Cytolethal distending toxin: creating a gap in the cell cycle
2005 ◽
Vol 54
(3)
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pp. 207-216
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Keyword(s):
Cytolethal distending toxin (CDT) is a novel bacterial toxin that is produced by a variety of pathogenic bacteria. The mechanism of cytotoxicity of CDT is unique in that it enters into eukaryotic cells and breaks double-stranded DNA. This initiates the cell's own DNA damage-response mechanisms, resulting in the arrest of the cell cycle at the G2/M boundary. Affected cells enlarge until they finally undergo programmed cell death. This review encompasses recent work on CDT and focuses on the molecular mechanisms used by this toxin to block cell-cycle progression, the benefit to the bacterium of possession of this toxin and the clinical relevance of intoxication.
2019 ◽
Vol 32
(6)
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pp. 1123-1133
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Keyword(s):
Keyword(s):
Keyword(s):
2004 ◽
Vol 125
(1-2)
◽
pp. 47-59
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2003 ◽
Vol 23
(5)
◽
pp. 1717-1725
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1997 ◽
Vol 16
(9)
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pp. 485-494
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