Epidemiological, Clinical Characteristics and Outcome of Medical Staff Infected with COVID-19 in Wuhan, China: A Retrospective Case Series Analysis

SummaryBackgroundsSince December 2019, a novel coronavirus epidemic has emerged in Wuhan city, China and then rapidly spread to other areas. As of 20 Feb 2020, a total of 2,055 medical staff confirmed with coronavirus disease 2019 (COVID-19) caused by SARS-Cov-2 in China had been reported. We sought to explore the epidemiological, clinical characteristics and prognosis of novel coronavirus-infected medical staff.MethodsIn this retrospective study, 64 confirmed cases of novel coronavirus-infected medical staff admitted to Union Hospital, Wuhan between 16 Jan, 2020 to 15 Feb, 2020 were included. Two groups concerned were extracted from the subjects based on duration of symptoms: group 1 (≤10 days) and group 2 (>10 days). Epidemiological and clinical data were analyzed and compared across groups. The Kaplan-Meier plot was used to inspect the change in hospital discharge rate. The Cox regression model was utilized to identify factors associated with hospital discharge.FindingsThe median age of medical staff included was 35 years old. 64% were female and 67% were nurses. None had an exposure to Huanan seafood wholesale market or wildlife. A small proportion of the cohort had contact with specimens (5%) as well as patients in fever clinics (8%) and isolation wards (5%). Fever (67%) was the most common symptom, followed by cough (47%) and fatigue (34%). The median time interval between symptoms onset and admission was 8.5 days. On admission, 80% of medical staff showed abnormal IL-6 levels and 34% had lymphocytopenia. Chest CT mainly manifested as bilateral (61%), septal/subpleural (80%) and ground-glass (52%) opacities. During the study period, no patients was transferred to intensive care unit or died, and 34 (53%) had been discharged. Higher body mass index (BMI) (≥ 24 kg/m2) (HR 0.14; 95% CI 0.03-0.73), fever (HR 0.24; 95% CI 0.09-0.60) and higher levels of IL-6 on admission (HR 0.31; 95% CI 0.11-0.87) were unfavorable factors for discharge.InterpretationIn this study, medical staff infected with COVID-19 have relatively milder symptoms and favorable clinical course, which may be partly due to their medical expertise, younger age and less underlying diseases. Smaller BMI, absence of fever symptoms and normal IL-6 levels on admission are favorable for discharge for medical staff. Further studies should be devoted to identifying the exact patterns of SARS-CoV-2 infection among medical staff.

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Epidemiological,clinical and radiological findings in medical staff with COVID-19 in Wuhan, China: a single-centered, retrospective cohort study

10.21203/rs.3.rs-28753/v1 ◽

2020 ◽

Author(s):

Jie Liu ◽

Liu Ouyang ◽

Pi Guo ◽

Haisheng Wu ◽

Peng Fu ◽

...

Keyword(s):

Small Proportion ◽

Medical Staff ◽

Cox Regression ◽

Early Stage ◽

Wholesale Market ◽

Regression Methods ◽

Kaplan Meier ◽

Union Hospital ◽

Potential Risk Factors ◽

Novel Coronavirus

Abstract Backgrounds In December 2019, a pneumonia associated with the severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) emerged in Wuhan city, China. As of 20 Feb 2020, a total of 2,055 medical staff infected with SARS-Cov-2 in China had been reported. The predominant cause of the infection and the failure of protection among medical staff remains unclear. We sought to explore the epidemiological, clinical characteristics and prognosis of novel coronavirus-infected medical staff.Methods Medical staff who infected with SARS-Cov-2 and admitted to Union Hospital, Wuhan between 16 Jan, 2020 to 25 Feb, 2020 were included retrospectively. Epidemiological, clinical and radiological data were compared by occupation and analyzed with the Kaplan-Meier and Cox regression methods.Results A total of 101 medical staff (32 males and 69 females; median age: 33 years old) were included in this study and 74% were nurses. None had an exposure to Huanan seafood wholesale market or wildlife. A small proportion of the cohort had contact with specimens (3%) as well as patients infected with SARS-Cov-2 in fever clinics (15%) and isolation wards (3%). 80% of medical staff showed abnormal IL-6 levels and 33% had lymphocytopenia. Chest CT mainly manifested as bilateral (62%), septal/subpleural (77%) and groundglass opacities (48%). The major differences between doctors and nurses manifested in laboratory indicators. As of the last observed date, no patient was transferred to intensive care unit or died, and 98 (97%) had been discharged. Fever (HR=0.57; 95% CI 0.36-0.90) and IL-6 levels greater than >2.9 pg/ml (HR=0.50; 95% CI 0.30-0.86) on admission were unfavorable factors for discharge.Conclusions Our findings suggested that the infection of medical staff mainly occurred at the early stages of SARS-CoV-2 epidemic in Wuhan, and only a small proportion of infection had an exact mode. Meanwhile, medical staff infected with COVID-19 have relatively milder symptoms and favorable clinical course than other ordinary patients, which may be partly due to their medical expertise, younger age and less underlying diseases. The potential risk factors of presence of fever and IL-6 levels greater than >2.9 pg/ml could help to identify medical staff with poor prognosis at an early stage.

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Clinical Characteristics, Maternal and Neonatal Outcomes of COVID-19 Positive Pregnant Mothers at a Tertiary Hospital in Johannesburg, South Africa

10.21203/rs.3.rs-751147/v1 ◽

2021 ◽

Author(s):

Tanusha Devi Ramdin ◽

Rossella Marina Bandini ◽

Robin Terance Saggers ◽

Michael Radomsky ◽

Mphelekedzeni Mulaudzi ◽

...

Keyword(s):

Birth Weight ◽

Respiratory Distress ◽

Clinical Characteristics ◽

Tertiary Hospital ◽

Neonatal Outcomes ◽

Common Symptom ◽

Middle Income ◽

Symptomatic Disease ◽

Novel Coronavirus ◽

Pregnant Mothers

Abstract Background: The global spread of the novel coronavirus 2019 (COVID-19) has been sudden shock to the world and resulted in many questions that remain unanswered. Limited data has been published in low-middle-income country settings (LMICS) Objectives: To describe the clinical characteristics and outcome of mothers and neonates delivered from COVID-19 positive mothers, and to identify the incidence of COVID-19 positive neonates.Methods: A prospective, descriptive study, from 1 August 2020 to 31 March 2021 conducted at a tertiary hospital, in JohannesburgAll neonates born to mothers that were COVID-19 positive and that required admission to the neonatal unit were included. Informed consent was obtained from mothers prior to enrolment.Results: A total of 111 COVID-19 positive pregnant women delivered neonates at the tertiary hospital. In this study, only 28 of the 111 (25%) neonates born to COVID-19 positive mothers were admitted. The majority of the COVID-19 pregnant mothers were asymptomatic or had mild symptomatic disease (80%). Two (2/111 (2%) mothers required ICU admission and three (3/111 (3%) of them demised. In relation to neonatal outcomes, the majority of the neonates were delivered at a gestational age of 35 weeks with a birth weight of 2400 grams .The most common symptom was respiratory distress (89 %). The one (3%) neonate that tested positive for COVID-19 was born moderately preterm with a low birth weight and respiratory distress syndrome. Two (2/28 (7%) neonates demised, however the cause of death was not related to COVID-19. All the remaining (26/28 (93%) neonates were discharged and were well on follow up. Conclusion: Our study has shown that the risk of neonatal transmission from pregnant COVID-19 mothers is relatively low, and the majority of neonatal disease ranged from asymptomatic to mildly symptomatic disease. Further research efforts are essential to improve neonatal care in LMICS.

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Clinical characteristics of survivors and non-survivors, medical and non-medical staff members with 2019-nCoV pneumonia in Wuhan, China: a descriptive study

10.21203/rs.3.rs-20714/v1 ◽

2020 ◽

Author(s):

Jiaxun Hu ◽

You Lv ◽

Ying Xu ◽

Yushan Miao ◽

Wei Wang ◽

...

Keyword(s):

Medical Staff ◽

Clinical Characteristics ◽

Severe Pneumonia ◽

Study Data ◽

Disease Classification ◽

Staff Members ◽

Treatment Measures ◽

History Of ◽

Medical Compliance ◽

Novel Coronavirus

Abstract Objectives: In December 2019，the 2019 novel coronavirus ( 2019-nCoV ) emerged in Wuhan, China, leading to a cluster of severe pneumonia cases. Medical staff members on the front line were also infected. We compared the epidemiology, clinical characteristics, and treatment measures of survivors and non-survivors and the different clinical outcomes of medical staff members and non-medical members of the community infected with 2019-nCoV. Methods: We included 81 patients with adult 2019-nCoV in Hankou Hospital from mid-January to mid-February 2020 in this single-center retrospective study. Data were compared between survivors and non-survivors and between medical staff members and non-medical individuals. Results: All 38 medical staff members were infected by patients while working. Only 2 (2.5%) non-medical individuals had a clear history of exposure to 2019-nCoV patients. The median age was 49 years (interquartile range [IQR], 35-59; range, 23-89 years), and 42 (51.9%) were women. We found that the median age,comorbidity, and some laboratory outcomes(lymphocyte count, urea nitrogen, aspartate aminotransferase, lactate dehydrogenase, etc.)differed significantly between survivors and non-survivors. There were also significant differences in the time from onset to admission, disease classification, comorbidity, and prognosis between medical staff members and non-medical individuals. All medical staff members were cured, while 13 (30.2%) non-medical individuals died. Conclusions: Older males with comorbidities are more likely to be affected by 2019-nCoV. Significant changes in some laboratory markers may indicate a poor prognosis. Medical staff members may have had better prognoses due to fewer comorbidities and better medical compliance. Key words: 2019-nCoV; Clinical characteristics; Mortality; comorbidity; Survivors; Non-survivors; Medical Staff

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Asymptomatic COVID-19 Have Longer Treatment Cycle Than Moderate Type of Confirmed Patients

10.1101/2020.05.16.20103796 ◽

2020 ◽

Cited By ~ 1

Author(s):

Wei Zhang ◽

Qinying Long ◽

Yanbiao Huang ◽

Changju Chen ◽

Jinhua Wu ◽

...

Keyword(s):

Clinical Characteristics ◽

Treatment Cycle ◽

Clinical Laboratory ◽

Case Series ◽

Interquartile Range ◽

Control Group ◽

Single Center ◽

Clinical Trial Registry ◽

The Difference ◽

Novel Coronavirus

ABSTRACTObjectivesA kind of pneumonia caused by unknown causes that occurred in Wuhan, Hubei, China in December 2019, was reported as a result of novel coronavirus infection on January 7, 2020, and then WHO named it COVID-19. To compare the difference of epidemiology and clinical characteristics between asymptomatic COVID-19 infections and moderate type of confirmed cases.MethodsRetrospective, single-center cohort study of COVID-19 involving 52 infections of both 26 asymptomatic and 26 moderate type of confirmed cases in the recovery stage at Guizhou Provincial Staff Hospital in Guiyang, China, from January 29, to March 31, 2020; final date of follow-up was April 22. This study was registered in Chinese Clinical Trial Registry Center. Documented the asymptomatic COVID-19 infections and moderate type of confirmed cases. Epidemiological, demographic, clinical, laboratory, radiological, and treatment data were collected and analyzed. Epidemiological and clinical characteristics of asymptomatic COVID-19 infections and moderate type of confirmed cases were compared.ResultsThe median treatment cycle of asymptomatic COVID-19 infections was 16 days (interquartile range, 11-20 days) and longer than 13 days (interquartile range, 10-15 days) of moderate type of confirmed cases (p=0.049). The median incubation period of asymptomatic COVID-19 infections was 10 days (interquartile range, 0-21 days), while the control group was 7 days (interquartile range, 1-15 days) (p=0.27). On the initial chest computerized tomography (CT) check, 18 (69.2%, 18/26) asymptomatic COVID-19 infections were no imaging changes, which was of no significance compared with 12 (46.2%, 12/26) patients with moderate type of confirmed patients (p=0.092).ConclusionsIn this single-center study, we found that asymptomatic COVID-19 infections have longer treatment cycle than those moderate type of confirmed cases.Key PointsIn this single-center case series involving 52 infections with asymptomatic and moderate type of COVID-19 cases, asymptomatic COVID-19 infections have longer treatment cycle than those moderate type of confirmed patients.

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Associated risk factors with disease severity and antiviral drug therapy in patients with COVID-19

10.21203/rs.3.rs-70914/v2 ◽

2020 ◽

Author(s):

Xiaowei Gong ◽

Xianfeng Guo ◽

Shiwei Kang ◽

Yan Li ◽

Haixiang Gao ◽

...

Keyword(s):

Risk Factors ◽

Clinical Symptoms ◽

Discharge Rate ◽

Antiviral Drug ◽

Oxygenation Index ◽

Multivariable Logistic Regression Analysis ◽

Common Symptom ◽

Clinical Benefits ◽

Novel Coronavirus ◽

D Dimer

Abstract Background: Due to the latent onset of novel coronavirus disease 2019 (COVID-19), it is important to identify patients with increased probabilities for disease progression early in order to implement timely medical strategies. This study aimed to identify the factors associated with increased COVID-19 severity and evaluate the current antiviral drugs, especially in severe patients. Methods: This was a retrospective observational study performed at the No. 7 Hospital of Wuhan (Wuhan, China) with hospitalized patients confirmed with COVID-19 from January 11 to March 13, 2020. Multivariable logistic regression analysis was used to identify the associated factors of severe COVID. Treatments of antivirus drugs were collected and evaluated.Results: Of the 550 patients, 292 (53.1%) were female and 277 (50.4%) were >60 years old. The most common symptom was fever (n=372, 67.7%), followed by dry cough (n=257, 46.7%), and dyspnea (n=237, 43.1%), and fatigue (n=224, 40.7%). Among the severe patients, 20.2% required invasive ventilator support and 18.0% required non-invasive ventilator. The identified risk factors for severe cases were: age ≥60 years (odds ratio (OR) =3.02, 95% confidence interval (CI): 1.13-8.08, P=0.028), D-dimer >0.243 μg/ml (OR=2.734, 95%CI: 1.012-7.387, P=0.047), and low oxygenation index (OR=0.984, 95%CI: 0.980-0.989, P<0.001). In severe cases, the benefits (relief of clinical symptoms, clinical outcome, and discharge rate) of arbidol alone was 73.3%, which was better than ribavirin (7/17, 41.2%, P=0.029).Conclusions: Age >60 years, D-dimer >0.243 µg/ml, and lower oxygenation index were associated with severe COVID-19. Arbidol might provide more clinical benefits in treating patients with severe COVID-19 compared with ribavirin.

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Out-of-Hospital Cardiac Arrest in a Teaching Hospital in Hong Kong: Descriptive Study Using the Utstein Style

Hong Kong Journal of Emergency Medicine ◽

10.1177/102490790501200304 ◽

2005 ◽

Vol 12 (3) ◽

pp. 148-155 ◽

Cited By ~ 3

Author(s):

AKC Wai ◽

P Cameron ◽

CK Cheung ◽

P Mak ◽

TH Rainer

Keyword(s):

Cardiac Arrest ◽

Hong Kong ◽

Hospital Discharge ◽

Teaching Hospital ◽

Discharge Rate ◽

Demographic Data ◽

University Teaching ◽

Time Interval ◽

Utstein Style ◽

Hospital Cardiac Arrest

Objective To describe, using the Utstein template, the characteristics of patients presenting with out-of-hospital cardiac arrest to a university teaching hospital in the New Territories of Hong Kong, and to evaluate survival. Design Prospective study. Setting The emergency department of a teaching hospital in the New Territories, Hong Kong. Participants Patients older than 12 years with non-traumatic out-of-hospital cardiac arrest who were transported to the hospital between 1 July 2002 and 31 December 2002. Main outcome measures Demographic data, characteristics of cardiac arrest and response time intervals of the emergency medical service presented according to the Utstein style, and also survival to hospital discharge rate. Results A total of 124 patients were included (49.2% male; mean age 71.9 years). The majority of cardiac arrests occurred in patients' home. The overall bystander cardiopulmonary resuscitation (CPR) rate was 15.3% (19/124). The most common electrocardiographic rhythm at scene was asystole, whilst pulseless ventricular tachycardia (VT)/ventricular fibrillation (VF) was found in 18.0%. The overall survival was 0.8% (1/124), and survival to hospital discharge was significantly higher for patients with VF or pulseless VT than those patients with other rhythms of cardiac arrest (11.1% versus 0%). The median witnessed/recognised collapse to defibrillation time was 14 minutes. The median prehospital time interval from collapse/recognition to arrival at hospital was 33 minutes. Conclusion The prognosis of out-of-hospital cardiac arrest in Hong Kong was poor. Major improvements in every component of the chain of survival are necessary.

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Clinical characteristics and abnormal parameters evolution in patients with novel coronavirus infection: a case series of 272 cases in Guangzhou

Disaster Medicine and Public Health Preparedness ◽

10.1017/dmp.2021.149 ◽

2021 ◽

pp. 1-26

Author(s):

Yubing Wang ◽

Zhongwei Hu ◽

Jie Luo ◽

Fuchun Zhang ◽

Lianjiao Huang ◽

...

Keyword(s):

Early Warning ◽

Clinical Characteristics ◽

Severe Disease ◽

Case Series ◽

Laboratory Parameters ◽

Specificity And Sensitivity ◽

Early Warning Indicators ◽

Chief Complaints ◽

Novel Coronavirus ◽

Warning Indicators

Abstract Objective To present the clinical characteristics and dynamic changes in laboratory parameters of the COVID-19 in Guangzhou, and explore the probable early warning indicators of disease progressing. Method We enrolled all the patients diagnosed as COVID-19 in the Guangzhou No. 8 People’s Hospital. The patients’ demographic, and epidemiologic data were collected, including chief complaints, lab results and imaging examination. Results The characteristics of the patients in Guangzhou are different from that in Wuhan. They were younger in age, female dominated, not commonly combined with other disease. 75% of patients suffered fever on admission, followed by cough occurring in 62% patients. By comparing the mild/normal and severe/critical patients, male, aged, combined with hypertension, abnormal in blood routine result, raised creatine kinase, glutamic oxaloacetic transaminase, lactate dehydrogenase, CRP, procalcitonin, D-dimer, fibrinogen, APTT, and positive in proteinuria can be candidate of early warning indicators to severe disease. Conclusion The patients in outside epidemic areas showed different characteristics from that in Wuhan. The abnormal laboratory parameters were markedly changed in 4 weeks after admission, and also shown different between the mild and severe patients. The highest specificity and sensitivity potential early warning indicators of severe disease need more evidence to confirm.

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Clinical Characteristics and Prognostic Analysis of Multiple Myeloma with Extramedullary Disease: A SEER-Based Study

Journal of Oncology ◽

10.1155/2021/6681521 ◽

2021 ◽

Vol 2021 ◽

pp. 1-9

Author(s):

Guang Li ◽

Yan-Ping Song ◽

Yao Lv ◽

Zhen-Zhen Li ◽

Yan-Hua Zheng

Keyword(s):

Multiple Myeloma ◽

Prognostic Factors ◽

Clinical Characteristics ◽

Cox Regression ◽

Cox Model ◽

Rank Test ◽

Time Interval ◽

Risk Of Death ◽

Extramedullary Disease ◽

Prognostic Analysis

Background. Extramedullary disease (EMD), an infrequent manifestation of multiple myeloma (MM), can present at diagnosis or develop during the disease course. EMD can be clinically divided into bone-related EMD (EMD-B) and soft tissue-related EMD (EMD-S). The purpose of our study is to investigate the clinical characteristics, survival outcomes, and prognostic factors of MM patients with EMD. Methods. A total of 155 MM patients with EMD were ultimately enrolled in our study by retrieving the Surveillance, Epidemiology, and End Results (SEER) database. The Kaplan–Meier survival curves and log-rank test for overall survival (OS) and myeloma-specific survival (MSS) were conducted to compare each potential variable. Variables with a p value <0.1 in the univariate Cox regression were incorporated into the multivariate Cox model to determine the independent prognostic factors, with a hazard ratio (HR) >1 representing adverse prognostic factors. Results. The median age at diagnosis was 63 years old. EMD-B occurred in 99 patients (63.90%), while EMD-S occurred in 56 cases (36.10%). Patients with EMD-S had a significant survival disadvantage in MSS (HR = 1.844, 95% CI 1.117–3.042, p = 0.017) and OS (HR = 1.853, 95% CI 1.166–2.942, p = 0.009) compared to those with EMD-B. Patients with EMD interval ≤24 months were at higher risk of death than those with EMD at diagnosis in MSS (HR = 1.885, 95% CI 1.175–3.346, p = 0.042) and in OS (HR = 1.33, 95% CI 1.119–2.529, p = 0.036). Patients with EMD interval >24 months were at a lower risk of death as opposed to those with EMD at diagnosis. Conclusion. Age at MM diagnosis, site of EMD, and time interval from diagnosis to EMD occurrence were independent prognostic factors in MM patients with EMD. EMD-B bore a better prognosis than EMD-S.

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Clinical characteristics, management, maternal and neonatal outcome among seven severe and critically ill pregnant women with COVID-19 pneumonia

Clinical Journal of Obstetrics and Gynecology ◽

10.29328/journal.cjog.1001071 ◽

2020 ◽

Vol 3 (2) ◽

pp. 158-166

Author(s):

Hazari Komal Sundeep ◽

Paulose Litty ◽

Kurien Nimmi ◽

Mohammad Hozaifah ◽

A Elgergawi Taghrid Faek ◽

...

Keyword(s):

Pregnant Women ◽

Clinical Characteristics ◽

Case Series ◽

Fetal Outcome ◽

World Health ◽

Investigational Therapies ◽

Serious Disease ◽

Novel Coronavirus ◽

Health Organization ◽

In Pregnancy

Pneumonia caused by the Novel coronavirus disease 2019 (COVID-19) is a highly infectious disease and the ongoing outbreak has been declared as a Pandemic by the World health organization. Pneumonia is a serious disease in pregnancy and requires prompt attention. Viral pneumonia has higher morbidity and mortality compared to bacterial pneumonia in pregnancy. All efforts are well exerted to understand the newly emerged disease features but still some areas are gray. The treatment is primarily supportive with antivirals, steroids, anticoagulation and antibiotics for secondary bacterial infection. Severe cases require intensive care monitoring with oxygen support, mechanical ventilation. Investigational therapies include convalescent plasma, cytokine release inhibitors and other immunomodulatory agents like interferons. The mortality appears driven by the presence of severe Adult Respiratory Syndrome (ARDS) and organs failure. COVID pandemic is a challenging and stressful socio-economic situation with widespread fear of infection, disease and death. In the specialty of obstetrics and gynecology, studies are being conducted to ascertain the manifestation of disease in pregnant women and the fetal outcome. The aim of our case series is to describe the demographics, clinical characteristics, laboratory and radiological findings, feto- maternal outcome of severe and critical COVID pneumonia in pregnant women in Latifa Hospital.

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Clinical Characteristics of Coronavirus Disease 2019 (COVID-19): An Updated Systematic Review

10.1101/2020.03.07.20032573 ◽

2020 ◽

Cited By ~ 13

Author(s):

Zhangfu Fang ◽

Fang Yi ◽

Kang Wu ◽

Kefang Lai ◽

Xizhuo Sun ◽

...

Keyword(s):

Systematic Review ◽

Clinical Characteristics ◽

Case Fatality ◽

Admission Rate ◽

Final Analysis ◽

Common Symptom ◽

Laboratory Findings ◽

Large Patient ◽

Unbiased Manner ◽

Novel Coronavirus

AbstractOBJECTIVEClinical characteristics of novel coronavirus disease (COVID-19) have been described in numerous studies but yielded varying results. We aimed to conduct a systematic review on scientific literatures and to synthesize critical data on clinical traits of COVID-19 from its initial outbreak to pandemic.METHODSSystematic searches were conducted to identify retrospective observational study that contained clinical characteristics on COVID-19 through multiple databases. Two reviewers independently evaluated eligible publications. Data on clinical characteristics of COVID-19 were extracted and analyzed.RESULTSSeventy-two retrospective studies demonstrating the clinical characteristics of COVID-19 were included. A total of 3470 COVID-19 patients were synthesized to the final analysis in an unbiased manner. The most common symptom was fever (2878 [83.0%]), and 63.4% of the patients presented fever as onset symptom. There were 2528 [88.2%] of 2866 cases had abnormal lung findings on chest CT scan. Laboratory findings showed that 1498 [62.8%] of 2387 cases had lymphopenia, and 1354 [64.8%] of 2091 cases had an increased level of C-reactive protein (CRP). A total of 185 [11.5%] patients were admitted to intensive care unit (ICU) while the overall case fatality rate (CFR) was 3.7%. Compared to patients admitted outside of Hubei, China, those from Hubei had a significant higher ICU admission rate (21.9% vs. 2.5%, p<0.001). Also, CFR attributed to COVID-19 was significantly higher in Hubei than that of non-Hubei admissions (10.4% vs. 0.6%, p<0.001).INTERPRETATIONThis large patient-based systematic review presents a more precise profiling of the COVID-19 from its outbreak to current pandemic. Dynamic evolvements of COVID-19 are needed to be characterized in future studies.

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