A transient three-dimensional analysis of non-uniform dislocation distribution growth by climb and glide over non-planar surfaces

As a basis for obtaining insight into both plastic flow described in terms of dislocation motion and dynamic crack extension, a transient 3D analysis of the non-uniform growth of dislocation distributions by climb and glide over largely arbitrary non-planar surfaces is considered. An exact solution for the case of an unbounded, isotropic, homogeneous, linearly elastic solid is obtained in vector form. It is found that information about essential distribution and surface properties are contained in the solution in a symmetric tensor. This tensor arises as a generalized consequence of the body-force equivalent representation of dislocations in elastic continua. The solution is also found to have two components: one component depends on the velocity discontinuity induced across the surface, the other depends on the displacement discontinuity at the moving boundary of the distribution and the speed of the boundary. Two examples are then considered to illustrate the utility of the solution.

1985 ◽  
Vol 52 (3) ◽  
pp. 565-570 ◽  
Author(s):  
T. C. T. Ting ◽  
Yijian Jin ◽  
S. C. Chou

When a two-dimensional elastic body that contains a notch or a crack is under a plane stress or plane strain deformation, the asymptotic solution of the stress near the apex of the notch or crack is simply a series of eigenfunctions of the form ρδf (ψ,δ) in which (ρ,ψ) is the polar coordinate with origin at the apex and δ is the eigenvalue. If the body is a three-dimensional elastic solid that contains axisymmetric notches or cracks and subjected to an axisymmetric deformation, the eigenfunctions associated with an eigenvalue contains not only the ρδ term, but also the ρδ+1, ρδ+2… terms. Therefore, the second and higher-order terms of the asymptotic solution are not simply the second and subsequent eigenfunctions. We present the eigenfunctions for transversely isotropic materials under an axisymmetric deformation. The degenerate case in which the eigenvalues p1 and p2 of the elasticity constants are identical is also considered. The latter includes the isotropic material as a special case.


2014 ◽  
Vol 6 (06) ◽  
pp. 732-763 ◽  
Author(s):  
Zhiqiang Xin ◽  
Chuijie Wu

AbstractBased on the boundary vorticity-flux theory, topology optimization of the caudal fin of the three-dimensional self-propelled swimming fish is investigated by combining unsteady computational fluid dynamics with moving boundary and topology optimization algorithms in this study. The objective functional of topology optimization is the function of swimming efficiency, swimming speed and motion direction control. The optimal caudal fin, whose topology is different from that of the natural fish caudal fin, make the 3D bionic fish achieve higher swimming efficiency, faster swimming speed and better maneuverability. The boundary vorticity-flux on the body surface of the 3D fish before and after optimization reveals the mechanism of high performance swimming of the topology optimization bionic fish. The comparative analysis between the swimming performance of the 3D topology optimization bionic fish and the 3D lunate tail bionic fish is also carried out, and the wake structures of two types of bionic fish show the physical nature that the swimming performance of the 3D topology optimization bionic fish is significantly better than the 3D lunate tail bionic fish.


2017 ◽  
Author(s):  
Amritha Gourisankar ◽  
Sarah A. Eisenstein ◽  
Nicholas T. Trapp ◽  
Jonathan M. Koller ◽  
Meghan C. Campbell ◽  
...  

AbstractThe anatomical connections of the subthalamic nucleus (STN) have driven hypotheses about its functional anatomy, including the hypothesis that the precise anatomical location of STN deep brain stimulation (DBS) determines the variability of motor and non-motor responses across Parkinson disease (PD) patients. We previously tested that hypothesis using a three-dimensional (3D) statistical method to interpret the acute effects of unilateral DBS at each patient’s clinically optimized DBS settings and active contact. Here we report a similar analysis from a new study in which DBS parameters were standardized and DBS locations were chosen blind to clinical response. In 74 individuals with PD and STN DBS, STN contacts were selected near the dorsal and ventral border of the STN contralateral to the more affected side of the body. Participants were tested off PD medications in each of 3 conditions (ventral STN DBS, dorsal STN DBS and DBS off) for acute effects on mood, apathy, working memory, response inhibition and motor function. Voltage, frequency, and pulse width were standardized, and participants and raters were blind to condition. In a categorical analysis, both dorsal and ventral STN DBS improved mean motor function without affecting cognitive measures. Dorsal STN DBS induced greater improvement in rigidity than ventral STN DBS, whereas ventral STN DBS was more effective for improving anxiety and mood. In the 3D analysis, contact location was significant only for bradykinesia and resting tremor, with the greatest improvement occurring with DBS in dorsal STN and zona incerta. These results provide new, direct functional evidence for the anatomically-derived model of STN using the novel 3D analysis, in which motor function is most represented in dorsal STN. However, our data suggest that functional segregation between motor and non-motor areas of the STN is limited, since locations that induced improvements in motor function and mood overlapped substantially.


2018 ◽  
Vol 5 (7) ◽  
pp. 171177 ◽  
Author(s):  
Amritha Gourisankar ◽  
Sarah A. Eisenstein ◽  
Nicholas T. Trapp ◽  
Jonathan M. Koller ◽  
Meghan C. Campbell ◽  
...  

The anatomical connections of the subthalamic nucleus (STN) have driven hypotheses about its functional anatomy, including the hypothesis that the precise anatomical location of STN deep brain stimulation (DBS) contributes to the variability of motor and non-motor responses across patients with Parkinson's disease (PD). We previously tested the hypothesis using a three-dimensional (3D) statistical method to interpret the acute effects of unilateral DBS at each patient's clinically optimized DBS settings and active contact. Here, we report a similar analysis from a new study in which DBS parameters were standardized and DBS locations were chosen blind to clinical response. In 74 individuals with PD and STN DBS, STN contacts were selected near the dorsal and ventral borders of the STN contralateral to the more affected side of the body. Participants were tested off PD medications in each of three unilateral DBS conditions (ventral STN DBS, dorsal STN DBS and DBS off) for acute effects on mood, apathy, working memory, response inhibition and motor function. Voltage, frequency and pulse width were standardized, and participants and raters were blind to condition. In a categorical analysis, both dorsal and ventral STN DBS improved mean motor function without affecting cognitive measures. Ventral STN DBS induced greater improvement in rigidity and anxiety than dorsal STN DBS. In the 3D analysis, contact location was significant for body hypokinesia, rigidity and resting tremor, with the greatest improvement occurring with DBS in dorsal STN and zona incerta. The 3D results provide new, direct functional evidence for the anatomically derived model of STN, in which motor function is best represented in dorsal STN. However, our data suggest that functional segregation between motor and non-motor areas of the STN is limited, because locations that induced improvements in motor function and mood overlapped substantially.


Author(s):  
O. Faroon ◽  
F. Al-Bagdadi ◽  
T. G. Snider ◽  
C. Titkemeyer

The lymphatic system is very important in the immunological activities of the body. Clinicians confirm the diagnosis of infectious diseases by palpating the involved cutaneous lymph node for changes in size, heat, and consistency. Clinical pathologists diagnose systemic diseases through biopsies of superficial lymph nodes. In many parts of the world the goat is considered as an important source of milk and meat products.The lymphatic system has been studied extensively. These studies lack precise information on the natural morphology of the lymph nodes and their vascular and cellular constituent. This is due to using improper technique for such studies. A few studies used the SEM, conducted by cutting the lymph node with a blade. The morphological data collected by this method are artificial and do not reflect the normal three dimensional surface of the examined area of the lymph node. SEM has been used to study the lymph vessels and lymph nodes of different animals. No information on the cutaneous lymph nodes of the goat has ever been collected using the scanning electron microscope.


2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Cheng Zhou ◽  
Youzhou Yang ◽  
Jiaxin Wang ◽  
Qingyang Wu ◽  
Zhuozhi Gu ◽  
...  

AbstractIn vivo bioprinting has recently emerged as a direct fabrication technique to create artificial tissues and medical devices on target sites within the body, enabling advanced clinical strategies. However, existing in vivo bioprinting methods are often limited to applications near the skin or require open surgery for printing on internal organs. Here, we report a ferromagnetic soft catheter robot (FSCR) system capable of in situ computer-controlled bioprinting in a minimally invasive manner based on magnetic actuation. The FSCR is designed by dispersing ferromagnetic particles in a fiber-reinforced polymer matrix. This design results in stable ink extrusion and allows for printing various materials with different rheological properties and functionalities. A superimposed magnetic field drives the FSCR to achieve digitally controlled printing with high accuracy. We demonstrate printing multiple patterns on planar surfaces, and considering the non-planar surface of natural organs, we then develop an in situ printing strategy for curved surfaces and demonstrate minimally invasive in vivo bioprinting of hydrogels in a rat model. Our catheter robot will permit intelligent and minimally invasive bio-fabrication.


Author(s):  
Matías Reolid ◽  
Francisco J. Cardenal ◽  
Jesús Reolid

AbstractThe aim of this work is to obtain diverse morphometric data from digitized 3D models of scientifically accurate palaeoreconstructions of theropods from eight representative families. The analysed polyvinyl chloride (PVC) models belong to the genera Coelophysis, Dilophosaurus, Ceratosaurus, Allosaurus, Baryonyx, Carnotaurus, Giganotosaurus, and Tyrannosaurus. The scanned 3D models were scaled considering different body-size estimations of the literature. The 3D analysis of these genera provides information on the skull length and body length that allows for recognition of major evolutionary trends. The skull length/body length in the studied genera increases according with the size of the body from the smallest Coelophysis with a ratio of 0.093 to ratios of 0.119–0.120 for Tyrannosaurus and Giganotosaurus, the largest study theropods. The study of photogrammetric 3D models also provides morphometric information that cannot be obtained from the study of bones alone, but knowing that all reconstructions begin from the fossil bones, such as the surface/volume ratio (S/V). For the studied theropod genera surface/volume ratio ranges from 35.21 for Coelophysis to 5.55 for Tyrannosaurus. This parameter, closely related to the heat dissipation, help in the characterization of the metabolism of extinct taxa. Accordingly, slender primitive forms of the Early Jurassic (i.e. Coelophysis and Dilophosaurus) had relatively smaller skulls and higher mass-specific metabolic rates than the robust large theropods of the Cretaceous (i.e. Giganotosaurus and Tyrannosaurus). This work presents a technique that, when applied to proper dinosaur models, provides extent and accurate data that may help in diverse study areas within the dinosaur palaeontology and palaeobiology.


Author(s):  
So Young Joo ◽  
Seung Yeol Lee ◽  
Yoon Soo Cho ◽  
Sangho Yi ◽  
Cheong Hoon Seo

Abstract Hands are the part of the body that are most commonly involved in burns, and the main complications are finger joint contractures and nerve injuries. Hypertrophic scarring cannot be avoided despite early management of acute hand burn injuries, and some patients may need application of an exoskeleton robot to restore hand function. To do this, it is essential to individualize the customization of the robot for each patient. Three-dimensional (3D) technology, which is widely used in the field of implants, anatomical models, and tissue fabrication, makes this goal achievable. Therefore, this report is a study on the usefulness of an exoskeleton robot using 3D technology for patients who lost bilateral hand function due to burn injury. Our subject was a 45-year-old man with upper limb dysfunction of 560 days after a flame and chemical burn injury, with resultant impairment of manual physical abilities. After wearing an exoskeleton robot made using 3D printing technology, he could handle objects effectively and satisfactorily. This innovative approach provided considerable advantages in terms of customization of size and reduction in manufacturing time and costs, thereby showing great potential for use in patients with hand dysfunction after burn injury.


2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Jae-Young Kim ◽  
Michael D. Han ◽  
Kug Jin Jeon ◽  
Jong-Ki Huh ◽  
Kwang-Ho Park

Abstract Background The purpose of this study was to investigate the differences in configuration and dimensions of the anterior loop of the inferior alveolar nerve (ALIAN) in patients with and without mandibular asymmetry. Method Preoperative computed tomography images of patients who had undergone orthognathic surgery from January 2016 to December 2018 at a single institution were analyzed. Subjects were classified into two groups as “Asymmetry group” and “Symmetry group”. The distance from the most anterior and most inferior points of the ALIAN (IANant and IANinf) to the vertical and horizontal reference planes were measured (dAnt and dInf). The distance from IANant and IANinf to the mental foramen were also calculated (dAnt_MF and dInf_MF). The length of the mandibular body and symphysis area were measured. All measurements were analyzed using 3D analysis software. Results There were 57 total eligible subjects. In the Asymmetry group, dAnt and dAnt_MF on the non-deviated side were significantly longer than the deviated side (p < 0.001). dInf_MF on the non-deviated side was also significantly longer than the deviated side (p = 0.001). Mandibular body length was significantly longer on the non-deviated side (p < 0.001). There was no significant difference in length in the symphysis area (p = 0.623). In the Symmetry group, there was no difference between the left and right sides for all variables. Conclusion In asymmetric patients, there is a difference tendency in the ALIAN between the deviated and non-deviated sides. In patients with mandibular asymmetry, this should be considered during surgery in the anterior mandible.


2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Robert J. Francis ◽  
Gillian Robb ◽  
Lee McCann ◽  
Bhagwati Khatri ◽  
James Keeble ◽  
...  

AbstractTuberculosis (TB) preclinical testing relies on in vivo models including the mouse aerosol challenge model. The only method of determining colony morphometrics of TB infection in a tissue in situ is two-dimensional (2D) histopathology. 2D measurements consider heterogeneity within a single observable section but not above and below, which could contain critical information. Here we describe a novel approach, using optical clearing and a novel staining procedure with confocal microscopy and mesoscopy, for three-dimensional (3D) measurement of TB infection within lesions at sub-cellular resolution over a large field of view. We show TB morphometrics can be determined within lesion pathology, and differences in infection with different strains of Mycobacterium tuberculosis. Mesoscopy combined with the novel CUBIC Acid-Fast (CAF) staining procedure enables a quantitative approach to measure TB infection and allows 3D analysis of infection, providing a framework which could be used in the analysis of TB infection in situ.


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