SARS-CoV-2 neutralization and serology testing of COVID-19 convalescent plasma from donors with non-severe disease
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AbstractWe determined the antigen binding activity of convalescent plasma units from 47 individuals with a history of non-severe COVID-19 using three clinical diagnostic serology assays (Beckman, DiaSorin, and Roche) with different SARS-CoV-2 targets. We compared these results with functional neutralization activity using a fluorescent reporter strain of SARS-CoV-2 in a microwell assay. This revealed positive correlations of varying strength (Spearman r = 0.37-0.52) between binding and neutralization. Donors age 48-75 had the highest neutralization activity. Units in the highest tertile of binding activity for each assay were enriched (75-82%) for those with the highest levels of neutralization.
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1986 ◽
Vol 164
(5)
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pp. 1809-1814
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2003 ◽
Vol 278
(22)
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pp. 20436-20443
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2020 ◽
pp. 37-42
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2021 ◽
Vol 15
(Supplement_1)
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pp. S501-S501