offspring body mass index (BMI). We undertook a retrospective cohort study using linked records from the Women’s and Children’s Health Network in South Australia. Among a cohort of women delivering a singleton, live-born infants between January 2000 and December 2005 (n=7658), 5961 reported not smoking during pregnancy, 297 reported quitting smoking during the first trimester of pregnancy, and 1400 reported continued smoking throughout pregnancy. Trained nurses measured the height and weight of the children at preschool visits in a state-wide surveillance programme. The main outcome measure was age- and sex-specific BMI z-score. At 4 to 5 years, mean (s.d.) BMI z-score was 0.40 (1.05), 0.60 (1.07) and 0.65 (1.18) in children of mothers who reported never smoking, quitting smoking and continued smoking during pregnancy, respectively. Compared with the group of non-smokers, both quitting smoking and continued smoking were associated with an increase in child BMI z-score of 0.15 (95% confidence interval: 0.01–0.29) and 0.21 (0.13–0.29), respectively. A significant dose–response relationship was also observed between the number of cigarettes smoked per day on average during the second half of pregnancy and the increase in offspring BMI z-score (P<0.001). In conclusion, any maternal smoking in pregnancy, even if mothers quit, is associated with an increase in offspring BMI at 4 to 5 years of age.

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