The Filter Detection Task for measurement of breathing-related interoception and metacognition

AbstractThe study of the brain’s processing of sensory inputs from within the body (‘interoception’) has been gaining rapid popularity in neuroscience, where interoceptive disturbances have been postulated to exist across a wide range of chronic physiological and psychological conditions. Here we present a task and analysis procedure to quantify specific dimensions of breathing-related interoception, including interoceptive sensitivity (accuracy), decision bias, metacognitive bias, and metacognitive performance. We describe a task that is tailored to methods for assessing respiratory interoceptive accuracy and metacognition, and pair this with an established hierarchical statistical model of metacognition (HMeta-d) to overcome significant challenges associated with the low trial numbers often present in interoceptive experiments. Two major new developments have been incorporated into this task analysis by pairing: (i) a novel adaptive algorithm to maintain task performance at 70-75% accuracy, and (ii) an extended metacognitive model developed to hierarchically estimate multiple regression parameters linking metacognitive performance to relevant (e.g. clinical) variables. We demonstrate the utility of both developments, using both simulated and empirical data from three separate studies. This methodology represents an important step towards accurately quantifying interoceptive dimensions from a simple experimental procedure that is compatible with the practical constraints in clinical settings. Both the task and analysis code are publicly available.

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Interoceptive dimensions across cardiac and respiratory axes

Philosophical Transactions of the Royal Society B Biological Sciences ◽

10.1098/rstb.2016.0014 ◽

2016 ◽

Vol 371 (1708) ◽

pp. 20160014 ◽

Cited By ~ 72

Author(s):

Sarah N. Garfinkel ◽

Miranda F. Manassei ◽

Giles Hamilton-Fletcher ◽

Yvo In den Bosch ◽

Hugo D. Critchley ◽

...

Keyword(s):

Internal State ◽

The Body ◽

Metacognitive Awareness ◽

Self Report ◽

Affective Processing ◽

Organ Specific ◽

Interoceptive Sensitivity ◽

Interoceptive Accuracy ◽

Future Work ◽

Insight Into

Interoception refers to the sensing of signals concerning the internal state of the body. Individual differences in interoceptive sensitivity are proposed to account for differences in affective processing, including the expression of anxiety. The majority of investigations of interoceptive accuracy focus on cardiac signals, typically using heartbeat detection tests and self-report measures. Consequently, little is known about how different organ-specific axes of interoception relate to each other or to symptoms of anxiety. Here, we compare interoception for cardiac and respiratory signals. We demonstrate a dissociation between cardiac and respiratory measures of interoceptive accuracy (i.e. task performance), yet a positive relationship between cardiac and respiratory measures of interoceptive awareness (i.e. metacognitive insight into own interoceptive ability). Neither interoceptive accuracy nor metacognitive awareness for cardiac and respiratory measures was related to touch acuity, an exteroceptive sense. Specific measures of interoception were found to be predictive of anxiety symptoms. Poor respiratory accuracy was associated with heightened anxiety score, while good metacognitive awareness for cardiac interoception was associated with reduced anxiety. These findings highlight that detection accuracies across different sensory modalities are dissociable and future work can better delineate their relationship to affective and cognitive constructs. This article is part of the themed issue ‘Interoception beyond homeostasis: affect, cognition and mental health’.

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Creating the Wind

Latin American and Latinx Visual Culture ◽

10.1525/lavc.2020.2.4.14 ◽

2020 ◽

Vol 2 (4) ◽

pp. 14-31

Author(s):

Élodie Dupey García

Keyword(s):

Indigenous Communities ◽

The Body ◽

Historical Sources ◽

Natural Behavior ◽

Sensory Experiences ◽

Identity And Agency ◽

Wide Range ◽

Late Postclassic ◽

Comparative Examination ◽

Meteorological Phenomenon

This article explores how the Nahua of late Postclassic Mesoamerica (1200–1521 CE) created living and material embodiments of their wind god constructed on the basis of sensory experiences that shaped their conception of this divinized meteorological phenomenon. In this process, they employed chromatic and design devices, based on a wide range of natural elements, to add several layers of meaning to the human, painted, and sculpted supports dressed in the god’s insignia. Through a comparative examination of pre-Columbian visual production—especially codices and sculptures—historical sources mainly written in Nahuatl during the viceregal period, and ethnographic data on indigenous communities in modern Mexico, my analysis targets the body paint and shell jewelry of the anthropomorphic “images” of the wind god, along with the Feathered Serpent and the monkey-inspired embodiments of the deity. This study identifies the centrality of other human senses beyond sight in the conception of the wind god and the making of its earthly manifestations. Constructing these deity “images” was tantamount to creating the wind because they were intended to be visual replicas of the wind’s natural behavior. At the same time, they referred to the identity and agency of the wind god in myths and rituals.

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Theory-Practice Gap: The Experiences of Nigerian Nursing Students

Africa Journal of Nursing and Midwifery ◽

10.25159/2520-5293/3694 ◽

2018 ◽

Vol 20 (1) ◽

Cited By ~ 1

Author(s):

Titilayo Dorothy Odetola ◽

Olusola Oluwasola ◽

Christoph Pimmer ◽

Oluwafemi Dipeolu ◽

Samson Oluwayemi Akande ◽

...

Keyword(s):

Clinical Practice ◽

Nursing Students ◽

Developing Country ◽

The Body ◽

Clinical Staff ◽

Clinical Settings ◽

Practice Gap ◽

The Difference ◽

Analyse Data ◽

Theory Practice Gap

The “disconnect” between the body of knowledge acquired in classroom settings and the application of this knowledge in clinical practice is one of the main reasons for professional fear, anxiety and feelings of incompetence among freshly graduated nurses. While the phenomenon of the theory-to-practice gap has been researched quite extensively in high-income country settings much less is known about nursing students’ experiences in a developing country context. To rectify this shortcoming, the qualitative study investigated the experiences of nursing students in their attempt to apply what they learn in classrooms in clinical learning contexts in seven sites in Nigeria. Thematic content analysis was used to analyse data gained from eight focus group discussions (n = 80) with the students. The findings reveal a multifaceted theory-practice gap which plays out along four tensions: (1) procedural, i.e. the difference between practices from education institutions and the ones enacted in clinical wards – and contradictions that emerge even within one clinical setting; (2) political, i.e. conflicts that arise between students and clinical staff, especially personnel with a lower qualification profile than the degree that students pursue; (3) material, i.e. the disconnect between contemporary instruments and equipment available in schools and the lack thereof in clinical settings; and (4) temporal, i.e. restricted opportunities for supervised practice owing to time constraints in clinical settings in which education tends to be undervalued. Many of these aspects are linked to and aggravated by infrastructural limitations, which are typical for the setting of a developing country. Nursing students need to be prepared regarding how to deal with the identified procedural, political, material and temporal tensions before and while being immersed in clinical practice, and, in so doing, they need to be supported by educationally better qualified clinical staff.

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Conducting a Virtual Study with Special Considerations for Working with Persons with Aphasia

10.31234/osf.io/m72va ◽

2020 ◽

Author(s):

Ashleigh Doub ◽

Anne Hittson ◽

Brielle C Stark

Keyword(s):

Data Storage ◽

Study Data ◽

The Body ◽

Retention Rates ◽

Clinical Settings ◽

Use Of Technology ◽

Quality Check ◽

Assessment Procedures ◽

Post Assessment ◽

Larger Sample

Purpose: The use of technology (e.g., telehealth) in clinical settings has rapidly increased and its use in research settings continues to grow. The aim of this report is to provide detailed methods for conducting a multi-timepoint (test-retest) virtual paradigm, assessing lifestyle, physiological, cognitive, and linguistic factors in persons with and without aphasia. Methods: Procedures for virtual assessment are detailed in a sample of non-brain damaged adults (NB; N=24) and persons with aphasia (PWA; N=9) on a test-retest paradigm (data collection approximately 10 +/- 3 days apart). This report provides practical information about pre-assessment (e.g. recruitment, scheduling), assessment (e.g. aphasia-friendly consent presentation, investigator fidelity), and post-assessment (e.g. data storage, quality check) procedures for human behavior research using a virtual platform.Results: Preliminary study data is provided, demonstrating high retention rates and feasibility. Common technological troubles and solutions are discussed, and solutions offered. The results suggest that our pre-assessment, assessment, and post-assessment procedures were core to the success of our study. Conclusion: We provide practical methodology for conducting a multi-timepoint study, with considerations for persons with aphasia, adding to the body of research on telehealth in clinical populations. Future studies should continue to evaluate tele-methodology, which may be core for diversifying studies, improving study retention, and enrolling larger sample sizes.

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Coleridge and Contemplation

10.1093/oso/9780198799511.001.0001 ◽

2017 ◽

Cited By ~ 3

Keyword(s):

Historical Background ◽

New Developments ◽

English Departments ◽

Original Essays ◽

Wide Range ◽

Romantic Era ◽

Renaissance Man ◽

Dynamic Quality ◽

Philosophical Writings

In his philosophical writings, Coleridge increasingly developed his thinking about imagination, a symbolizing precursor to contemplation, to a theory of contemplation itself, which for him occurs in its purest form as a manifestation of ‘Reason’. Coleridge is a particularly challenging figure because he was a thinker in process, and something of an omnimath, a Renaissance man of the Romantic era. The dynamic quality of his thinking, the ‘dark fluxion’ pursued but ultimately ‘unfixable by thought’, and his extensive range of interests make essential an approach that is philosophical yet also multi-disciplinary. This is the first collection of essays to be written mainly by philosophers and intellectual historians on a wide range of Coleridge’s philosophical writings. With a foreword by Baroness Mary Warnock, and original essays on Coleridge and Contemplation by prominent philosophers such as Sir Roger Scruton, David E. Cooper, Michael McGhee, and Andy Hamilton, this volume provides a stimulating collection of insights and explorations into what Britain’s foremost philosopher-poet had to say about the contemplation that he considered to be the highest of the human mental powers. The essays by philosophers are supported by new developments in philosophically minded criticism from Coleridge scholars in English departments, including Jim Mays, Kathleen Wheeler, and James Engell. They approach Coleridge as an energetic yet contemplative thinker concerned with the intuition of ideas and the processes of cultivation in self and society. Other essays, from intellectual historians and theologians, clarify the historical background, and ‘religious musings’, of Coleridge’s thought regarding contemplation.

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Development and Validation of a New Scoring Tool to Evaluate the Clinical Evolution of Adult Patients with Nonsegmental Vitiligo

Dermatology ◽

10.1159/000511890 ◽

2021 ◽

pp. 1-9

Author(s):

María Luisa Peralta-Pedrero ◽

Denisse Herrera-Bringas ◽

Karla Samantha Torres-González ◽

Martha Alejandra Morales-Sánchez ◽

Fermín Jurado Santa-Cruz ◽

...

Keyword(s):

Body Surface ◽

Task Force ◽

Intraclass Correlation ◽

The Body ◽

Response To Treatment ◽

Similar Response ◽

Clinical Evolution ◽

Wide Range ◽

Patient Reported ◽

Extreme Groups

Background: Vitiligo has an unpredictable course and a variable response to treatment. Furthermore, the improvement of some vitiligo lesions cannot be considered a guarantee of a similar response to the other lesions. Instruments for patient-reported outcome measures (PROM) can be an alternative to measure complex constructions such as clinical evolution. Objective: The aim of this study was to validate a PROM that allows to measure the clinical evolution of patients with nonsegmental vitiligo in a simple but standardized way that serves to gather information for a better understanding of the disease. Methods: The instrument was created through expert consensus and patient participation. For the validation study, a prospective cohort design was performed. The body surface area affected was measured with the Vitiligo Extension Score (VES), the extension, the stage, and the spread by the evaluation of the Vitiligo European Task Force assessment (VETFa). Reliability was determined with test-retest, construct validity through hypothesis testing, discriminative capacity with extreme groups, and response capacity by comparing initial and final measurements. Results: Eighteen semi-structured interviews and 7 cognitive interviews were conducted, and 4 dermatologists were consulted. The instrument Clinical Evolution-Vitiligo (CV-6) was answered by 119 patients with a minimum of primary schooling. A wide range was observed in the affected body surface; incident and prevalent cases were included. The average time to answer the CV-6 was 3.08 ± 0.58 min. In the test-retest (n = 53), an intraclass correlation coefficient was obtained: 0.896 (95% CI 0.82–0.94; p < 0.001). In extreme groups, the mean score was 2 (2–3) and 5 (4–6); p < 0.001. The initial CV-6 score was different from the final one and the change was verified with VES and VETFa (p < 0.05, n = 92). Conclusions: The CV-6 instrument allows patient collaboration, it is simple and brief, and it makes it easier for the doctor to focus attention on injuries that present changes at the time of medical consultation.

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Hydromechanics of low-Reynolds-number flow. Part 2. Singularity method for Stokes flows

Journal of Fluid Mechanics ◽

10.1017/s0022112075000614 ◽

1975 ◽

Vol 67 (4) ◽

pp. 787-815 ◽

Cited By ~ 300

Author(s):

Allen T. Chwang ◽

T. Yao-Tsu Wu

Keyword(s):

Exact Solutions ◽

Stokes Flow ◽

Fundamental Solutions ◽

The Body ◽

Circular Cylinders ◽

Geometrical Parameters ◽

Flow Problems ◽

Singularity Method ◽

Wide Range ◽

Body Shapes

The present study further explores the fundamental singular solutions for Stokes flow that can be useful for constructing solutions over a wide range of free-stream profiles and body shapes. The primary singularity is the Stokeslet, which is associated with a singular point force embedded in a Stokes flow. From its derivatives other fundamental singularities can be obtained, including rotlets, stresslets, potential doublets and higher-order poles derived from them. For treating interior Stokes-flow problems new fundamental solutions are introduced; they include the Stokeson and its derivatives, called the roton and stresson.These fundamental singularities are employed here to construct exact solutions to a number of exterior and interior Stokes-flow problems for several specific body shapes translating and rotating in a viscous fluid which may itself be providing a primary flow. The different primary flows considered here include the uniform stream, shear flows, parabolic profiles and extensional flows (hyper-bolic profiles), while the body shapes cover prolate spheroids, spheres and circular cylinders. The salient features of these exact solutions (all obtained in closed form) regarding the types of singularities required for the construction of a solution in each specific case, their distribution densities and the range of validity of the solution, which may depend on the characteristic Reynolds numbers and governing geometrical parameters, are discussed.

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A Computational Study on the Role of Parameters for Identification of Thyroid Nodules by Infrared Images (and Comparison with Real Data)

Sensors ◽

10.3390/s21134459 ◽

2021 ◽

Vol 21 (13) ◽

pp. 4459

Author(s):

José R. González ◽

Charbel Damião ◽

Maira Moran ◽

Cristina A. Pantaleão ◽

Rubens A. Cruz ◽

...

Keyword(s):

Heat Transfer ◽

Thyroid Nodules ◽

Numerical Study ◽

Computational Study ◽

Internal Heat ◽

Heat Transfer Process ◽

The Body ◽

Physical Parameters ◽

Infrared Sensors ◽

Wide Range

According to experts and medical literature, healthy thyroids and thyroids containing benign nodules tend to be less inflamed and less active than those with malignant nodules. It seems to be a consensus that malignant nodules have more blood veins and more blood circulation. This may be related to the maintenance of the nodule’s heat at a higher level compared with neighboring tissues. If the internal heat modifies the skin radiation, then it could be detected by infrared sensors. The goal of this work is the investigation of the factors that allow this detection, and the possible relation with any pattern referent to nodule malignancy. We aim to consider a wide range of factors, so a great number of numerical simulations of the heat transfer in the region under analysis, based on the Finite Element method, are performed to study the influence of each nodule and patient characteristics on the infrared sensor acquisition. To do so, the protocol for infrared thyroid examination used in our university’s hospital is simulated in the numerical study. This protocol presents two phases. In the first one, the body under observation is in steady state. In the second one, it is submitted to thermal stress (transient state). Both are simulated in order to verify if it is possible (by infrared sensors) to identify different behavior referent to malignant nodules. Moreover, when the simulation indicates possible important aspects, patients with and without similar characteristics are examined to confirm such influences. The results show that the tissues between skin and thyroid, as well as the nodule size, have an influence on superficial temperatures. Other thermal parameters of thyroid nodules show little influence on surface infrared emissions, for instance, those related to the vascularization of the nodule. All details of the physical parameters used in the simulations, characteristics of the real nodules and thermal examinations are publicly available, allowing these simulations to be compared with other types of heat transfer solutions and infrared examination protocols. Among the main contributions of this work, we highlight the simulation of the possible range of parameters, and definition of the simulation approach for mapping the used infrared protocol, promoting the investigation of a possible relation between the heat transfer process and the data obtained by infrared acquisitions.

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Polymer-Drug Conjugates as Nanotheranostic Agents

Journal of Nanotheranostics ◽

10.3390/jnt2010005 ◽

2021 ◽

Vol 2 (1) ◽

pp. 63-81

Author(s):

Sajana Manandhar ◽

Erica Sjöholm ◽

Johan Bobacka ◽

Jessica M. Rosenholm ◽

Kuldeep K. Bansal

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Treatment Options ◽

The Body ◽

Drug Conjugates ◽

Imaging Characteristics ◽

Wide Range ◽

Systemic Side Effects ◽

Theranostic Agents ◽

The Stability

Since the last decade, the polymer-drug conjugate (PDC) approach has emerged as one of the most promising drug-delivery technologies owing to several benefits like circumventing premature drug release, offering controlled and targeted drug delivery, improving the stability, safety, and kinetics of conjugated drugs, and so forth. In recent years, PDC technology has advanced with the objective to further enhance the treatment outcomes by integrating nanotechnology and multifunctional characteristics into these systems. One such development is the ability of PDCs to act as theranostic agents, permitting simultaneous diagnosis and treatment options. Theranostic nanocarriers offer the opportunity to track the distribution of PDCs within the body and help to localize the diseased site. This characteristic is of particular interest, especially among those therapeutic approaches where external stimuli are supposed to be applied for abrupt drug release at the target site for localized delivery to avoid systemic side effects (e.g., Visudyne®). Thus, with the help of this review article, we are presenting the most recent updates in the domain of PDCs as nanotheranostic agents. Different methodologies utilized to design PDCs along with imaging characteristics and their applicability in a wide range of diseases, have been summarized in this article.

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Age-Dependency of Total Tau in the Cerebrospinal Fluid Is Corrected by Amyloid-β 1–40: A Correlational Study in Healthy Adults

Journal of Alzheimer s Disease ◽

10.3233/jad-210286 ◽

2021 ◽

pp. 1-8

Author(s):

Paul Theo Zebhauser ◽

Achim Berthele ◽

Marie-Sophie Franz ◽

Oliver Goldhardt ◽

Janine Diehl-Schmid ◽

...

Keyword(s):

Cerebrospinal Fluid ◽

Amyloid Β ◽

Healthy Adults ◽

Tau Proteins ◽

Clinical Settings ◽

Inclusion Criteria ◽

Total Tau ◽

Potential Marker ◽

Wide Range ◽

The Relationship

Background: Tau proteins are established biomarkers of neuroaxonal damage in a wide range of neurodegenerative conditions. Although measurement of total-Tau in the cerebrospinal fluid is widely used in research and clinical settings, the relationship between age and total-Tau in the cerebrospinal fluid is yet to be fully understood. While past studies reported a correlation between age and total-Tau in the cerebrospinal fluid of healthy adults, in clinical practice the same cut-off value is used independently of patient’s age. Objective: To further explore the relationship between age and total-Tau and to disentangle neurodegenerative from drainage-dependent effects. Methods: We analyzed cerebrospinal fluid samples of 76 carefully selected cognitively healthy adults and included amyloid-β 1–40 as a potential marker of drainage from the brain’s interstitial system. Results: We found a significant correlation of total-Tau and age, which was no longer present when correcting total-Tau for amyloid-β 1–40 concentrations. These findings were replicated under varied inclusion criteria. Conclusion: Results call into question the association of age and total-Tau in the cerebrospinal fluid. Furthermore, they suggest diagnostic utility of amyloid-β 1–40 as a possible proxy for drainage-mechanisms into the cerebrospinal fluid when interpreting biomarker concentrations for neurodegenerative diseases.

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