scholarly journals Gonadulins, the fourth type of Insulin-related peptides in Decapods

Author(s):  
Jan A. Veenstra

AbstractInsulin and related peptides play important roles in the regulation of growth and reproduction. Until recently three different types of insulin-related peptides had been identified from decapod crustaceans. The identification of two novel insulin-related peptides from Sagmariasus verreauxi and Cherax quadricarinatus suggested that there might a fourth type. Publicly available short read archives show that orthologs of these peptides are commonly present in these animals. Most decapods have two genes coding such peptides, but Penaeus species have likely only one and some palaemonids have three. Interestingly, expression levels can vary more than thousand-fold in the gonads of Portunus trituberculatus, where gonadulin 1 is expressed by the testis and gonadulin 2 by the ovary. Although these peptides are also expressed in other tissues, the occasionally very high expression in the gonads led to them being called gonadulins.

Nanomaterials ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 507
Author(s):  
Luca Seravalli ◽  
Claudio Ferrari ◽  
Matteo Bosi

In this paper, we model the electrical properties of germanium nanowires with a particular focus on physical mechanisms of electrical molecular sensing. We use the Tibercad software to solve the drift-diffusion equations in 3D and we validate the model against experimental data, considering a p-doped nanowire with surface traps. We simulate three different types of interactions: (1) Passivation of surface traps; (2) Additional surface charges; (3) Charge transfer from molecules to nanowires. By analyzing simulated I–V characteristics, we observe that: (i) the largest change in current occurs with negative charges on the surfaces; (ii) charge transfer provides relevant current changes only for very high values of additional doping; (iii) for certain values of additional n-doping ambipolar currents could be obtained. The results of these simulations highlight the complexity of the molecular sensing mechanism in nanowires, that depends not only on the NW parameters but also on the properties of the molecules. We expect that these findings will be valuable to extend the knowledge of molecular sensing by germanium nanowires, a fundamental step to develop novel sensors based on these nanostructures.


2012 ◽  
Vol 16 (02) ◽  
pp. 192-199 ◽  
Author(s):  
H. Yasemin Yenilmez Akkurt ◽  
Ali ihsan Okur ◽  
Ahmet Gül

In this study, a synthetic procedure for unsymmetrical metallophthalocyanines of the form M[Pc(AB3)], where A and B refer to two different types of peripheral functionality, has been developed and the new compounds have been converted to monomeric and dimeric palladium complexes. Asymmetrically substituted phthalocyanines were synthesized with the well-known statistical condensation method, by using two differently substituted precursors, namely 4-(2-ethoxyethoxy)-1-2-dicyanobenzene (1) and 4-{4-[Z/E]-phenylazo]-1-naphthyl}oxy-1,2-dicyanobenzene (2). Consequently, electron-donating 2-ethoxyethoxy groups and electron-withdrawing palladium complex are present in the same structure. Cyclopalladation was performed with [Pd(PhCN)2Cl2] to yield the bis-μ-chloro-bridged dimers and subsequently, the corresponding monomers were obtained by refluxing with three equivalents of potassium acetylacetonate. The resulting products were purified by column chromatography and characterized by several chemical and spectroscopic analysis methods. All compounds have very high solubility in organic solvents due to the presence of 2-ethoxyethoxy moiety.


2015 ◽  
Vol 229 (1-2) ◽  
Author(s):  
Beatriz H. Juarez ◽  
Luis M. Liz-Marzán

AbstractThe integration of different types of materials in a single hybrid system allows the combination of multiple functionalities, which can even be used in conjunction with each other. This strategy has been exploited in nanoscale systems for the creation of so-called smart nanomaterials. Within this category, the combination of inorganic nanoparticles with stimuli-responsive microgels is of very high interest because of the wide variety of potential applications. We present here a short overview of this type of materials in which the nano- and micro-scales get nicely integrated, with a great potential to expand the range of technological applications. We focus mainly on the integration of metal nanoparticles, either by themselves or in combination with semiconductor and magnetic nanoparticles. Various examples of the synergic properties that can be obtained are described, as well as the possibility to extract useful information when optical tweezers are used to manipulate single particles. We expect that this review will stimulate additional research in this field.


Author(s):  
L. Hang ◽  
G. Y. Cai

Abstract. The detection and reconstruction of building have attracted more attention in the community of remote sensing and computer vision. Light detection and ranging (LiDAR) has been proved to be a good way to extract building roofs, while we have to face the problem of data shortage for most of the time. In this paper, we tried to extract the building roofs from very high resolution (VHR) images of Chinese satellite Gaofen-2 by employing convolutional neural network (CNN). It has been proved that the CNN is of a higher capability of recognizing detailed features which may not be classified out by object-based classification approach. Several major steps are concerned in this study, such as generation of training dataset, model training, image segmentation and building roofs recognition. First, urban objects such as trees, roads, squares and buildings were classified based on random forest algorithm by an object-oriented classification approach, the building regions were separated from other classes at the aid of visually interpretation and correction; Next, different types of building roofs mainly categorized by color and size information were trained using the trained CNN. Finally, the industrial and residential building roofs have been recognized individually and the results have been validated individually. The assessment results prove effectiveness of the proposed method with approximately 91% and 88% of quality rates in detection industrial and residential building roofs, respectively. Which means that the CNN approach is prospecting in detecting buildings with a very higher accuracy.


The complexity of human olfaction is very high and the importance of being able to measure it directly, objectively and qualitatively has led experts to search for mechanisms that can be applied. Human beings use this sense, which is one of the oldest, to recognize danger and distinguish between pleasant and unpleasant odors. Smells are mixtures of molecules that, at different concentrations in the inhaled air, stimulate the olfactory area and are recognized at the brain level. Therefore, there is a coding and decoding system. Human olfactometer techniques use equipment designed to be able to measure its intensity and quality of volatile substances. If we are able to measure this sense, we will be able to know its variations and be able to make clinical diagnoses in normal and pathological conditions and diagnose the losses that occur in certain infectious, degenerative diseases, traumatic processes and other variants. For many years, systems have been developed that can measure subjective olfaction in humans, as well as objective forms, but it is also true that there is no equipment available that is fast, simple handling and that can be applied in daily clinical services. Aim of the Study Present the recent achievements in olfactometer technology; Elaborate the scientific articles about olfactometry published mainly in the last 10 years; To gather the information published in the last years in relation to the usefulness, existence in the market and purposes of equipment that can measure the odors, what we will call the Smell-o-meter or olfactometer for human use. Material and Methods: In the first part of this research we will gather most of the information existing so far in international bibliography, as well as the achievements and utilities obtained to date. Following, we will analyze all the new concepts related to smell-o-meters devices that exist on the market and assess the possibility, based on what has been done so far, to seek new practical systems for application in the medical field.


2013 ◽  
Vol 6 (1-2) ◽  
pp. 41-49
Author(s):  
Sharmistha Mitra ◽  
Robiul Hasan Bhuiyan ◽  
Md Arifuzzaman ◽  
Mohammad Sayedul Islam ◽  
Mahmood A Chowdhury ◽  
...  

Meningitis is referred to as an inflammatory process of the leptomeninges and cerebrospinal fluid (CSF) within the sub-arachnoid space of the brain. We have investigated glucose status in CSF in different types of meningitis together with detailed medical history in children. In addition, we have also carried out the detailed cytological and microbiological examinations. A total of 40 subjects were investigated. We observed that the glucose level was significantly decreased (<20 mg/dl) in 65%, moderately decreased (20-40 mg/dl) in 20% and mildly decreased (40-50mg/dl) in 15% of the patients in our study. Patients with Pyogenic meningitis had tremendously reduced glucose level (9.0 mg/dl) in their CSF whereas in viral meningitis the CSF glucose level is highly variable (10 to 65 mg/dl). Furthermore, 5 (12.5%) patients showed high lymphocyte counts and 34 (85%) patients showed high neutrophil counts. Interestingly, in Pyogenic meningitis, the neutrophil count was very high compared to that in viral meningitis. The present study clearly demonstrates that biochemical parameters such as glucose level in CSF might be a potential tool for detecting meningitis and as well as differentiation of the different types of meningitis. DOI: http://dx.doi.org/10.3329/cujbs.v6i1-2.17080 The Chittagong Univ. J. B. Sci.,Vol. 6(1&2):41-49, 2011


2007 ◽  
Vol 28 (4) ◽  
pp. 503-508 ◽  
Author(s):  
Fabio Pupin ◽  
Roberto Sacchi ◽  
Stefano Scali ◽  
Alessandra Binda ◽  
Marco Zuffi ◽  
...  

Abstract The morphology of erythrocytes, trombocytes, monocytes, basophils and lymphocytes on Moorish geckos (Tarentola mauritanica) is quite similar to that of other reptiles, even though some peculiarities were detected for heterophils and eosinophils. Moreover, we found a fourth type of granulocyte whose morphology highly differs from both heterophils and eosinophils. Sexually-based differences in the relative abundance of different types of leukocytes was detected: lymphocytes were the most frequent in females, while heterophils and eosinophils prevailed in males. Interestingly, in most individuals we found intra-erythrocytic vacuoles whose structure is similar to that previously described as Chelonoplasma in tortoises and Serpentoplasma in snakes.


2000 ◽  
Vol 203 (21) ◽  
pp. 3279-3287 ◽  
Author(s):  
M.E. Castello ◽  
P.A. Aguilera ◽  
O. Trujillo-Cenoz ◽  
A.A. Caputi

This paper describes the peripheral mechanisms involved in signal processing of self- and conspecific-generated electric fields by the electric fish Gymnotus carapo. The distribution of the different types of tuberous electroreceptor and the occurrence of particular electric field patterns close to the body of the fish were studied. The density of tuberous electroreceptors was found to be maximal on the jaw (foveal region) and very high on the dorsal region of the snout (parafoveal region), decaying caudally. Tuberous type II electroreceptors were much more abundant than type I electroreceptors. Type I electroreceptors occurred exclusively on the head and rostral trunk regions, while type II electroreceptors were found along as much as 90 % of the fish. Electrophysiological data indicated that conspecific- and self-generated electric currents are ‘funnelled’ by the high conductivity and geometry of the body of the fish. These currents are concentrated at the peri-oral zone, where most electroreceptors are located. Moreover, within this region, field vector directions were collimated, constituting the most efficient stimulus for electroreceptors. It can be concluded that the passive properties of the fish tissue represent a pre-receptor device that enhances exafferent and reafferent electrical signals at the fovea-parafoveal region.


1989 ◽  
Vol 93 (3) ◽  
pp. 457-465
Author(s):  
H.U. Keller ◽  
V. Niggli ◽  
A. Zimmermann

Shape changes have been determined in human blood lymphocytes stimulated with OAG, diC8, PMA, colchicine or the hexapeptide fNLPNTL in short-term assays (30 min). Distinct types of shape-change responses were observed. Colchicine was active in generating a relatively small proportion of polarized lymphocytes (front-tail polarity). OAG, diC8 and PMA produced different types of shape change (non-polar cells with surface projections), and these were closely associated with an increase in actin polymerization and a shift of F-actin into the projections at the cell periphery. The diacylglycerols OAG and diC8 produced biphasic dose-response curves leading to rounding up of cells at very high stimulant concentrations. PMA produced no comparable biphasic response when tested over a much wider concentration range. Though the nonpolar cells with surface projections generated by OAG, diC8 or PMA showed vigorous shape changes, they lacked significant locomotor activity. alpha-Phorbol, 4 alpha-PDD, lumicolchicine or fNLPNTL were inactive. Small blood lymphocytes stimulated by OAG, diC8 or PMA showed a very small increase in the net uptake of FITC-dextran by fluid pinocytosis. Unlike neutrophils, which show a high net uptake, lymphocytes did not concentrate FITC-dextran in large granules, indicating that they do not develop a ‘storage’ compartment in the form of large vesicles. However, small fluorescent spots were consistently found in at least a fraction of blood lymphocytes. The results indicate that stimulated surface movement may be instrumental in fluid pinocytosis. Diacylglycerols may act as second messengers to induce pinocytosis, shape changes and altered actin polymerization in lymphocytes.


2020 ◽  
pp. 030573561989343 ◽  
Author(s):  
Xiaonuo Li

This article reports the high prevalence of Absolute Pitch (AP) among students at Shanghai Conservatory of Music and explores the effects of timbre on AP judgment through a large-scale direct-test study. This study used two types of timbres (piano timbre and string timbre) to explore the correlation between the different types of timbre and note-naming accuracy. The participants included 71 undergraduate students majoring in piano and string at Shanghai Conservatory of Music, who had begun musical training at an age ⩽ 9 and focused on Western tonal music. The main results showed that the overall performance levels were very high and that the students scored 73% correct without semitone errors and 80% with semitone errors. All groups exhibited higher performance in judging pitches in piano timbre than string timbre. In addition, after listening to piano timbre, the accuracy in judging pitches in string timbre was significantly increased, and after listening to string timbre, the accuracy in judging pitches in piano timbre decreased but not significantly.


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