Meta-analysis of nursing-related organizational and psychosocial predictors of sickness absence

Abstract Background Nursing is a stressful occupation with high rates of sickness absence. To date, there are no meta-analyses that statistically determined the correlates of sickness absence in this population. Aims This meta-analysis examined organizational and psychosocial predictors of sickness absence among nursing staff. Methods As a registered systematic review (PROSPERO: CRD42017071040), which followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses, five databases (CINAHL, PROQuest Allied, PROQuest database theses, PsycINFO, PubMed) were reviewed to examine predictors of sickness absence in nurses and nursing assistants between 1990 and 2019. The Population/Intervention/Comparison/Outcome tool was used to support our searches. Effect sizes were analysed using random-effects model. Results Following critical appraisals using (i) National Institutes of Health’s Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies and (ii) Strengthening the Reporting of Observational Studies in Epidemiology, 21 studies were included. Nursing assistants had greater odds of sickness absence than nurses. Working night shifts, in paediatrics or psychiatric units, experiencing poor mental health, and fatigue, also increased the odds of sickness absence. There was no evidence that job satisfaction or job strain influenced sickness absence; however, job demand increased the likelihood. Finally, work support reduced the odds of lost-time. Conclusions We synthesized three decades of research where several factors influenced sickness absence. Due to limited recent research, the results should be interpreted with caution as some practices may have changed overtime or between countries. Nevertheless, these findings could help in applying preventative strategies to mitigate lost-time in a vulnerable working population.

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Abstract P155: Phenotyping The Association Between Nocturia And Hypertension: A Systematic Review And Meta-analysis

Hypertension ◽

10.1161/hyp.76.suppl_1.p155 ◽

2020 ◽

Vol 76 (Suppl_1) ◽

Author(s):

Syed N Rahman ◽

Daniel J Cao ◽

Thomas F Monaghan ◽

Viktor X Flores ◽

Matthew W Moy ◽

...

Keyword(s):

Assessment Tool ◽

Meta Analysis ◽

Current Evidence ◽

Quality Assessment Tool ◽

Observable Effect ◽

Cross Sectional ◽

Observational Cohort ◽

Meta Analyses ◽

The Relationship

Introduction: The association between nocturia and hypertension has been widely reported, yet remains poorly characterized, precluding a more refined understanding of blood pressure as it relates to the clinical urology setting. We synthesized current evidence on the relationship between nocturia and hypertension as a function of nocturia severity, age, sex, race, and diuretic use. Methods: We searched PubMed, EMBASE, and Cochrane databases for studies published up to May 2020. Random effects meta-analyses were performed to identify the pooled odds ratio (OR) for nocturia given the presence of hypertension. Meta-regression and subgroup analyses were performed to identify differences across demographic factors. We applied the Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies to evaluate the quality of evidence. Results: Of 1530 identified studies, 23 met the criteria for inclusion. The overall pooled OR for the association of hypertension with nocturia was 1.26 (95% CI 1.22-1.29, p<0.001). Pooled estimates were 1.21 (1.16-1.25, p<0.001) and 1.31 (1.26-1.36, p<0.001) using a 1- and 2-void cutoff for nocturia, respectively (p<0.001 between cutoffs). The association was stronger in females compared to males (1.41 [1.29-1.53] vs. 1.26 [1.20-1.32], p<0.001), and in African-American (1.56 [1.25-1.94]) and Asian (1.28 [1.24-1.32]) versus Caucasian populations (1.16 [1.09-1.24]) (p<0.05for both). Age and diuretic use had no observable effect on the association between nocturia and hypertension. Conclusions: There exists an increased odds of nocturia in hypertensive individuals. This association is stronger following a higher nocturia cutoff, in females, and in some racial subgroups, but unrelated to age and diuretic utilization.

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A systematic review and meta-analysis on Bolton’s ratios: Normal occlusion and malocclusion

Journal of Orthodontics ◽

10.1177/1465312519886322 ◽

2019 ◽

Vol 47 (1) ◽

pp. 7-29

Author(s):

Vanessa Machado ◽

João Botelho ◽

Paulo Mascarenhas ◽

José João Mendes ◽

Ana Delgado

Keyword(s):

Assessment Tool ◽

Meta Analysis ◽

Credible Interval ◽

Class Ii ◽

Mean Deviation ◽

Class Iii ◽

Cross Sectional ◽

Mean Values ◽

Normal Occlusion ◽

Meta Analyses

Introduction: The purpose of this study was to seek and summarise the Bolton overall index (OI) and anterior index (AI) regarding normal occlusion and Angle’s malocclusion according to gender, and to assess if these indices support Bolton’s standards as general references. Methods: PubMed, LILACS, Embase, CENTRAL and Google Scholar databases were searched up to June 2019 (CRD42018088438). Non-randomised clinical studies, published in English and assessing Bolton’s OI and/or AI in normal occlusion and Angle’s malocclusion groups, were included. OI and AI means, sample size and SDs were collected. The National Heart, Lung, and Blood Institute’s Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies was used to assess the risk of bias. Pairwise random-effects and multilevel Bayesian network meta-analyses were used to synthesise available data. Results: Fifty-three observational studies were included (11,411 participants; 3746 men, 4430 women; 15 studies lacked gender information). For normal occlusion, pooled estimates for OI and AI means were 91.78% (95% confidence interval [CI] = 91.42–92.14; I2 = 92.87%) and 78.25% (95% CI = 77.87–78.62; I2 = 90.67%), respectively. We could identify in Angle’s Class III patients meaningful OI and AI mean deviations from normal occlusion (0.76, 95% credible interval [CrI] = 0.55–0.98 and 0.61, 95% CrI = 0.35–0.87, respectively), while in Class II patients we found a meaningful mean deviation from normal occlusion only for OI (−0.28, 95% CrI = −0.52–−0.05). Concerning gender impact, male patients presented higher OI (0.30, 95% CI = 0.00–0.59) and AI (0.41, 95% CI = 0.00–0.83) mean values than female patients in Class I. Conclusion: Normal occlusion OI and AI mean values differ from Bolton’s original values. Class II division 2, for OI mean values, and Class III, for both OI and AI, are proportionally larger than normal occlusion patients. Gender had almost no impact on teeth mesiodistal proportion.

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The association between dietary inflammatory index and risk of central obesity in adults: An updated systematic review and meta-analysis

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000648 ◽

2020 ◽

Vol 90 (5-6) ◽

pp. 535-552 ◽

Cited By ~ 2

Author(s):

Mahdieh Abbasalizad Farhangi ◽

Mahdi Vajdi

Keyword(s):

Systematic Review ◽

Observational Studies ◽

Central Obesity ◽

Assessment Tool ◽

Weighted Mean Difference ◽

Meta Analysis ◽

Dietary Factors ◽

Cross Sectional ◽

Inflammatory Status ◽

Obesity Indices

Abstract. Backgrounds: Central obesity, as a pivotal component of metabolic syndrome is associated with numerous co-morbidities. Dietary factors influence central obesity by increased inflammatory status. However, recent studies didn’t evaluate the association between central obesity and dietary inflammation index (DII®) that give score to dietary factors according to their inflammatory potential. In the current systematic review and meta-analysis, we summarized the studies that investigated the association between DII® with central obesity indices in the general populations. Methods: In a systematic search from PubMed, SCOPUS, Web of Sciences and Cochrane electronic databases, we collected relevant studies written in English and published until 30 October 2019. The population of included studies were apparently healthy subjects or individuals with obesity or obesity-related diseases. Observational studies that evaluated the association between DII® and indices of central obesity including WC or WHR were included. Results: Totally thirty-two studies were included; thirty studies were cross-sectional and two were cohort studies with 103071 participants. Meta-analysis of observational studies showed that higher DII® scores were associated with 1.81 cm increase in WC (Pooled weighted mean difference (WMD) = 1.813; CI: 0.785–2.841; p = 0.001). Also, a non-significant increase in the odds of having higher WC (OR = 1.162; CI: 0.95–1.43; p = 0.154) in the highest DII category was also observed. In subgroup analysis, the continent, dietary assessment tool and gender were the heterogeneity sources. Conclusion: The findings proposed that adherence to diets with high DII® scores was associated with increased WC. Further studies with interventional designs are necessary to elucidate the causality inference between DII® and central obesity indices.

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To which extent are per-and poly-fluorinated substances associated to metabolic syndrome?

Reviews on Environmental Health ◽

10.1515/reveh-2020-0144 ◽

2021 ◽

Vol 0 (0) ◽

Author(s):

Maryam Zare Jeddi ◽

Rozita Soltanmohammadi ◽

Giulia Barbieri ◽

Aline S. C. Fabricio ◽

Gisella Pitter ◽

...

Keyword(s):

Metabolic Syndrome ◽

General Population ◽

Meta Analysis ◽

Small Body ◽

Epidemiological Studies ◽

Cross Sectional ◽

Random Effects Models ◽

Epidemiologic Evidence ◽

Adults And Children ◽

Meta Analyses

Abstract Exposure to per- and polyfluoroalkyl substances (PFAS), ubiquitous persistent environmental contaminants, has led to substantial global concern due to their potential environmental and human health effects. Several epidemiological studies have assessed the possible association between PFAS exposure and risk of metabolic syndrome (MetS), however, the results are ambiguous. The aim of this study was to assess the current human epidemiologic evidence on the association between exposure to PFAS and MetS. We performed a systematic search strategy using three electronic databases (PubMed, Scopus, and Web of Science) for relevant studies concerning the associations of PFAS with MetS and its clinical relevance from inception until January 2021. We undertook meta-analyses where there were five or more studies with exposure and outcomes assessments that were reasonably comparable. The pooled odd ratios (ORs) were calculated using random effects models and heterogeneity among studies was assessed by I2 index and Q test. A total of 12 cross-sectional studies (10 studies on the general population and two studies in the occupational settings) investigated the association between PFAS exposure and MetS. We pooled data from seven studies on the general population for perfluorooctanoic acid (PFOA) and perfluorooctanesulfonate (PFOS) and five studies for perfluorohexanesulfonate (PFHxS) and perfluorononanoic acid (PFNA). Predominately, most studies reported no statistically significant association between concentrations of PFAS and MetS. In the meta-analysis, the overall measure of effect was not statistically significant, showing no evidence of an association between concentrations of PFOA, PFOS, PFNA, and PFHxS and the risk of MetS. Based on the results of the meta-analysis, current small body of evidence does not support association between PFAS and MetS. However, due to limited number of studies and substantial heterogeneity, results should be interpreted with caution. Further scrutinizing cohort studies are needed to evaluate the association between various and less well-known PFAS substances and their mixture with MetS and its components in both adults and children in different settings.

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Prevalence of Cognitive Impairment and Dementia in Older Adults Living at High Altitude: A Systematic Review and Meta-Analysis

Dementia and Geriatric Cognitive Disorders ◽

10.1159/000514471 ◽

2021 ◽

pp. 1-11

Author(s):

Diego Urrunaga-Pastor ◽

Diego Chambergo-Michilot ◽

Fernando M. Runzer-Colmenares ◽

Josmel Pacheco-Mendoza ◽

Vicente A. Benites-Zapata

Keyword(s):

Older Adults ◽

Cognitive Impairment ◽

High Altitude ◽

Web Of Science ◽

Meta Analysis ◽

Cross Sectional ◽

Language Restriction ◽

Newcastle Ottawa Scale ◽

Meta Analyses ◽

Ottawa Scale

Introduction: Dementia is a chronic disease with a variable prevalence throughout the world; however, this could be higher at high-altitude populations. We aimed to summarize the prevalence of cognitive impairment and dementia in older adults living at high altitude. Methods: We searched in PubMed, Medline, Scopus, Web of Science, and Embase and included the studies published from inception to July 20, 2020, with no language restriction, which reported the frequency of cognitive impairment or dementia in older adults living at high-altitude populations. Random-effects meta-analyses were performed to calculate the overall prevalence and 95% confidence intervals (95% CI) of cognitive impairment and dementia. The risk of bias was evaluated using the Newcastle-Ottawa Scale (NOS) adapted for cross-sectional studies. Results: Six studies were included (3,724 participants), and 5 of the 6 included studies were carried out in Latin America. The altitude ranged from 1,783 to 3,847 m, the proportion of women included varied from 38.7 to 65.6%, and the proportion of participants with elementary or illiterate educational level ranged from 71.7 to 97.6%. The overall prevalence of cognitive impairment was 22.0% (95% CI: 8–40, I2: 99%), and the overall prevalence of dementia was 11.0% (95% CI: 6–17, I2: 92%). In a subgroup analysis according to the instrument used to evaluate cognitive impairment, the prevalence of cognitive impairment was 21.0% (95% CI: 5–42, I2: 99%) in the MMSE group while the prevalence was 29.0% (95% CI: 0–78) in the non-MMSE group. Conclusions: The prevalence of cognitive impairment and dementia in older adults living at high altitude is almost twice the number reported in some world regions.

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The Impact of Vegan Diet in the Prevention and Treatment of Type 2 Diabetes: A Systematic Review

Nutrients ◽

10.3390/nu13062123 ◽

2021 ◽

Vol 13 (6) ◽

pp. 2123

Author(s):

Daniela Pollakova ◽

Aikaterini Andreadi ◽

Francesca Pacifici ◽

David Della-Morte ◽

Davide Lauro ◽

...

Keyword(s):

Type 2 Diabetes ◽

Assessment Tool ◽

Vegan Diet ◽

Cochrane Library ◽

Diabetic Patients ◽

Cross Sectional ◽

Observational Cohort ◽

Meta Analyses ◽

The Impact

A protective effect of vegan diets on health outcomes has been observed in previous studies, but its impact on diabetes is still debated. The aim of this review is to assess the relationship between vegan diets and the risk for type 2 diabetes (T2D) along with its effect on glycemic control and diabetes-related complications. In accordance with PRISMA (Preferred Reporting Items for Systematic Reviews and Meta–Analyses) guidelines, Pubmed and Cochrane library databases were systematically searched for all relevant studies. Seven observational and eight randomized controlled (RCTs) studies were included. The methodological quality of studies was assessed using the National Institutes of Health quality assessment tool for observational cohort and cross-sectional studies and the Cochrane Risk of Bias Tool for RCTs. We found that a vegan diet is associated with lower T2D prevalence or incidence and in T2D patients decreases high glucose values and improves glucose homeostasis, as reported from the majority of included studies. This approach seems to be comparable to other recommended healthful eating models, but as it may have potential adverse effects associated with the long-term exclusion of some nutrients, appropriate nutritional planning and surveillance are recommended, particularly in specific groups of diabetic patients such as frail elderly, adolescents, and pregnant or breastfeeding women.

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Arm Based on LEg blood pressures (ABLE-BP): can systolic leg blood pressure measurements predict systolic brachial blood pressure? Protocol for an individual participant data meta-analysis from the INTERPRESS-IPD Collaboration

BMJ Open ◽

10.1136/bmjopen-2020-040481 ◽

2021 ◽

Vol 11 (3) ◽

pp. e040481

Author(s):

Sinead T J McDonagh ◽

James P Sheppard ◽

Fiona C Warren ◽

Kate Boddy ◽

Leon Farmer ◽

...

Keyword(s):

Blood Pressure ◽

Public Involvement ◽

Meta Analysis ◽

Patient And Public Involvement ◽

Prognostic Models ◽

Individual Participant Data ◽

Dissemination Strategy ◽

Cross Sectional ◽

Individual Participant ◽

Meta Analyses

IntroductionBlood pressure (BP) is normally measured on the upper arm, and guidelines for the diagnosis and treatment of high BP are based on such measurements. Leg BP measurement can be an alternative when brachial BP measurement is impractical, due to injury or disability. Limited data exist to guide interpretation of leg BP values for hypertension management; study-level systematic review findings suggest that systolic BP (SBP) is 17 mm Hg higher in the leg than the arm. However, uncertainty remains about the applicability of this figure in clinical practice due to substantial heterogeneity.AimsTo examine the relationship between arm and leg SBP, develop and validate a multivariable model predicting arm SBP from leg SBP and investigate the prognostic association between leg SBP and cardiovascular disease and mortality.Methods and analysisIndividual participant data (IPD) meta-analyses using arm and leg SBP measurements for 33 710 individuals from 14 studies within the Inter-arm blood pressure difference IPD (INTERPRESS-IPD) Collaboration. We will explore cross-sectional relationships between arm and leg SBP using hierarchical linear regression with participants nested by study, in multivariable models. Prognostic models will be derived for all-cause and cardiovascular mortality and cardiovascular events.Ethics and disseminationData originate from studies with prior ethical approval and consent, and data sharing agreements are in place—no further approvals are required to undertake the secondary analyses proposed in this protocol. Findings will be published in peer-reviewed journal articles and presented at conferences. A comprehensive dissemination strategy is in place, integrated with patient and public involvement.PROSPERO registration numberCRD42015031227.

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Magnesium and mood disorders: systematic review and meta-analysis

BJPsych Open ◽

10.1192/bjo.2018.22 ◽

2018 ◽

Vol 4 (4) ◽

pp. 167-179 ◽

Cited By ~ 12

Author(s):

Danny Phelan ◽

Patricio Molero ◽

Miguel A. Martínez-González ◽

Marc Molendijk

Keyword(s):

Systematic Review ◽

Mood Disorders ◽

Symptom Severity ◽

Odds Ratio ◽

Potential Role ◽

Meta Analysis ◽

Blood Levels ◽

Cross Sectional ◽

Bodily Fluids ◽

Meta Analyses

BackgroundMagnesium (Mg2+) has received considerable attention with regards to its potential role in the pathophysiology of the mood disorders, but the available evidence seems inconclusive.AimsTo review and quantitatively summarise the human literature on Mg2+intake and Mg2+blood levels in the mood disorders and the effects of Mg2+supplements on mood.MethodSystematic review and meta-analyses.ResultsAdherence to a Mg2+-rich diet was negatively associated with depression in cross-sectional (odds ratio = 0.66) but not in prospective studies. Mg2+levels in bodily fluids were on average higher in patients with a mood disorder (Hedge'sg = 0.19), but only in patients treated with antidepressants and/or mood stabilisers. There was no evident association between Mg2+levels and symptom severity. Mg2+supplementation was associated with a decline in depressive symptoms in uncontrolled (g = −1.60) but not in placebo-controlled trials (g = −0.21).ConclusionOur results provide little evidence for the involvement of Mg2+in the mood disorders.Declaration of interestNone.

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Is Sensory Loss an Understudied Risk Factor for Frailty? A Systematic Review and Meta-analysis

The Journals of Gerontology Series A ◽

10.1093/gerona/glaa171 ◽

2020 ◽

Vol 75 (12) ◽

pp. 2461-2470

Author(s):

Benjamin Kye Jyn Tan ◽

Ryan Eyn Kidd Man ◽

Alfred Tau Liang Gan ◽

Eva K Fenwick ◽

Varshini Varadaraj ◽

...

Keyword(s):

Systematic Review ◽

Risk Factor ◽

Longitudinal Studies ◽

Meta Analysis ◽

Sensory Loss ◽

Cross Sectional ◽

Sensory Impairments ◽

Subgroup Analyses ◽

Meta Regression ◽

Meta Analyses

Abstract Background Age-related sensory loss and frailty are common conditions among older adults, but epidemiologic research on their possible links has been inconclusive. Clarifying this relationship is important because sensory loss may be a clinically relevant risk factor for frailty. Methods In this systematic review and meta-analysis, we searched 3 databases for observational studies investigating 4 sensory impairments—vision (VI), hearing (HI), smell (SI), and taste (TI)—and their relationships with frailty. We meta-analyzed the cross-sectional associations of VI/HI each with pre-frailty and frailty, investigated sources of heterogeneity using meta-regression and subgroup analyses, and assessed publication bias using Egger’s test. Results We included 17 cross-sectional and 7 longitudinal studies in our review (N = 34,085) from 766 records. Our cross-sectional meta-analyses found that HI and VI were, respectively, associated with 1.5- to 2-fold greater odds of pre-frailty and 2.5- to 3-fold greater odds of frailty. Our results remained largely unchanged after subgroup analyses and meta-regression, though the association between HI and pre-frailty was no longer significant in 2 subgroups which lacked sufficient studies. We did not detect publication bias. Longitudinal studies largely found positive associations between VI/HI and frailty progression from baseline robustness, though they were inconclusive about frailty progression from baseline pre-frailty. Sparse literature and heterogenous methods precluded meta-analyses and conclusions on the SI/TI–frailty relationships. Conclusions Our meta-analyses demonstrate significant cross-sectional associations between VI/HI with pre-frailty and frailty. Our review also highlights knowledge gaps on the directionality and modifiability of these relationships and the impact of SI/TI and multiple sensory impairments on frailty.

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Is sexual content in new media linked to sexual risk behaviour in young people? A systematic review and meta-analysis

Sexual Health ◽

10.1071/sh16037 ◽

2016 ◽

Vol 13 (6) ◽

pp. 501 ◽

Cited By ~ 18

Author(s):

Lucy Watchirs Smith ◽

Bette Liu ◽

Louisa Degenhardt ◽

Juliet Richters ◽

George Patton ◽

...

Keyword(s):

Systematic Review ◽

Young People ◽

New Media ◽

Sexual Intercourse ◽

Sexual Attitudes ◽

Meta Analysis ◽

Sexual Content ◽

Cross Sectional ◽

Causal Pathways ◽

Meta Analyses

Background: Social networking and digital media increasingly have an impact on the lives of young people. We undertook a systematic review and meta-analysis of studies that examined the relationship between exposure to sexually explicit websites (SEWs) and ‘sexting’ (i.e. sending semi-nude or nude photos from a mobile phone) and the sexual attitudes and practices of young people. Methods: In accordance with the Preferred Reporting Items for Systematic Reviews and Meta Analyses statement, Medline, EMBASE and PsycINFO were searched for papers that described the statistical association between viewing SEWs or sexting by young people (defined as 10–24 years) and their sexual attitudes and behaviours. Results: Fourteen studies, all cross-sectional in design, met the inclusion criteria. Six studies (10 352 participants) examined young people’s exposure to SEWs and eight (10 429 participants) examined sexting. There was substantial variation across studies in exposure and outcome definitions. Meta-analyses found that SEW exposure was correlated with condomless sexual intercourse (odds ratio (OR) 1.23, 95% confidence interval (CI): 1.08–1.38, two studies); sexting was correlated with ever having had sexual intercourse (OR 5.58, 95% CI: 4.46–6.71, five studies), recent sexual activity (OR 4.79, 95% CI: 3.55–6.04, two studies), alcohol and other drug use before sexual intercourse (OR 2.65, 95% CI: 1.99–3.32, two studies) and multiple recent sexual partners (OR 2.79, 95% CI: 1.95–3.63, two studies). Most studies had limited adjustment for important potential confounders. Conclusions: Cross-sectional studies show a strong association between self-reported exposure to sexual content in new media and sexual behaviours in young people. Longitudinal studies would provide a greater opportunity to adjust for confounding, and better insight into the causal pathways underlying the observed associations.

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