scholarly journals Detailed Analysis of Surface Infection Barrier on Hands: Relationship with Morbidity to Infection Diseases and Identification of Antimicrobial Components

2020 ◽  
Author(s):  
Yuki Nishioka ◽  
Kenichi Nagano ◽  
Yoshitaka Koga ◽  
Yasuhiro Okada ◽  
Ichiro Mori ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Lactic Acid ◽  
Hand Hygiene ◽  
Infectious Diseases ◽  
Organic Acids ◽  
Comprehensive Analysis ◽  
Hygiene Practices ◽  
History Of ◽  
Highly Correlated ◽  
The Relationship

AbstractAlthough the surface of hands in humans is known to harbor high levels of antimicrobial activity, reports investigating the relationship between antimicrobial activity and morbidity in infectious diseases are lacking. Additionally, the precise components involved in this activity are not known. Therefore, in this study, a method was developed to quantitatively measure the antimicrobial activity of the components found on the surface of hands, which was then compared with the medical history of the participants for infectious diseases. As a result, the antimicrobial activity of the surface of the hands was found to be positively associated with the history of infection in individuals. Furthermore, a comprehensive analysis of the components on the surface of hands indicated that organic acids and antimicrobial peptides are highly correlated with antimicrobial activity. The high amounts of lactic acid found on the surface of hands suggested it is an important factor in the hand surface infection barrier. Here we showed that the application of lactic acid within the range of the amounts present on the hand surface was found to significantly improve the antimicrobial activity of the hands. Taken together, these results demonstrate that this new method can be used to quantify antimicrobial activity, which opens new avenues for the development of hand hygiene practices by enhancing the antimicrobial activity on the surface of hands using natural ingredients against pathogens.

scholarly journals Lactic acid as a major contributor to hand surface infection barrier and its association with morbidity to infectious disease

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yuki Nishioka ◽  
Kenichi Nagano ◽  
Yoshitaka Koga ◽  
Yasuhiro Okada ◽  
Ichiro Mori ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Lactic Acid ◽  
Infectious Diseases ◽  
Positive Association ◽  
Human Hand ◽  
High Morbidity ◽  
Natural Antimicrobial ◽  
History Of ◽  
Medical Histories ◽  
Highly Correlated

AbstractAlthough the surface of the human hands contains high antimicrobial activity, studies investigating the precise components involved and the relationship between natural antimicrobial activity and morbidity in infectious diseases are limited. In this study, we developed a method to quantitatively measure the antimicrobial activity of hand surface components. Using a clinical survey, we validated the feasibility of our method and identified antimicrobial factors on the surface of the human hand. In a retrospective observational study, we compared the medical histories of the participants to assess infectious diseases. We found that the antimicrobial activity on the surface of the hands was significantly lower in the high morbidity group (N = 55) than in the low morbidity group (N = 54), indicating a positive association with the history of infection in individuals. A comprehensive analysis of the hand surface components indicated that organic acids, especially lactic acid and antimicrobial peptides, are highly correlated with antimicrobial activity. Moreover, the application of lactic acid using the amount present on the surface of the hand significantly improved the antimicrobial activity. These findings suggest that hand hygiene must be improved to enhance natural antimicrobial activity on the surface of the hands.

scholarly journals THE RELATIONSHIP OF VITAMIN A SUPPLEMENTATION, GIVING IMMUNIZATION, AND HISTORY OF INFECTION DISEASE WITH THE STUNTING OF CHILDREN AGED 24-59 MONTHS IN PUSKESMAS MULYOREJO, SURABAYA

2021 ◽  
Vol 10 (1) ◽  
pp. 72
Author(s):  
Melvanda Gisela Putri ◽  
Roedi Irawan ◽  
Indri Safitri Mukono
Keyword(s):  
Vitamin A ◽  
Infectious Diseases ◽  
Secondary Data ◽  
Z Score ◽  
Chi Square ◽  
Cross Sectional ◽  
Vitamin A Supplementation ◽  
Chi Square Test ◽  
History Of ◽  
The Relationship

ABSTRAKLatar Belakang: Stunting merupakan suatu istilah yang menggambarkan kondisi pertumbuhan tinggi badan kurang berdasarkan umur disesuaikan dengan Z-Score (<-2SD). Stunting pada balita dapat diakibatkan oleh kurangnya asupan zat gizi yang diperlukan bagi pertumbuhan anak. Penelitian dilakukan untuk mengetahui hubungan suplementasi vitamin A, pemberian imunisasi dan riwayat penyakit infeksi yakni diare dan ISPA terhadap kejadian stunting.Tujuan: Mengetahui hubungan suplementasi vitamin A, pemberian imunisasi, dan penyakit infeksi terhadap stunting pada anak usia 24-59 bulan di Puskesmas Mulyorejo, Surabaya.Metode: Penelitian ini merupakan penelitian analitik observasional dengan metode cross sectional. Besar sampel adalah 107 anak usia 24-59 bulan di Puskesmas Mulyorejo, Surabaya. terdiri dari 25 anak kelompok stunting dan 82 anak kelompok non- stunting. Cara pengambilan data melalui data sekunder posyandu dan wawancara langsung orang tua anak dengan pengisian kuisioner. Data dianalisis menggunakan uji Chi-Square, Fisher Exact, dan Mann Whitney.Hasil: Penelitian ini menunjukkan hasil terdapat hubungan suplementasi vitamin A dengan stunting (p=0,000), tidak ada hubungan antara pemberian imunisasi terhadap stunting (p=0,332). Dalam riwayat penyakit infeksi, frekuensi diare dan ISPA ditemukan tidak ada hubungan dengan  stunting (p=0,053 dan p=0,082), begitu pula pada lama diare dan lama ISPA tidak berhubungan dengan stunting (p= 0,614 dan p=0,918).Kesimpulan: Suplementasi vitamin A berhubungan signifikan dengan stunting yang diamati pada anak usia 24-59 bulan di Puskesmas Mulyorejo, Surabaya. Kata kunci: kejadian stunting, vitamin A, imunisasi, penyakit infeksi, anak usia 24-59 bulanABSTRACTBackground: Stunting is a term that describes condition of lower height-for-age Z-Score (<-2SD). Stunting among children can be caused by a lack of nutrients needed for children's growth. This study was conducted to determine the relationship between vitamin A supplementation, immunization and a history of infectious diseases, namely diarrhea and ARI to the incidence of stunting.Objectives: To determine the relationship between vitamin A supplementation, immunization, and history of infectious disease with the incidence of stunting in children aged 24-59 months at Puskesmas Mulyorejo, Surabaya.Methods: This study was an observational analytic study with cross sectional method. The sample size was 107 children aged 24-59 months at Puskesmas Mulyorejo, Surabaya. This study consisted of 25 children in the stunting group and 82 children in the non-stunting group. The method of data collection was through secondary data from posyandu and direct interviews with parents by filling out questionnaires. Data were analyzed using the chi-square test, fisher exact, and Mann Whitney.Results: The results of this study indicated that there was a relationship between vitamin A supplementation and with stunting (p = 0.000). There was no relationship between immunization and stunting (p = 0.332). In the history of infectious diseases, the frequency of diarrhea and ARI was found to have no relationship with stunting (p = 0.053 and p = 0.082), as well as the duration of diarrhea and duration of ARI there was no association with the stunting (p = 0.614 and p = 0.918).Conclusion: Vitamin A supplementation has significant relationship with stunting in children aged 24-59 months at Puskesmas Mulyorejo, Surabaya.

scholarly journals Hand Hygiene Practices Among Adults with Diabetes Living in Communities: The 2015 Korea Community Health Survey

2019 ◽  
Vol 16 (7) ◽  
pp. 1279
Author(s):  
Mi Ah Han
Keyword(s):  
Hand Hygiene ◽  
Infectious Diseases ◽  
Community Health ◽  
Health Survey ◽  
Diabetes Management ◽  
Comparison Group ◽  
Regression Analyses ◽  
Improve Hand Hygiene ◽  
Hygiene Practices ◽  
Community Health Survey

Hand hygiene is the most effective strategy to prevent infectious diseases. This study investigated and compared the hand hygiene practices of adults with diabetes and an age- and gender-matched comparison group. Adults with diabetes (n = 22,920) who participated in the 2015 Korea Community Health Survey and an appropriate comparison group (n = 22,920) were selected. Descriptive analyses, chi-square tests, and multiple logistic regression analyses were used. Greater than 98% of participants with diabetes recognized that hand hygiene helps prevent infectious diseases. Among participants with diabetes, 84.3%, 82.4%, 72.5%, and 64.1% washed their hands frequently before eating, after using the restroom, after returning from the outdoors, and with soap or hand sanitizer, respectively, but these values were significantly lower than those of the comparison group. After performing multiple regression analyses, treatments for diabetes, being educated about diabetes management and handwashing, and awareness of hemoglobin A1c levels were significantly associated with hand hygiene practices in participants with diabetes. Almost all people with diabetes were aware of the efficacy of hand hygiene, but handwashing rates were significantly lower in people with diabetes than in the comparison group. Considering treatments for diabetes, educational campaigns regarding handwashing, and increasing awareness of handwashing efficacy will help improve hand hygiene in people with diabetes.

scholarly journals A-41 Exploring the Influence of Referral Source on State Anxiety Levels of Concussed Patients

2020 ◽  
Vol 35 (5) ◽  
pp. 637-637
Author(s):  
K Stephenson ◽  
M N Womble ◽  
R J Elbin
Keyword(s):  
State Anxiety ◽  
Statistical Significance ◽  
Urgent Care ◽  
Athletic Trainer ◽  
Referral Source ◽  
State Trait Anxiety Inventory ◽  
Clinical Visit ◽  
History Of ◽  
Highly Correlated ◽  
The Relationship

Abstract Objective To explore the influence of referral source on state anxiety in concussed athletes. Method One hundred thirty athletes (mean age = 16.46, SD = 1.93 yrs; 42% female) seeking care for a concussion at a specialty clinic within 30 days of injury (M = 8.83, SD = 6.12 days) were enrolled in the study. Demographic (e.g., age, sex, and history of anxiety) and referral source (e.g., emergency department/urgent care, primary care/pediatrician, and athletic trainer) information were collected, and the State-Trait Anxiety Inventory (STAI) was administered to all participants. A one-way analysis of variance (ANOVA) was conducted to compare STAI scores between referral groups, and a logistic regression (LR) was used to assess the relationship between referral sources and patients with and without clinical levels of state anxiety (STAI &gt; 40). Statistical significance for all analyses was (p &lt; .05). Results Approximately 25% (32/130) of patients reported a history of anxiety, and 46% (60/130) scored above clinical cutoffs for clinical anxiety. The referral groups did not differ on STAI scores (F(3, 130) = 1.12, p = .34), and the LR was not significant, (χ2(2, N = 130) = 3.75, p = 0.15). Conclusions History of anxiety was highly correlated with state anxiety at the first clinical visit; however, patients referred from different medical sources did not differ on clinical levels of anxiety at the first clinical visit following concussion.

Antimicrobial activity of selected lactic acid cocci and production of organic acids

2012 ◽  
Vol 5 (1) ◽  
pp. 80-85 ◽  
Author(s):  
Zuzana Hladíková ◽  
Jana Smetanková ◽  
Gabriel Greif ◽  
Mária Greifová
Keyword(s):  
Escherichia Coli ◽  
Antimicrobial Activity ◽  
Lactic Acid ◽  
Organic Acids ◽  
Rhizopus Oryzae ◽  
Streptococcus Thermophilus ◽  
Inhibitory Effect ◽  
Penicillium Funiculosum ◽  
Phenyllactic Acid ◽  
Indicator Microorganisms

Antimicrobial activity of selected lactic acid cocci and production of organic acidsAntimicrobial activity and production of organic acids by selected lactic acid bacteria were monitored in this study. The largest antimicrobial activity against indicator microorganisms showed Pediococcus sp. G5, whereasStreptococcus thermophilushad no inhibitory effect. The inhibitory effect ofPediococcussp. G5 was strongest againstBacillus subtilis(17.78 %). Lactococci inhibited the growth ofEscherichia coli, Pseudomonas aeruginosaandStaphylococcus aureus(% of inhibition ≤ 5.25). The growth ofAsperglillus flavus, Penicillium funiculosumandRhizopus oryzaewas not inhibited by all of tested cocci. Cocci produced varying quantities of organic acids (lactic acid, acetic acid, succinic acid, etc.). Lactic acid was in large amounts and phenyllactic acid was produced only byPediococcussp. G5 (49.65 mg/L).

scholarly journals Relationship between the Toothbrushing Behavior and Hand Hygiene Practices of Korean Adolescents: A Study Focused on the 15th Korea Youth Risk Behavior Survey Conducted in 2019

2021 ◽  
Vol 18 (11) ◽  
pp. 5913
Author(s):  
Eun-Jeong Kim ◽  
Hye-Ju Lee
Keyword(s):  
Hand Hygiene ◽  
Risk Behavior ◽  
Oral Hygiene ◽  
Personal Hygiene ◽  
School Type ◽  
Odds Ratios ◽  
Korean Adolescents ◽  
Hygiene Practices ◽  
Youth Risk Behavior ◽  
The Relationship

Hand hygiene is one of the most important measures available to prevent infectious diseases such as COVID-19, and it is recommended that individuals wash their hands periodically before and after meals, after using toilets, before preparing food at home, at schools, and in public places. The aim of this study was to investigate the relationship between oral hygiene and hand hygiene in Korean adolescents. Data from 57,303 adolescents who participated in the 2019 Korea Youth Risk Behavior web-based survey were analyzed to determine the relationship between oral hygiene and hand hygiene. A complex sample logistic regression analysis was performed to determine association between toothbrushing behavior and handwashing practices. According to the results of this study, adolescents who brushed their teeth after lunch were 1.48 times more likely to practice handwashing before lunch than were those who did not brush their teeth after lunch (p < 0.001). In addition, the odds ratios adjusted for gender, grade, school type, and residence were found to be 1.87 (p < 0.001). Moreover, these adjusted odds ratios were higher in students who received personal hygiene education (OR: 1.98, p < 0.001). Oral hygiene practices were found to be related to personal hygiene, as assessed by handwashing, in Korean adolescents. Additional studies are needed to develop ways of improving the hygiene and health of adolescents.

scholarly journals HUBUNGAN ANTARA PEMBERIAN ASI EKSLUSIF DENGAN RIWAYAT PENYAKIT INFEKSI PADA ANAK UMUR 1- 3 TAHUN DI DESA MOPUSI KECAMATAN L OLAYAN KABUPATEN BOLAANG MONGONDOW INDUK

2015 ◽  
Vol 3 (3) ◽  
Author(s):  
Hesty R. Masela ◽  
Shirley Kawengian ◽  
Nelly Mayulu
Keyword(s):  
Infectious Disease ◽  
Developing Countries ◽  
Infectious Diseases ◽  
Exclusive Breastfeeding ◽  
Correlation Method ◽  
Cross Sectional ◽  
History Of ◽  
Cross Sectional Design ◽  
Relationship Of ◽  
The Relationship

Abstract: Infectious diseases are still major problems in many developing countries, including Indonesia. The effectiveness of exclusive breastfeeding is manifested in the reduction of specific disease incidences in infants who receive breast milk compared to formula -fed infants. This study used correlation method with a cross sectional design. Respondents were 90 women who had toddlers (aged less than 3 years) with histories of infectious disesases from September 2014 until Desember 2014. Data were obtained by using questionnaires. The results showed that there were as many as 23 toddlers (26%) with exclusive breastfeeding. History of infectious disease was found in 26 toddlers (28.9%). Regarding the relationship of exclusive breastfeeding with a history of infectious disease (α = 0.05) was found (p) = 0.001 and x2 = 11.883. There was a relationship between breastfeeding with a history of infectious disease in children aged less than 1-3 years in the Mopusi village, Lolayan Bolaang Mongondow Induk.Keywords: exclusive breastfeeding , history of infectious diseases , toddlers .Abstrak: Penyakit infeksi masih merupakan penyakit utama di banyak Negara berkembang, terutama Indonesia. Efektivitas ASI dalam mengendalikan infeksi dapat dibuktikan dengan berkurangnya kejadian beberapa penyakit spesifik pada bayi yang mendapat ASI di banding bayi yang mendapat susu formula. Penelitian ini bertujuan untuk mengetahui hubungan antara pemberian ASI ekslusif dengan riwayat penyakit infeksi pada batita di desa Mopusi kecamatan Lolayan kabupaten Bolaang Mongondow Induk. Penelitian ini menggunakan metode korelasi dengan pendekatan potong lintang. Responden ialah ibu yang memiliki batita dengan riwayat penyakit infeksi sebanyak 90 orang di desa Mopusi pada bulan September 2014-Desember 2014. Pengambilan data dengan menggunakan kuesioner. Hasil penelitian memperlihatkan sebanyak 23 batita (26%) mendapatkan ASI ekslusif. Riwayat penyakit infeksi ditemukan pada 26 batita (28,9%). Mengenai hubungan pemberian ASI ekslusif dengan riwayat penyakit infeksi (α = 0,05) didapatkan p = 0,001 dan x2 = 11,883. Simpulan: Terdapat hubungan antara pemberian ASI dan riwayat penyakit infeksi pada anak umur 1-3 tahun di desa Mopusi kecamatan Lolayan kabupaten Bolaang Mongondow Induk.Kata kunci: ASI ekslusif, riwayat penyakit infeksi, batita

scholarly journals FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN KEJADIAN STUNTING PADA BALITA DI WILAYAH KERJA PUSKESMAS TATAH MAKMUR KABUPATEN BANJAR

2020 ◽  
Vol 4 (1) ◽  
pp. 13
Author(s):  
Nor Isna Tauhidah
Keyword(s):  
Risk Factors ◽  
Infectious Diseases ◽  
Pregnant Women ◽  
Health Center ◽  
Sampling Technique ◽  
Health Centers ◽  
Cross Sectional ◽  
Spearman Rank ◽  
History Of ◽  
The Relationship

ABSTRAK  Stunting merupakan sebuah kondisi di mana tinggi badan anak lebih pendek dibanding tinggi badan anak seusianya. Kejadian anak stunting di Kalimantan Selatan khususnya di Kab Banjar masih berada pada angka kejadian yang sangat tinggi 13.3% dan di Puskesmas Tatah Makmur 38,06%. Penelitian ini bertujuan mengetahui hubungan riwayat penyakit infeksi, riwayat imunisasi dasar, riwayat ASI eksklusif dan pemberian MP-ASI terhadap kejadian stunting pada balita di wilayah kerja Puskesmas Tatah Makmur Kabupaten Banjar.Penelitian ini merupakan survei analitik dengan pendekatan cross sectional. Populasi adalah ibu yang mempunyai balita mengalami stunting di wilayah kerja Puskesmas Tatah Makmur Kecamatan Tatah Makmur Kabupaten Banjar tahun 2018 sebanyak 537 orang. Sampel berjumlah 50 orang dengan teknik pengambilan accidental sampling. Analisis data melalui uji Spearman Rank. Hasil penelitian sebagian besar memiliki riwayat penyakit infeksi sebanyak 26 orang (52%), telah mendapatkan imunisasi lengkap sebanyak 32 orang (64%), pemberian MP-ASI sebagian besar cukup 32 orang (64%), riwayat pemberian ASI parsial 40 orang (80%) dan balita sebagian besar pendek sebanyak 33 orang (66%). Terdapat hubungan riwayat penyakit infeksi, kelengkapan imunisasi, pemberian MP-ASI, riwayat ASI eksklusif dengan kejadian Stunting. Puskesmas hendaknya meningkatkan pemberian informasi kepada ibu hamil tentang faktor yang dapat mempengaruhi terjadinya Stunting sehingga bahwa faktor risiko dapat dikendalikan lebih dini.  Kata Kunci : Imunisasi Dasar, Penyakit Infeksi, Pemberian MP-ASI, ASI eksklusif, Stunting   ABSTRACT   Stunting is a condition in which a person's height turns out to be shorter than the height of another person's age. Stunting in Banjar District by 13.3% and in Tatah Makmur Health Center 38.06%.The purpose of this study was to determine the relationship between infectious diseases and basic immunization against the incidence of stunting in infants in Tatah Makmur Health Center. The study design was an analytic survey with cross sectional approach. The population is mothers who have toddlers stunted in Tatah Makmur Health Center in 2018 as many as 537 people. Samples amounted to 50 people with a purposive sampling technique. Analysis of data through the Spearman Rank.  The results of the study of toddlers mostly have a history of infectious diseases as many as 26 people (52%), have received complete immunization as many as 32 people (64%) and toddlers are mostly short as many as 33 people (66%). There is a relationship between the history of infectious diseases, the completeness of immunization with the incidence of stunting. Health centers should increase the provision of information to pregnant women about factors that influence the occurrence of stunting so that risk factors can be controlled earlier. Keywords: History of Basic Immunization, History of Infectious Diseases, Stunting

scholarly journals XV. Researches on acids of the lactic series.—No. 1. Synthesis of acids of the lactic series

1866 ◽  
Vol 156 ◽  
pp. 309-359 ◽  
Keyword(s):  
Organic Chemistry ◽  
Lactic Acid ◽  
Oxalic Acid ◽  
Organic Acids ◽  
Royal Society ◽  
New Members ◽  
History Of ◽  
The Subject ◽  
Complete History ◽  
General Method

With the exception of the acetic series, no family of organic acids has excited so much interest amongst chemists, and been the subject of such numerous researches, as that represented by lactic acid. Its character, intermediate between the monobasic and dibasic acids, its close relations to the acetic and acrylic families, and the numerous important transformations which it undergoes, have all contributed to render this family an attractive subject for experimental inquiry and a fruitful source of theoretical specu­lation. These inquiries and hypotheses have contributed greatly to the elucidation of the habits of these acids, and still more to the general progress of organic chemistry. Nevertheless there are two circumstances which have materially interfered with their complete success; these are, the comparatively small number of the known members of this series, and the absence of any synthetical proof of the nature of their consti­tuent radicals. These obstacles to a more satisfactory conception of the internal archi­tecture of the acids in question we have endeavoured to remove by the production, according to purely synthetical methods, of a number of new members of this series, a brief notice of which we have from time to time had the honour of submitting to the Royal Society, and the more complete history of which we propose to develope in the following pages. Our general method for synthetically producing the acids of the lactic series depends upon the replacement of one of the atoms of dyad oxygen in oxalic acid, or rather in the ethereal salts of oxalic acid, by two atoms of monad alcohol radicals. Such a replacement at once transforms dibasic oxalic acid into a monobasic acid of the lactic series. The nature of this transformation, as well as the relations of oxalic acid to the lactic family, is clearly seen from the following comparison of the formulae of oxalic acid and of its derivative, dimethoxalic acid.

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