scholarly journals The IPF fibroblastic focus is an active collagen biosynthesis factory embedded in a distinct extracellular matrix

2021 ◽  
Author(s):  
Jeremy A. Herrera ◽  
Lewis Dingle ◽  
M. Angeles Montero ◽  
Rajesh Shah ◽  
Rajamiyer V. Venkateswaran ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Surrounding Tissue ◽  
Collagen Biosynthesis ◽  
Qualitative And Quantitative Analysis ◽  
Essential Information ◽  
Main Site ◽  
Qualitative And Quantitative ◽  
End Stage ◽  
And Function ◽  
Laser Capture

Background: The Fibroblastic Focus (FF) is the signature lesion of Idiopathic Pulmonary Fibrosis (IPF) where myofibroblasts accumulate and extracellular matrix (ECM) is produced. However, the molecular composition and function of the FF and surrounding tissue remain undefined. Methods: Utilizing laser capture microdissection coupled mass spectrometry (LCM-MS), we interrogated the FF, adjacent mature scar, and adjacent alveoli in 6 IPF specimens plus 6 non-fibrotic alveolar specimens as controls. The data were subject to qualitative and quantitative analysis, and validation by immunohistochemistry. Results: We found that the protein signature of IPF alveoli is defined by immune deregulation as the strongest category. The IPF mature scar was classified as end-stage fibrosis whereas the FF contained an overabundance of a distinctive ECM compared to non-fibrotic control. Conclusion: Spatial proteomics demonstrated distinct protein compositions in the histologically defined regions of IPF tissue. These data revealed that the FF is the main site of collagen biosynthesis and that the alveoli adjacent to the FF are abnormal. This new and essential information will inform future mechanistic studies on mechanisms of IPF progression.

Designing a business unit and creating the first ever responsive kitchen

2019 ◽  
Vol 2 (1) ◽  
Author(s):  
Paolo FESTA ◽  
Tommaso CORA ◽  
Lucilla FAZIO
Keyword(s):  
Value Creation ◽  
Product Innovation ◽  
Research Laboratory ◽  
Direct Relationship ◽  
Multidisciplinary Approach ◽  
Design Thinking ◽  
Business Unit ◽  
Qualitative And Quantitative Analysis ◽  
Qualitative And Quantitative ◽  
The Relationship

Is it possible to transform stone into a technological and innovative device? The meeting with one of the main stone transformers in Europe produced the intention of a disruptive operation that could affect the strategy of the whole company. A contagious singularity. By intertwining LEAN methodologies and the human-centric approach of design thinking, we mapped the value creation in the company activating a dialogue with the workers and the management, listening to people, asking for ambitions, discovering problems and the potential of production. This qualitative and quantitative analysis conducted with a multidisciplinary approach by designers, architects and marketing strategists allowed us to define a new method. We used it to design a platform that could let all the players express their potential to the maximum. This is how the group's research laboratory was born, with the aim of promoting the relationship between humans and stone through product innovation. With this goal, we coordinated the new team, developing technologies that would allow creating a more direct relationship between man and surface, making the stone reactive. The result was the first responsive kitchen ever.

ANALISIS FAKTOR TINGKAT PENDIDIKAN DAN KOMPETENSI SUMBER DAYA MANUSIA TERHADAP PRODUKTIVITAS KERJA KARYAWAN PADA PT. TRAKTOR NUSANTARA CABANG LAMPUNG

2017 ◽  
Vol 2 (1) ◽  
pp. 46-63
Author(s):  
Raditee Sanusi Husin
Keyword(s):  
Work Productivity ◽  
Positive Influence ◽  
Education Level ◽  
Observation Data ◽  
Employee Productivity ◽  
Qualitative And Quantitative Analysis ◽  
Employee Education ◽  
Level Of Education ◽  
Qualitative And Quantitative ◽  
Level Variable

Achievement of company goals, PT. Traktor Nusantara often faces problems, where from within and from outside the company. One of the problems that comes from within the company in relation to human resources is the level of work productivity of employees who are still far from expectation. This is allegedly caused by the level of employee education that has not been in accordance with the function of office, in addition to the competence of employees who have not been in accordance with the field of work. This study aims to determine the influence of education level and competence on employee productivity. The sample used is 22 employees. Data collection techniques with questionnaires, documentation and observation. Data analysis with qualitative and quantitative analysis methods with the help of statistical tools SPSS application for linear regression model calculation. The results showed that the level of education has a positive influence on the productivity of employees of PT. Traktor Nusantara. The amount of influence of education level variable to productivity based on test of determination is equal to 38,1%. Competence influence on work productivity of employees of PT. Traktor Nusantara with contribution of 19.1%. The level of education and competence together have a positive influence and able to explain 38.2% of the changes in work productivity, while the remaining 4.7% sebesat is another variable outside the study.

MEMIKAT HATI WAJIB PAJAK SEHINGGA MEMILIKI WILLINGNESS TO COMPLY MELALUI PENYULUHAN PAJAK BERDASARKAN FOGG BEHAVIORAL MODEL

INFO ARTHA ◽  
2017 ◽  
Vol 2 ◽  
pp. 56-79
Author(s):  
NFN Khusnaini ◽  
Agung Widi Hatmoko
Keyword(s):  
Data Analysis ◽  
Quantitative Analysis ◽  
Statistical Data ◽  
Tax Compliance ◽  
Behavioral Model ◽  
Control Group ◽  
Qualitative And Quantitative Analysis ◽  
Qualitative And Quantitative ◽  
Quasi Experimental ◽  
Experimental Process

Attitudes towards tax compliance (willingness to comply) Indonesian society is still low. Required an innovative tax dissemination to increase it. The purpose of this study was to determine whether the tax dissemination based on Fogg Behavioral Model (FBM) approach may increase wiliingness to comply. The FBM based tax dissemination asserts that for a person to perform a target behavior, which is a willingness to comply, he or she must be sufficiently motivated, have the ability to perform the behavior, and be trigerred, to perform the behavior. This research is a combination of qualitative and quantitative analysis of statistical data results of the questionnaire, interviews, and observations of the respondent and the experimental process of dissemination. The method used in this study is a quasi experimental with patterns of nonequivalent control group (pretest-post which is not equivalent). Based on the results of data analysis, interviews and observations of the respondent and the experiment, this research showed that theFBMbasedtaxdissemination hasapositiveimpactto willingnesstocomplyofthetaxpayers. 

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