Study of Effect of Whitening Creams on Serum Basal Cortisol level In Egyptian Females

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Yara Muhammed Eid ◽  
Iman Zaky Ahmed ◽  
Merhan Samy Nasr ◽  
Hany Khairy Mansour ◽  
Mohammed Omar Awadh Baqraf ◽  
...  
Keyword(s):  
Adrenal Gland ◽  
Cortisol Level ◽  
Serum Cortisol ◽  
Early Morning ◽  
Serum Cortisol Level ◽  
P Value ◽  
Study Group ◽  
Adrenocortical Insufficiency ◽  
Topical Corticosteroids ◽  
Significant Difference

Abstract Objective The aim of the present study is to evaluate the relationship between practice of whitening creams (Topical Corticosteroids) and serum cortisol level in a sample of healthy females at Ain- shams University Teaching hospital. Background Topical corticosteroids (TCs) are widely used as depigmenting agents alone or in combination with other fairness creams. Secondary adrenocortical insufficiency occurs due to deficiency of corticotropin (adrenocorticotropic hormone) [ACTH] in the pituitary gland. With low levels of corticotropin, cortex layer in the adrenal gland is not sufficiently stimulated to release adequate amount of cortisol. Excessive glucocorticoid therapy is the primary cause of adrenocortical insufficiency. Methods we recruited 45 subjects practice whitening creams (TCs) for three months or more; matched with a healthy control group consists of 45 participants. Early morning basal serum cortisol level (8:00 am) done by one-step competitive immunoassay using Beckman Coulter device. Cortisol ELISA Kit provided by CALBIOTECH, Inc (Co_103S). Results Early morning serum cortisol level was statistically insignificant among subjects practice whitening creams in combination with TCs vs. healthy controls (p value 0.307). However, there were 7 out of 45 participants in the study group (15.6%) had low serum cortisol level (<5ug/dl) with highly statistically significant difference regarding whitening creams usage methods. In comparison and data analysis between subjects of the study group regarding practice duration, used quantity, application frequency, and method of exposure, there was high statistically significant difference between subjects with normal cortisol level vs. subjects with low cortisol level (p value <0.001). There were, no significant difference found regarding BMI, and arterial blood pressure between study group and controls. Conclusion Whitening creams abuse especially high potency TCs is a common phenomenon that may induce several local and systemic complications including adrenal gland insufficiency.

scholarly journals Yoga is an effective technique of stress reduction within the medical population: a biochemical study in MBBS students of BRD Medical College, Gorakhpur, Uttar Pradesh, India

2020 ◽  
Vol 8 (4) ◽  
pp. 1326
Author(s):  
Vikash K. Tiwari ◽  
Shashi Pandey ◽  
Ragini Mishra
Keyword(s):  
Cortisol Level ◽  
Stress Reduction ◽  
Serum Cortisol ◽  
Serum Cortisol Level ◽  
Control Group ◽  
P Value ◽  
First Year ◽  
Medical College ◽  
Stress Marker ◽  
Yoga Group

Background: Medicine is a profession with high-stress prevalence. There are many stress markers but cortisol is one of the commonly used stress marker. Stress begins in the first year of medical carrier and increases with subsequent years of medical education. There is a decrease in overall academic performance and many health-related adverse effects due to stress. In this study, yoga was performed in the first year MBBS students of BRD Medical College, Gorakhpur and the impact of yoga in stress reduction was studied using serum cortisol as stress a marker.Methods: Study groups, yoga and control contained 26 and 27 subjects including male and female MBBS students. Yoga group practiced selected yogic asana, pranayama, and yoga nidra for 3 months. The control group as a stress marker had been kept in touch and allowed to go on their usual activity as before. Morning (8.00 AM to 9.00 AM) serum cortisol level was used as a stress marker in both group, pre and post-study.Results: There was a significant reduction in morning serum cortisol level (stress level) in yoga group (p-value = 0.0271) but there was no significant change in morning serum cortisol level of the control group (p-value = 0.8573).Conclusions: Yoga is an effective stress reduction technique for medical students. Yoga classes should be introduced in the first year of the medical carrier under the supervision of expert physiologists. This may lead to the implantation of a healthy lifestyle in our future healthcare providers. Yogic practice by health care providers may have long term positive impacts on our healthcare system.

Cortisol Secretion and Urinary MHPG in Unipolar Depression

1984 ◽  
Vol 13 (4) ◽  
pp. 261-266 ◽  
Author(s):  
Harvey A. Sternbach ◽  
Irl Extein ◽  
Donald R. Sweeney ◽  
Mark S. Gold ◽  
A. L. C. Pottash
Keyword(s):  
Cortisol Level ◽  
Unipolar Depression ◽  
Serum Cortisol ◽  
Serum Cortisol Level ◽  
Cortisol Secretion ◽  
Significant Difference ◽  
Suppression Test ◽  
The Mean ◽  
The Relationship ◽  
Dexamethasone Suppression

The authors examined the relationship between both pre-dexamethasone 8:00 AM serum cortisol level and the dexamethasone suppression test (DST) with urinary 3-methoxy-4-hydroxyphenyl glycol (MHPG) excretion in a group of fifteen men and fourteen women with unipolar depression. No significant difference was found between the mean MHPG excretion for either male or female DST suppressors or non-suppressors. No significant correlation was found between the pre-dexamethasone 8:00 AM serum cortisol level and urinary MHPG. These results do not support the hypothesis that DST non-suppression in depression is related to central noradrenergic deficiency.

The Incidence of Adrenal Insufficiency in Myeloma Patients Receiving Pulse-Dose Dexamethasone

Blood ◽  
2016 ◽  
Vol 128 (22) ◽  
pp. 5640-5640
Author(s):  
Aimaz Afrough ◽  
Amy Sidorski ◽  
Roberto Salvatori ◽  
Ivan Borrello
Keyword(s):  
Adrenal Insufficiency ◽  
Cortisol Level ◽  
Research Funding ◽  
Serum Cortisol ◽  
Stimulation Test ◽  
Serum Cortisol Level ◽  
Acth Stimulation Test ◽  
Acth Stimulation ◽  
Pulse Dose ◽  
Significant Difference

Abstract Introduction: Glucocorticoids (GC's) are major drugs in the treatment of multiple myeloma (MM). Chronic administration of supra-physiological doses of GC's suppresses the hypothalamus-pituitary-adrenal (HPA) axis and is associated with secondary adrenal insufficiency (AI). In MM, GC's are usually administered in weekly high dose pulses. Due to long GC-free periods in such therapy, GC-induced AI is not usually considered to be a consequence of GC therapy in MM (Krasner, AS. JAMA, 1999. 282(7): p. 671-6). Here we report on the incidence of AI in MM patients treated at our center with pulse-dose GC. Methods: This is a retrospective cross-sectional study of patients with MM treated with GC-based regimens. Patients were required to have at least a random serum cortisol or a standard 250 mcg ACTH stimulation test result available in their medical record during dexamethasone-based chemotherapy. Patients were excluded if they were on dexamethasone more than 1 day a week, were lost to follow-up, had prior use of synthetic progestational agents such as megestrol or had been on oral glucocorticoids for any other medical indication. Diagnosis of AI was established by a frankly low AM serum cortisol level (<3 ug/dL) or an inadequate cortisol response to ACTH stimulation test (Salvatori, R. JAMA, 2005. 294(19): p. 2481-8). Results: A total of 45 patients were included in this study with median age of 62 (range, 49-89). Fifteen (33.3%) of patients were diagnosed with AI. The median random cortisol level in AI group was 2.3 ug/dL (range, 0.3-7.4 ug/dL) compared to 9.9 ug/dL (range, 1.0-21.2 ug/dL) in the non-AI group. The median time between the last dexamethasone dose and the serum cortisol assay was 5 days (range, 1-21). The median number of GC-based chemotherapy cycles taken before diagnosis of AI was 15 (range, 2-60). The median cumulative dexamethasone consumption was 1280 mg (range, 180-5220 mg). There was no correlation between developing AI and dose or duration of dexamethasone treatment. We observed clinical trend between cumulative doses of ≥1500 mg (P= 0.055) or use of clarithromycin (P=0.079) and developing AI, without reaching a statistically significant difference. Conclusion: The rate of AI was 33% among patients with MM on weekly pulse-dose dexamethasone. As such, patients should be periodically evaluated for this to enable early detection and proper management. Disclosures Borrello: BMS: Honoraria, Research Funding; WindMIL Therapeutics: Equity Ownership, Patents & Royalties, Research Funding; Celgene: Honoraria, Research Funding, Speakers Bureau.

scholarly journals Study of serum cortisol level in severe falciparum malaria presenting with unexplained hypotension

2014 ◽  
Vol 6 (3) ◽  
pp. 30-32 ◽  
Author(s):  
Susant Pradhan ◽  
Sagar Khadanga ◽  
Kashinath Padhiary ◽  
Biranchi Narayan Mohapatra ◽  
Tadepalli Karuna ◽  
...  
Keyword(s):  
Falciparum Malaria ◽  
Cortisol Level ◽  
Tertiary Care ◽  
Serum Cortisol ◽  
World Health ◽  
Serum Cortisol Level ◽  
Control Group ◽  
Study Group ◽  
Adrenal Deficiency ◽  
Severe Falciparum Malaria

Background: Hypotension in malaria can be due to various causes. One among them is relative adrenal deficiency. World Health Organisation (WHO) and Indian malaria guidelines do not allow the use of steroid in malaria patients. But it appears prudent to use systemic steroid in those subset of malaria patients having adrenal deficiency. So the aim of the study was to prove or disprove the existence of adrenal deficiency in malaria patients. Methodology: This is a case control study which was conducted in two tertiary care centres, single blind and prospective in nature. SPSS 19 was used at the end of the study for all statistical analysis. Patient characteristics and outcome of interest is calculated with 95% confidence limits. The probability of <0.05 is considered to be significant. Results: Compared with control group the study group had significantly lower serum cortisol level at presentation (36.56±6.52 µg/dl vs. 19.43±7.29 µg/dl, p=0.006). In the study group there is significant rise in serum cortisol level after recovery from hypotension (19.96±7.29 µg/dl vs. 35.86±8.26 µg/dl, p=0.01). In control group there is slight decrease of serum cortisol level after recovery (36.85±6.42 µg/dl vs. 34.72±9.12 µg/dl, p=0.83). Conclusion: Adrenal insufficiency may be the cause of unexplained hypotension in severe falciparum malaria. Administration of systemic corticosteroid in this subset of patients seems to be justified.DOI: http://dx.doi.org/10.3126/ajms.v6i3.11282Asian Journal of Medical Sciences Vol.6(3) 2015 30-32

scholarly journals Study of serum cortisol levels in complicated and uncomplicated Plasmodium vivax malaria patients

2020 ◽  
Vol 9 (1) ◽  
pp. 254
Author(s):  
Sandeep B. R. ◽  
M. G. Bhutto ◽  
Suresh Babu K. P.
Keyword(s):  
Plasmodium Vivax ◽  
Cortisol Level ◽  
Vivax Malaria ◽  
Serum Cortisol ◽  
Treatment Modalities ◽  
Serum Cortisol Level ◽  
Control Group ◽  
Significant Difference ◽  
Plasmodium Vivax Malaria ◽  
Cortisol Levels

Background: Malaria results in pathological changes in various body organs, as the parasite invade and multiply in circulating red blood cells. Despite of advances in diagnostic and treatment modalities, worldwide incidences of malaria are significant. Current study was conducted to investigate serum cortisol level changes as a promising biomarker for risk prediction in malaria and to study adrenal insufficiency in malaria patients.Methods: Current investigation was a prospective observational study, conducted on complicated and uncomplicated Plasmodium vivax malaria patients. Serum cortisol levels in patients were investigated through immunoassay using direct chemiluminescent technology and were statistically correlated with Plasmodium vivax malaria infection.Results: Results of present investigation revealed that on day 1 there was significant difference in mean serum cortisol levels between the Plasmodium vivax malaria patients and control group and cortisol levels were significantly higher in complicated Plasmodium vivax malaria patients compared to uncomplicated cases on day 1 and 7. Cortisol levels were observed to be normal on day 1 and 7 in uncomplicated malaria cases and in patients with bleeding manifestations, renal failure and jaundice. In 10 out of 15 cases of cerebral malaria, significant increase in serum cortisol levels were observed on day 1, while on day 7 levels were normal in all 15 cases.Conclusions: Rise in serum cortisol level had a positive correlation with temperature and thus can be useful to predict the severity of disease in Plasmodium vivax malaria patients. No cortisol insufficiency was observed in during active and convalescent stages of illness.

scholarly journals Effect of yoga and meditation on serum cortisol level in first-year medical students

2018 ◽  
Vol 6 (5) ◽  
pp. 1699
Author(s):  
Kislay Kumar ◽  
Vinay Singh ◽  
Devesh Kumar ◽  
A. B. Asthana ◽  
Divya Mishra
Keyword(s):  
Medical Students ◽  
Cortisol Level ◽  
Stress Level ◽  
High Stress ◽  
Serum Cortisol ◽  
Serum Cortisol Level ◽  
Control Group ◽  
P Value ◽  
Yoga Group ◽  
Morning Serum Cortisol

Background: Yoga is a traditional technique to conserve and purify body, mind and soul. It is a mind-body bridge which involves relaxation, meditation and a set of physical exercises performed in association with breathing. In this new era of evolution, most of the population are depressed or in stress, irrespective of their age and gender.Methods: This study is performed on 1st yr. medical students whose stress level is in higher side due to academic burden. An 55 medical students were selected as participants through counseling and were divided into yoga group (n= 27) and control group (n=28). Their morning serum cortisol level was assessed, and yoga group were instructed to practice yoga (1hr/day for 12 weeks) under supervision of yoga instructor. No such instruction was given to control group.Results: Serum cortisol level is the marker of stress and inflammation. Higher cortisol level means high stress level. Yoga and meditation is documented to reduce stress level in regular practitioners.  Statistical analysis has shown decrease in morning serum cortisol level (572.18±168.03 to 544.98±139.89, 4.8% decrease, P value ˂0.05, significant) in yoga group after study. Control group have shown marked increase in cortisol level (558.89±162.69 to 577.26±254.5, 3.4% increase, P value = 0.74, not significant) after three months of study.Conclusions: This study concludes that practicing Yoga has a significant effect on the reduction of stress and anxiety level in medical students.

Nighttime serum cortisol level for diagnosis of hypercortisolism in hospitalized patients

2019 ◽  
Author(s):  
Liana Khatsimova ◽  
Uliana Tsoy ◽  
Natalia Kuritsyna ◽  
Elena Grineva ◽  
Elena Litvinenko ◽  
...  
Keyword(s):  
Cortisol Level ◽  
Serum Cortisol ◽  
Hospitalized Patients ◽  
Serum Cortisol Level

scholarly journals Comparison of cortisol levels in patients with vasovagal syncope and postural tachycardia syndrome

2021 ◽  
Vol 38 (1) ◽  
Author(s):  
Humaira Fayyaz ◽  
Shazadi Ambreen ◽  
Hammad Raziq ◽  
Azmat Hayyat
Keyword(s):  
Vasovagal Syncope ◽  
Serum Cortisol ◽  
Tilt Test ◽  
Control Group ◽  
Postural Tachycardia Syndrome ◽  
P Value ◽  
Cross Sectional ◽  
Postural Tachycardia ◽  
Significant Difference ◽  
Cortisol Levels

Objectives: To compare the levels of cortisol in patients of vasovagal syncope (VVS) and postural tachycardia syndrome (POTS). Methods: A cross-sectional analytical study was conducted at Islamic International Medical College, Rawalpindi and Electrophysiology Department at (AFIC). This study included 80 subjects, comprising of 35 patients in each group of vasovagal syncope and postural tachycardia syndrome and 10 healthy subjects. Patients with complaint of syncope was evaluated for vasovagal syncope and postural tachycardia syndrome using Head Up Tilt Test (HUTT). Blood samples of all the participants were taken and serum cortisol was analyzed using ELISA method. Results were analyzed on SPSS Statistics 21 using ANOVA with a p-value of ≤0.05 regarded as significant. Results: Hormonal analysis shows that cortisol levels in the vasovagal, postural tachycardia syndrome and in control group was 153±16.7pg/ml, 160.17±pg/ml, and 69.65±5.8pg/ml respectively. Cortisol levels were significantly higher in both vasovagal and POTS groups as compared to controls with a p-value of 0.04 and 0.023 respectively. However, there was no significant difference between vasovagal and POTS patients with p value 0.570. Conclusion: It is concluded from the study that cortisol responses of VVS and POTS were positive. doi: https://doi.org/10.12669/pjms.38.1.4122 How to cite this:Khan HF, Ambreen S, Raziq H, Hayat A. Comparison of cortisol levels in patients with vasovagal syncope and postural tachycardia syndrome. Pak J Med Sci. 2022;38(1):---------. doi: https://doi.org/10.12669/pjms.38.1.4122 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Serum Cortisol Abnormalities after Craniocerebral Trauma

Neurosurgery ◽  
1979 ◽  
Vol 5 (5) ◽  
pp. 559-565 ◽  
Author(s):  
Paul Steinbok ◽  
Gordon Thompson
Keyword(s):  
Head Injury ◽  
Cortisol Level ◽  
Diurnal Rhythm ◽  
Elevated Serum ◽  
Craniocerebral Trauma ◽  
Serum Cortisol ◽  
Feedback Mechanism ◽  
Serum Cortisol Level ◽  
Skull Fractures ◽  
Middle Fossa

Abstract Serial estimations of serum cortisol were performed in 49 patients with craniocerebral trauma. Abnormalities of serum cortisol, including alterations in diurnal rhythm and elevations of serum cortisol level, occurred in 21 patients. The frequency and severity of the abnormalities correlated with the severity of the head injury, and there was a trend suggesting that middle fossa basal skull fractures predisposed to cortisol abnormalities. A further 6 patients were studied to assess the effects of exogenous dexamethasone, and in all patients there was suppression of elevated serum cortisol levels by the dexamethasone. The findings suggest that hypercortisolemia after head injury is related to an alteration rather than an abolition of the normal feedback mechanism.

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