scholarly journals Impact of fenbendazole resistance in Ascaridia dissimilis on the economics of production in turkeys

2021 ◽  
Author(s):  
James Collins ◽  
Brian Jordan ◽  
Anand Vidyashankar ◽  
Pablo Jimenez Castro ◽  
Ray M Kaplan
Keyword(s):  
Post Infection ◽  
Health Management ◽  
Anthelmintic Resistance ◽  
Resistant Isolate ◽  
Parasitic Nematodes ◽  
Intestinal Helminth ◽  
Drug Resistant ◽  
Feed Conversion ◽  
Susceptible Isolate ◽  
The Impact

Feed conversion efficiency is among the most important factors affecting profitable production of poultry. Infections with parasitic nematodes can decrease efficiency of production, making parasite control through the use of anthelmintics an important component of health management. In ruminants and horses, anthelmintic resistance is highly prevalent in many of the most important nematode species, which greatly impacts their control. Recently, we identified resistance to fenbendazole in an isolate of Ascaridia dissimilis, the most common intestinal helminth of turkeys. Using this drug-resistant isolate, we investigated the impact that failure to control infections has on weight gain and feed conversion in growing turkeys. Birds were infected on Day 0 with either a fenbendazole-susceptible or -resistant isolate, and then half were treated with fenbendazole (SafeGuard® Aquasol) at 4- and 8-weeks post infection. Feed intake and bird weight were measured for each pen weekly throughout the study, and feed conversion rate was calculated. Necropsy was performed on birds from each treatment group to assess worm burdens at weeks 7 and 9 post infection. In the birds infected with the susceptible isolate, fenbendazole-treated groups had significantly better feed conversion as compared to untreated groups. In contrast, there were no significant differences in feed conversion between the fenbendazole-treated and untreated groups in the birds infected with the resistant isolate. At both weeks 7 and 9, worm burdens were significantly different between the treated and untreated birds infected with the drug-susceptible isolate, but not in the birds infected with the drug-resistant isolate. These significant effects on feed conversion were seen despite having a rather low worm establishment in the birds. Overall, these data indicate that A. dissimilis can produce significant reductions in feed conversion, and that failure of treatment due to the presence of fenbendazole-resistant worms can have a significant economic impact on turkey production. Furthermore, given the low worm burdens and an abbreviated grow out period of this study, the levels of production loss we measured may be an underestimate of the true impact that fenbendazole-resistant worms may have on a commercial operation.

114 What Is the Impact of Dairy Influence Cattle on the Traditional Beef Industry Structure?

2021 ◽  
Vol 99 (Supplement_1) ◽  
pp. 38-39
Author(s):  
Bradley J Johnson ◽  
Luke Fuerniss
Keyword(s):  
Dairy Cows ◽  
Dairy Herd ◽  
The United States ◽  
Reproductive Technologies ◽  
Industry Structure ◽  
Data Availability ◽  
Beef Production ◽  
Feed Conversion ◽  
Beef Industry ◽  
The Impact

Abstract The U.S. cow inventory includes approximately 31 million beef cows and 9 million dairy cows, so flow of cattle from dairies into beef production influences the traditional beef industry structure. Dairy-influenced cattle have historically entered the beef supply chain as cull cows and calf-fed Holstein steers. Culled dairy cows account for approximately half of the cows harvested in the United States annually. Fed steers and heifers of dairy influence are estimated to account for 15% of annual steer and heifer slaughter. Advancements in data availability, genomics, and reproductive technologies have enabled more precise selection of dairy replacement heifers and more pregnancies to be allocated to a terminal sire. Recently, the use of beef semen to breed dairy cows that are not desirable for producing replacement heifers has become more widespread. Beef-on-dairy calves are often moved to calf ranches shortly after birth where they are weaned and grown before transitioning to traditional grow yards or feedlots. In comparison to traditional range beef production, calves of dairy origin are weaned at a younger age, have more restricted mobility early in life, and are fed a delivered ration for a greater number of days. While carcasses of dairy-originated fed cattle excel in subcutaneous leanness and marbling, calves originating from dairies typically experience greater morbidity, poorer feed conversion, and poorer dressed yields compared to native fed cattle. Future opportunities to optimize beef production from the dairy herd include refining sire selection to consistently produce high quality calves, reducing variation in calfhood management, and identifying optimal nutrition and growth technology programs for calves from dairies.

scholarly journals Application of Nematode Community Analyses-Based Models towards Identifying Sustainable Soil Health Management Outcomes: A Review of the Concepts

Soil Systems ◽  
2021 ◽  
Vol 5 (2) ◽  
pp. 32
Author(s):  
Haddish Melakeberhan ◽  
Gregory Bonito ◽  
Alexandra N. Kravchenko
Keyword(s):  
Nutrient Cycling ◽  
Health Management ◽  
Management Strategies ◽  
Soil Health ◽  
Agricultural Practices ◽  
Nematode Community ◽  
Parasitic Nematodes ◽  
Worst Case ◽  
Pests And Diseases ◽  
Water Holding

Soil health connotes the balance of biological, physicochemical, nutritional, structural, and water-holding components necessary to sustain plant productivity. Despite a substantial knowledge base, achieving sustainable soil health remains a goal because it is difficult to simultaneously: (i) improve soil structure, physicochemistry, water-holding capacity, and nutrient cycling; (ii) suppress pests and diseases while increasing beneficial organisms; and (iii) improve biological functioning leading to improved biomass/crop yield. The objectives of this review are (a) to identify agricultural practices (APs) driving soil health degradations and barriers to developing sustainable soil health, and (b) to describe how the nematode community analyses-based soil food web (SFW) and fertilizer use efficiency (FUE) data visualization models can be used towards developing sustainable soil health. The SFW model considers changes in beneficial nematode population dynamics relative to food and reproduction (enrichment index, EI; y-axis) and resistance to disturbance (structure index, SI; x-axis) in order to identify best-to-worst case scenarios for nutrient cycling and agroecosystem suitability of AP-driven outcomes. The FUE model visualizes associations between beneficial and plant-parasitic nematodes (x-axis) and ecosystem services (e.g., yield or nutrients, y-axis). The x-y relationship identifies best-to-worst case scenarios of the outcomes for sustainability. Both models can serve as platforms towards developing integrated and sustainable soil health management strategies on a location-specific or a one-size-fits-all basis. Future improvements for increased implementation of these models are discussed.

scholarly journals 1457. Serial Passage of Enterobacteriaceae to Explore Development of Carbapenem Resistance

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S731-S731
Author(s):  
Yosef Nissim ◽  
Douglas Slain ◽  
P Rocco LaSala
Keyword(s):  
Susceptibility Testing ◽  
Klebsiella Oxytoca ◽  
Carbapenem Resistance ◽  
Serial Passage ◽  
Resistant Isolate ◽  
Mueller Hinton ◽  
The Us ◽  
Zones Of Inhibition ◽  
Mueller Hinton Agar ◽  
The Impact

Abstract Background Carbapenems are broad-spectrum antibacterials that have seen increased usage for the Enterobacteriales family in recent years. While carbapenem usage has been associated with increased antibacterial resistance, there is currently a lack of data comparing the risk of reduced susceptibility selection by the two most commonly used carbapenems in the US, ertapenem (ERT) and meropenem (MER). We conducted a novel serial passage experiment with clinical isolates of Enterobacteriales to assess the impact of repeated exposure to ERT or MER on phenotypic susceptibility patterns. Methods Non-duplicate clinical Enterobacteriales isolates were selected randomly for inclusion. Antimicrobial susceptibility testing was performed by CLSI disc diffusion methods. Standardized suspensions of isolates were plated on Mueller-Hinton agar, and ERT (10mcg) and MER (10mcg) discs applied. Zones of inhibition were measured and recorded after 16-18 hours incubation. Growth from the innermost zone of inhibition around each disc was used to prepare subsequent suspensions for serial susceptibility testing. This process would be repeated daily for 10 days. Each subsequent serially-passaged isolated was tested against both ERT and MER. Daily zones of inhibition were measured and interpreted. Baseline & final susceptibilities were determined by automated methods (Vitek 2). Results Seventeen Enterobacteriaceae isolates were selected, including: Klebsiella pneumoniae (n=11), Klebsiella oxytoca (n=2), Escherichia coli (n=1), Morganella morganii (n=1), and Enterobacter cloacae (n=2). Despite a greater degree of reductions in zones of inhibition with repeated ERT exposure (vs MER), the overall 10 day trends were not found to be significant different (P=0.529). Resistance developed to ERT in six isolates compared to one MER-resistant isolate (P = 0.053). E. cloacae was the only species to show a significant change between drugs (P=0.010). Two of three isolates that developed reduced zone changes > 10mm to MER were initially exposed to ERT on an earlier plate. Conclusion This novel experiment identified the development of some nonsignificant reductions in susceptibility with ERT after serial exposure. Results from this pilot study should encourage larger well-designed studies in this area. Disclosures All Authors: No reported disclosures

scholarly journals Cost-Effectiveness of Black Soldier Fly Larvae Meal as Substitute of Fishmeal in Diets for Layer Chicks and Growers

2021 ◽  
Vol 13 (11) ◽  
pp. 6074
Author(s):  
Esther Khayanga Sumbule ◽  
Mary Kivali Ambula ◽  
Isaac Maina Osuga ◽  
Janice Ghemoh Changeh ◽  
David Miano Mwangi ◽  
...  
Keyword(s):  
Weight Gain ◽  
Live Weight ◽  
Daily Weight Gain ◽  
Feed Conversion ◽  
Alternative Source ◽  
Black Soldier Fly ◽  
Promising Alternative ◽  
Black Soldier Fly Larvae ◽  
Fly Larvae ◽  
The Impact

The acceptance of eco-friendly black soldier fly larvae meal (BSFLM) as sustainable alternative protein ingredient in poultry feeds continues to gain momentum worldwide. This study evaluates the impact of BSFLM in layer chick and grower diets on the growth, carcass quality and economic returns. Mean weekly weight gain and total live weight per chick and grower varied significantly. The highest final weight gain was achieved when birds were provided diet with 25.6% BSFLM. Average daily feed intake (ADFI), average daily weight gain (ADG) and overall weight gain of the chick varied significantly, except for the feed conversion ratio (FCR). For grower birds, ADFI, ADG, FCR and overall weight gain did not vary significantly across the various feeding regimes. The weight of the wings and drumsticks had a quadratic response with a maximum weight obtained at 33% inclusion of BSFLM. The weight of the internal organs were not significantly affected by dietary types. Positive cost–benefit ratio and return on investment was recorded for diet types with higher BSFLM inclusion levels (>75%). Diets with 25% and 100% BSFLM inclusion were the most suitable and cost-effective, respectively. Thus, BSFLM represents a promising alternative source of protein that could be sustainably used in the poultry industries.

The role of plant-parasitic nematodes in reducing yield of sugarcane in fine-textured soils in Queensland, Australia

2007 ◽  
Vol 47 (5) ◽  
pp. 620 ◽  
Author(s):  
B. L. Blair ◽  
G. R. Stirling
Keyword(s):  
Growth And Yield ◽  
Parasitic Nematodes ◽  
Plant Parasitic Nematodes ◽  
Root Knot Nematode ◽  
Population Densities ◽  
Lesion Nematode ◽  
Yield Responses ◽  
The Impact ◽  
Stalk Length ◽  
Plant Parasitic

Damage to sugarcane caused by root-knot nematode (Meloidogyne spp.) is well documented in infertile coarse-textured soils, but crop losses have never been assessed in the fine-textured soils on which more than 95% of Australia’s sugarcane is grown. The impact of nematodes in these more fertile soils was assessed by repeatedly applying nematicides (aldicarb and fenamiphos) to plant and ratoon crops in 16 fields, and measuring their effects on nematode populations, sugarcane growth and yield. In untreated plant crops, mid-season population densities of lesion nematode (Pratylenchus zeae), root-knot nematode (M. javanica), stunt nematode (Tylenchorhynchus annulatus), spiral nematode (Helicotylenchus dihystera) and stubby-root nematode (Paratrichodorus minor) averaged 1065, 214, 535, 217 and 103 nematodes/200 mL soil, respectively. Lower mean nematode population densities were recorded in the first ratoon, particularly for root-knot nematode. Nematicides reduced populations of lesion nematode by 66–99% in both plant and ratoon crops, but control of root-knot nematode was inconsistent, particularly in ratoons. Nematicide treatment had a greater impact on shoot and stalk length than on shoot and stalk number. The entire community of pest nematodes appeared to be contributing to lost productivity, but stalk length and final yield responses correlated most consistently with the number of lesion nematodes controlled. Fine roots in nematicide-treated plots were healthier and more numerous than in untreated plots, and this was indicative of the reduced impact of lesion nematode. Yield responses averaged 15.3% in plant crops and 11.6% in ratoons, indicating that nematodes are subtle but significant pests of sugarcane in fine-textured soils. On the basis of these results, plant-parasitic nematodes are conservatively estimated to cost the Australian sugar industry about AU$82 million/annum.

scholarly journals The effects of flubendazole and its metabolites on the larval development of Haemonchus contortus (Nematoda: Trichostrongylidae): an in vitro study

2010 ◽  
Vol 47 (4) ◽  
pp. 269-272 ◽  
Author(s):  
H. Bártíková ◽  
L. Skálová ◽  
J. Lamka ◽  
B. Szotáková ◽  
M. Várady
Keyword(s):  
Larval Development ◽  
Haemonchus Contortus ◽  
Anthelmintic Activity ◽  
In Vitro Study ◽  
Lethal Concentration ◽  
Resistant Isolate ◽  
Susceptible Isolate ◽  
Marked Resistance ◽  
Larval Development Test

AbstractThe anthelmintic effects of flubendazole (FLU), its two main metabolites reduced flubendazole (FLU-R) and hydrolyzed flubendazole (FLU-H), and thiabendazole (TBZ) were compared using an in vitro larval development test in two isolates of Haemonchus contortus, a fully susceptible isolate (HCS) and a multi-resistant isolate (HCR). Results were quantified as 50 % lethal concentration (LC50), 99 % lethal concentration (LC99), efficacy factor (EF), and resistance factor (RF). For HCS, both LC50 and LC99 of FLU were lower than those of the reference TBZ. The anthelmintic activity of FLU-R in HCS and HCR was 13 and 6 times lower than the activity of FLU, respectively. The anthelmintic activity of FLU-H was negligible (approximately 363–853 times lower) compared to that of FLU. Although a marked resistance of the HCR isolate to TBZ was confirmed, only a low tolerance to FLU-R and slightly higher tolerance to FLU were found.

scholarly journals Prospects of Using High-Throughput Proteomics to Underpin the Discovery of Animal Host–Nematode Interactions

Pathogens ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 825
Author(s):  
Tao Wang ◽  
Robin Gasser
Keyword(s):  
Mass Spectrometry ◽  
High Throughput ◽  
Anthelmintic Resistance ◽  
Nematode Species ◽  
Economic Losses ◽  
Future Research ◽  
Parasitic Nematodes ◽  
Public Health Burden ◽  
Host Parasite Interactions ◽  
Host Parasite

Parasitic nematodes impose a significant public health burden, and cause major economic losses to agriculture worldwide. Due to the widespread of anthelmintic resistance and lack of effective vaccines for most nematode species, there is an urgent need to discover novel therapeutic and vaccine targets, informed through an understanding of host–parasite interactions. Proteomics, underpinned by genomics, enables the global characterisation proteins expressed in a particular cell type, tissue and organism, and provides a key to insights at the host–parasite interface using advanced high-throughput mass spectrometry-based proteomic technologies. Here, we (i) review current mass-spectrometry-based proteomic methods, with an emphasis on a high-throughput ‘bottom-up’ approach; (ii) summarise recent progress in the proteomics of parasitic nematodes of animals, with a focus on molecules inferred to be involved in host–parasite interactions; and (iii) discuss future research directions that could enhance our knowledge and understanding of the molecular interplay between nematodes and host animals, in order to work toward new, improved methods for the treatment, diagnosis and control of nematodiases.

HR Management in Russia: concepts of a new Normality. Book 8

2021 ◽  
Author(s):  
Yuliya Dolzhenkova ◽  
Galina Rudenko ◽  
Fedor Mihaylov ◽  
Svetlana Sotnikova ◽  
Anatoliy Zhukov ◽  
...  
Keyword(s):  
Personnel Management ◽  
Health Management ◽  
Well Being ◽  
Teaching Staff ◽  
Economic Determinants ◽  
Higher Education System ◽  
Statics And Dynamics ◽  
The Impact ◽  
Labor Success ◽  
Main Factor

The monograph contains the results of research, systematized in five groups. The first group is presented with information about the current vectors of the development of the personnel management system, the harmonization of its statics and dynamics, the benchmarking of human resources, the impact of personnel management on the growth of labor productivity as the main factor of efficiency. The content of the second group is the specifics of health management in the workplace. The third group presents issues of social well-being and social interaction of employees, najing, and corporate remuneration. The fourth group includes the problems of personnel aging, the biological and socio-economic determinants of the phenomenon, and the idea of maintaining labor success. The content of the fifth group focuses on the representation of parental labor, as well as the readiness of the domestic higher education system to respond to the requirements of the modern economy and perceive it as a new normality. For postgraduates, undergraduates, students, researchers who are engaged in research in the field of personnel management, as well as the teaching staff of universities and employers.

Patient Segmentation Based on Patient Loyalty

2018 ◽  
Vol 20 (4) ◽  
pp. 508-534
Author(s):  
Remedios Calero ◽  
Carlota Lorenzo ◽  
Martina G. Gallarza
Keyword(s):  
Health Care ◽  
Health Management ◽  
Health Care Financing ◽  
Secondary Data ◽  
Patient Loyalty ◽  
Health Council ◽  
Patient Segmentation ◽  
Patient Profiles ◽  
The One ◽  
The Impact

The present study aims to perform a segmentation of patients based on their loyalty behaviour. The analysis focuses on Valencia, a region in Spain that features a capitated financing and free-elective framework; such a framework is particularly suitable for this type of study because patient loyalty directly affects the system’s budget and economic viability. Using secondary data from the regional health council, the study focuses on relationships of influence and latent segmentation in answering seven research questions. The two-pronged statistical analysis is designed to analyse relationships of influence, on the one hand, and latent segmentation, on the other. Significant differences were found among the various scales analysed in the three patient loyalty behavioural models (capture, retention and desertion) for each variable within the scope, that is, subjective (gender, age and nationality) and circumstantial (size of the assigned and receiving hospital, location of the province of the assigned hospital). This finding indicates that it may be possible to develop patient profiles based on such variables to analyse different loyalty behaviours in patients and the impact of hospital communication strategies on these behaviours. Patient loyalty is essential to the viability of a capitated health care financing and management system. Likewise, identifying patient profiles would contribute to a better Valencian public health management. Accordingly, it might be applied to evaluate other health care financing systems.

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