Comment on: Association of serum levels of inflammatory markers and adipokines with joint symptoms and structures in participants with knee osteoarthritis: Reply

Abstract Objectives To investigate whether the perioperatively combined application of dexamethasone and furosemide could alleviate the inflammation in patients undergoing percutaneous nephrolithotomy (PCNL). Patients and methods 147 patients undergoing PCNL between November 2018 and October 2019 were enrolled in the study. 77 patients accepted a single dose of dexamethasone and furosemide administration (EXP group, n = 77), and 70 patients did not (CON group, n = 70). Demographic and perioperative data, inflammatory markers including interleukin-6 (IL-6) and procalcitonin (PCT), and clinical outcomes were compared between the two groups. Results Compared with the CON group, the incidence rate of urosepsis of the EXP group were significantly lower (11.69% vs. 24.29%, p = 0.046). 3 patients developed severe urosepsis in the EXP group, while 5 patients developed severe urosepsis in the CON group. Compared with those in the CON group, the patients with postoperative urosepsis in the EXP group showed lower serum levels of IL-6 at postoperative hour two (p = 0.045) and at postoperative day one (p = 0.031) and lower serum levels of PCT at postoperative day one (p = 0.015). There was a better clinical outcome of a shorter postoperative hospital stay (p = 0.015) in patients with postoperative urosepsis in the EXP group than in those in the CON group. Conclusion The perioperatively combined application of dexamethasone and furosemide was beneficial for alleviating postoperative inflammatory reaction and caused a better clinical outcome of a shorter postoperative hospital stay.

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Evaluation of the Use of Sterilized and Non-Sterilized Peruibe Black Mud in Patients with Knee Osteoarthritis

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18041666 ◽

2021 ◽

Vol 18 (4) ◽

pp. 1666 ◽

Cited By ~ 1

Author(s):

Paulo Fávio Macedo Gouvêa ◽

Zélia Maria Nogueira Britschka ◽

Cristina de Oliveira Massoco Salles Gomes ◽

Nicolle Gilda Teixeira de Queiroz ◽

Pablo Antonio Vásquez Salvador ◽

...

Keyword(s):

Quality Of Life ◽

Knee Osteoarthritis ◽

Short Form ◽

Serum Levels ◽

Double Blind ◽

Sf 36 ◽

Radiographic Grade ◽

Physical Functions ◽

Kellgren And Lawrence

This study aimed to evaluate the effects of treatment with Peruíbe Black Mud (PBM) on the clinical parameters and quality of life of patients with knee osteoarthritis and to compare the effects of PBM samples simply matured in seawater and PBM sterilized by gamma radiation. A controlled, double-blind trial was conducted with 41 patients divided into two treatment groups composed of 20 and 21 patients: one group was treated with matured PBM and the other with sterilized PBM. Evaluations were done using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and the Medical Outcomes Study Short Form 36 (SF-36) questionnaires, the Kellgren and Lawrence (KL) radiographic scale, and the quantification of the serum levels of inflammatory biomarkers. An improvement in pain, physical functions, and quality of life was observed in all of the patients who underwent treatment with both simply matured and sterilized PBM. Nine patients showed remission in the KL radiographic scale, but no statistically significant differences were observed in the serum levels of inflammatory mediators before or after treatment. Peruíbe Black Mud proves to be a useful tool as an adjuvant treatment for knee osteoarthritis (OA), as shown by the results of the WOMAC and SF-36 questionnaires and by the remission of the radiographic grade of some patients on the Kellgren and Lawrence scale.

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Effects of age and comorbidities on serum levels of inflammatory markers in community‐acquired pneumonia

European Journal of Clinical Investigation ◽

10.1111/eci.13480 ◽

2021 ◽

Author(s):

Diego Viasus ◽

Antonella F. Simonetti ◽

Andrés F. Estupiñan‐Bohórquez ◽

Jordi Carratalà

Keyword(s):

Inflammatory Markers ◽

Serum Levels ◽

Community Acquired Pneumonia

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Synovial fluid but not plasma interleukin-8 is associated with clinical severity and inflammatory markers in knee osteoarthritis women with joint effusion

Scientific Reports ◽

10.1038/s41598-021-84582-2 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

María García-Manrique ◽

Joan Calvet ◽

Cristóbal Orellana ◽

Antoni Berenguer-Llergo ◽

Silvia Garcia-Cirera ◽

...

Keyword(s):

Synovial Fluid ◽

Knee Osteoarthritis ◽

Correlation Coefficient ◽

Inflammatory Markers ◽

Partial Correlation ◽

Statistical Significance ◽

Clinical Severity ◽

Joint Effusion ◽

Cross Sectional ◽

Partial Correlation Coefficient

AbstractSeveral cytokines and adipokines are related to clinical severity and progression in knee osteoarthritis. The aim of this study was to evaluate the associations of IL-8 with clinical severity and with local and systemic adipokines and cytokines. This is a Cross-sectional study including 115 women with symptomatic primary knee osteoarthritis with ultrasound-confirmed joint effusion. Age, symptoms duration and body mass index were collected. Radiographic severity was evaluated according to Kellgren–Lawrence. Pain and disability were assessed by Lequesne and Knee injury and Osteoarthritis Outcome Score pain, symptoms and function scales. Three inflammatory markers and five adipokines were measured by ELISA in serum and synovial fluid. Partial correlation coefficient (PCC) and corresponding 95% confidence interval were used to evaluate association. Synovial fluid IL-8 was significantly associated with clinical severity scales. After controlling for potential confounders, associations measured by a Partial Correlation Coefficient (PCC) remained essentially unaltered for Lequesne (PCC = 0.237), KOOS pain (PCC = − 0.201) and KOOS symptoms (PCC = − 0.209), KOOS function (PCC = − 0.185), although the later did not reach statistical significance. Also in synovial fluid samples, associations were found between IL-8 and TNF (PCC = 0.334), IL6 (PCC = 0.461), osteopontin (PCC = 0.575), visfatin (PCC = 0.194) and resistin (PCC = 0.182), although significance was not achieved for the later after statistical control for confounders. None of these associations were detected in serum. In conclusion, IL-8 was associated with clinical severity, inflammatory markers and adipokines in synovial fluid, but not in blood. Although the reported associations are weak to moderate in magnitude, these findings reinforce the notion that local and not systemic inflammation is more relevant to clinical severity in knee OA women with joint effusion.

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Evaluation of Inflammatory Markers in Pregnant Women at Risk, for the Prediction of Preeclampsia

Acta Medica Marisiensis ◽

10.2478/amma-2014-0019 ◽

2014 ◽

Vol 60 (3) ◽

pp. 94-98 ◽

Cited By ~ 1

Author(s):

Mihaela Daniela Oancea ◽

N. Costin ◽

Daria Maria Pop ◽

R. Ciortea ◽

Ioana Trif ◽

...

Keyword(s):

Pregnant Women ◽

Inflammatory Markers ◽

High Sensitivity ◽

Serum Levels ◽

Second Trimester ◽

Prospective Longitudinal Study ◽

Reactive Protein ◽

Group I ◽

Hs Crp ◽

Prospective Longitudinal

Abstract Introduction: A low degree of inflammation has been associated with complications in pregnancies, including preeclampsia (PE). The aim of our study was to determine the serum values of high sensitivity C Reactive Protein (hs-CRP) and Interleukin-6 (IL-6) in the first and second trimesters of pregnancy in pregnant women with risk factors for the development of PE, and to evaluate their relevance for the prediction of this disorder. Material and methods: We performed a prospective longitudinal study on 120 pregnant women, who were divided based on the pregnancy evolution, into two groups: group I - 26 pregnant women who developed preeclampsia and group II - 94 pregnant women with physiological evolution of pregnancy. Results: Our study has shown an increase in serum levels of hs-CRP and IL-6 in the first and second trimester of pregnancy in patients from group I, significant values being revealed only in the second trimester of pregnancy. The predictive power of the selected inflammatory markers was significant only for values of hs-CRP in the second trimester of pregnancy, while the association with IL-6 increased the prediction. Conclusions: Increased values of hs-CRP and IL-6 in the second trimester of pregnancy are associated with higher risk for preeclampsia, however the study provided only a modest efficiency of the prediction capacity.

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Effects of Synbiotics and Probiotics Supplementation on Serum Levels of Endotoxin, Heat Shock Protein 70 Antibodies and Inflammatory Markers in Hemodialysis Patients: a Randomized Double-Blinded Controlled Trial

Probiotics and Antimicrobial Proteins ◽

10.1007/s12602-018-9509-5 ◽

2019 ◽

Vol 12 (1) ◽

pp. 144-151 ◽

Cited By ~ 2

Author(s):

Neda Haghighat ◽

Majid Mohammadshahi ◽

Shokouh Shayanpour ◽

Mohammad Hossein Haghighizadeh

Keyword(s):

Heat Shock ◽

Heat Shock Protein ◽

Heat Shock Protein 70 ◽

Inflammatory Markers ◽

Controlled Trial ◽

Serum Levels ◽

Hemodialysis Patients ◽

Double Blinded

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Acute elevation of serum inflammatory markers predicts symptom recovery after concussion

Neurology ◽

10.1212/wnl.0000000000007864 ◽

2019 ◽

Vol 93 (5) ◽

pp. e497-e507 ◽

Cited By ~ 17

Author(s):

Morgan E. Nitta ◽

Jonathan Savitz ◽

Lindsay D. Nelson ◽

T. Kent Teague ◽

James B. Hoelzle ◽

...

Keyword(s):

Inflammatory Markers ◽

Assessment Tool ◽

Characteristic Curve ◽

Serum Levels ◽

Outcome Variable ◽

Duration Of Symptoms ◽

Severity Scores ◽

Symptom Recovery ◽

Factor C ◽

Serum Inflammatory Markers

ObjectiveTo test the hypothesis that acute elevations in serum inflammatory markers predict symptom recovery after sport-related concussion (SRC).MethodsHigh school and collegiate football players (n = 857) were prospectively enrolled. Forty-one athletes with concussion and 43 matched control athletes met inclusion criteria. Serum levels of interleukin (IL)–6, IL-1β, IL-10, tumor necrosis factor, C-reactive protein, interferon-γ, and IL-1 receptor antagonist and Sport Concussion Assessment Tool, 3rd edition (SCAT3) symptom severity scores were collected at a preinjury baseline, 6 and 24–48 hours postinjury, and approximately 8, 15, and 45 days following concussion. The number of days that athletes were symptomatic following SRC (i.e., duration of symptoms) was the primary outcome variable.ResultsIL-6 and IL-1RA were significantly elevated in athletes with concussion at 6 hours relative to preinjury and other postinjury visits, as well as compared to controls (ps ≤ 0.001). IL-6 and IL-1RA significantly discriminated concussed from control athletes at 6 hours postconcussion (IL-6 area under receiver operating characteristic curve 0.79 [95% confidence interval (CI) 0.65–0.92], IL-1RA AUC 0.79 [95% CI 0.67–0.90]). Further, IL-6 levels at 6 hours postconcussion were significantly associated with the duration of symptoms (hazard ratio for symptom recovery = 0.61 [95% CI 0.38–0.96], p = 0.031).ConclusionsResults support the potential utility of IL-6 and IL-1RA as serum biomarkers of SRC and demonstrate the potential of these markers in identifying athletes at risk for prolonged recovery after SRC.Classification of evidenceThis study provides Class III evidence that serum levels of IL-6 and IL-1RA 6 hours postconcussion significantly discriminated concussed from control athletes.

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Anti-Inflammatory Effects of Exercise on Metabolic Syndrome Patients: A Systematic Review and Meta-Analysis

Biological Research For Nursing ◽

10.1177/1099800420958068 ◽

2020 ◽

pp. 109980042095806 ◽

Cited By ~ 1

Author(s):

Heidar Alizaei Yousefabadi ◽

Arghavan Niyazi ◽

Sahar Alaee ◽

Mehrdad Fathi ◽

Gholam Rasul Mohammad Rahimi

Keyword(s):

Metabolic Syndrome ◽

Exercise Training ◽

Inflammatory Markers ◽

Meta Analysis ◽

Serum Levels ◽

Future Research ◽

The Metabolic Syndrome ◽

Inflammatory Status ◽

Tnf Α ◽

Training Impact

Background: Increments in inflammatory indicators and low levels of physical activity are correlated to the expansion of the metabolic syndrome (MetS). Objective: The purpose of this study was to establish if exercise training ameliorates inflammatory status in MetS patients. Data sources: PubMed, CINAHL, and Medline, Google Scholar, and Scopus databases and reference lists of included studies were searched. Study selection: Twenty randomized controlled trials (RCTs) of exercise-training impact on inflammatory markers (tumor necrosis factor (TNF) α, C-reactive protein (CRP), interleukin (IL) 6, IL-8, IL-10, and IL-18) with concurrent control groups were included in this analysis. Results: Results demonstrated an overall significant decrease in serum levels of TNF-α (mean difference (MD): −1.21 pg/ml; 95% confidence interval (CI): −1.77, −0.66), CRP (MD: −0.52 mg/l; 95% CI: −0.79, −0.25), IL-8 (MD: −1.31 pg/ml; 95% CI: −2.57, −0.06), and a significant increase in IL-10 (MD: 0.48 pg/ml; 95% CI: 0.10, 0.86). But exercise training did not change the level of IL-6 (MD: −0.69 pg/ml; 95% CI: −1.53, 0.14) and IL-18 (MD: −53.01 pg/ml; 95% CI: −166.64, 60.62). Conclusion: Exercise training improves TNF-α, CRP, IL-8, and IL-10 levels in patients with MetS. For some variables, isolated aerobic exercise, and combined aerobic and resistance exercise appears to be optimal. Future research is needed to clarify the mechanisms underlying exercise training’s effect on this population’s inflammatory markers. More studies are required to confirm these findings.

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