The Virtual Kidney: an eScience interface and Grid portal

2009 ◽  
Vol 367 (1896) ◽  
pp. 2141-2159 ◽  
Author(s):  
Peter J. Harris ◽  
Rajkumar Buyya ◽  
Xingchen Chu ◽  
Tom Kobialka ◽  
Ed Kazmierczak ◽  
...  
Keyword(s):  
Communication Networks ◽  
Three Dimensional ◽  
Theoretical Models ◽  
Grid Resource ◽  
Knowledge Resources ◽  
High Bandwidth ◽  
Complex Models ◽  
Simulation Results ◽  
Access To Knowledge ◽  
Parameter Values

The Virtual Kidney uses a web interface and distributed computing to provide experimental scientists and analysts with access to computational simulations and knowledge databases hosted in geographically separated laboratories. Users can explore a variety of complex models without requiring the specific programming environment in which applications have been developed. This initiative exploits high-bandwidth communication networks for collaborative research and for shared access to knowledge resources. The Virtual Kidney has been developed within a specialist community of renal scientists but is transferable to other areas of research requiring interaction between published literature and databases, theoretical models and simulations and the formulation of effective experimental designs. A web-based three-dimensional interface provides access to experimental data, a parameter database and mathematical models. A multi-scale kidney reconstruction includes blood vessels and serially sectioned nephrons. Selection of structures provides links to the database, returning parameter values and extracts from the literature. Models are run locally or remotely with a Grid resource broker managing scheduling, monitoring and visualization of simulation results and application, credential and resource allocation. Simulation results are viewed graphically or as scaled colour gradients on the Virtual Kidney structures, allowing visual and quantitative appreciation of the effects of simulated parameter changes.

Design of finite-time guidance law based on observer and head-pursuit theory

2021 ◽  
pp. 095441002098456
Author(s):  
Chenqi Zhu
Keyword(s):  
Finite Time ◽  
Three Dimensional ◽  
Hypersonic Vehicle ◽  
Two Dimensional ◽  
Dimensional Model ◽  
Reaching Law ◽  
Guidance Law ◽  
Fast Power ◽  
Simulation Results ◽  
Guidance Laws

In order to improve the guiding accuracy in intercepting the hypersonic vehicle, this article presents a finite-time guidance law based on the observer and head-pursuit theory. First, based on a two-dimensional model between the interceptor and target, this study applies the fast power reaching law to head-pursuit guidance law so that it can alleviate the chattering phenomenon and ensure the convergence speed. Second, target maneuvers are considered as system disturbances, and the head-pursuit guidance law based on an observer is proposed. Furthermore, this method is extended to a three-dimensional case. Finally, comparative simulation results further verify the superiority of the guidance laws designed in this article.

Macromolecular Structure Visualization Tools at NCMI

2000 ◽  
Vol 6 (S2) ◽  
pp. 282-283
Author(s):  
Matthew Dougherty ◽  
Wah Chiu
Keyword(s):  
Human Factors ◽  
3D Visualization ◽  
Three Dimensional ◽  
Theoretical Models ◽  
Biological Research ◽  
Macromolecular Structure ◽  
X Ray ◽  
Visualization Tools ◽  
Types Of Information ◽  
3D Em

Sophisticated tools are needed to examine the results of cyro-microscopy. As the size and resolution of three dimensional macromolecular structures steadily improve, and the speed at with which they can be generated increases, researchers are finding they are inundated with larger datasets and at the same time are compelled to expediently evaluate these structures in unforeseen ways. Integration of EM data with other types of information is becoming necessary and routine; for example X-ray data, 3D EM reconstructions, and theoretical models, must be evaluated in concert to discount or propose hypothesis. To create such tools, the developer must take into account not only the empirical and theoretical possibilities, but also they must master the human factors and computational limits. During the last five years, the National Center for Macromolecular Imaging (NCMI) has progressed from a remedial 3D visualization capability to a collection of visualization tools allowing researchers to focus on the discovery phase of biological research.

Direct simulation of evolution and control of three-dimensional instabilities in attachment-line boundary layers

1995 ◽  
Vol 291 ◽  
pp. 369-392 ◽  
Author(s):  
Ronald D. Joslin
Keyword(s):  
Boundary Layer ◽  
Stokes Equations ◽  
Three Dimensional ◽  
Plate Boundary ◽  
Navier Stokes ◽  
Two Dimensional ◽  
Computationally Efficient ◽  
Simulation Results ◽  
Dimensional Simulation ◽  
Attachment Line

The spatial evolution of three-dimensional disturbances in an attachment-line boundary layer is computed by direct numerical simulation of the unsteady, incompressible Navier–Stokes equations. Disturbances are introduced into the boundary layer by harmonic sources that involve unsteady suction and blowing through the wall. Various harmonic-source generators are implemented on or near the attachment line, and the disturbance evolutions are compared. Previous two-dimensional simulation results and nonparallel theory are compared with the present results. The three-dimensional simulation results for disturbances with quasi-two-dimensional features indicate growth rates of only a few percent larger than pure two-dimensional results; however, the results are close enough to enable the use of the more computationally efficient, two-dimensional approach. However, true three-dimensional disturbances are more likely in practice and are more stable than two-dimensional disturbances. Disturbances generated off (but near) the attachment line spread both away from and toward the attachment line as they evolve. The evolution pattern is comparable to wave packets in flat-plate boundary-layer flows. Suction stabilizes the quasi-two-dimensional attachment-line instabilities, and blowing destabilizes these instabilities; these results qualitatively agree with the theory. Furthermore, suction stabilizes the disturbances that develop off the attachment line. Clearly, disturbances that are generated near the attachment line can supply energy to attachment-line instabilities, but suction can be used to stabilize these instabilities.

Key Technologies Research on Color Contour Map of 3D Injection Molding Simulation Results

2012 ◽  
Vol 217-219 ◽  
pp. 1998-2001
Author(s):  
Tie Geng ◽  
Qing Hai Ren ◽  
Wei Qing Tu ◽  
Dan Dan Liu
Keyword(s):  
Injection Molding ◽  
Color Image ◽  
Three Dimensional ◽  
Physical Field ◽  
Contour Map ◽  
Image Rendering ◽  
Color Range ◽  
Key Technologies ◽  
Injection Molding Simulation ◽  
Simulation Results

According to the color contour map of the 3D injection molding simulation results, the commonly used color contour map drawing algorithm was researched, and a three-dimensional color image rendering algorithm which based on the "physical field values and color range mapping" was given too. And the key technologies of the algorithm which was used to draw 3D color contour map were introduced in detail. In the end, an example was given.

Investigation on penetration model of shaped charge jet in water

2016 ◽  
Vol 30 (02) ◽  
pp. 1550268 ◽  
Author(s):  
Jinwei Shi ◽  
Xingbai Luo ◽  
Jinming Li ◽  
Jianwei Jiang
Keyword(s):  
Numerical Simulation ◽  
Theoretical Model ◽  
Model Simulation ◽  
Theoretical Models ◽  
Theoretical Research ◽  
Water Medium ◽  
Simulation Results ◽  
Jet Penetration ◽  
The Impact ◽  
Penetration Velocity

To analyze the process of jet penetration in water medium quantitatively, the properties of jet penetration spaced target with water interlayer were studied through test and numerical simulation. Two theoretical models of jet penetration in water were proposed. The theoretical model 1 was established considering the impact of the shock wave, combined with the shock equation Rankine–Hugoniot and the virtual origin calculation method. The theoretical model 2 was obtained by fitting theoretical analysis and numerical simulation results. The effectiveness and universality of the two theoretical models were compared through the numerical simulation results. Both the models can reflect the relationship between the penetration velocity and the penetration distance in water well, and both the deviation and stability of theoretical model 1 are better than 2, the lower penetration velocity, and the larger deviation of the theoretical model 2. Therefore, the theoretical model 1 can reflect the properties of jet penetration in water effectively, and provide the reference of model simulation and theoretical research.

scholarly journals A study about signal variation with minor receiver displacement in a meeting room at 60 GHz: measurements and simulations

2021 ◽  
Vol 2021 (1) ◽  
Author(s):  
Muhammad Usman Sheikh ◽  
Kalle Ruttik ◽  
Riku Jäntti ◽  
Jyri Hämäläinen
Keyword(s):  
Power Level ◽  
Three Dimensional ◽  
60 Ghz ◽  
System Configuration ◽  
Conference Room ◽  
Channel Characteristics ◽  
Received Power ◽  
Simulation Results ◽  
Small Change ◽  
The Impact

AbstractThe aim of this work is to study the impact of small receiver displacement on a signal propagation in a typical conference room environment at a millimeter wave frequency of 60 GHz. While channel measurements provide insights on the propagation phenomena, their use for the wireless system performance evaluation is challenging. Whereas, carefully executed three-dimensional ray tracing (RT) simulations represent a more flexible option. Nevertheless, a careful validation of simulation methodology is needed. The first target of this article is to highlight the benefits of an in-house built three-dimensional RT tool at 60 GHz and shows the effectiveness of simulations in predicting different characteristics of the channel. To validate the simulation results against the measurements, two different transmitter (Tx) positions and antenna types along with ten receiver (Rx) positions are considered in a typical conference room. In first system configuration, an omnidirectional antenna is placed in the middle of the table, while in the second system configuration a directed horn antenna is located in the corner of the meeting room. After validating the simulation results with the measurement data, in the second part of this work, the impact of a small change, i.e., 20 cm in the receiver position, is studied. To characterize the impact, we apply as performance indicators the received power level, root mean square delay spread (RMS-DS) and RMS angular spread (RMS-AS) in azimuth plane. The channel characteristics are considered with respect to the direct orientation (DO), i.e., the Rx antenna is directed toward the strongest incoming path. Different antenna configurations at the Tx and Rx side are applied to highlight the role of antenna properties on the considered channel characteristics. Especially, in the second system configuration the impact of different antenna half power beamwidth on different considered channel characteristics is highlighted through acquired simulation results. The validation of results shows the RMS error of only 2–3 dB between the measured and simulated received power levels for different Tx configurations in the direction of DO. Results indicate that only a small change of the Rx position may result a large difference in the received power level even in the presence of line-of-sight between the Tx and Rx. It is found that the STD of received power level across the room increases with the decrease in HPBW of the antenna. As can be expected, directed antennas offer lower value of RMS-DS and RMS-AS compared with isotropic antenna.

Top down nano technologies in surface modification of materials

Open Physics ◽  
2011 ◽  
Vol 9 (2) ◽  
Author(s):  
Branislav Radjenović ◽  
Marija Radmilović-Radjenović
Keyword(s):  
Surface Modification ◽  
Three Dimensional ◽  
Wet Etching ◽  
Plasma Reactors ◽  
Top Down ◽  
Isotropic Etching ◽  
Microelectronic Devices ◽  
Etching Profile ◽  
Simulation Results ◽  
Low K

AbstractThis article contains a broad overview of etch process as one of the most important top-down technologies widely used in semiconductor manufacturing and surface modification of nanostructures. In plasma etching process, the complexity comes from the introduction of new materials and from the constant reduction in dimensions of the structures in microelectronics. The emphasis was made on two types of etching processes: dry etching and wet etching illustrated by three dimensional (3D) simulation results for the etching profile evolution based on the level set method. The etching of low-k dielectrics has been demonstrated via modelling the porous materials. Finally, simulation results for the roughness formation during isotropic etching of nanocomposite materials as well as smoothing of the homogeneous materials have also been shown and analyzed. Simulation results, presented here, indicate that with shrinking microelectronic devices, plasma and wet etching interpretative and predictive modeling and simulation have become increasingly more attractive as a tool for design, control and optimization of plasma reactors.

scholarly journals Roles of cell and microvillus deformation and receptor-ligand binding kinetics in cell rolling

2008 ◽  
Vol 295 (4) ◽  
pp. H1439-H1450 ◽  
Author(s):  
Parag Pawar ◽  
Sameer Jadhav ◽  
Charles D. Eggleton ◽  
Konstantinos Konstantopoulos
Keyword(s):  
Ligand Binding ◽  
Three Dimensional ◽  
Theoretical Models ◽  
Binding Kinetics ◽  
Cell Deformation ◽  
Receptor Ligand ◽  
Length Scales ◽  
Bond Behavior ◽  
Cell Rolling ◽  
Threshold Phenomenon

Polymorphonuclear leukocyte (PMN) recruitment to sites of inflammation is initiated by selectin-mediated PMN tethering and rolling on activated endothelium under flow. Cell rolling is modulated by bulk cell deformation (mesoscale), microvillus deformability (microscale), and receptor-ligand binding kinetics (nanoscale). Selectin-ligand bonds exhibit a catch-slip bond behavior, and their dissociation is governed not only by the force but also by the force history. Whereas previous theoretical models have studied the significance of these three “length scales” in isolation, how their interplay affects cell rolling has yet to be resolved. We therefore developed a three-dimensional computational model that integrates the aforementioned length scales to delineate their relative contributions to PMN rolling. Our simulations predict that the catch-slip bond behavior and to a lesser extent bulk cell deformation are responsible for the shear threshold phenomenon. Cells bearing deformable rather than rigid microvilli roll slower only at high P-selectin site densities and elevated levels of shear (≥400 s−1). The more compliant cells (membrance stiffness = 1.2 dyn/cm) rolled slower than cells with a membrane stiffness of 3.0 dyn/cm at shear rates >50 s−1. In summary, our model demonstrates that cell rolling over a ligand-coated surface is a highly coordinated process characterized by a complex interplay between forces acting on three distinct length scales.

Study on the Thermo-Hydrodynamic of a Dry Gas Seal in Helium Circulator for High Temperature Gas-Cooled Reactor

2011 ◽  
Author(s):  
Jianshu Lin ◽  
Hong Wang
Keyword(s):  
High Temperature ◽  
Film Flow ◽  
Three Dimensional ◽  
Maximum Temperature ◽  
Analysis Method ◽  
Dry Gas Seal ◽  
Safety Requirements ◽  
Simulation Results ◽  
Gas Seals ◽  
High Temperature Gas

A comprehensive analysis method is proposed to resolve the problem of simulating a complex thermo-flow with two kinds of distinct characteristic length in the dry gas seal, and a conjugated simulation of the complicated heat transfer and the gas film flow is carried out by using the commercial CFD software CFX. By using the proposed method, a three dimensional of velocity and pressure field in the gas film flow and the temperature distribution within the sealing rings are investigated for three kinds of film thickness, respectively. A comparison of thermo-hydrodynamics of the dry gas seals is conducted between the sealed gas of air and helium. The latter one is used in a helium circulator for High Temperature Gas-cooled Reactor (HTGR). From comparisons and discussions of a series of simulation results, it will be found that the comprehensive proposal is effective and simulation results are reasonable, and the maximum temperature rise in the dry gas seal is within the acceptable range of HTGR safety requirements.

Sign in / Sign up

Export Citation Format

Share Document