scholarly journals Study of serum cortisol level in severe falciparum malaria presenting with unexplained hypotension

2014 ◽  
Vol 6 (3) ◽  
pp. 30-32 ◽  
Author(s):  
Susant Pradhan ◽  
Sagar Khadanga ◽  
Kashinath Padhiary ◽  
Biranchi Narayan Mohapatra ◽  
Tadepalli Karuna ◽  
...  
Keyword(s):  
Falciparum Malaria ◽  
Cortisol Level ◽  
Tertiary Care ◽  
Serum Cortisol ◽  
World Health ◽  
Serum Cortisol Level ◽  
Control Group ◽  
Study Group ◽  
Adrenal Deficiency ◽  
Severe Falciparum Malaria

Background: Hypotension in malaria can be due to various causes. One among them is relative adrenal deficiency. World Health Organisation (WHO) and Indian malaria guidelines do not allow the use of steroid in malaria patients. But it appears prudent to use systemic steroid in those subset of malaria patients having adrenal deficiency. So the aim of the study was to prove or disprove the existence of adrenal deficiency in malaria patients. Methodology: This is a case control study which was conducted in two tertiary care centres, single blind and prospective in nature. SPSS 19 was used at the end of the study for all statistical analysis. Patient characteristics and outcome of interest is calculated with 95% confidence limits. The probability of <0.05 is considered to be significant. Results: Compared with control group the study group had significantly lower serum cortisol level at presentation (36.56±6.52 µg/dl vs. 19.43±7.29 µg/dl, p=0.006). In the study group there is significant rise in serum cortisol level after recovery from hypotension (19.96±7.29 µg/dl vs. 35.86±8.26 µg/dl, p=0.01). In control group there is slight decrease of serum cortisol level after recovery (36.85±6.42 µg/dl vs. 34.72±9.12 µg/dl, p=0.83). Conclusion: Adrenal insufficiency may be the cause of unexplained hypotension in severe falciparum malaria. Administration of systemic corticosteroid in this subset of patients seems to be justified.DOI: http://dx.doi.org/10.3126/ajms.v6i3.11282Asian Journal of Medical Sciences Vol.6(3) 2015 30-32

scholarly journals STUDY OF ADRENAL INSUFFICIENCY IN SEVERE FALCIPARUM MALARIA WITH SHOCK KEY WORDS: Falciparum Malaria, Shock, Adrenal

2021 ◽  
pp. 261-264
Author(s):  
Sudhanshu Sekhar Sethi ◽  
Saiprasanna Behera
Keyword(s):  
Adrenal Insufficiency ◽  
Falciparum Malaria ◽  
Cortisol Level ◽  
Research Work ◽  
Serum Cortisol ◽  
Serum Cortisol Level ◽  
Relative Adrenal Insufficiency ◽  
Eastern Region ◽  
South East Asian Region ◽  
Severe Falciparum Malaria

Malaria remains a serious health problem in South East Asian Region (SEAR) with nearly 290 million people are estimated to be at high risk.India accounts for 77% of the regional total malarial cases.Most of deaths in malaria are due to severe falciparum malaria. Odisha is a unique state in the eastern region of India, which contributes 4% of the population and counting up to >40% of total falciparum malaria cases of India. Malaria is one of the most important public health disease in Odisha. In spite of such an important disease, there are many areas on severe falciparum malarias where research work is scanty. One among of them is detection of relative adrenal insufficiency in severe falciparum malaria. As there is limited work about the relative adrenal insufficiency in severe falciparum malaria with shock and its relation to mortality. This study has been undertaken with the following aims and objectives, firstly detection of relative adrenal insufficiency in severe falciparum malaria with shock and secondly to establish the relation of mortality with or without adrenal insufficiency in severe falciparum malaria.The present study has established that relative adrenal insufficiency is an important cause contributing to shock and increased mortality. Thus addition of corticosteroid saves life and must be used in the relative adrenal insufficiency. However the firm diagnosis of relative adrenal insufficiency depends upon estimation of basal serum cortisol level & post ACTH serum cortisol level. As corticosteroid reduces the mortality rate, it should be empirically used in critically ill severe falciparum malaria cases with shock.

scholarly journals Effects of Surgical Stress on Serum Cortisol Level: A Comparative Study between Elective and Emergency Surgery

1970 ◽  
Vol 2 ◽  
pp. 28-33
Author(s):  
SM Selimuzzaman ◽  
Noorzahan Begum ◽  
Nadira Islam ◽  
Shelina Begum
Keyword(s):  
Surgical Treatment ◽  
Cortisol Level ◽  
Surgical Stress ◽  
Serum Cortisol ◽  
Study Groups ◽  
Serum Cortisol Level ◽  
Control Group ◽  
Surgical Interventions ◽  
Group I ◽  
Healthy Control

The study was designed to observe the effects of surgical stress on serum level of cortisol in patients undergoing surgical treatment and to find out any differences in hormonal response between elective and emergency surgical procedures. A total number of 60 male subjects aged between 18 and 45 years were included in the study. Of them, 20 were healthy control (Group I), 20 underwent elective surgical treatment (Group II) and emergency surgical interventions were applied in rest 20 subjects (Group III). Study Groups were further divided into subgroups A (preoperative samples were collected 1- hour before operation), B (postoperative samples were collected 1-hour after the end of the operation) and C (postoperative samples were collected 24-hours after operation).Serum cortisol level was estimated by invitro-immunolytic test.Statistical analysis was done by paired, unpaired ‘t' test and regression analysis. The preoperative mean serum cortisol concentration in elective surgical cases was almost similar to that of healthy control. On the contrary, in the emergency surgical cases, a significantly increased mean cortisol level were observed (I vs IIIA and IIA vs IIIA; P < 0.05). The serum cortisol concentrations were increased both in elective and emergency surgical cases after operations but the magnitude of rise was more marked in emergency group of patients (IIB vs IIIB; P < 0.05). Therefore, this study reveals that surgical intervention causes increase in serum cortisol which is more marked in emergency procedure. Key Words: Stress; Cortisol; Surgery DOI:10.3329/jbsp.v2i0.981 J Bangladesh Soc Physiol. 2007 Dec;(2): 28-33.

scholarly journals Effects of Serum Cortisol Levels on Perinatal Prognosis in Patients with Hypertensive Disorder

2020 ◽  
Vol 4 (2) ◽  
Author(s):  
Gaoxiang Huo ◽  
Yeqiang Qin ◽  
Xiucui Bao ◽  
Xiaoling Yao ◽  
Zhangwei Pu ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Cortisol Level ◽  
Gestational Hypertension ◽  
Serum Cortisol ◽  
The Other ◽  
Serum Cortisol Level ◽  
Control Group ◽  
Hypertensive Disorder ◽  
Cortisol Levels ◽  
Case Number

Objective: To investigate the effect of serum cortisol level on perinatal prognosis in patients with hypertensive disorder during pregnancy. Methods: In this study, different degrees of patients with hypertensive disorder during pregnancy who were admitted from August 2018 to August 2019 in our hospital were selected as the research subjects, and divided into groups according to the severity of the patients' conditions. The 120 patients were divided into gestational hypertension group, preeclampsia group and eclampsia group, with 40 cases each, and another 40 healthy pregnant women were selected. The detection of serum cortisol levels was carried out for the above 4 groups of pregnant women. Results: The serum cortisol level in the control group was (260.35 ± 10.96) nmol / L. The case number of neonatal asphyxia was 1 (2.50%), the case number of premature births was 1 (2.50%), the number of fetal growth restriction was 1 (2.50%), the number of deaths was 0, and the other three groups were higher than this. It showed as gestational hypertension <preeclampsia <eclampsia. The Apgar score of pregnant women in the control group was (9.13 ± 0.29), the ZL index was (1.07 ± 0.07), and the other three groups were lower than this. It showed as gestational hypertension> preeclampsia> eclampsia. There were significant differences between groups (all P<0.05). Conclusion: Early detection of serum cortisol levels in pregnant women is beneficial to timely improve the symptoms of gestational hypertension, thereby suppressing the effects of serum cortisol on perinatal infants and improving the prognosis of newborns.

scholarly journals Yoga is an effective technique of stress reduction within the medical population: a biochemical study in MBBS students of BRD Medical College, Gorakhpur, Uttar Pradesh, India

2020 ◽  
Vol 8 (4) ◽  
pp. 1326
Author(s):  
Vikash K. Tiwari ◽  
Shashi Pandey ◽  
Ragini Mishra
Keyword(s):  
Cortisol Level ◽  
Stress Reduction ◽  
Serum Cortisol ◽  
Serum Cortisol Level ◽  
Control Group ◽  
P Value ◽  
First Year ◽  
Medical College ◽  
Stress Marker ◽  
Yoga Group

Background: Medicine is a profession with high-stress prevalence. There are many stress markers but cortisol is one of the commonly used stress marker. Stress begins in the first year of medical carrier and increases with subsequent years of medical education. There is a decrease in overall academic performance and many health-related adverse effects due to stress. In this study, yoga was performed in the first year MBBS students of BRD Medical College, Gorakhpur and the impact of yoga in stress reduction was studied using serum cortisol as stress a marker.Methods: Study groups, yoga and control contained 26 and 27 subjects including male and female MBBS students. Yoga group practiced selected yogic asana, pranayama, and yoga nidra for 3 months. The control group as a stress marker had been kept in touch and allowed to go on their usual activity as before. Morning (8.00 AM to 9.00 AM) serum cortisol level was used as a stress marker in both group, pre and post-study.Results: There was a significant reduction in morning serum cortisol level (stress level) in yoga group (p-value = 0.0271) but there was no significant change in morning serum cortisol level of the control group (p-value = 0.8573).Conclusions: Yoga is an effective stress reduction technique for medical students. Yoga classes should be introduced in the first year of the medical carrier under the supervision of expert physiologists. This may lead to the implantation of a healthy lifestyle in our future healthcare providers. Yogic practice by health care providers may have long term positive impacts on our healthcare system.

scholarly journals Is ECLIA Serum Cortisol Concentration Measurement, an Accurate Indicator of Pain Severity in Dogs with Locomotor Pain?

Animals ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 2036
Author(s):  
Adela Katalin Markovszky ◽  
Corinna Weber ◽  
Otília Biksi ◽  
Mihai Danes ◽  
Eugenia Dumitrescu ◽  
...  
Keyword(s):  
Cortisol Level ◽  
Cruciate Ligament ◽  
Life Quality ◽  
Serum Cortisol ◽  
Stress Axis ◽  
Serum Cortisol Level ◽  
Control Group ◽  
Disc Disease ◽  
Cranial Cruciate Ligament ◽  
Normal Limits

The purpose of determining serum cortisol level is to reflect the activity of stress axis, ethological alterations, acute and chronic pain, life quality, or psychogenic stress. Although it is stated that stress can produce a measurable influence on the cortisol level, a certified value of this pain biomarker in dogs was not generally accepted yet. This study aimed to investigate if serum cortisol measured follows allopathic treatments only, or it is associated with physiotherapy, point out pain level in dogs with orthopedic disease, which could reveal the healing progress. The diagnostic identified: hip dysplasia, cranial cruciate ligament rupture, or intervertebral disc disease. Ortolani and Barden tests, together with clinical examination, drawer sign, and tibia compression test, were done in dogs exhibiting postures, and motion alteration, and X-Ray confirmed. A total of 30 dogs were grouped in healthy (n = 10) and pain groups (n = 20), the blood sampling is done at the beginning of the investigation, and after ten days of the study. Dogs were handled in two ways: G1—treated with Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) only and respectively, G2—by therapy and physiotherapy. The analysis was performed on a Roche Cobas Analyzer (Roche, USA), serum cortisol being determined by Electrochemiluminescence immunoassay (ECLIA), and statistics using ANOVA, following Tukey’s Multiple Comparison Test. The results revealed that, out of ten specimens in the Control group, nine were within the normal limits: 5–65 ng × mL−1 (24.76 ± 19.48678), and one sample under the set limit. In G1, it was observed that the plasmatic P1 values were below the levels of P2, in six situations. In G2, although the status of all subjects improved radically with the removal or evident reduction of pain, confirmed clinically and imagistically, the P2 values in five dogs were higher than the initial P1 values, and in contradiction with the observed clinical reality. Comparing results, the mean difference in G1 was 0.41, and in G2 = 2.54, with an SD for G1 = 13.38, and G2 = 16.66, registering moderate development. Standard deviation illustrated that the values of treated groups were highly spread throughout the interval, and the serum cortisol assay did not generate significant statistical differences between groups in our case. This inferred the doubt whether the used detection method or values registered correctly indicates the pain levels in dog species.

scholarly journals Association of occupational exposure on semen density in male industrial workers undergoing infertility treatment at tertiary care hospital

2019 ◽  
Vol 8 (6) ◽  
pp. 2453
Author(s):  
Leena Wadhwa ◽  
Ashish Fauzdar ◽  
Sanjana N. Wadhwa ◽  
Lata Singh ◽  
Sumit Chakravarti ◽  
...  
Keyword(s):  
Tertiary Care ◽  
Occupational Exposures ◽  
World Health ◽  
Semen Parameters ◽  
Controlled Study ◽  
Control Group ◽  
Study Group ◽  
Care Hospital ◽  
Industrial Workers ◽  
Male Partners

Background: Working with particular substances or under certain working situations may cause some workers to experience abnormalities in their sexual or reproductive health. Occupational exposures can lead to infertility, but the workers may not be aware of such problems. The purpose of the study was to determine the association between male infertility and occupation of industrial workers in organized sector.Methods: Prospective case-controlled study that included 136 industrial workers working in organized sector and attending infertility clinic for treatment. This study included male partners aged between 21-46 years with primary or secondary infertility and undertaking same occupation for at least last three months. Complete infertility workup of all male partners attending infertility clinic was done that included detailed history and information related to occupation. Routine semen parameters were evaluated according to the 2010 World Health Organization (WHO) criteria.Results: In the present study, significant semen abnormalities were observed in male partners with age more than 31 years and undertaking arduous jobs for more than 5 years (p <0.05) in study group (n=136) as compared to control group (n=62). The abnormal semen count were observed in 114 (83.2%) workers in the study group that included 43 (31.6%) with total sperm concentration (TSC) less than 10 million/ml and azoospermia in 44 (32.3%). Reduced motility (asthenozoo-spermia) was observed in majority 125 (91.9%) of male partners. The findings were significant (p <0.05) as compared to control group.Conclusions: Preventive measures in the workplace need to be established to reduce the effect of occupational hazards and its influence in the semen parameters ultimately leading to infertility.

Study of Effect of Whitening Creams on Serum Basal Cortisol level In Egyptian Females

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Yara Muhammed Eid ◽  
Iman Zaky Ahmed ◽  
Merhan Samy Nasr ◽  
Hany Khairy Mansour ◽  
Mohammed Omar Awadh Baqraf ◽  
...  
Keyword(s):  
Adrenal Gland ◽  
Cortisol Level ◽  
Serum Cortisol ◽  
Early Morning ◽  
Serum Cortisol Level ◽  
P Value ◽  
Study Group ◽  
Adrenocortical Insufficiency ◽  
Topical Corticosteroids ◽  
Significant Difference

Abstract Objective The aim of the present study is to evaluate the relationship between practice of whitening creams (Topical Corticosteroids) and serum cortisol level in a sample of healthy females at Ain- shams University Teaching hospital. Background Topical corticosteroids (TCs) are widely used as depigmenting agents alone or in combination with other fairness creams. Secondary adrenocortical insufficiency occurs due to deficiency of corticotropin (adrenocorticotropic hormone) [ACTH] in the pituitary gland. With low levels of corticotropin, cortex layer in the adrenal gland is not sufficiently stimulated to release adequate amount of cortisol. Excessive glucocorticoid therapy is the primary cause of adrenocortical insufficiency. Methods we recruited 45 subjects practice whitening creams (TCs) for three months or more; matched with a healthy control group consists of 45 participants. Early morning basal serum cortisol level (8:00 am) done by one-step competitive immunoassay using Beckman Coulter device. Cortisol ELISA Kit provided by CALBIOTECH, Inc (Co_103S). Results Early morning serum cortisol level was statistically insignificant among subjects practice whitening creams in combination with TCs vs. healthy controls (p value 0.307). However, there were 7 out of 45 participants in the study group (15.6%) had low serum cortisol level (&lt;5ug/dl) with highly statistically significant difference regarding whitening creams usage methods. In comparison and data analysis between subjects of the study group regarding practice duration, used quantity, application frequency, and method of exposure, there was high statistically significant difference between subjects with normal cortisol level vs. subjects with low cortisol level (p value &lt;0.001). There were, no significant difference found regarding BMI, and arterial blood pressure between study group and controls. Conclusion Whitening creams abuse especially high potency TCs is a common phenomenon that may induce several local and systemic complications including adrenal gland insufficiency.

scholarly journals Study of serum cortisol levels in complicated and uncomplicated Plasmodium vivax malaria patients

2020 ◽  
Vol 9 (1) ◽  
pp. 254
Author(s):  
Sandeep B. R. ◽  
M. G. Bhutto ◽  
Suresh Babu K. P.
Keyword(s):  
Plasmodium Vivax ◽  
Cortisol Level ◽  
Vivax Malaria ◽  
Serum Cortisol ◽  
Treatment Modalities ◽  
Serum Cortisol Level ◽  
Control Group ◽  
Significant Difference ◽  
Plasmodium Vivax Malaria ◽  
Cortisol Levels

Background: Malaria results in pathological changes in various body organs, as the parasite invade and multiply in circulating red blood cells. Despite of advances in diagnostic and treatment modalities, worldwide incidences of malaria are significant. Current study was conducted to investigate serum cortisol level changes as a promising biomarker for risk prediction in malaria and to study adrenal insufficiency in malaria patients.Methods: Current investigation was a prospective observational study, conducted on complicated and uncomplicated Plasmodium vivax malaria patients. Serum cortisol levels in patients were investigated through immunoassay using direct chemiluminescent technology and were statistically correlated with Plasmodium vivax malaria infection.Results: Results of present investigation revealed that on day 1 there was significant difference in mean serum cortisol levels between the Plasmodium vivax malaria patients and control group and cortisol levels were significantly higher in complicated Plasmodium vivax malaria patients compared to uncomplicated cases on day 1 and 7. Cortisol levels were observed to be normal on day 1 and 7 in uncomplicated malaria cases and in patients with bleeding manifestations, renal failure and jaundice. In 10 out of 15 cases of cerebral malaria, significant increase in serum cortisol levels were observed on day 1, while on day 7 levels were normal in all 15 cases.Conclusions: Rise in serum cortisol level had a positive correlation with temperature and thus can be useful to predict the severity of disease in Plasmodium vivax malaria patients. No cortisol insufficiency was observed in during active and convalescent stages of illness.

scholarly journals Effect of yoga and meditation on serum cortisol level in first-year medical students

2018 ◽  
Vol 6 (5) ◽  
pp. 1699
Author(s):  
Kislay Kumar ◽  
Vinay Singh ◽  
Devesh Kumar ◽  
A. B. Asthana ◽  
Divya Mishra
Keyword(s):  
Medical Students ◽  
Cortisol Level ◽  
Stress Level ◽  
High Stress ◽  
Serum Cortisol ◽  
Serum Cortisol Level ◽  
Control Group ◽  
P Value ◽  
Yoga Group ◽  
Morning Serum Cortisol

Background: Yoga is a traditional technique to conserve and purify body, mind and soul. It is a mind-body bridge which involves relaxation, meditation and a set of physical exercises performed in association with breathing. In this new era of evolution, most of the population are depressed or in stress, irrespective of their age and gender.Methods: This study is performed on 1st yr. medical students whose stress level is in higher side due to academic burden. An 55 medical students were selected as participants through counseling and were divided into yoga group (n= 27) and control group (n=28). Their morning serum cortisol level was assessed, and yoga group were instructed to practice yoga (1hr/day for 12 weeks) under supervision of yoga instructor. No such instruction was given to control group.Results: Serum cortisol level is the marker of stress and inflammation. Higher cortisol level means high stress level. Yoga and meditation is documented to reduce stress level in regular practitioners.  Statistical analysis has shown decrease in morning serum cortisol level (572.18±168.03 to 544.98±139.89, 4.8% decrease, P value ˂0.05, significant) in yoga group after study. Control group have shown marked increase in cortisol level (558.89±162.69 to 577.26±254.5, 3.4% increase, P value = 0.74, not significant) after three months of study.Conclusions: This study concludes that practicing Yoga has a significant effect on the reduction of stress and anxiety level in medical students.

Nighttime serum cortisol level for diagnosis of hypercortisolism in hospitalized patients

2019 ◽  
Author(s):  
Liana Khatsimova ◽  
Uliana Tsoy ◽  
Natalia Kuritsyna ◽  
Elena Grineva ◽  
Elena Litvinenko ◽  
...  
Keyword(s):  
Cortisol Level ◽  
Serum Cortisol ◽  
Hospitalized Patients ◽  
Serum Cortisol Level
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